• 한국임상수의학회지
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• 제24권3호
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• pp.358-366
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• 2007

This study was performed to investigate the application of bovine amniotic membrane for canine corneal ulcer and to compare bovine amniotic membrane flap to nictitating membrane flap. Corneas were treated with 8.0mm trephine and 100% ethanol was applied and corneal epithelium was removed. This experiment was divided into three groups; control group, nictitating membrane flap group and amniotic membrane + nictitating membrane flap group. To compare corneal healing, fluorescein dye test, histopathological examination and TUNEL assay were performed. The healing size of the corneal epithelium in was largest among groups and it was significantly different with the other groups (P<0.05). Also, inflammatory cell deposits and keratocyte apoptosis in amniotic membrane flap group were smallest, but the width of the corneal epithelium was thickest among groups. Therefore, we tentatively predicted that the amniotic membrane flap would be an alternative effective method for the treatment of superficial canine corneal ulcer.

• 한국임상수의학회지
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• 제23권3호
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• pp.334-336
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• 2006

1.6년령 암컷 시쮸가 좌안에 각막천공, 데스메막류 및 심한 melting ulcer를 나타냈다. 손상된 각막에 소에서 유래한 양막을 이식하고 동시에 제3안검판을 실시하였다. 14일후에 제 3안검판을 제거하고 각막은 형광염색 음성을 보였다. 수술 후 42일째 각막 중앙에 중등도의 반흔이 존재하였고 10개월 후 각막은 거의 투명하였으며 가벼운 반흔만이 나타났다.

• 한국임상수의학회지
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• 제32권4호
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• pp.356-358
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• 2015

큰 크기의 각막천공에 안내용물 손상이 된 눈을 안구적출술을 시도하지 않고, 안구내용물적출술과 실리콘볼 삽입후 각막이식을 적용하여 치료하여 안구적출술보다 미용상 만족한 눈의 외관을 얻은 증례를 소개 하였다.

• 대한수의학회지
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• 제60권4호
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• pp.229-232
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• 2020

A 15-year-old, spayed, female American shorthair cat presented with recurrent corneal sequestrum in the right eye. The cat had undergone superficial keratectomy twice for corneal sequestrum treatment 5 and 11 months previously. Two layers of porcine small intestinal submucosa (SIS; Vetrix BioSIS®) were applied to the surgical corneal defect after keratectomy. Thereafter, clinical signs, such as lacrimation, blepharospasm, and corneal ulcer, disappeared 50 days postoperatively. Moreover, the application of SIS with keratectomy prevented recurrence until 651 days after surgery. SIS could be applied as an additional bioscaffold for surgical repair of corneal sequestrum recurring after superficial keratectomy alone in cats.

• 한국임상수의학회지
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• 제36권1호
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• pp.88-92
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• 2019

A 6-month-old male thoroughbred foal with melting ulcer after left eye trauma was referred to Equine Hospital of Jeju National University. The left eye did not respond to the menace reflex test. Bacteria were not observed on corneal smear and culture test, and fluorescein staining revealed corneal injury. Subpalpebral Lavage (SPL) catheter was installed through the upper left eyelid. And the antibiotics, mydriatic and antifungal agents were administered using SPL. In addition, temporary tarsorrhaphy was performed and a hard cup hood was applied. After 2 weeks, the temporary tarsorrhaphy was removed and severe corneal neovascularization was found. On the 39th day of treatment, the left eye was responding to the menace reflex test and granular tissue formation was confirmed in the ulcer area. During the 2 months follow-up, we found that the granulation tissues decreased significantly. This case report describes a successful recovery of severe melting ulcers in a foal by intensive treatment.

• Journal of Veterinary Science
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• 제24권2호
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• pp.30.1-30.6
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• 2023

A 4-year-old Chihuahua dog was referred for bilateral corneal ulcers. Slightly raised white fluorescein-positive plaque-like corneal lesions in both eyes appeared as intense hyperreflective areas with posterior shadowing on optical coherence tomography (OCT). Based on corneal cytology and culture, Candida albicans-induced fungal keratitis was diagnosed. Despite treatment, on OCT, endothelial plaques, increased stromal infiltration thickness, vertical shapes of the ulcer edge, and necrotic stromal space were judged to be aggravation of the disease, and surgery was performed. Conjunctival grafting surgery with topical 1% voriconazole effectively resolved fungal keratitis. OCT can provide detailed and objective information related to the disease prognosis.

• 한국컴퓨터정보학회논문지
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• 제27권9호
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• pp.1-12
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• 2022

안과 환자의 질병을 판단하기 위해서는 특수 촬영 장비를 통해 찍은 안구영상을 이용한 안과의사의 주관적 판단의 개입이 전통적으로 활용되고 있다. 본 연구에서는 안과 의료진이 질병을 판단할 때 보조적 도움이 될 수 있도록 객관적 진단결과를 제시해주는 각막궤양 의미론적 분할방법에 대하여 제안하였다. 이를 위해 DeepLab 모델을 활용하였고 그 중 Backbone network으로 Xception과 ResNet 네트워크를 이용하였다. 실험결과를 나타내기 위한 평가지표로 다이스 유사계수와 IoU 값을 이용하였고 ResNet101 네트워크를 사용하였을 때 'crop & resized' 이미지에 대해 최대 평균 정확도 93%의 다이스 유사계수 값을 보였다. 본 연구는 객체 검출을 위한 의미론적 분할모델 또한 안구의 각막궤양 부분과 같은 불규칙하고 특이한 모양을 추출하고 분류하는데 뛰어난 결과를 도출할 수 있는 성능을 보유하고 있음을 보여주었다. 향후 학습용 Dataset을 양적으로 보강하여 실험결과의 정확도를 제고할 수 있도록 하고 실제 의료진단 환경에서 구현되어 사용되어 질 수 있도록 할 계획이다.

• 한국임상수의학회지
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• 제40권2호
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• pp.152-157
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• 2023

A two-year-old, spayed female, Bichon Frise, was referred for severe corneal edema and corneal ulcer in the left eye (OS). The cornea had gradually swelled over one week after phacoemulsification performed a month prior, and that was refractory to 5% sodium chloride eye drop instillation or temporary partial tarsorrhaphy. A complete ophthalmic examination was performed. Severe corneal edema with intrastromal bullae and moderate anterior chamber flare was found on slit-lamp biomicroscopy in the OS, which obstructed the fundus examination. Corneal thickness was measured using high-resolution ultrasound biomicroscopy. The thickness of the OS cornea was 2.74 mm. The "letter-box" conjunctival flap was planned. Dorsal and ventral superficial keratectomy followed by a hood conjunctival flap was performed. Topical and systemic antibiotics and 5% sodium chloride eye drops were prescribed. Decreased corneal thickness was observed at one week, two weeks, and two months postoperatively (1.53 mm, 1.32 mm, and 0.92 mm, respectively). There were no postoperative complications, such as ocular discomfort or recurrent corneal ulcers. The "letter-box" conjunctival flap, a type of superficial keratectomy and conjunctival advancement hood flap, effectively relieved the severe irreversible corneal edema. This could be a simple but effective surgical intervention for patients with endothelial cell damage especially after phacoemulsification.

• 한국임상수의학회지
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• 제30권1호
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• pp.41-44
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• 2013

4년령 중성화한 수컷 시츄견이 우안에 녹는 궤양이라는 기왕력으로 전북동물의료센터에 내원했다. 안과 검사결과 우안에 각막 전체의 70%에 해당하는 각막 연화를 동반한 각막 천공이 관찰되었다. 또한 홍채 탈출과 섬유소 응괴가 각막 천공 중앙부에서 관찰되었다. 좌안의 위협 반사와 대광 반사는 정상이었다. 각막 결손 부위가 너무 컸기 때문에 각결막 판을 이용한 방법이나 각막 직접 봉합을 배제하였으며 말양막이식술을 시행하기로 결정했다. 말양막은 각막 윤부에 전체 각막을 다 덮을 수 있도록 9-0 나일론 봉합사를 이용하여 봉합을 실시했다. 양막이식 후 79일 째 육아조직과 색소침착이 다소 남아있었으나 우안의 위협 반사와 눈부심 반사는 모두 정상이었다. 비록 색소 침착과 육아조직이 각막에 남아있기는 했지만 개에서 말양막이식술은 녹는 궤양으로 기인한 각막 천공에서 시행해 볼 수 있는 유용한 치료법으로 생각된다.

• 한국임상수의학회지
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• 제38권3호
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• pp.115-119
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• 2021

This study was designed to investigate the characteristics of corneal ulcers in dogs with chronic kidney disease (CKD). Medical records of dogs that had been diagnosed with corneal ulcers and chronic kidney disease at Haemaru Referral Animal Hospital between April 1, 2011 and March 31, 2016 were investigated. A control group was randomly selected during the same time period. This group included patients with corneal ulcers but no evidence of systemic disease. The mean healing time of superficial corneal ulcers in the CKD group was 21.0 ± 15.0 days. This was a significantly longer healing time than was observed in the control group (11.0 ± 6.6 days, p = 0.019). The incidence rates of uveitis and keratoconjunctivitis sicca in the CKD group were significantly higher than in the control group (p = 0.000 and p = 0.026, respectively). Additionally, non-healing ulcers had significantly elevated white blood cell counts, while those with healing ulcers had WBC counts within the normal range in CKD group (p = 0.000). This study revealed that corneal ulcers in CKD patients would be delayed epithelial healing process and accompanied by ocular disease which affected to corneal healing compared to non-CKD patients.