• Natural Product Sciences
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• 제28권3호
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• pp.143-152
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• 2022

In our study, sixteen known phenolic compounds, including quercetin (1), methyl gallate (2), caesalpiniaphenol C (3), 8S,8'S,7'R-(-)-lyoniresinol (4), 7,3',5'-trihydroxyflavanone (5), sappanchalcone (6), sappanone A (7), taxifolin (8), fisetin (9), fustin (10), (+)-catechin (11), brazilin (12), 3,4,5-trimethoxyphenyl β-ᴅ-glucopyranoside (13), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (14), (+)-epi-catechin (15), and astragalin (16) and one mixture of two conformers of protosappanin B (17/18) were isolated from the stems of Caesalpinia decapetala var. japonica. Their structures were elucidated based on a comparison of their physicochemical and spectral data with those of literature. To the best of our knowledge, this represents the first isolation of compounds 3, 4, 8, 9, and 10 from C. decapetala and compounds 13 and 14 from the Caesalpinia genus. All the isolated compounds were evaluated for their inhibitory effect against the α-glucosidase enzyme. Among them, two flavonols (1 and 9), one chalcone (6), and one homoisoflavanone (7) exhibited an inhibitory effect on α-glucosidase action with an IC₅₀ range value of 5.08-15.01 μM, stronger than that of the positive control (acarbose, IC₅₀ = 152.22 μM). Kinetic analysis revealed that compounds 1 and 9 showed non-competitive α-glucosidase inhibition, while the inhibition type was mixed for compounds 6 and 7.

• International Journal of Computer Science & Network Security
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• 제22권9호
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• pp.287-299
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• 2022

The article deals with the formation of managerial competence of the future head of preschool education institution by means of information and communication technology as a prerequisite for his ability to act competently and objectively evaluate actions and understand the interaction of forms and content of preschool education. The article aimed to study the effectiveness of information and communication technologies in the formation of managerial competence of the future head of preschool education institution. To achieve the objectives, the methods of comparative and systematic analysis were used to compare different views on the problem under study, namely, the formation of managerial competence of the future head of preschool education institution by means of information and communication technologies. The authors of the article determined that the use of information and communication technologies in the preparation of future heads of preschool educational institutions is of great importance and is an indicator in the structure of managerial competence. The priority directions of the use of various software products for the study of the modern Ukrainian language, methods of teaching the Ukrainian language contribute to the intensification of learning material. It is noted that the current state of development of information technologies and their widespread use in education satisfies the requirements of the objectivity of the assessment obtained the quality of the control process of forming the managerial competence of the future leader in the context of the general problems of pre-school education. It is noted that the means of information and communication technologies play a leading role in creating new educational policies and projects, as they motivate the way of access to knowledge.

• Journal of Korea Trade
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• 제24권7호
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• pp.54-72
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• 2020

Purpose - This study explores the contextual factors that affect the relationship between CEO overseas experience and firm internationalization. This study incorporates a wide range of contextual factors, including mega, macro, and micro variables. In particular, this study goes a step further from prior studies by incorporating a higher-order variable i.e., the global financial crisis that can constrain the managerial discretion of a CEO. Design/methodology - To structure the balanced data set before and after the 2008 global financial crisis, we used the data for the years from 2002 to 2014 from a sample of Korean manufacturing firms. Ultimately, 1101 firm-year unbalanced panel observations from 101 firms were used for the analysis. Findings - Our main findings can be summarized as follows. CEO overseas experience is positively related to firm internationalization. However, this relationship varies depending on the CEOs level of managerial discretion. As for the constraining moderation, the global financial crisis weakened the positive relationship between CEO overseas experience and firm internationalization. As for the enabling moderation, the CEOs tenure strengthened the relationship. Originality/value - This study adopted the knowledge, skills, and abilities (KSA) framework to explain the relationship between CEO overseas experience and firm internationalization. Moreover, we argue that the CEO-internationalization relationship depends on the specific context of the managerial discretion, focusing on the 2008 global financial crisis. Empirically, this study adopted the 2SLS procedure to correct endogeneity. Instead of taking the actual value of prior internationalization as a control, we estimated prior internationalization using the instrument variables at an industry level. This procedure made our estimation more robust.

• 대한한의학회지
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• 제42권1호
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• pp.99-109
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• 2021

Objectives: Objective: The purpose of this study is to investigate the treatment of herbal medicine for patients with COVID-19 asymptomatic infections. Method: In English, search engines such as 'PubMed', 'Science Direct', and 'Cumulative Index to Nursing and Allied Health Literature (CINAHL)' were used. In Chinese, search engines such as 'China National Knowledge Infrastructure (CNKI)' and Wanfang were used. The keywords for the search engines were 'COVID-19', 'asymptomatic infection', 'Korean Medicine', 'traditional Chinese medicine', 'herbal medicine', and etc. Only clinical studies using herbal medicine for patients without fever or respiratory symptoms were selected. We excluded the cases that do not fit the research topic. Results: A total of 5 studies were finally selected. Among them, four of them used integrated herbal medicine and Western medicine, and one of the studies treated exclusively for herbal medicine. There were a total of seven prescriptions for herbal medicine used in the study. Outcome variables were used as following: lab test, nucleic acid conversion time, hospitalization period, chest CT, and etc. In the RCT study, herbal medicine and Western medicine decreased nucleic acid conversion time, average hospitalization time compared to the control group, but it was not statistically significant. No other adverse reactions were reported in all studies. Conclusion: According to the results, integrated herbal medicine and Western medicine might be an effective treatment for patients with COVID-19 asymptomatic infection reducing hospitalization period, time of nucleic acid turning negative. No severe adverse effects were reported. However, it is thought that better-designed research will be needed in the future.

• 한국경제지리학회지
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• 제24권2호
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• pp.163-180
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• 2021

원자력발전은 위험을 안고 있음에도 많은 국가에서 에너지 공급원으로 그리고 지구온난화 대응으로 중요하게 자리잡고 있다. 핵에너지는 방사능 오염의 위험과 핵무기의 위협 그리고 핵폐기물 처리의 문제를 가지고 있으나 효율적인 신기술로 안전 관리가 가능하다는 기술낙관주의가 전문가 그리고 정부 주도로 주류를 이루어 왔다. 그러나 체르노빌 그리고 후쿠시마 원전 사고는 전세계적으로 핵발전의 대안을 모색하는 관심과 노력은 확대되어 대안 모색으로 지속가능한 재생 에너지의 생산을 확대하는 노력, 에너지의 효율적 전달을 위한 스마트그리드와 환경친화적 소비 행태를 통한 에너지 사용 절감, 그리고 핵폐기물의 처리 등을 포함한 환경의 수용능력을 감안한 청지기 정신을 강조한다. 보다 근본적인 대안 운동으로는 대규모 원전 사고를 경험하며 기존 전문가와 정부가 중심이 되어 형성해온 기술주의가 배제했던 지역에서의 피해 사례와 이를 고려하지 못하는 접근에 대한 불만이 보다 광범위하게 피해자, 기술자, 일반인 등이 대안운동을 전개한다. 이들 비전문가들은 지역의 오염을 감지하고 대중의 일상생활에 심각하게 영향을 위험과 감정을 고려하는 능력을 가진 반전문가로 등장한다. 이들은 광범위한 지역에서 원자력에 대한 대안적 지식을 구성하고 합법화하는데 중요한 역할을 한다.

• 한국융합학회논문지
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• 제13권5호
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• pp.267-278
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• 2022

본 연구는 목격자 증언 맥락에서 진술 정확성에 영향을 미치는 정서의 기능에 관한 문헌 고찰을 시도하였다. 목격자 증언의 정확성과 정서 간의 관계를 살펴본 연구에서 소개된 주요 이론과 개념들, 연구 방법을 토대로 살펴보았다. 해당 결과는 정서의 정의, 정서 유도 방식, 정서 측정 방식 순으로 제시하였다. 구체적으로 부정 정서, 각성, 스트레스, 기분을 중심으로 정서의 정의를 기술하였고, 정서 유도 방식은 실험실에서 주로 사용되는 영상, 가상현실, 연구자가 연출한 모의 사건을 중심으로 기술하였다. 정서 측정 방식은 자기보고식, 행동 측정, 정신생리학을 중심으로 기술하였다. 또한, 객관적이고 과학적 정서 연구를 위한 접근 방식, 적절한 실험 설계와 기억 검사, 개인차 통제의 필요성에 대해 논의하였다. 본 연구는 목격자 증언 맥락에서 진술 정확성에 미치는 정서의 기능을 살펴봄으로써 선행 연구의 비일관된 결과를 검토하고, 관련 연구들을 비교 분석하는 구조를 제시하는 데 의의를 두었다. 이와 같은 지식은 목격자 증언의 신뢰성 판단에 기초 자료로도 활용될 수 있을 것이다.

• Computers and Concrete
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• 제30권6호
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• pp.421-432
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• 2022

Recently, the interminable ozone depletion and the global warming concerns has led to construction industries to seek for construction materials which are eco-friendly. Regarding this, Geopolymer Concrete (GPC) is getting great interest from researchers and scientists, since it can operate by-product waste to replace cement which can lead to the reduction of greenhouse gas emission through its production. Also, compared to ordinary concrete, geopolymer concrete belongs improved mechanical and durability properties. In spite of its positive properties, the practical use of geopolymer concrete is currently limited. This is primarily owing to the scarce structural, design and application knowledge. This study investigates the Mechanical and Durability of Geopolymer Concrete Containing Fibers and Recycled Aggregate. Mixtures of elastoplastic fiber reinforced geopolymer concrete with partial replacement of recycled coarse aggregate in different proportions of 10, 20, 30, and 40% with natural aggregate were fabricated. On the other hand, geopolymer concrete of 100% natural aggregate was prepared as a control specimen. To consider both strength and durability properties and to evaluate the combined effect of recycled coarse aggregate and elastoplastic fiber, an elastoplastic fiber with the ratio of 0.4% and 0.8% were incorporated. The highest compressive strength achieved was 35 MPa when the incorporation of recycled aggregates was 10% with the inclusion of 0.4% elastoplastic fiber. From the result, it was noticed that incorporation of 10% recycled aggregate with 0.8% of the elastoplastic fiber is the perfect combination that can give a GPC having enhanced tensile strength. When specimens exposed to freezing-thawing condition, the physical appearance, compressive strength, weight loss, and ultrasonic pulse velocity of the samples was investigated. In general, all specimens tested performed resistance to freezing thawing. the obtained results indicated that combination of recycled aggregate and elastoplastic fiber up to some extent could be achieved a geopolymer concrete that can replace conventional concrete.

• 한국농촌간호학회지
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• 제17권1호
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• pp.9-22
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• 2022

Purpose: This study was conducted to suggest the direction of follow-up research by comparing and analyzing studies related to emerging infectious diseases (EID) in the field of nursing published in Korea since 2000 and before the outbreak of COVID-19 to identify overall themes and trends. Methods: The data search period was limited to papers from 2000 to 2019, and a literature review was conducted through a domestic DB search. 1574 papers extracted through search terms were excluded according to the criteria, and the final 39 papers were selected and analyzed. Results: Nursing studies related to EID consisted of 35 quantitative studies and most of them were descriptive research studies. As for specific disease types, MERS accounted for the largest number with 22, followed by 11 influenza A, 4 EID and 2 SARS. Nurses were the most common subjects with 19 cases (48.7%), and the number of study subjects was 200 or more, 23 cases (59.0%). The outcome variables of the analysis target literature were infection prevention behavior performance, knowledge, attitude, stress, anxiety, nursing intention, and infection control. Conclusion: This study is meaningful in suggesting the direction of follow-up research by identifying the trends in EID research.

• 대한통합의학회지
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• 제10권4호
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• pp.113-120
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• 2022

Purpose : Lymphedema is a common complication in mastectomy patients and is usually characterized by pain, swelling, and limited range of motion (ROM) in the arm. Electromyostimulation (EMS) is widely used for the rehabilitation and recovery of subjects with various neuromusculoskeletal disorders after breast cancer. However, EMS has not yet been used in many Pilates exercises. This study was aimed at comparing the effects of instrument Pilates integrated with EMS on pain, lymphedema, and ROM of the upper extremity (UE) in breast cancer subjects after mastectomy. Methods : Nine female breast cancer subjects who had undergone mastectomy participated in the study. The subjects underwent instrument Pilates with EMS (experimental group) or instrument Pilates only (control group). Pain, lymphedema, and ROM of the UE were measured using the visual analog scale (VAS), the circumference length of the UE, and the ROM of the UE. The Wilcoxon signed-rank test was used to compare the pain, lymphedema, and ROM of the arm before and after the intervention, and the Mann-Whitney U test was used to compare the two groups. The statistical significance level was set to p < .05. Results : In the experimental group, there were significant differences in pain (p<.05) and UE circumference (p<.05) before and after intervention. However, there was no significant difference between the two groups in VAS (p>.05) or circumference length of the UE (p>.05). There was one significant difference between the groups in terms of internal rotation of the ROM of the UE (p<.05). Conclusion : These results show that instrument Pilates exercises combined with EMS may positively affect the internal rotation of the ROM of the UE in breast cancer patients after mastectomy, thus contributing to existing knowledge about instrument Pilates using EMS for the effective management of in breast cancer subjects after mastectomy.

• The Plant Pathology Journal
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• 제38권2호
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• pp.115-130
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• 2022

Though information exists regarding the pathogenesis of the shot-hole disease (SH) in flowering cherry (FC), there has been a lack of research focusing on SH management. Therefore, here, we investigated the inhibitory activities of antagonistic bacteria against SH pathogens both in vitro and in vivo as well as their biochemical characteristics and bioactive compounds. Two biosurfactant-producing bacterial antagonists, identified as Bacillus velezensis strains JCK-1618 and JCK-1696, exhibited the best effects against the growth of both bacterial and fungal SH pathogens in vitro through their cell-free culture filtrates (CFCFs). These two strains also strongly inhibited the growth of the pathogens via the action of their antimicrobial diffusible compounds and antimicrobial volatile organic compounds (VOCs). Crude enzymes, solvent extracts, and biosurfactants of the two strains exhibited antimicrobial activities. Liquid chromatography/electrospray ionization time-of-flight mass spectrometric analysis of the partially purified active fractions revealed that the two antagonists produced three cyclic lipopeptides, including iturin A, fengycin A, and surfactin, and a polyketide, oxydifficidin. In a detached leaf assay, pre-treatment and co-treatment of FC leaves with the CFCFs led to a large reduction in the severity of the leaf spots caused by Epicoccum tobaicum and Bukholderia contaminans, respectively. In addition, the two antagonists produced indole-3-acetic acid, siderophore, and a series of hydrolytic enzymes, along with the formation of a substantial biofilm. To our knowledge, this is the first report of the antimicrobial activities of the diffusible compounds and VOCs of B. velezensis against the SH pathogens and their efficiency in the biocontrol of SH.