• Title/Summary/Keyword: Controlled models

검색결과 579건 처리시간 0.031초

In vitro and in vivo studies on theophylline mucoadhesive drug delivery system

  • Bandyopadhyay, AK;Perumal, P
    • Advances in Traditional Medicine
    • /
    • 제7권1호
    • /
    • pp.51-64
    • /
    • 2007
  • Mucus is an aqueous gel complex with a constitution of about 95% water, high molecular weight glycoprotein (mucin), lipid, salts etc. Mucus appears to represent a significant barrier to the absorption of some compounds. Natural mucoadhesive agent was isolated and purified from the aqueous extract of the seeds of prosopis pallida (PP). Formulated tablet with the isolated material by wet granulation method. Some natural edible substances are in consideration for candidates as mucoadhesive agents to claim more effective controlled drug delivery as an alternative to the currently used synthetic mucoadhesive polymers. Subjected the materials obtained from natural source i.e. PP and standard synthetic substance, sodium carboxymethyl cellulose for evaluation of mucoadhesive property by various in vitro and in vivo methods. Through standard dissolution test and a model developed with rabbit, evaluated in vitro controlled release and bioadhesive property of theophylline formulation. Mucoadhesive agent obtained from PP showed good mucoadhesive potential in the demonstrated in vitro and in viνo models. The results suggest that the mucoadhesive agent showed controlled release properties by their application, substantially. In order to assess the gastrointestinal transit time in vivo, a radio opaque X-ray study performed in healthy rabbit testing the same controlled release formulation with and without bioadhesive polymer. Plasma levels of theophylline determined by the HPLC method and those allowed correlations to the in vitro mucoadhesive study results. Better correlation found between the results in different models. PP may acts as a better natural mucoadhesive agent in the extended drug delivery system.

Fault Analysis Method for Power Distribution Grid with PCS-based Distributed Energy Resources

  • Kim, Dong-Eok;Cho, Namhun
    • Journal of Electrical Engineering and Technology
    • /
    • 제12권2호
    • /
    • pp.522-532
    • /
    • 2017
  • In this study, we propose a fault analysis method for a power distribution grid with PCS-based DERs. We first explain the characteristics of a PCS-based DER. According to the characteristics, the DER is considered as a current-controlled voltage source, which produces varying voltages within a certain limit so that currents equal to given references flowing from the DER to the grid (currents controlled). So, we introduce the symmetrical equivalent models in the form of varying voltage source for fault analysis and then, construct a convex optimization problem to solve the fault problem associated with the equivalent models and grid conditions. Thus, the proposed method enables to perform a proper fault analysis considering the characteristics of the DER, which are currents controlled, voltage limited, and unity power factor achievement. To verify the validity of the proposed method, we perform computer simulations with the proposed method and with MATLAB Simulink, and the results are compared.

다변 환경 적응형 비선형 모델링 제어 신경망 (A Controlled Neural Networks of Nonlinear Modeling with Adaptive Construction in Various Conditions)

  • 김종만;신동용
    • 한국전기전자재료학회:학술대회논문집
    • /
    • 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.2
    • /
    • pp.1234-1238
    • /
    • 2004
  • A Controlled neural networks are proposed in order to measure nonlinear environments in adaptive and in realtime. The structure of it is similar to recurrent neural networks: a delayed output as the input and a delayed error between tile output of plant and neural networks as a bias input. In addition, we compute the desired value of hidden layer by an optimal method instead of transfering desired values by backpropagation and each weights are updated by RLS(Recursive Least Square). Consequently, this neural networks are not sensitive to initial weights and a learning rate, and have a faster convergence rate than conventional neural networks. This new neural networks is Error Estimated Neural Networks. We can estimate nonlinear models in realtime by the proposed networks and control nonlinear models. To show the performance of this one, we have various experiments. And this controller call prove effectively to be control in the environments of various systems.

  • PDF

전자제어식 자동변속기 장착 승용차의 구동성능 해석 (Analysis of Driving Performance for the Passenger Car Equipped with an Electronically Controlled Automatic Transaxle)

  • 김선일;임원식
    • 동력기계공학회지
    • /
    • 제6권2호
    • /
    • pp.73-81
    • /
    • 2002
  • In this study, electronically controlled automatic transmission adopted on a subcompact model in the market was modelled, and the driving performances of the transmission were simulated with the models. Kinetic and dynamic models of working components are established. The driving simulation program is developed with those models, and the various driving conditions are analyzed. With the results, the dynamic behaviour of the engine and the automatic transmission is easily understood. Especially, the transient performances of torque converter and clutches are deeply analyzed. Skipping the vehicle road test by using this analyzing tool, we can expect the cost down and the reduction of the development period of automatic transmission.

  • PDF

구획실 내 가스연료 화재의 CO 농도에 대한 FDS 연소모델의 예측성능 평가 (Evaluation of the Prediction Performance of FDS Combustion Models for the CO Concentration of Gas Fires in a Compartment)

  • 백빛나;오창보;황철홍;윤홍석
    • 한국화재소방학회논문지
    • /
    • 제32권1호
    • /
    • pp.7-15
    • /
    • 2018
  • 구획실 내 프로판 가스화재에 대해 Fire Dynamics Simulator (FDS)를 이용한 수치계산을 수행하고 실험과의 비교를 통해 적용된 연소모델 예측성능을 평가하였다. 검토된 연소모델은 FDS v5.5.3의 혼합분율 연소모델과 FDS v6.6.3의 Eddy Dissipation Concept (EDC) 모델이며, EDC 모델에서 화학반응기구는 1-step Mixing Controlled, 2-step Mixing Controlled, 3-step Mixing Controlled 및 Mixing Controlled 반응과 유한화학반응이 혼합된 3-step Mixed 반응을 적용하였다. 구획실 내부의 온도에 대해서는 각 연소모델들 간의 예측성능 차이는 그다지 크지 않음을 확인하였다. 연소모델 차이에 의한 $O_2$$CO_2$ 농도에 대한 예측성능 차이보다는 CO에 대한 예측결과 차이가 크게 나타났다. CO 농도에 대해서는 EDC 3-step Mixing Controlled 모델이 가장 높게 예측하며 혼합분율 연소모델은 실험보다는 낮게 예측하였다. EDC 3-step Mixed 모델이 가장 예측성능이 좋았지만 EDC 2-step Mixing Controlled 모델도 충분히 합리적인 수준으로 예측하고 있음을 확인하였다. EDC 1-step Mixing Controlled 모델에 기존에 제안된 CO 수율을 적용할 경우 CO 농도에 대해서 너무 과소 예측하며 CO 예측 정확도를 높이기 위해 수율을 높이면 $CO_2$ 농도에 대한 합리적인 예측이 어려워지는 문제점이 있었다.

반구형 공진 자이로의 동작모델과 기초 제어특성 실험 (Dynamic Models of Hemispherical Resonator Gyros and Tests of Basic Control Characteristics)

  • 진재현;최홍택;윤형주;김동국
    • 제어로봇시스템학회논문지
    • /
    • 제19권10호
    • /
    • pp.947-954
    • /
    • 2013
  • This article focuses on a hemispherical resonator gyro driven by the Coriolis effect. The operational principle of resonator gyros and mathematical models are introduced. These models are useful to explain the behavior of a resonator and to design controllers. Several control tests of a resonator have been done. A resonator has been excited by electromagnets controlled by a computer. Its amplitude has been adjusted by a PI control. The transient response is matched with a simulation result based on a mathematical model. A vibrating pattern may drift due to non-uniform factors of a resonator. The drift of the vibrating pattern is controlled and aligned to a reference direction by a PI control. These results are very useful to understand the behavior of resonator gyros and to design advanced control algorithm for better performance.

Prediction of Dry Matter Intake in Lactating Holstein Dairy Cows Offered High Levels of Concentrate

  • Rim, J.S.;Lee, S.R.;Cho, Y.S.;Kim, E.J.;Kim, J.S.;Ha, Jong K.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제21권5호
    • /
    • pp.677-684
    • /
    • 2008
  • Accurate estimation of dry matter intake (DMI) is a prerequisite to meet animal performance targets without penalizing animal health and the environment. The objective of the current study was to evaluate some of the existing models in order to predict DMI when lactating dairy cows were offered a total mixed ration containing a high level of concentrates and locally produced agricultural by-products. Six popular models were chosen for DMI prediction (Brown et al., 1977; Rayburn and Fox, 1993; Agriculture Forestry and Fisheries Research Council Secretariat, 1999; National Research Council (NRC), 2001; Cornell Net Carbohydrate and Protein System (CNCPS), Fox et al., 2003; Fuentes-Pila et al., 2003). Databases for DMI comparison were constructed from two different sources: i) 12 commercial farm investigations and ii) a controlled dairy cow experiment. The model evaluation was performed using two different methods: i) linear regression analysis and ii) mean square error prediction analysis. In the commercial farm investigation, DMI predicted by Fuentes-Pila et al. (2003) was the most accurate when compared with the actual mean DMI, whilst the CNCPS prediction showed larger mean bias (difference between mean predicted and mean observed values). Similar results were observed in the controlled dairy cow experiment where the mean bias by Fuentes-Pila et al. (2003) was the smallest of all six chosen models. The more accurate prediction by Fuentes-Pila et al. (2003) could be attributed to the inclusion of dietary factors, particularly fiber as these factors were not considered in some models (i.e. NRC, 2001; CNCPS (Fox et al., 2003)). Linear regression analysis had little meaningful biological significance when evaluating models for prediction of DMI in this study. Further research is required to improve the accuracy of the models, and may recommend more mechanistic approaches to investigate feedstuffs (common to the Asian region), animal genotype, environmental conditions and their interaction, as the majority of the models employed are based on empirical approaches.

라인압력제어 전자화 CVT 차량의 응답 특성 (Response Characteristics of Metal Belt CVT Vehicle with Electronic Controlled Line Pressure)

  • 송한림;김정철;김현수
    • 한국자동차공학회논문집
    • /
    • 제6권2호
    • /
    • pp.191-202
    • /
    • 1998
  • An electronic-hydraulic controlled line pressure system was suggested based on the mechanical controlled CVT base model. As a high level control strategy, a 3-D optimal line pressure map was obtained considering the driver's desire, driving conditions. Also, PID type low level controller was designed. Using the high level control strategy and the dynamic models of the base model CVT with electronic controlled line pressure system, performance simulations were carried out. It is seen from the simulation results that fuel economy of the electronic controlled strategy keeps the line pressure low, which results in the improved efficiency of the hydraulic system.

  • PDF

Modeling and Simulation of LEACH Protocol to Analyze DEVS Kernel-models in Sensor Networks

  • Nam, Su Man;Kim, Hwa Soo
    • 한국컴퓨터정보학회논문지
    • /
    • 제25권4호
    • /
    • pp.97-103
    • /
    • 2020
  • 무선 센서 네트워크는 인간의 개입 없이 다양한 환경에서 센싱 데이터를 수집하고 분석한다. 센서 네트워크는 초기에 설치된 라우팅 프로토콜들에 따라 네트워크 수명이 변경된다. 게다가, 네트워크가 운영 중에 라우팅 경로를 변경하기 위해 센서들은 많은 에너지를 소모해야 한다. 센서 네트워크를 실제 필드에 구축하기 전에 시뮬레이션을 통해 성능 측정하는 것은 중요하다. 본 논문은 DEVS 커널 모델들을 사용하여 저전력 적응형 클러스터링 계층 프로토콜을 위한 WSN 모델을 제안한다. 제안 모델은 커널 모델인 브로드캐스트 모델과 컨트롤드 모델로 구현된다. 실험 결과, 컨트롤드 기반의 WSN 모델은 데이터 전송 부분에서는 효율적이지만, 컨트롤드 모델에서 특정 모델을 선택하기 위해 CPU 사용량이 높은 것을 확인했다.

예술분야 정보의 주제전거를 위한 CONA와 FRSAD의 연계방안 연구 (Applying CONA to FRSAD for Organizing Cultural Works Information)

  • 박지영
    • 한국비블리아학회지
    • /
    • 제23권2호
    • /
    • pp.27-44
    • /
    • 2012
  • 본 연구의 목적은 Getty 재단의 Cultural Objects Name Authority(CONA)를 분석하여, 그 결과를 문헌정보학 분야의 주제전거 개념 모형인 Functional Requirements for Subject Authority Data(FRSAD)에 적용하는 방안을 제시하는 것이다. CONA는 AAT나 ULAN, TGN과 같은 기존의 어휘제어 도구와 연계성이 뛰어나고, LCSH와 같은 도서관 분야의 제어어휘 도구와도 연계할 수 있다. 그러나 CONA는 도서관보다는 박물관이나 미술관의 관점을 기반으로 개발되었으므로 우리 분야의 표준과 정확히 일치하지 않는다. CONA를 우리 분야에서 활용하거나 연계하고자 할 때는 이 점을 고려해야 할 것이다. 본 연구의 의의는 CONA의 관점을 통해 문화 객체에 대한 접근을 제공하는 방식을 검토하여, 유관 분야의 기술도구에 대한 이해를 증진시키고 이를 우리 분야에서 활용하는 방안을 검토하였다는 점에 있다.