• 대한한의학회지
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• 제32권4호
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• pp.48-67
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• 2011

Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment. Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide. Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.

• 한국시스템다이내믹스연구
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• 제15권3호
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• pp.61-79
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• 2014

This paper deals with system thinking in the resilience of the SES (Social-Ecological Systems) around Mt. Gariwang, located in Jeongseon County, Gangwon Province, in particular with the disturbance that a new ski slope is planned to be built for the PyeongChang 2018 Winter Olympic. It first performs a literature survey and newspaper article search to summarize the controversy with regards to credible environmental and socio-economical impacts of the plan, and then elaborates a series of CLDs (Causal Loop Diagrams) to infer the dynamics of the impacts. The results imply that the natural restoration seems to be hard because the development activities can cause a great deal of damage to the ecosystem mainly due to soil degradation and the mitigation of icy valley effects with water exploitation for making artificial snow and so on. Moreover most of the households near the planned site seem to leave with land compensation, thus more policy efforts are needed to enhance the resilience of the ecosystem and the nearby society based on ecotourism.

• 한국식품영양과학회지
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• 제15권3호
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• pp.306-312
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• 1986

Demonstration of the highly positive correlation between blood cholestrol levels and heart disease has made consumers wary of the fats in meat, milk and eggs. The egg, as perhaps the single largest common source of cholesterol, has been cited by many members of the medical and scientific world as a food contributing to heart disease. In light of decreasing per capita egg consumption and continuing dietary egg cholesterol controversy, many researchers have focused their efforts on egg nutrition. The results reported, however, are often contradictory. In spite of the disputable scientific evidence, the egg has been labelled (erroneously) as a highly cholesterogenic food. The objective of this presentation is to present a general picture of the problem and discuss our laboratory findings relevant to the problem. An isotope technique was utilized to incorporate $^{14}C$-cholesterol into egg yolk lipoproteins and study the metabolic fate of dietary ovo-cholesterol in rats. Two hundred and fifty micro-curies of 4-$^{14}C$-cholesterol, emulsified in corn oil, were orally administered to five Single Comb White Leghorn laying hens. Eggs were collected, hard-boiled, and the hot dried egg yolk powder (HEY) was prepared. Total radioactivity excreted via feces was determined. The rat groups fed egg yolk powder excreted more than 95% of the ingested ovo-cholesterol, whereas the rat chow group excreted only 47%. No difference was observed between HEY and CEY treatments. Therefore, an unknown lipid factor present in egg folk accelerates cholesterol turnover rate and excretion via feces.

• 한국문헌정보학회지
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• 제38권2호
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• pp.119-136
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• 2004

이 연구의 목적은 구십 년대 중반 이후 편목 업무의 부분적 혹은 전면적 외주를 수행하였던 국내외 대학 도서관들의 사례를 분석하여, 대학도서관의 편목 업무 외주의 현황과 그에 관련된 문제점을 살펴보는 것이다. 비용 절감과 업무 효율 증대라는 외주에 대한 기대는 목록 레코드의 품질 저하 및 그에 따른 레코드의 수정 위한 추가 비용과 업무 부담이라는 결과를 초래하여, 외주의 실질적 효과에 대한 논쟁의 원인이 되고 있다. 특히 국내 대학도서관에서의 편목 업무의 외주는 참조할 우수한 서지 유틸리티나 공동목록의 부재, 외주 서비스 제공자의 전문성 결여, 실질적 비용 효과 분석 데이터의 결핍 등의 문제로 인해 타당성이 제한적인 것으로 나타나고 있다.

• 보건행정학회지
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• 제17권3호
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• pp.106-128
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• 2007

The Korean health care system is under great controversy. Over the last 30 years, main goal of health policies was to pursue equal access of health care services. However, another goal of health policies laid on efficiency and Quality of care, it had lower priorities. Superficially, controversy stems from priority setting among goals of health care system, equity, efficiency and quality. At a deeper level, arguments arise from disagreement and confusion about the values of Korean health care system. One of the value spectrums believes that health care is the basic right of human beings, therefore it should be produced and distributed on need approach, and needs are known to be decided by professionals. If we accept need approach, health care is a pubic good. Another value of spectrums considers that health care should be distributed on demand approach. Demand approach means that health care is a consumption good on the positive economics, while normative judgement believes that health care is a public good. In equity aspect, health care is considered as a public good. Over the last several years, some of scholars proposed health care reform based on the principle of competition which is based on demand approach. Others argue that the competition principle based on demand approach is not appropriate for the reform proposal, because health care has to be approached on need base. If we do not make explicit values we should adopt, consensus building for reform is nearly impossible. From this perspective, this article will review an ideology and reality in health policies in Korea.

• 한국압력기기공학회 논문집
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• 제18권1호
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• pp.1-10
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• 2022

Currently, there is no technical standard and regulation for seismic analysis of non-nuclear safety piping. Accordingly, ASME Sec.III ND, a standards applied to safety class 3 piping, is applied. However, the technical standard applied for other than seismic analysis is ASME B31, which leads to controversy. In this study, the feasibility of applying ASME B31E was confirmed by reviewing rulescomparing technical standards, and evaluating piping allowable stress margins. The evaluation revealed that applying ASME B31.1 as a technical standard is too conservative compared to ASME Sec.III ND. On the other hand, ASME B31E (issued at the request of the industry) clearly presents the technical standards for seismic analysis of ASME B31 piping, and shows a similar level of conservatism compared to ASME Sec.III ND. It is expected to reduce the controversy over technical standards for seismic analysis of non-nuclear safety piping by applying ASME B31E.

• IMMUNE NETWORK
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• 제9권5호
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• pp.147-152
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• 2009

Ascorbate (vitamin C) is a cofactor for a number of metabolic enzymes and is an indisputable essential vitamin C for humans. However, the potential of ascorbate as an anticancer agent has been a topic of controversy. A number of previous reports have addressed both positive aspects and limitations of ascorbate in cancer therapy. In this review, we briefly summarize the potential antitumor effects of ascorbate and its prospects for clinical use.

• Journal of Chest Surgery
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• 제17권4호
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• pp.687-690
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• 1984

Aortic dissection, a condition characterized by hemorrhage into the media and variable extension along the length of the aorta, has long been recognized as a catastrophic Cardiovascular event. Recent developments in diagnostic and therapeutic skills have improved the prognosis considerably, but there is still controversy as to how cases should be managed. We experienced a case of dissecting aortic aneurysm [DeBakey Type III ], which were managed using intensive medical treatment. The period of follow up was about 11 years. At last, patient was died by progression of dissection into proximal aorta and resulted in aortic insufficiency and congestive heart failure.

• 진공이야기
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• 제1권1호
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• pp.11-16
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• 2014

A variety of metal vacuum systems displays the celebrated 1/t pressure, namely, power-law dependence on time t, with the exponent close to unity, as to the origin of which there has been long-standing controversy. Here we propose a chemisorption model for water adsorbates, based on the argument for 2D fermion behavior of water adsorbed on a metal surface, and obtain analytically the power-law behavior of pressure with an exponent unity. Further, the model predicts that the pressure should depend on the temperature T according to $T^{1.5}$, which is indeed confirmed by our experiment.

• Tuberculosis and Respiratory Diseases
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• 제71권2호
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• pp.81-87
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• 2011

Asthma is the most common chronic illness to affect children and is a major cause of morbidity in adults, affecting 4~17% of children and 7.3~10.1% of adults, which translates to approximately 300 million people globally. This article reviews recently published data over the past 1~2 years on asthma, and covers the 3 aspects of current advancement for the diagnosis of severe asthma, including the controversy to long-acting bronchodilator treatment for treatment of asthma, and the role of long-acting anticholinergics treatment in asthma patients.