• BMB Reports
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• v.57 no.6
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• pp.281-286
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• 2024

Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer's disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD.

• Korean Journal of Mathematics
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• v.31 no.3
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• pp.349-361
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• 2023

In this article, we construct lacunary ∆^m-statistical convergence for triple sequences within the context of intuitionistic fuzzy n-normed spaces (IFnNS). For lacunary ∆^m-statistical convergence of triple sequence in IFnNS, we demonstrate numerous results. For this innovative notion of convergence, we further built lacunary ∆^m-statistical Cauchy sequences and offered the Cauchy convergence criterion.

• Journal of Korean Society for Quality Management
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• v.49 no.1
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• pp.97-112
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• 2021

Purpose: The purpose of this paper is to analyze the technology convergence and its characteristics, focusing on the defense technologies in South Korea. Methods: Patents applied by the Agency for Defense Development (ADD) during 1979~2019 were utilized in this paper. Information Entropy analysis has been conducted on the patents to analyze the usability and potential for development. To analyze the trend of technology convergence in defense technologies, Social Network Analysis(SNA) and Association Rule Mining Analysis were applied to the co-occurrence networks of International Patent Classification (IPC) codes. Results: The results show that sensor, communication, and aviation technologies played a key role in recent development of defense science and technology. The co-occurrence network analysis also showed that the convergence has gradually enhanced over time, and the convergence between different technology sectors largely emerged, showing that the convergence has been diversified. Conclusion: By analyzing the patents of the defense technologies during the last 30 years, this study presents the comprehensive perspectives on trends and characteristics of technology convergence in defense industry. The results of this study are expected to be used as a guideline for decision making in the government's R&D policies in defence industry.

• Carbon letters
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• v.14 no.2
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• pp.99-104
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• 2013

We investigated the effects of parametric synthesis conditions of catalysts such as sintering temperature, sorts of supports and compositions of catalysts on alignment and length-control of carbon nanotubes (CNTs) using catalyst powders. To obtain aligned CNTs, several parameters were changed such as amount of citric acid, calcination temperature of catalysts, and the sorts of supports using the combustion method as well as to prepare catalyst. CNTs with different lengths were synthesized as portions of molybdenum and iron using a chemical vapor deposition reactor. In this work, the mechanisms of alignment of CNTs and of the length-control of CNTs are discussed.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.5
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• pp.451-461
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• 2014

This paper analyzed the degree of perception and performance of technology-humanities convergence in Korean SMEs. First, the meaning and activities of technology-humanities convergence were defined. Second, a survey data was collected from 277 Korean SMEs and analyzed from two perspectives-degree of performance and degree of perceived importance. Finally, based on the results, this paper signposted the important points to activate the technology-humanities convergence in SMEs.

• Journal of Industrial and Engineering Chemistry
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• v.68
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• pp.117-123
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• 2018

Recently, aqueous method has attracted lots of attention because it enables the solution-processed metal oxide thin film with high electrical properties in low temperature fabrication condition to various flexible devices. Focusing the development of aqueous route, many researchers are only focused on metal oxide materials. However, for expansive application of the aqueous-based metal oxide films, the systematic study of performance change with process variables for the development of aqueous-based metal oxide insulator film is urgently required. Here, we propose importance of process variables to achieve high electrical-performance metal oxide insulator based on the aqueous method. We found that the significant process variables including precursor solution temperature and humidity during the spincoating process strongly affect chemical, physical, and electrical properties of $AlO_x$ insulators. Through the optimization of significant variables in process, an $AlO_x$ insulator with a leakage current value approximately $10^5$ times smaller and a breakdown voltage value approximately 2-3 times greater than un-optimized $AlO_x$ was realized. Finally, by introducing the optimized $AlO_x$ insulators to solutionprocessed $InO_x$ TFTs, we successfully achieved $InO_x/AlO_x$ TFTs with remarkably high average field-effect mobility of ${\sim}52cm^2V^{-1}\;s^{-1}$ and on/off current ratio of 106 at fabrication temperature of $250^{\circ}C$.

• Mass Spectrometry Letters
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• v.3 no.1
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• pp.4-9
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• 2012

• Carbon letters
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• v.16 no.4
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• pp.270-274
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• 2015

• Proceedings of the Korean Magnestics Society Conference
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• 2013.12a
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• pp.153-154
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• 2013

• Proceedings of the Korean Magnestics Society Conference
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• 2013.05a
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• pp.11-11
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• 2013