• 제목/요약/키워드: Controversy

검색결과 812건 처리시간 0.023초

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

  • Kalita, Dipti;Pant, Leela;Singh, Sompal;Jain, Gaurav;Kudesia, Madhur;Gupta, Kusum;Kaur, Charanjeet
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권5호
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    • pp.3315-3318
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    • 2013
  • Gall bladder carcinoma is the most common cancer of biliary tree, characterized by rapid progression and a very high mortality rate. Detection at an early stage, however, is indicative of a very good prognosis and prolonged survival. The practice of histopathological examination of gall bladder specimens removed for clinically benign conditions and its usefulness has been a subject of controversy. The present prospective study was carried out over a period of four years in order to find out the incidence of unsuspected gallbladder carcinoma in cholecystectomy specimens received in our histopathology laboratory and to analyze their clinico-pathological features. A total of 4,115 cases were examined. Incidentally detected cases comprised 0.44%, which accounted for 72% of all gall bladder carcinomas detected. The majority were in an early, surgically resectable stage. From the results of this study we recommend that in India and other countries with relatively high incidences of gall bladder carcinoma, all cholecystectomy specimens should be submitted to histopathology laboratory, as this is the only means by which malignancies can be detected at an early, potentially curable stage.

대퇴과간절흔 성형술에서 유연성 연마기를 이용한 방법 (Notchyplasty with Flexible Reamer)

  • 채인정;이광석;백종륜
    • 대한관절경학회지
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    • 제1권1호
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    • pp.123-127
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    • 1997
  • Arthroscopic anterior cruciate ligament reconstructions using bone-patella tendon-bone have been considered the best method by which others are compared. The notchyplasty is one of the important steps of this procedure and it is emphasized recently to prevent retear of the reconstructed ACL caused by impingement. However, until now, there is controversy about adequate amount of notchyplasty. Also, it is hard to examine the adequacy of notchyplasty even in the arthroscopic field, The purpose of this paper is to describe the surgical technique of notchyplasty, using the flexible reamer and preliminary result of its operation. In this study the results of ACL reconstruction with notchyplasty which is made by us were analized from January. 1994 to December, 1995. The results were as follows: 1. The notchyplasty with flexible reamer is the method that can be obtained adequate amount of removal, perfectly smooth notchyplasty. 2. The range of motion of the affected knee joint was normal ROM after post operation 6 month. 3. In the last follow up, 2 cases were positive in anterior drawer test 4 cases were positive in Lachmann's test and 1 knee was positive in Pivot shift test 4. Average Lysholm knee scoring scale was 70 points at preoperative and 92 points at the last follow up.

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국제물품매매계약에 관한 UN협약(CISG)과 Incoterms(R) 2010의 위험이전에 관한 연구 (A Study on the Passing of Risk in the United Nations Convention on Contracts for the International Sale of Goods & Incoterms(R) 2010)

  • 임천혁
    • 무역상무연구
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    • 제53권
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    • pp.31-48
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    • 2012
  • If see CISG's passing of risk and altered regulations first, when sales contract accompanies transport of goods and seller does not have duty to deliver goods at particular place, when deliver to the first carter to send to purchaser according to sales contract risk passes to purchaser, and when there is duty that seller must deliver goods to carter at specification place, when goods are delivered to carter at same place, risk does not pass to purchaser. Second, risk about transporting goods passes to purchaser at signing a contract. But, when there is special assessment, risk passes to purchaser when goods are delivered to carter who publish document that embody contract of carriage. Nevertheless, it is loss if seller did not notify this truth to occasion purchaser who could knew loss or damage of goods or know justly at sales contract conclusion defamation danger seller of be burdensome. Third, seller has responsibility about damage or loss as long as hide in own artificiality or forbearance after risk passes to purchaser. Regulation about risk in Incoterms 2010 was separated into 11 condition, and move time of risk differs in angle condition. It is appeared that the substance handles relatively comprehensively because compare in Incoterms 2010 although it is because it becomes if it examines regulation about deliver and passing of risk of goods setting in CISG relatively concise. Also, segments that can become posibility of analysis controversy exist.

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시상골절단과 사선골절단술을 이용한 하악골 과두골절의 외과적 치험예 (SURGICAL REDUCTION OF DISPLACED SUBCONDYLAR FRACTURES OF MANDIBLE USING OF SAGITTAL SPLIT AND OBLIQUE SUBCONDYLAR OSTEOTOMY)

  • 김현철
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제11권2호
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    • pp.87-95
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    • 1989
  • 하악골 과두골절의 치로에 대해서는 여러가지 술식이 문헌상 보고되었으나 어떤 특정한 술식이 모든 증례에 적용될 수는 없으므로 각 증례에 따라 방사선 사진검사와 세밀한 임상검사 및 술자의 판단등에 따라 보존적인 치료법이나 외과적 수술법이 적절하게 선택되어야 한다. 대부분의 과두골절은 보존적인 치료만으로 만족스러운 결과를 얻을 수 있으나 보존적 처치후 장기간에 걸친 술후 검사시 하악의 기능장애, 부정교합, 하악골의 이환측으로의 전위, 위관절증 및 악관절 강직등의 병발증이 나타날 수 있으므로 골편이 심하게 전위된 경우나 무치악 환자, 구치부 고경유지가 어려운 환자 및 보존적 처치후 기능장애를 초래한 골편의 부정유합이나 비유합 환자에서는 관혈적 정복술로 보다 양호한 결과를 얻을 수 있다. 저자는 하악골 과두골절시 골편전위가 비교적 심한 6증례에서 악하부 피부절개를 통해 통상의 금속선 고정법, Kirschner 금속선을 이용한 고정법을 각 1예씩 사용하였고 4예는 골절선이 비교적 높아 통상의 수술방법으로 접근이 용이하지 않아 시상골절단과 사선골절단술을 이용하여 골편정복과 고정술을 시행하여 다소의 지견을 얻어 이에 보고하는 바이다.

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요통과 천장관절기능이상에 대한 고찰 (A Study on Low Back Pain with Sacroiliac Joint Dysfunction)

  • 오승길
    • 대한물리치료과학회지
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    • 제5권3호
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    • pp.697-706
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    • 1998
  • Motion at the sacroiliac joints(SIJ) has been reported in the medical literature since the mid-19th century. However, for many years authorities vie~d that no movement occurred at the sacroiliac joints and therefore were not clinically significant. Recent contributions from both the basic and clinical sciences caused a change in perception of the role of the sacroiloiac joint in low back pain(LBP). Movement within the sacroiliac joint is now generally recognized, although it is only a small amount. Controversy continues as to the type of motion available and the axes of motion, and continues as to the ability of a clinician to identify a significant sacroiliac dysfunction. Dysfunction of the pelvic girdle is complex and not easily understood. It is common to find serveral dysfunctions within the same pelvic girdle. Each needs to be individually diagnosed and appropriately treated. The diagnostic and therapeutic system designed by Philip E. Greenmam, D. O. allows the operator to deal with any combination of physical findings that are found within the pelvic girdle Restoration of pelvic girdle function within the walking cycle is a major therapeutic goal, particularly from the biomechanical postural-structural model.

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골프장 유출수가 하류수계에 미치는 영향 (The Impact Analyses on the Downstream by the Existing Golf Course)

  • 이병호;김성득;조홍제;조태규
    • 대한토목학회논문집
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    • 제12권3호
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    • pp.239-251
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    • 1992
  • 골프장에서 사용하는 농약에의한 오염 정도에 대해 많은 논쟁이 되고 있다. 이의 연구를 위해 기존의 골프장과 관련된 저수지와 하류수계에 대해 6개월 간에 걸쳐 조사하였다. 그중엔 부영양화에 관련된 수질항목들, 중금속, 농약, 그리고 수중 생태계 등의 전반적인 수질의 결과를 조사수계에 속한 골프장과 관련지어 분석하였다. 골프장으로부터 유출된 농약등의 오염이 조사수계의 수중 생태계에 미치는 영향은 심각한 정도가 아닌 것으로 나타났다. 골프장으로부터 유출되는 잔류농약의 분해를 돕기 위한 댐내에서는 수중 생태계가 잘 보전 돼있었고 전형적인 먹이의 연쇄가 확립돼 있었다. 일반적인 인식과는 달리 가축 축사와 논으로부터 유출되는 오염이 수계에 훨씬 더 약 영향을 미치는 것으로 나타났다.

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cyclic GMP Mediated Inhibition of Spontaneous Germinal Vesicle Breakdown Both with and without Cumulus in Mouse Oocyte

  • Hwang, Heekyung;Cheon, Yong-Pil
    • 한국발생생물학회지:발생과생식
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    • 제20권4호
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    • pp.359-365
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    • 2016
  • Intact germinal vesicle (GV) arrest and release are essential for maintaining the fertility of mammals inducing human. Intact germinal vesicle release, maturation of oocytes is maintained by very complex procedures along with folliculogenesis and is a critical step for embryonic development. Cyclic guanosine monophosphate (cGMP) has been suggested a key factor for meiotic arrest but so far its mechanisms are controversy. In this study we examine the effects of cGMP on germinal vesicle breakdown in cumulus-enclosed oocytes and denuded oocytes. Spontaneous maturation was inhibited by a cGMP agonist, 8-Br-cGMP with concentration dependent manners both in cumulus-enclosed oocytes and denuded oocytes. The inhibitory effect was more severe in denuded oocytes than cumulus-enclosed oocytes. The Rp-8-Br-cGMP and Rp-pCPT-8-Br-cGMP did not severely block GVB compared to 8-Br-cGMP. The spontaneous GVB inhibitory effects were different by the existence of cumulus. Based on them it is suggested that the cumulus modulates the role of cGMP in GV arrest.

GH Increases the Progesterone at Peri-estrus Stage in Mice Co-injected with PMSG for Superovulation

  • Kim, Young-Gee;Ryoo, Zae-Young;Park, Young-Sik
    • Reproductive and Developmental Biology
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    • 제35권4호
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    • pp.519-525
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    • 2011
  • Growth hormone (GH) is obligatory for growth and development. But, there is controversy on the GH effect about reproductive processes of sexual differentiation, pubertal maturation, gonadal steroidogenesis, gametogenesis and ovulation. This study was conducted to investigate the effect of GH on estrus, ovulation and embryo implantation. The results obtained were as follows. GH stimulated to increase estrus rate (p<0.05), pregnancy rate (p<0.05), and total fetus number in mice treated for superovulation. Also, the correlation between GH and steroids, E2 and P4, at peri-estrus stage/ peri-ovulation stage/ peri-implantation stage of the superovulation-induced mice was examined. Consequently, GH co-injected with PMSG especially increased P4 level (p<0.05) at peri-estrus stage of superovulationinduced mice. In conclusion, GH co-treatment in superovulation system boosted the rate of estrus, pregnancy and total fetus by increasing progesterone level at peri-estrus stage of superovulation-induced mice.

관절내 종골 골절 및 합병증에 대한 치료 (Treatment of the Intraarticular Calcaneal Fractures and its Complications)

  • 정형진;한용택;송승택;이창수
    • 대한족부족관절학회지
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    • 제7권1호
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    • pp.68-77
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    • 2003
  • Purpose: The treatment of calcaneal fractures remains a controversy in orthopaedic field because of its complications. The purpose of this study is to evaluate the efficacy of the treatment of calcaneal fractures and its complications. Materials and Methods: Clinical and radiological results were retrospectively analyzed in 28 patients, 34 cases with fractures of calcaneus which were treated in our department from September 1998 to march 2003. Results: According to the Creighton-Nebraska Foundation Assessment score, there were 3 excellent, 11 good, and 12 fair 6 poor results. Bohler angle was corrected from $8.3^{\circ}$ to $18.3^{\circ}$, Gissane angle was corrected from $121^{\circ}$ to $135^{\circ}$, and calcaneal width was corrected from 46.8mm to 37mm. Conclusion: Open reduction and internal fixation for joint depression type calcaneal fractures thought to be a good method of treatment. Closed reduction and percutaneous axial pinning should be chosed in selected cases of tongue type fractures. In treatment of complicated calcaneal fractures as malunion, subtalar distraction arthrodesis and lateral wall exostectomy will reduce disability of the disease.

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비타민 E: α-토코페롤 대 그외 비타민 E (Vitamin E: α-Tocopherol and the Other Forms of Vitamin E)

  • 조성희
    • Journal of Nutrition and Health
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    • 제43권3호
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    • pp.304-314
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    • 2010
  • Vitamin E has been a generic term for all tocopherol and tocotrienol derivatives. The most active form of vitamin E isoforms in vivo is regarded to be $\alpha$-tocopherol which is the only form defined as vitamin E in the US Food and Nutrition Board, causing controversy over setting dietary reference intake (DRI) of vitamin E. However, most of the countries other than the US maintain the original concept that all isoforms are accepted as vitamin E but with different biopotency. The roles of the isoforms of vitamin E other than $\alpha$-tocopherol have received continuous attention. Among them those of $\gamma$-tocopherol and $\alpha$-tocotrienol have been most studied in comparison with $\alpha$-tocopherol, since $\gamma$-tocopherol comprises major form of vitamin E in many plant seeds and those of the both vitamin E have been implicated in unique physiological functions. This review summarizes findings that have led a better understanding of vitamin E absorption, transport, tissue storage and various functions common and specific to vitamin E isoforms focusing $\alpha$- and $\gamma$-tocopherol as well as tocotrienols. It is expected to help redefining vitamin E and setting its DRI for Koreans.