• 제목/요약/키워드: Core Quality

검색결과 1,420건 처리시간 0.026초

Evaluating the Efficacy of a Formalin Alternative in Fixing Pathological Tissues for Histological and Molecular Diagnoses

  • Min-A Je;Haneul Lee;Heechul Park;Dong Hyeok Kim;Yeongdon Ju;Jaewon Lim;Sunghyun Kim;Jungho Kim
    • 대한의생명과학회지
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    • 제29권1호
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    • pp.48-52
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    • 2023
  • Formaldehyde use is associated with serious health risks, which can affect medical personnel and technicians. Therefore, we investigated the efficacy of an alternative fixative, with respect to two types of formalin fixatives, by hematoxylin and eosin (H&E) staining, periodic acid Schiff (PAS) staining, immunohistochemical (IHC) staining, and RNA extraction. For H&E staining, the circular nucleus was stained dark blue by the basic dye hematoxylin and the cytoplasm was stained red by the acid dye eosin in all three fixative samples. No difference was found in the Duksan General Science (DGS), Sigma-Aldrich, and Core-Fix fixative samples (Corebiotech) used to fix kidney tissue, after PAS staining. IHC staining showed that CD4 was significantly increased in the lippolysaccharide (LPS)-treated group compared to the control group (vehicle), confirming the changes in specific molecules. The quantity and quality of RNA from tissues fixed in the three types of fixatives were evaluated. The average concentration of RNA was 106 ng/µL and average purity at A 260/280 ratio was 1.7~2.0, regardless of fixative used. For quality of protein, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein was confirmed by Western blotting. In conclusion, Core-Fix can be used as a fixative for pathological tissues, in histological and molecular diagnoses.

스마트 통합플랫폼 보안위협과 대응방안 연구 (A Study on the Security Threat Response in Smart Integrated Platforms)

  • 유승재
    • 융합보안논문지
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    • 제22권1호
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    • pp.129-134
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    • 2022
  • 스마트플랫폼이란 기존 플랫폼과 첨단 IT기술을 결합함으로써 물리 및 가상공간을 초연결 환경으로 구현한 진화된 플랫폼이라 정의된다. 초연결로 언급되는 정보와 정보, 인프라와 인프라, 인프라와 정보, 공간과 서비스가 연결은 사용자의 삶의 질과 환경을 획기적으로 변화시켜 주는 고품질의 서비스 구현 및 제공을 가능하게 한다. 특히 스마트 정부와 스마트 헬스케어 구현으로 사회안전망과 개인건강관리 수준을 획기적으로 개선시킨 효과를 모두에게 제공하고 있다. 이 과정에서 생산되고 소비되는 수많은 정보들은 그 자체로서 혹은 빅데이터 분석을 통해 공공 및 개인의 기본권을 위협하는 요인으로 작용할 수 있다. 특히 스마트시티의 생태계를 형성하는 핵심기능으로서의 스마트플랫폼은 자연스럽게 지속적으로 확장되어 가기 때문에 그에 따르는 데이터의 처리운용과 네트워크 운영 상 커다란 보안 부담에 직면하고 있다. 이 논문에서는 스마트시티의 핵심 기능으로서의 플랫폼 구성 요소와 그에 대한 적절한 보안위협 및 대응 방안을 연구한다.

서비스 속성과 고객만족과의 비대칭적, 비선형적 관계에 근거한 서비스 속성 분류와 전략적 고객서비스 경영 (Classification of Service Attributes and Strategic Customer Service Management based on the Asymmetric and Non-linear Relationship between Service Attributes and Customer Satisfaction)

  • 박정영;이계희
    • 한국식생활문화학회지
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    • 제23권5호
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    • pp.605-615
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    • 2008
  • The principal objective of this study was to categorize service attributes on the basis of the asymmetric and non-linear relationship existing between service attributes and customer satisfaction. Researchers generally assume that service attribute performances and customer satisfaction are both symmetrical and linear. That is to say, improvements in attribute performance will inevitably result in increased customer satisfaction. However, this is not always the case. Certain attributes have been shown not to create satisfaction even when improved, and others do not create dissatisfaction even when their performance ratings become negative. Understanding this relationship is crucial not only to researchers, but also to service managers. Service managers can arrange their priorities with regard to which attributes must be improved or promoted first, in an environment of limited technical, financial, and human resources. Many studies into this asymmetric and non-linear relationship have recently been conducted, beginning with Herzberg's motivation-hygiene theory (1976) and the disconfirmation theory, which was eventually developed into Kano's model (1984). This study attempted to determine the impact level of service attributes on incidents of satisfaction or dissatisfaction. It used 30 service attributes generated by Park (2008) in the CIT research into family restaurants. The data were collected from 600 participants, 300 incidences of satisfaction and 300 incidents of dissatisfaction, via an online survey. The t-test was used to confirm the difference between the satisfaction group's and dissatisfaction group's attributes. 11 attributes were found to be significant at a level of p>0.05. This indicates that the 11 attributes exerted different impacts on satisfaction and dissatisfaction, which confirmed the asymmetric and non-linear relationship. 14 attributes were categorized into the core service, 1 attribute into the quality service, 7 attributes into the basic service, and 8 attributes into the neutral service. Strategic customer service management was recommended for the 'A' family restaurant as an example, on the basis of the asymmetric and non-linear relationship and the characteristics of the four service factors.

Developing a short standard questionnaire for assessing work organization hazards: the Healthy Work Survey (HWS)

  • BongKyoo Choi;Youngju Seo
    • Annals of Occupational and Environmental Medicine
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    • 제35권
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    • pp.7.1-7.14
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    • 2023
  • Background: At present, no short standard questionnaire exists for assessing and comparing major work organization hazards in the workplaces of the United States. Methods: We conducted a series of psychometric tests (content validity, factor analysis, differential-item functioning analysis, reliability, and concurrent validity) to validate and identify core items and scales for major work organization hazards using the data from the 2002-2014 General Social Surveys (GSSs), including the Quality of Worklife (QWL) questionnaire. In addition, an extensive literature review was undertaken to find other major work organization hazards which were not addressed in the GSS. Results: Although the overall validity of the GSS-QWL questionnaire was satisfactory in the psychometric tests, some GSS-QWL items of work-family conflict, psychological job demands, job insecurity, use of skills on the job, and safety climate scales appeared to be weak. In the end, 33 questions (31 GSS-QWL and 2 GSS) were chosen as the least, but best validated core questions and included in a new short standard questionnaire (called the Healthy Work Survey [HWS]). And their national norms were established for comparisons. Furthermore, based on the literature review, fifteen more questions for assessing other significant work organization hazards (e.g., lack of scheduling control, emotional demands, electronic surveillance, wage theft) were included in the new questionnaire. Thus, the HWS includes 48 questions in total for assessing traditional and emerging work organization hazards, which covers seven theoretical domains: work schedule/arrangement, control, support, reward, demands, safety, and justice. Conclusions: The HWS is a short standard questionnaire for assessing work organization hazards which can be used as a first step toward the risk management of major work organization hazards in the workplaces of the US.

FT-NIR SPECTROSCOPY FOR QUALITY AND PROCESS CONTROL IN DEPTH FILTER SHEETS PRODUCTION

  • Jansen, Christoph;Ebert, Jurgen
    • 한국근적외분광분석학회:학술대회논문집
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    • 한국근적외분광분석학회 2001년도 NIR-2001
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    • pp.3122-3122
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    • 2001
  • Documented quality control plays a vital role I the production of technical “Depth filter” sheets used in industries such as Beverage and pharmaceutical. Depth filter sheets which can be up to several millimeters thick are stacker in plate and frame filter systems. They are the core of stainless steel filter systems which can be up to several meters high. FT-NIR Spectroscopy has many potential applications in the whole production line of filter sheets. Raw materials such as different types of cellulose pads, white powdery fillers (e.g. Kieelgur, Perlite) or liquid chemicals such as wet-strength agents we, with the help of NIR, easy to identify. NIR can also determine physical parameters such as particle size, essential for the filtration behavior. FT-NIR can be used for the quality parameters of the final product. Moisture and permeability can be determined, and with the help of the speed of this NIR method it is possible to correct possible faults quickly in the production process. Waste production can be minimized which is good for both the product profitability and the environment. Further tests have shown that it is also possible to use NIR on-line in the production area, to check the concentrations and the homogeneity of the paper suspension consisting of cellulose fibres, fillers and additives.

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불량만두소 사건에 대한 음식 윤리적 접근 (Food Ethics Approach to Court Case of Inferior Quality Mandu Stuffing)

  • 김석신
    • 한국식생활문화학회지
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    • 제26권5호
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    • pp.437-444
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    • 2011
  • This study was performed to approach the 2004 case of inferior quality mandu stuffing from the stance of food ethics. The court convicted the producers of inferior quality mandu stuffing and also decided against the plaintiffs who filed a damage suit. The core of the mandu stuffing case was not safety, but the wholesomeness. The principles of food ethics include a respect for life, justice, environmental preservation, and the priority of safety. The virtues of food professionals include wisdom, honesty, faithfulness, courage, moderation, and integrity. A food producer should possess not only the ability but also the morality to make food. The consumer should urge the producers to strengthen their morality and be conscious of responsibility and fairness. The government should organize a system to establish food ethics, and make efforts to reduce wasteful law enforcement. The media should lead public opinion toward justice by doing an unbiased and in-depth report and help establish the idea of food ethics. The necessity of food ethics and the spread of the ethical mind are the most important points of all.

NC 데이터 정량화를 통한 고품질 사출금형 NC 가공데이터 선정 방안 (Development of a System for Selecting High-Quality Mold Manufacturing NC Data Using Evaluating the NC Data)

  • 허은영;김보현;김동원
    • 한국정밀공학회지
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    • 제23권4호
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    • pp.99-108
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    • 2006
  • Since mold industries are regarded as belonging to three types of bad business, capable young people are reluctant to work in this field. The industries are hard to employ skilled workers who have much experience and knowledge On the mold manufacturing. Thus, effective CAM systems are required for unskilled workers to create process plans and NC data for the manufacturing, and process plans play important roles in the downstream manufacturing processes, such as NC machining, polishing, and final assembly. This study proposes a decision support system that facilitates unskilled workers to easily select high quality NC-data, as well as to increase productivity. The proposed system is assumed to follow a CAM operation scenario that consists of next three steps: 1) identifying several process plans and enumerating feasible unit machining operations (UMOs) from material and part surface information, 2) creating all feasible NC-data based on UMOs using a commercial CAM system, 3) selecting the best NC data among the feasible NC data using four screening criteria, such as machining accuracy, machining allowance, cutting load, and processing time. A case study on the machining of a camera core mold is provided to demonstrate the proposed system.

보온재를 사용한 고강도 매스 콘크리트의 품질관리에 관한 연구 (An Experimental Study on Quality Management of Strength in High Strength Mass Concrete Structure Using Thermal Insulation Material)

  • 조규현;백민수;김성식;임남기;이영도
    • 한국건축시공학회지
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    • 제4권2호
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    • pp.113-118
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    • 2004
  • This study is a basic experiment on quality management of the compression strength of high strength concrete, aiming. at quality management of high strength mass concrete by giving the temperature hysteresis of the mass test pieces to managerial test pieces. Different from ordinary concrete, high strength concrete generally shows the temperature high rising caused by hydration heat inside the concrete. It is known that, in mass concrete, thermal stress occurs due to the difference in temperature between the inside and the outside, which causes a significant difference in compression strength between structure beams and managerial test pieces. It is also reported that there is a large difference between the compression strength of cylindrical managerial test pieces of standard underwater curing and the strength of structure beam concrete. Thus, this study made concrete test pieces in an optimal mix ratio for each strength level, and also created thermal insulation curing box and managerial test pieces. Then it carried out comparative analysis in relation to core strength and suggested equipment and a technique that can control the strength of high strength concrete mass more conveniently and accurately.

Dissemination of Advanced Mouse Resources and Technologies at RIKEN BioResource Center

  • Yoshiki, Atsushi
    • Interdisciplinary Bio Central
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    • 제2권4호
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    • pp.15.1-15.5
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    • 2010
  • RIKEN BioResource Center (BRC) has collected, preserved, conducted quality control of, and distributed mouse resources since 2002 as the core facility of the National BioResource Project by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Our mouse resources include over 5,000 strains such as humanized disease models, fluorescent reporters, and knockout mice. We have developed novel mouse strains such as tissue-specific Cre-drivers and optogenetic strains that are in high demand by the research community. We have removed all our specified pathogens from the deposited mice and used our quality control tests to examine their genetic modifications and backgrounds. RIKEN BRC is a founding member of the Federation of International Mouse Resources and the Asian Mouse Mutagenesis and Resource Association, and provides mouse resources to the one-stop International Mouse Strain Resource database. RIKEN BRC also participates in the International Gene Trap Consortium, having registered 713 gene-trap clones and their sequences in a public library, and is an advisory member of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium which represents major European and international mouse database holders for the integration and dissemination of Cre-driver strains. RIKEN BRC provides training courses in the use of advanced technologies for the quality control and cryopreservation of mouse strains to promote the effective use of mouse resources worldwide.

SW일자리 창출을 위한 지속가능성과 개방형 관점에서의 산업클러스터 사례 비교 분석 (A Comparative Study on the Industrial Cluster Cases for Job Creation from the Viewpoint of Sustainability and Open Innovation)

  • 임규건;이지윤;최진호
    • 경영과학
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    • 제34권2호
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    • pp.85-101
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    • 2017
  • Currently, the SW industry is the center of digital economy and it is very important industry in terms of market scale and ripple effect. Due to the suffering from poor working environment of the SW industry and the disproportion of manpower supply due to the lack of experienced SW manpower, it is hard to create jobs of high quality for the SW professionals who can be applied to various convergence industries. In this study, we try to analyze the benchmarking cases of successful foreign industrial innovative clusters in order to promote sustainable development direction of SW industry and to create high quality SW jobs. First, the comparison criteria are derived from the viewpoint of creation of high quality SW jobs through an analysis of SW environment by using expert FGI (Focus Group Interview) technique. The critical success factors (CSFs) are derived by comparing and analyzing each industrial cluster cases in terms of SW job creation. This article presents the desirable implications of the cluster of SW industry that can generate SW jobs continuously from the viewpoint of ecosystem environment infrastructure. Through this study, we propose a meaningful direction of SW clusters for job creation, and solve the business inconsistency and suggest ways to increase the sustainability of core competence manpower.