• Journal of Acupuncture Research
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• 제37권3호
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• pp.137-150
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• 2020

The purpose of this study was to evaluate the evidence supporting the effectiveness of moxibustion treatment for osteoarthritis. There were 9 databases used to retrieve randomized controlled trials (RCTs) that used moxibustion as treatment for osteoarthritis. The quality of methodology for the RCTs was assessed using the Cochrane Risk of Bias tool [Review Manager (RevMan) Version 5.3 Windows, The Nordic Cochrane Centre, Copenhagen, Denmark]. The inclusion criteria for this review was met by 27 RCTs. All studies were conducted in China. A 4-week moxibustion treatment period was the most common. EX-LE4 and SP10 and GB34 acupoints were most frequently selected in the treatment of osteoarthritis. The most commonly used evaluation index was the visual analog scale (VAS). All studies, including a meta-analysis showed that moxibustion treatments were statistically significantly effective at treating knee osteoarthritis. However, well-designed randomized RCTs without a high risk of bias should be designed in the future.

• 대한치과교정학회지
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• 제46권1호
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• pp.3-12
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• 2016

Objective: The purpose of this study was to compare the precision of three-dimensional (3D) images acquired using iTero$^{(R)}$(Align Technology Inc., San Jose, CA, USA) and Trios$^{(R)}$(3Shape Dental Systems, Copenhagen, Denmark) digital intraoral scanners, and to evaluate the effects of the severity of tooth irregularities and scanning sequence on precision. Methods: Dental arch models were fabricated with differing degrees of tooth irregularity and divided into 2 groups based on scanning sequence. To assess their precision, images were superimposed and an optimized superimposition algorithm was employed to measure any 3D deviation. The t-test, paired t-test, and one-way ANOVA were performed (p < 0.05) for statistical analysis. Results: The iTero$^{(R)}$ and Trios$^{(R)}$ systems showed no statistically significant difference in precision among models with differing degrees of tooth irregularity. However, there were statistically significant differences in the precision of the 2 scanners when the starting points of scanning were different. The iTero$^{(R)}$ scanner (mean deviation, $29.84{\pm}12.08{\mu}m$) proved to be less precise than the Trios$^{(R)}$ scanner ($22.17{\pm}4.47{\mu}m$). Conclusions: The precision of 3D images differed according to the degree of tooth irregularity, scanning sequence, and scanner type. However, from a clinical standpoint, both scanners were highly accurate regardless of the degree of tooth irregularity.

• 천문학회보
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• 제40권2호
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• pp.28.3-29
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• 2015

$Ly{\alpha}$ nebulae, or "$Ly{\alpha}$ blobs", are extended (~100 kpc), bright (L[$Ly{\alpha}$] ~ 1044 erg/s) clouds of $Ly{\alpha}$-emitting gas. The origin of the $Ly{\alpha}$ emission remains unknown, but recent theoretical work suggests that measuring the polarization could discriminate among powering mechanisms. we will discuss current status of $Ly{\alpha}$ polarization observations at high-redshift and our on-going survey program. We will present the first narrow-band, imaging polarimetry of a $Ly{\alpha}$ blob, B3 J2330+3927 at z=3.09, with an embedded, radio-loud AGN (C. You et al. in prep.). The AGN lies near the blob's $Ly{\alpha}$ emission peak and its radio lobes align roughly with the blob's semi-major axis. With the SPOL polarimeter on the MMT telescope, we map the polarization in a grid of circular apertures of radius 0.6" (4.4 kpc), detecting a significant (>$2{\sigma}$) polarization fraction P% in 10 apertures and achieving strong upper-limits (as low as 2%) elsewhere. The degree of the polarization map increases from P% ~ 5% at ~5 kpc from the blob center to ~20% at the outer part (~30 kpc). The detections are distributed asymmetrically, roughly along the blob's major axis. The polarization angles (${\Theta}$) are mostly perpendicular to this axis. These results are consistent with the picture that $Ly{\alpha}$ photons produced at the AGN (or the host galaxy) are resonantly scattered away from the center. Higher polarization fraction on the radio jet suggests that the gas is more optically thin along the jet than the off-axis region.

• 대한두경부종양학회지
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• 제9권1호
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• pp.74-87
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• 1993

Immunohistochemical studies on S-100 protein and lactoferrin were carried out to evaluate the existence and distribution pattern of S-100 protein and lactoferrin positive cells in salivary gland tumors. The specimens used were 25 cases of pleomorphic adenoma, 2 cases of monomorphic adenoma, 2 cases of mucoepidermoid tumor, 2 cases of acinic cell tumor, 3 cases of adenoid cystic carcinoma and 2 cases of adenocarcinoma occured in parotid and submandibular salivary gland. ABC kits(Dako corp. Copenhagen. Denmark) for S-100 protein and lactoferrin were used. The results obtained were summarized as follows: In the normal salivary gland. positive immunoreaction for S-100 protein was observed in myoepithelial cells of acini and intercalated ducts. Positive immunoreaction for lactoferrin was observed in serous acinic cells, epithelial cells of intercalated ducts, and excretory material in the ductal lumina. In the pleomorphic and monomorphic adenomas. most of tumor cells were positive for S-100 protein, while luminal tumor cells in gland-like or duct-like structures were rarely positive for lactoferrin. In mucoepidermoid tumor, most of squamous cells and a few of intermediate cells were positive for S-100 protein, but all of tumor cells were negative for lactoferrin. In acinic cell tumor, most of tumor cells were positive for lactoferrin, but all of tumor cells were negative for S-100 protein. In adenoid cystic carcinoma, basaloid tumor cells in trabecular structure were focally positive for S-100 protein. and in adenocarcinoma, many of tumor cells were posivive for both S-100 protein and lactoferrin. Thus, according to the embryonic stage of the development of the tumor cell origin, it was possible to classify the salivary gland tumor as followings: mucoepidermoid carcinoma which originated from the earliest stage, acinic cell tumor which originated from the end stage. Between these two extremes, there were pleomorphic adenoma, adenoid cystic carcinoma and adenocarcinoma which originated in the middle stage of the development of .the salivary glands. Based on the above results, it can be stated that S-100 protein is demonstrated in tumor cells orginated from myoepithelial cells and lactoferrin in glandular differentiated tumor cells.

• Journal of Microbiology and Biotechnology
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• 제24권2호
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• pp.160-167
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• 2014

Oligopeptidase B (OpdB) is a serine peptidase widespread among bacteria and protozoa that has emerged as a virulence factor despite its function has not yet been precisely established. By using an OpdB-overexpressing Escherichia coli strain, we found that the overexpressed peptidase makes the bacterial cells specifically less susceptible to several proline-rich antimicrobial peptides known to penetrate into the bacterial cytosol, and that its level of activity directly correlates with the degree of resistance. We established that E. coli OpdB can efficiently hydrolyze in vitro cationic antimicrobial peptides up to 30 residues in length, even though they contained several prolines, shortening them to inactive fragments. Two consecutive basic residues are a preferred cleavage site for the peptidase. In the case of a single basic residue, there is no cleavage if proline residues are present in the $P_1$ and $P_2$ positions. These results also indicate that cytosolic peptidases may cause resistance to antimicrobial peptides that have an intracellular mechanism of action, such as the proline-rich peptides, and may contribute to define the substrate specificity of the E. coli OpdB.

• 자원ㆍ환경경제연구
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• 제21권4호
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• pp.851-891
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• 2012

본 연구는 배출규제가 탄소누출에 미치는 영향을 소비관점의 탄소회계와 국경조치의 영향을 중심으로 살펴보았다. 대표적으로 논의되는 국경조치인 탄소관세는 가장 포괄적일 경우 소비관점에서 계산된 제품에 내재된 탄소함율을 기반으로 계산되게 된다. 본 연구는 다지역 투입산출 모형과 연산가능 일반균형 모형 등의 방법론을 사용하여 소비관점의 탄소회계에 따른 우리나라의 위상변화와 여기서 계산된 탄소관세를 포함한 여러 국경조치가 적용될 때 탄소누출과 각국 경제에 미치는 영향을 관찰하였다. 이를 위해 정태적 글로벌 연산가능 일반균형 모형을 구축하였다. 코펜하겐 합의문을 기반으로 한 각국의 2020년 중기감축목표의 달성이 탄소누출에 미치는 영향과 국경조치를 포함한 여러 자국 산업 보호조치가 미치는 영향을 분석하였으며, 의무감축국가군 및 국경조치에 대한 다양한 시나리오를 설정하였다. 결과적으로 우리나라를 중심으로 한 정책적 함의를 제시하였다.

• 융합보안논문지
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• 제19권5호
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• pp.99-105
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• 2019

본 연구에서는 사이버 위협이 사회적으로 담론화 과정을 통해 안보화 되는 이론적 배경과 주요 동향을 제시하였다. 특히 사이버 위협의 안보화에 대한 비판적 논의을 코펜하겐학파의 안보화 이론을 바탕으로 설명하였다. 또한 사이버 위협의 안보화 과정을 설명한 비전통적 위협의 안보화와 신흥안보이슈의 안보화를 기존 연구를 바탕으로 제시하였으며 이에 대한 한계점을 설명하였다. 또한 현재 나타나고 있는 사이버 위협의 군사화 현상이 기술담론과 군사담론의 결합을 통해 나타나는 현상임과 이에 대한 경계적 시각을 제시하고자 하였다. 본 연구를 통해 사이버 위협의 안보화 과정에 대한 객관적 통찰력을 바탕으로 보편적 해법 제시의 한계와 함께 군사화의 경계적 시각을 우리군에 제시하고자 한다.

• BMB Reports
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• 제44권5호
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• pp.335-340
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• 2011

In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin-8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a $C_{18}$ reverse phase HPLC column. By determination of its structure by MALDITOF and $^1H$- and $^{13}C$-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureus-engulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2009년도 International Meeting of the Microbiological Society of Korea
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• pp.78-78
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• 2009

$^1H$ NMR spectroscopy coupled with multivariate statistical analysis was used for the first time to investigate metabolic changes in musts during alcoholic fermentation and wines during ageing. Three Saccharomyces cerevisiae yeast strains (RC-212, KIV-1116 and KUBY-501) were also evaluated for their impacts on the metabolic changes in must and wine. Pattern recognition (PR) methods, including PCA, PLS-DA and OPLS-DA scores plots, showed clear differences for metabolites among musts or wines for each fermentation stage up to 6 months. Metabolites responsible for the differentiation were identified to valine, 2,3-butanediol (2,3-BD), pyruvate, succinate, proline, citrate, glycerol, malate, tartarate, glucose, N-methylnicotinic acid (NMNA), and polyphenol compounds. PCA scores plots showed continuous movements away from days 1 to 8 in all musts for all yeast strains, indicating continuous and active fermentation. During alcoholic fermentation, highest levels of 2,3-BD, succinate and glycerol were found in musts with the KIV-1116 strain, which showed the fastest fermentation or highest fermentative activity of the 3 strains, whereas the KUBY-501 strain showed the slowest fermentative activity. This study highlights the applicability of NMR-based metabolomics for monitoring wine fermentation and evaluating the fermentative characteristics of yeast strains.

• 대한물리치료과학회지
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• 제24권2호
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• pp.61-70
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• 2017

Purpose : The purpose of this study was to examine the effect of therapeutic massage and Mckenzie exercise on pain and range of motion in chronic neck pain patient: a case study. Method : A Twenty-year old female subject with chronic neck pain was selected, she received therapeutic massage and Mckenzie exercise for 30 minutes a day, three days a week for five weeks. Pain was measured visual analog scale(VAS), neck disability index(NDI) and the Copenhagen neck functional disability scale (CNFDS). Range of motion was measured using a goniometer(shoulder joint) and the CROM Deluxe(cervical range of motion instrument). Result : VAS, NDI and CNFDS were decreased 3 score, 4 score and 6 score(respectively) than before the training. The range of motion was increased in shoulder joint and neck movement than before the training. Conclusion : The massage and Mckenzie exercise increased range of motion in shoulder joint and neck movement, and decreased neck pain in chronic neck pain patient. Additional research on therapeutic massage and Mckenzie exercise for improving pain and range of motion is need.