• 제목/요약/키워드: Controlled Release

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Counterplan of Manufacturers in Accordance with ISO 9001:2015 Revision Conversion (ISO 9001:2015 개정규격 전환에 따른 제조업체의 대응 방안)

  • Kim, Ho Gyun;Kang, Byung Hwan;Park, Dong Joon
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.39 no.3
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    • pp.71-82
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    • 2016
  • The ISO (International Organization for Standardization) 9000 QMS (Quality Management System) standards specify requirements that need to demonstrate an organization's ability to consistently provide products or services. Korean companies have been implementing ISO 9000 QMS to compete in global markets. ISO 9000 QMS standards have been revised in 1994, 2000, 2008, and 2015 since the first release in 1987. The key change in ISO 9001:2015 is focused on risk-based thinking. It means that risk inherent within an organization is early identified and proactively controlled by use of all aspects of QMS rather than taking preventive actions. In this article we did literature review mainly on empirical study related to motivation and operation performance of ISO 9000 implementation. We present the necessity of changeover, features of new version, and comparison between new and old version. In order to see how well organizations can implement the new ISO 9001:2015 we focus on manufacturing companies that are going to convert to ISO 9001:2015 registration. We collect their key characteristics such as yearly sales, the number of MPI (Management Performance Indicators), the number of KPI (Key Performance Indicators), the number of quality control engineers, quality control engineer work experience, and the degree of adaptiveness between new ISO 9001:2015 QMS and QMS currently operating in manufacturing companies. Especially the degree of adaptiveness is analyzed by correlation analysis, regression analysis, ANOVA, and t-tests to discover the relationships among their characteristics. We found out that the degree of adaptiveness is linearly related to quality control engineer work experience and the number of MPI and KPI that is practically utilized in manufacturing companies. We summarize the implications discovered to help manufacturing industry convert to ISO 9001:2015 registration.

Antimicrobial Mechanisms of Nitric Oxide and Strategies for Developing Nitric Oxide-based Antimicrobial Agents (산화질소가 미생물에 미치는 영향 및 이를 이용한 항균전략)

  • Choi, Eun Young;Noh, Jin-Ki;Hasan, Nurhasni;Yoo, Jin-Wook
    • Korean Journal of Microbiology
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    • v.50 no.2
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    • pp.87-94
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    • 2014
  • Nitric oxide (NO), which has been recognized as an integral molecule in maintaining homeostasis, plays an important role in host defense against microbes. NO has diverse antimicrobial mechanisms by directly and/or indirectly interacting with microbes. Under the circumstance that there is an urgent need for a new class of antimicrobial agents due to antibiotic resistance, much effort has been made to develop a NO-based antimicrobial agent. In order to make it possible, strategies to store and release NO in a controlled manner are required because NO has a gaseous property and a very short half-life. In this review, we described NO biochemistry and its mechanisms of antimicrobial activity. In additions, we introduced various NO-releasing systems that improve NO's antimicrobial activity.

Calculating Average Residence Time Distribution Using a Particle Tracking Model (Particle Tracking Model을 이용한 평균체류시간의 공간분포 계산)

  • Park, Sung-Eun;Hong, Sok-Jin;Lee, Won-Chan
    • Journal of Ocean Engineering and Technology
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    • v.23 no.2
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    • pp.47-52
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    • 2009
  • A Lagrangian particle tracking model coupled with the Princeton Ocean Model were used to estimate the average residence time of coastal water in Masan Bay, Korea. Our interest in quantifying the transport time scales in Masan Bay was stimulated by the search for a mechanistic understanding of this spatial variability, which is consistent with the concept of spatially variable transport time scales. Tidal simulation was calibrated through a comparison with the results of semi-diurnal current and water elevation measured at the tidal stations of Masan, Gadeokdo. In the model simulations, particles were released in eight cases, including slack before ebb, peak ebb, slack before flood, and peak flood, during both spring and neap tides. The averaged values obtained from the particle release simulations were used for the average residence times of the coastal water in Masan Bay. The average residence times for the southeastern parts of Somodo and the Samho River, Masan Bay were estimated to be about 20~50days and 70~80days, respectively. The spatial difference for the average residence time was controlled by the tidal currents and distance from the mouth of the bay. Our results might provide useful for understanding the transport and behavior of coastal water in a bay and might be used to estimate the dissimilative capacity for environmental assessment.

Relationship between the Conception Rate after Estrus Induction using CIDR and Other Parameters in Dairy Cows (젖소에서 CIDR 투여에 의한 발정 유도 후 수태율과 다른 인자와의 관계)

  • Park, Chul-Ho;Son, Chang-Ho
    • Journal of Embryo Transfer
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    • v.26 no.1
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    • pp.1-7
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    • 2011
  • The purpose of this study was to determine the relationship between conception rate and other parameters (body condition score; BCS, progesterone concentrations and follicle size) before estrus induction with CIDR(intravaginal progesterone-releasing controlled internal drug release). The conception rate in cows with < 2.75, 2.75 to 3.25, and 3.25 <, BCS regardless of AI (artificial insemination) time was 46.6%, 63.3%, and 46.6% at CIDR insertion, respectively. The conception rate regardless of BCS was 54.9% in cows inseminated based on detected estrus, and 48.7% in cows inseminated at 72 to 80 hours (timed artificial insemination, TAI) after removal of CIDR. The conception rate regardless of AI time was 40.0% in cows with low progesterone concentrations (less than 1.0 ng/ml), and 56.6% in cows with high progesterone concentrations (more than 1.0 ng/ml) at CIDR injection. The conception rate regardless of progesterone concentrations was 53.8% in cows inseminated based on detected estrus, and 38.0% in cows of TAI after removal of CIDR. The conception rate regardless of AI time was 43.3% in cows with small follicle (less than 5 mm), 53.3% in cows between 5 mm to 10 mm of follicle, and 63.3% in cows with large folliclc (more than 10 mm) at CIDR injection, respectively. The conception rate regardless of follicle size was 58.4% in cows inseminated based on detected estrus, and 45.9% in cows of TAI after removal of CIDR. These results indicated that if the cows with BCS 2.75 to 3.25, active corpus luteum, and/or large dominant follicle (more than 10 mm) are used for estrus induction, the conception rate will be greater.

Combustion Characteristics of Gasoline HCCI Engine with DME as an Ignition Promoter (DME를 착화촉진제로 사용한 가솔린 예혼합 압축 착화 엔진의 연소 특성)

  • Yeom, Ki-Tae;Jang, Jin-Young;Bae, Choong-Sik
    • Transactions of the Korean Society of Automotive Engineers
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    • v.14 no.3
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    • pp.178-185
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    • 2006
  • This paper investigates the steady-state combustion characteristics of the Homogeneous charge compression ignition(HCCI) engine with variable valve timing(VVT) and dimethyl ether(DME) direct injection, to find out its benefits in exhaust gas emissions. HCCI combustion is an attractive way to lower carbon dioxide($CO_2$), nitrogen oxides(NOx) emission and to allow higher fuel conversion efficiency. However, HCCI engine has inherent problem of narrow operating range at high load due to high in-cylinder peak pressure and consequent noise. To overcome this problem, the control of combustion start and heat release rate is required. It is difficult to control the start of combustion because HCCI combustion phase is closely linked to chemical reaction during a compression stroke. The combination of VVT and DME direct injection was chosen as the most promising strategy to control the HCCI combustion phase in this study. Regular gasoline was injected at intake port as main fuel, while small amount of DME was also injected directly into the cylinder as an ignition promoter for the control of ignition timing. Different intake valve timings were tested for combustion phase control. Regular gasoline was tested for HCCI operation and emission characteristics with various engine conditions. With HCCI operation, ignition delay and rapid burning angle were successfully controlled by the amount of internal EGR that was determined with VVT. For best IMEP and low HC emission, DME should be injected during early compression stroke. IMEP was mainly affected by the DME injection timing, and quantities of fuel DME and gasoline. HC emission was mainly affected by both the amount of gasoline and the DME injection timing. NOx emission was lower than conventional SI engine at gasoline lean region. However, NOx emission was similar to that in the conventional SI engine at gasoline rich region. CO emission was affected by the amount of gasoline and DME.

Preparation and Characterization of Polyurethane Microcapsules Containing Functional Oil (기능성 오일을 함유하는 폴리우레탄 마이크로캡슐의 제조 및 분석)

  • 김인회;서재범;김영준
    • Polymer(Korea)
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    • v.26 no.3
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    • pp.400-409
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    • 2002
  • Polyurethane microcapsules containing functional oil (citronella oil) were successfully prepared by conventional interfacial polymerization of tolulene 2,4-diisocyanate (TDI) and ethylene glycol (EG) and characterized by Fourier transform (FT-IR) spectroscopy, Ultraviolet spectroscopy, particle size analysis, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Tile effects of polymerization variables, such as surfactant concentration and agitation speed, on the particle size and particle size distribution were investigated. FT-IR spectroscopic data showed that citronella oil was successfully encapsulated in the microcapsule. Thermogravimetric analysis data showed that the microcapsule was thermally stable up to $220^{\circ}C$. The controlled release of the citronella oil present in the microcapsule core in a methanol medium was demonstrated by ultraviolet spectroscopy showing that the amount of released citronella oil was increased with increasing time. It was observed that the amount of released citronella oil was increased with increasing stirring speed and emulsifier concentration in the rnicrocapsule preparation step. Polyurethane microcapsules containing citronella oil showed excellent anti-moth property.

An Experimental Study on the Effect of Longitudinal Ventilation on the Variation of Burning Rate in Tunnel Fires (터널 화재시 종류식 환기가 연소율 변화에 미치는 영향에 관한 실험적 연구)

  • Yang Seung Shin;Kim Sung Chan;Ryou Hong Sun
    • Tunnel and Underground Space
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    • v.15 no.1 s.54
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    • pp.55-60
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    • 2005
  • In this study, the 1/20 reduced-scale experiments using Froude scaling were conducted to investigate the effect of longitudinal ventilation on the variation of burning rate in tunnel fires. The methanol square pool fires with heat release rate ranging from 3.57 kW to 10.95 kW were used. The burning rate of fuel was obtained by measured mass using load cell and temperature distribution were measured by K-type theomocouples in order to investigate smoke movement. The wind tunnel was connected with one side of the tested tunnel, and logitudinal ventilation velocity in the tested tunnel was controlled by power of the wind tunnel. In methanol fire case, the increase in ventilation velocity decreased the turning rate due to the direct cooling of fire plume. For the same dimensionless velocity(V), homing rate decreased as the size of pool fire increased.

Effects of Days Open on the Subsequent Reproductive Performance Following to CIDR-Based Estrus Synchronization in Lactating Dairy Cows

  • Kang, Hyun-Gu;Kim, Ill-Hwa
    • Journal of Embryo Transfer
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    • v.26 no.2
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    • pp.91-96
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    • 2011
  • The purpose of this study was to evaluate the effects of days open on subsequent reproductive performance following to estrus synchronization in the 114 lactating dairy cows. The animals were divided into two groups according to the time of estrus synchronization; viz, ${\leq}$ 85 days, and > 85 days postpartum, respectively. The estrus synchronization protocol consisted of insertion of a controlled internal drug release (CIDR) device containing 1.9 g progesterone with an injection of 250 ${\mu}g$ gonadorelin (Day 0), an injection of $PGF_2{\alpha}$ and removal of the device on Day 7, an injection of 250 ${\mu}g$ GnRH on Day 9, and TAI 17 h later. Pregnancy diagnosis was determined at 30 to 60 days after TAI using both ultrasonography and rectal palpation. The body condition score (BCS) gradually increased over the postpartum period. In estrus synchronized cows until 85 days, conception rate on first service, number of service per conception, interval from estrus synchronization to conception, and interval from calving to conception were not significantly different among two farms (P>0.05). In estrus synchronized cows after 85 days postpartum, conception rate on first service, number of service per conception and interval from calving to conception were significantly different ($P{\leq}0.05$) between herds A and B (26.8 vs 50.0%; $2.1{\pm}1.35$ vs $1.37{\pm}0.54$ times, $237.3{\pm}97.8$ vs $164.7{\pm}69.3$ days, respectively). In estrus synchronized cows after 85 days postpartum interval from estrus synchronization to conception was greater (P<0.01) in herd B than in herd A ($63.6{\pm}57.4$ vs $26.1{\pm}24.9$). These results indicate that the time of estrus synchronization for maximized the reproductive performance is before 85 days postpartum and feeding and management is important factor for high reproductive performance.

An Experimental Study on the Ventilation velocity of the Variation of Burning rate in Tunnel Fires - Heptane pool fire case (터널 화재시 배연속도가 연소율변화에 미치는 실험적 연구 - Heptane 풀화재 경우)

  • Ryou, Hong-Sun;Yang, Seung-Shin
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.7 no.2
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    • pp.109-117
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    • 2005
  • In this study, the 1/20 reduced-scale experiments using Froude scaling were conducted to investigate the ventilation velocity of the variation of burning rate in tunnel fires. The heptane square pool fire with heat release rate ranging from 3.71~15.6 kW were used. The burning rate of fuel was obtained by measuring mass using load cell and temperature distributions were measured by K-type theomocouples in order to investigate smoke movement. The ventilation velocity in the tested tunnel was controlled by inverter of the wind tunnel. In heptane pool fire case, the increase in ventilation velocity incresed the burning rate due to the direct supply of oxygen to the fire plume. For the same dimensionless velocity($\bar{V}$), burning rate increased as the size of pool fire decreased.

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Follicle Stimulating Hormone (FSH) Dosage Based on Body Weight Enhances Ovulatory Responses and Subsequent Embryo Production in Goats

  • Rahman, M.R.;Rahman, M.M.;Khadijah, W.E. Wan;Abdullah, R.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.27 no.9
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    • pp.1270-1275
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    • 2014
  • An experiment was conducted to evaluate the efficacy of porcine follicle stimulating hormone (pFSH) dosage based on body weight (BW) on ovarian responses of crossbred does. Thirty donor does were divided into 3 groups getting pFSH dosages of 3, 5, and 8 mg pFSH per kg BW, respectively, and were named as pFSH-3, pFSH-5 and pFSH-8, respectively. Estrus was synchronized by inserting a controlled internal drug release (CIDR) device and a single injection of prostaglandin $F2{\alpha}$ ($PGF2{\alpha}$). The pFSH treatments were administered twice a day through 6 decreasing dosages (25, 25, 15, 15, 10, and 10% of total pFSH amount; decreasing daily). Ovarian responses were evaluated on Day 7 after CIDR removal. After CIDR removal, estrus was observed 3 times in a day and pFSH treatments were initiated at 2 days before the CIDR removal. All does in pFSH-5 and pFSH-8 showed estrus signs while half of the does in pFSH-3 showed estrus signs. No differences (p>0.05) were observed on the corpus luteum and total ovarian stimulation among the treatment groups, while total and transferable embryos were higher (p<0.05) in pFSH-5 (7.00 and 6.71) than pFSH-3 (3.00 and 2.80) and pFSH-8 (2.00 and 1.50), respectively. In conclusion, 5 mg pFSH per kg BW dosage gave a higher number of embryos than 3 and 8 mg pFSH per kg BW dosages. The results indicated that the dosage of pFSH based on BW is an important consideration for superovulation in goats.