• Investigative Magnetic Resonance Imaging
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• 제16권1호
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• pp.1-5
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• 2012

유방 MRI는 유방암의 유방촬영 스크리닝법에 대한 가장 정확한 보완 검사법이다. 아직까지 MRI 스크리닝의 효과에 대한 무작위 대조군연구가 없음에도 불구하고, 현재 미국암학회와 국립 종합암네트워크 (NCCN)에서는 MRI 스크리닝을 유방암 고위험여성에서 권고하고 있다. 국내에서는, 한 후향적 연구에서 유방암 환자의 반대쪽 유방암에 대한 MRI 스크리닝법이 유방촬영술과 초음파에서 발견하지 못한 암을 발견하고 이는 이후 유방암 발병을 감소시킴을 보고하고 있다. 국내에 유방촬영 스크리닝법의 보완법으로 MRI를 도입하기 위해서는 판독의 표준화와 교육, MR 유도하 조직검사법과 적절한 적응증의 확립, 비용-효용성에 대한 평가가 선결되어야 한다.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.373-377
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• 2022

Currently, robot-assisted latissimus dorsi muscle flap (RLDF) surgery is used in treating patients with Poland syndrome and for breast reconstruction. However, conventional RLDF surgery has several inherent issues. We resolved the existing problems of the conventional system by introducing the da Vinci single-port system in patients with Poland syndrome. Overall, three patients underwent RLDF surgery using the da Vinci single-port system with gas insufflation. In the female patient, after performing RLDF with silicone implant, augmentation mammoplasty was also performed on the contralateral side. Both surgeries were performed as single-port robotic-assisted surgery through the transaxillary approach. The mean operating time was 449 (335-480) minutes; 8.67 (4-14) minutes were required for docking and 59 (52-67) minutes for robotic dissection and LD harvesting. No patients had perioperative complication and postoperative problems related to gas inflation. The single-port robot-assisted surgical system overcomes the drawbacks of previous robotic surgery in patients with Poland syndrome, significantly shortens the procedure time of robotic surgery, has superior cosmetic outcomes in a surgical scar, and improves the operator's convenience. Furthermore, concurrent application to another surgery demonstrates the possibility in the broad application of the robotic single-port surgical system.

• Journal of Acupuncture Research
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• 제26권5호
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• pp.11-17
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• 2009

Objectives : The objectives of this study were to examine the specificity and the sensitivity of tenderness testing on the ear about the postpartum breast pain, and to improve the efficacy of the tenderness test. Methods : Thirty women who visited in the hospital for recuperating 2-14 days after childbirth participated in this study. They answered the questionnaire of the severity of breast pain and their auricular acupuncture points were tested by a long metal probe with round tip 1.1mm in diameter. We analyzed the relationship between auricular tenderness testing on mammary gland zone[CW6] and postpartum breast pain with validity and significance as grouping 8 diagnosis methods. Results : When we consider above 'moderate pain' or 'severe pain' in the auricular tenderness testing as a positive sign, and above 'evere pain' or 'very severe pain' in the self-reported breast pain score as a positive symptom, the diagnostic efficacy was highest. The sensitivity for tenderness testing was 0.62-0.75, and the specificity was 0.64-0.72, and the sensitivity and the specificity in the contralateral ear were a little higher than in the ipsilateral ear. Conclusions : These results suggest that auricular tenderness testing can be objectified clinically and be used in diagnosis.

• Radiation Oncology Journal
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• 제14권4호
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• pp.323-332
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• 1996

목적 : 방사선 치료에 있어서 조직내 등선량 분포곡선을 변형시킬 목적으로 쐐기 차폐물이 사용되고 있는데 최근 기존의 고정 쐐기와는 다르게 비대칭적인 콜리메이터인 Independent Jaw에 의해 등선량 분포곡선을 변형시키는 동적 쐐기 기법이 실용화 되고 있으나 아직 그 방사선 물리학적인 특성에 대해서는 잘 알려져 있지 않다. 이에 본 저자는 기존의 고정 쐐기와 비교하여 조직내 방사선량 분포의 특성을 알아보고자 본 연구를 계획하였다. 대상 및 방법 : 물 판톰, 폴리 스타이린 판톰, 평균 유방 모형 판톰을 대상으로 전리함, 필름, TLD 등을 이용하여 동적 쐐기와 고정 쐐기의 선량 분포를 측정하여 비교하였다. 방사선원은 선형 가속기의 6MV x선을 사용하였고 $15{\times}15$ 조사면에서 15, 30, 45도 쐐기를 이용하였다 조직내선량 분포는 전리함과 필름 선량계를 사용하였고, 유방 접선 치료방식에서의 반대편 유방 조사선량은 TLD를 사용하였다. 결과 : 1) 조직내 $\%$심도 선량은 고정 쐐기의 경우 심도 선량 깊이가 깊어지는 방사선의 경화 현상이 뚜렷하였으나 동적 쐐기의 경우에는 발견할 수 없었으며 그 $\%$심도선량은 개방 조사면과 유사하였다. 2) 조직내 등선량 분포 곡선을 보면 동적 쐐기의 경우 고정 쐐기와는 달리 원하는 깊이, 원하는 조사면에서 원하는 쐐기 각도를 얻을 수 있었으며 쐐기 각도를 이루는 등선량 분포 곡선이 고정 쐐기에 비해 더욱 직선적이었다. 3) 산란선량은 동적 쐐기의 경우 개방 조사면과 그 양이 거의 동일하였으며 유방보존술에서의 접선 조사방식의 방사선치료에서 고정 쐐기 대신에 동적 쐐기를 사용함으로써 반대측 유방으로의 피폭선량을 감소시킬 수 있었다. 결론적으로 동적 쫴기 기법은 단순히 고정 쐐기를 대체할 수 있을 뿐만 아니라 고정 쐐기의 단점을 보완해 줄 수 있으며 향후 방사선 치료에 있어서 더 다양한 유용성을 가질 수 있으리라 생각한다.

• Archives of Plastic Surgery
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• 제34권5호
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• pp.622-627
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• 2007

Purpose: Although the autogenous tissue transfer has been the mainstay of the breast reconstruction, concern for the donor site morbidity can lead to the superseded method using tissue expander with implant or permanent expander-implant. However, the additional procedure of tissue expansion possibly cause discomfort and raise the cost. We tried to verify the efficacy of using the saline-filled breast implant by itself for the safe and convenient immediate breast reconstruction modality if the patients have small, round and non-ptotic breasts and the sufficient breast skin can be saved with mastectomy. Methods: From July 2002 to July 2005, 29 breasts of 26 patients were restored only with the saline-filled breast implant immediately after the skin sparing or nipple-areolar skin sparing mastectomy in Asan Medical Center. A pocket with pectoralis major and serratus anterior muscle was created and the implant was covered with this muscle pocket. Simultaneous contralateral augmentation was performed in patients whose mastectomy specimen weighed less than 100g. Results: Using only the saline-filled breast implant resulted in the successful reconstruction with few complications including partial necrosis of nipple areolar skin (five cases, 17.2%), capsular contracture (three cases, 10.3%), hematoma (one case, 3.4%), depigmentation of areolar skin (one case, 3.4%), hypertrophic scar (one case, 3.4%), which were all healed by conservative management. There were no significant complications such as implant exposure and subsequent removal. Conclusion: Immediate breast reconstruction only with the saline-filled breast implant can be a satisfactory alternative option for the patients whose breast is small, round and non-ptotic, especially when the nipple-areolar skin of the breast is preserved in the mastectomy.

• Archives of Reconstructive Microsurgery
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• 제10권1호
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• pp.28-33
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• 2001

The numbers of breast cancer are increasing in Korea and the needs for breast reconstruction are also parallel with cancer frequency. The purpose of the study is to define the different state and condition between the delayed reconstruction and the immediate reconstruction of breasts and to suggest how to get more satisfactory outcome. The study included 22 patients who underwent delayed breast reconstruction using transverse rectus abdominis myocutaneous(TRAM) free flap from December, 1990 to January, 2001. Their ages ranged from 28 years to 58 years. We have used internal mammary artery and vein as a recipient vessel in 13 patients because of fibrosis and severe scarring in the axillary region and thoracodorsal artery and vein in 9 patients. When we used internal mammary artery with recipient vessel, we would use contralateral deep inferior epigastric artery with donor vessel. We obtained satisfactory result without any flap loss, and most patients satisfied with shape and volume of reconstructed breast. We found that delayed breast reconstruction have some differences compared with immediate breast reconstruction. First, we remove fibrotic and scar tissue as much as possible to achieve satisfactory shape of breast. Second, we plan preoperative design in standing position to obtain symmetrical recreation of inframammary fold. Third, we use internal mammary vessel in many cases with recipient vessel for microvascular anastomosis. Fourth, patients with delayed breast reconstruction feel more satisfaction than patients with immediate breast reconstruction do. Finally, economic burden is much higher in the delayed case than in the immediate case because of no coverage with insurance.

• Archives of Plastic Surgery
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• 제47권2호
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• pp.153-159
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• 2020

Background Perforator artery flaps based on the branches of intercostal arteries and lateral thoracic artery can be used for reconstruction after breast-conserving surgery (BCS). Although described more than a decade ago, these have not been adopted widely in clinical practice. We report on short-term and long-term surgical outcomes of partial breast reconstruction using chest wall perforator flaps from a prospective multicenter audit. Methods All patients operated for BCS and partial breast reconstruction using intercostal artery perforator or lateral thoracic artery perforator flaps from January 2015 to October 2018 were included in the analysis. Oncoplastic breast surgeons with appropriate level of training performed all tumor excisions and reconstructions as a single-stage procedure. Patient characteristics, treatment details and surgical outcomes were noted. Specific outcomes recorded were margin re-excision and complication rates. Results One hundred and twelve patients underwent the procedure in the given study period. The median age was 54 years. Median specimen weight was 62.5 g and median volume of excision was 121.4 mL. Fifteen patients (13.39%) underwent a margin re-excision for close or positive margins without additional morbidity. One patient required a completion mastectomy. Eight patients (7.14%) had an early complication. None of the patients required a contralateral symmetrization procedure. The results were comparable across the participating centers. Conclusions Chest wall artery perforator-based flaps are an excellent option for lateral and inferior quadrant partial breast reconstructions. The short and long-term surgical outcomes are comparable across sites and can be performed with minimal morbidity. Patient-reported outcome measures need to be studied.

• Investigative Magnetic Resonance Imaging
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• 제19권2호
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• pp.99-106
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• 2015

Purpose: To investigate factors influencing the evaluation of background parenchymal enhancement (BPE) at follow-up breast magnetic resonance imaging (MRI) after adjuvant endocrine therapy. Materials and Methods: One hundred twelve women with breast cancer and MRI of the contralateral unaffected breast before and after endocrine therapy were identified. Two readers in consensus performed blinded side-by-side comparison of BPE (minimal, mild, moderate, and marked) before and after therapy with categorical scales. Age, body mass index, menopausal status, treatment regimen (selective estrogen receptor modulator or aromatase inhibitor), chemotherapy, follow-up duration, BPE at baseline MRI, MRI field strength before and after therapy, and recurrence were analyzed for their influences on decreased BPE. Results: Younger age, premenopausal status, treatment with selective estrogen receptor modulator, MRI field strength, and moderate or marked baseline BPE were significantly associated with decreased BPE. In multivariate analysis, MRI field strength and baseline BPE showed a significant association. Conclusion: MRI field strength and baseline BPE before and after therapy .were associated with decreased BPE at post-therapy, follow-up MRI.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6529-6532
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• 2013

Background: Breast cancer is mostly the disease of postmenopausal women but very young affected women are seen more than occasionally in developing countries. We reviewed our cases of very young breast cancer in order to help in better understanding of such cases. Materials and Methods: The records of patients 25 years of age or less who had been admitted for breast cancer surgery in the Cancer Institute of Tehran from 1979 to 2012 were reviewed and relevant data were extracted. Results: From 5,265 cases of breast cancer, 62 patients had 25 years of age or less. There were 55 cases of breast adenocarcinoma, all female. More than 78% of the patients had presented with a palpable mass, the family history was positive in 2% of cases, and about 94% of the histologies were invasive ductal carcinoma. Gestational breast cancer constituted 10% of the cancers; another 10%were bilateral. The median size of the tumors was 5.72 centimeters, 63.2% of them had axillary lymphatic involvement, and more than half were negative for hormone receptors. Conclusions: Our study shows an incidence of 1.17% for very young breast cancer and a 10% rate of bilaterality which probably warrants special guidelines for contralateral screening. Cancer stage and features were poor in comparison with breast cancer in all ages.

• 한국의학물리학회지:의학물리
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• 제26권2호
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• pp.93-98
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• 2015

본 연구는 유방촬영술을 시행할 때 유방인접조직의 생체내선량 측정을 통해 방호복 착용의 유용성을 평가하고자 한다. 이를 위해 유방검진을 받는 일반 여성 중 연구의 목적과 방법을 정확히 이해하고 동의한 환자 30명을 대상으로 유방촬영시 유리선량계를 이용하여 측정을 실시 하였다. 유리선량계의 교정값을 구하기 위하여 팬텀(ACR phantom)을 이용하여 촬영 변수중 각각 관전압과 관전류의 중간값(27 kVp, 120 mAs)고정 시 mAs와 kVp를 변화시켜 장치에서 계산된 선량을 얻어 유리선량계 소자의 교정값을 구하였다. 측정 그룹은 방호복을 착용하지 않는 A 그룹과 착용하지 않은 B 그룹으로 나누었다. 생체내 선량측정 특성상 동일한 환자를 대상으로 반복 촬영을 할 수 없음으로 A 그룹은 좌 우 유방촬영에 따라 인접 정상조직의 선량이 차이가 없을 보고자 하였다. B 그룹은 한쪽 유방은 방호복으로 차폐를 하고 다른 쪽 유방은 방호복으로 차폐를 하지 않음으로 그 차이를 보고자 하였다. 인접 정상조직 측정에는 갑상선, 검사반대측 유방, 하복부로 각각의 부위에 유리선량계를 위치시켜 측정하였다. 실험 결과 유방촬영 시 입사표면선량은 A그룹의 경우, 왼쪽유방 상하방향 검사 시 갑상선은 0.0692 mGy, 오른쪽 유방은 0.6790 mGy, 하복부의 선량은 0.0122 mGy로 나타났고, 오른쪽 상하방향 검사 시에는 각각 0.0607 mGy, 0.4062 mGy 그리고 0.0166 mGy로 측정되었다. B그룹의 입사표면선량은 왼쪽유방 상하방향 검사 시 갑상선, 오른쪽 유방, 하복부의 선량이 각각 0.0922 mGy, 0.8575 mGy, 0.0150 mGy로 나타났다. 방호복을 착용한 오른쪽 상하방향 검사는 갑상선이 0.0158 mGy, 왼쪽유방은 0.0286 mGy, 하복부가 0.0173 mGy의 선량을 보여 갑상선과 유방의 선량이 대폭 감소되었고 통계적으로 유의하였다(p<0.05). 모니터의 유선선량을 관찰해 보면 A, B그룹 모두 권고값인 3 mGy 이하의 선량값을 보였다. 본 연구 결과 유방촬영시 환자의 결정장기가 받는 표면선량은 모두 기준치 이하의 선량을 보였으나 방호복 착용에 따른 선량 저감 효과를 볼 수 있어 방호복의 유용성을 확인할 수 있었다.