• Journal of Microbiology
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• 제37권2호
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• pp.90-96
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• 1999

The core protein of the hepatitis C virus (HCV) is a multifunctional protein. The HCV core protein was reported to regulate cellular gene expression and transform primary rat embryo fibroblast cells. However, the role of the core protein in the pathogenesis of HCV-associated liver diseases is not well understood. To investigate the functional role of the core protein in cytophathogenicity, we have constructed stable expression systems of full length or truncated HCV core protein lacking the C-terminal hyderophobic domains and established HepG2 cell clones constitutively expressing the core protein. The full length core protein was localized in the cytoplasm and the C-terminal truncated core protein was localized in the nucleus. HepG2 cells expressing nuclear, truncated core protein showed elevated cell death during cultivation compared to untransfected cells and full length core-expressing cells. In the treatment with bleomycin, both cell clones expressing full length or truncated core protein appeared to be more sensitive to blemoycin than the parental HepG2 cells. These results suggest that the core protein may play a role in HCV pathogenesis promoting apoptotic cell death of infected cells.

• BMB Reports
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• 제37권6호
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• pp.735-740
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• 2004

Hepatitis C virus (HCV) is a causal agent of the chronic liver infection. To understand HCV morphogenesis, we studied the assembly of HCV structural proteins in insect cells. We constructed recombinant baculovirus expression vectors consisting of either HCV core alone, core-E1, or core-E1-E2. These structural proteins were expressed in insect cells and were examined to assemble into particles. Neither core-E1 nor core-E1-E2 was capable of assembling into virus-like particles (VLPs). It was surprising that the core protein alone was assembled into core-like particles. These particles were released into the culture medium as early as 2 days after infection. In our system, HCV structural proteins including envelope proteins did not assemble into VLPs. Instead, the core protein itself has the intrinsic capacity to assemble into amorphous core-like particles. Furthermore, released core particles were associated with HCV RNA, indicating that core proteins were assembled into nucleocapsids. These results suggest that HCV may utilize a unique core release mechanism to evade the hosts defense mechanism, thus contributing to the persistence of HCV infection.

• 한국지능시스템학회논문지
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• 제21권2호
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• pp.276-282
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• 2011

CoreNet은 한-중-일 다국어 텍스트의 분석, 언어 간 변환을 포함한 자연어처리에 유용한 자원이다. CoreNet의 보다 광범위한 분야 및 응용에의 활용을 장려하고 다국어 어휘의미망으로서의 국제적 위상을 제고하기 위해 SUMO에 연결하는 작업을 하였다. CoreNet과 SUMO를 매핑하기 위해 간접 매핑과 직접 매핑 방법을 모두 사용하였는데, CoreNet-KorLex-PWN-SUMO에 이르는 간접 매핑 작업을 통하여 한국어 중심의 CoreNet과 영어로 기술된 SUMO의 언어 간 변환의 어려움을 완화하고 CoreNet 개념에 대응하는 SUMO 클래스의 재현율을 극대화하였다.

• 한국응급구조학회지
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• 제14권2호
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• pp.25-40
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• 2010

Purpose : The purpose of this study was to develop and apply a Core Skill-TLP(Core Skill-Tutorial, Laboratory, Practicum) package in Patient Management and to effect of core skill-TLP education. Methods : This study was used to developed Patient Management' Core Skill-TLP package throughout 14 steps of Core Skill-TLP package development model. Then, Core Skill-TLP Learning methodology was implemented in first year student in the undergraduate emergency medical technology, and survey was done. Results : 1. Core Skill-TLP package model was presented based on conceptual model of PBL(S-PBL). 2, The student in OSCE did significantly better in clinical patient management core skills performance. 3. As to the satisfaction of Core Skill-TLP package management, student, tutor and self-satisfaction score was 3.21, 3.42, 3.38 respectively. Conclusion : This study was suggested that Core Skill-TLP education would be necessary with well-structured package and achieved advantage of simulation and PBL.

• IEIE Transactions on Smart Processing and Computing
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• 제5권1호
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• pp.43-48
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• 2016

We propose plain fingerprint classification based on a core stochastic algorithm that effectively uses a core stochastic model, acquiring more fingerprint minutiae and direction, in order to increase matching performance. The proposed core stochastic algorithm uses core presence/absence and contains a ridge direction and distribution map. Simulations show that the fingerprint classification accuracy is improved by more than 14%, on average, compared to other algorithms.

• 한국전산유체공학회지
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• 제16권3호
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• pp.95-103
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• 2011

In the block type VHTR core, there are inevitable gaps among core blocks for the installation and refueling of the fuel blocks. These gaps are called bypass gap and the bypass flow is defined as a coolant flows through the bypass gap. Distribution of core bypass flow varies according to the reactor operation since the graphite core blocks are deformed by the fast neutron irradiation and thermal expansion. Furthermore, the cross-flow through an interfacial gap between the stacked blocks causes flow mixing between the coolant holes and bypass gap, so that complicated flow distribution occurs in the core. Since the bypass flow affects core thermal margin and reactor efficiency, accurate prediction and evaluation of the core bypass flow are very important. In this regard, experimental and computational studies were carried out to evaluate the core bypass flow distribution. A multi-block experimental apparatus was constructed to measure flow and pressure distribution. Multi-block effect such as cross flow phenomenon was investigated in the experiment. The experimental data were used to validate a CFD model foranalysis of bypass flow characteristics in detail.

• 한국구조물진단유지관리공학회 논문집
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• 제24권1호
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• pp.116-124
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• 2020

코어 위치변화에 따른 횡력저항성능 분석을 위하여, 대칭 평면형 20층 건물을 대상으로 3차원 구조해석을 수행하였다. 중심 코어, 1축 편심 코어, 2축 편심 코어로 구분하여 4가지 해석모델을 구성하고, 고유치해석, 풍하중 해석, 지진하중 해석을 수행하였다. 중심 코어 건물에서는 비틀림이 발생하지 않았으나, 편심 코어의 배치에 따라 휨과 비틀림이 복합적으로 발생하였으며 횡력저항성능이 저하되었다. 코어의 편심 배치에 따른 풍하중 크기의 변화는 작으나, 최대 횡변위는 코어의 편심 배치에 의하여 크게 증가하는 것으로 확인되었다. 또한, 편심 코어의 경우 횡방향 강성의 저하로 인하여 중심 코어에 비해 지진하중이 다소 감소하였으나, 비틀림의 영향으로 최대 층간변위비는 크게 증가하는 것으로 확인되었다. 이러한 결과들을 바탕으로 코어의 위치에 따른 구조거동을 확인하고, 계획 및 설계 단계에서 코어 배치의 가이드라인으로 활용할 수 있다.

• 디지털산업정보학회논문지
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• 제13권4호
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• pp.71-79
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• 2017

Recently, Fire watching and dangerous substances monitoring system has been being developed to enhance various fire related security. It is generally assumed that fire flame extraction plays a very important role on this monitoring system. In this study, we propose the fire flame extraction method of Non-Residential Facilities based on core object extraction in image. A core object is defined as a comparatively large object at center of the image. First of all, an input image and its decreased resolution image are segmented. Segmented regions are classified as the outer or the inner region. The outer region is adjacent to boundaries of the image and the rest is not. Then core object regions and core background regions are selected from the inner region and the outer region, respectively. Core object regions are the representative regions for the object and are selected by using the information about the region size and location. Each inner region is classified into foreground or background region by comparing its values of a color histogram intersection of the inner region against the core object region and the core background region. Finally, the extracted core object region is determined as fire flame object in the image. Through experiments, we find that to provide a basic measures can respond effectively and quickly to fire in non-residential facilities.

• 한국콘텐츠학회논문지
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• 제8권9호
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• pp.27-33
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• 2008

Linux에서 사용되는 Shared Memory는 동일한 메모리 영역에 여러 개의 프로세스가 접근할 수 있도록 해 주는 기술이다. 본 논문은 Linux 운영체제에서 지원해 주는 System V의 IPC 중 하나인 Shared Memory를 Dual Core 시스템 상에서 동작하도록 구현한다. 본 논문에서는 커널 단계에서 처리되는 SVR(System V Release) 형식의 Shared Memory를 다룬다. 기존의 공유메모리 방식은 단일 처리기를 이용한 방식이다. 본 논문에서는 dual core를 이용하여 공유메모리 처리를 할 수 있는 시스템을 제안한다. 본 논문에서 제안하는 Dual Core 시스템에서 공유 메모리 기능 구현은 기존의 단일 처리기 시스템에서보다 성능을 향상시킬 수 있도록 한다. 공유 메모리를 이용한 프로세스의 동작이 별개의 CPU에서 동작되도록 함으로써 성능 향상을 꾀한다.

• 한국전산유체공학회지
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• 제21권3호
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• pp.8-14
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• 2016

A numerical analysis is conducted to estimate the core expansion and the energy behaviors induced by a core disruptive accident in a sodium-cooled fast reactor. The numerical formulation based on underwater explosion theory is carried out to simulate the core explosion inside the reactor vessel. The transient pressure, temperature and expansion of the core are examined by solving the equation of state and nonlinear governing equation of momentum conservation in one-dimensional spherical coordinates. The energy balance inside the computation domain is examined during the core expansion process. Heat transfer between the core and the sodium coolant, and the bubble rise during the expansion process are briefly investigated.