• Journal of Ginseng Research
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• 제21권2호
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• pp.125-132
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• 1997

Our previous study showed that in vivo treatment of spontaneously hypertensive rats (SHR) with protopanaxatriol ginsenosides (PPT) reduces the blood pressure and inhibits the con- tractions induced by endothelium-derived contracting factor (prostaglandin endoperoxide ($PGH_2$) and superoxide anion) in aorta isolated from SHR. The aim of the present study is to examine whether PPT improves endothelial functions in the isolated thoracic aorta of SHR in vitro. Treatments of aortic rings with PPT, purified ginsenoside $Rg_1$ ($Rg_1$) or indomethacin normalized endotheliuln-dependent relaxation to acetylcholine, but not with protopanaxadiol ginsenosides (PPD) and purified ginsenoside Rb1 (Rb1). The effects of PPT were dose-dependent. PGH,- and oxygen free radical-inducted contractions in rat aorta without endothelium were inhibited by PPT or $Rg_1$, but not by PPD or $Rb_1$. Contractions induced by PGF2$\alpha$, U-46619, a stable thromboxane A2 agonist or KCI (60 mM) were not inhibited by PPT, $Rg_1$ or $Rb_1$. These findings demonstrate that PPT but not PPD scavenges the oxygen-derived free radicals and/or antagonize the effects of $PGH_2$ in the vascular smooth muscle and may explain the hypotensive effect of ginseng in the SHR.

• 복식문화연구
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• 제13권6호통권59호
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• pp.896-909
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• 2005

In need of studies on the kinds and structure of thread, the biggest variable factor in knitwear patterns, this study attempts: to examine the physical properties by thread type to basically establish systematic data in order to utilize various mixture and structure of yarn and to contribute to the development of optical patterns by building a systemic and scientific methods to produce knit wear patterns though a statistical analysis of the relation between the variations and physical properties. The results is as follows: with time, a feature of knit, which causes instability making it difficult to maintain the original shape, related to material properties, the weight and expansibility recovery rate have the greatest influence on the variation of wale lengths, though the amount varies by material. The variation of course contraction is closely related to density, the dense fabrics showing the highest values, due to the bust of the human body, the wale length variation of the front is greater than that of the back, by a regression analysis of material properties and the variations is obtained showing the weight, density and expansibility recovery rate have the greatest influence on the wale extension and course contraction of knit.

• 척추신경추나의학회지
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• 제4권2호
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• pp.1-12
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• 2009

Objectives : The purpose of this study was to investigate the relationship between pain and psychological state in female office workers with neck pain. Methods : Experimental group of 31 healthy subjects complained of neck and arm discomfort related to computer use which lasted more than 3 months in the past year and was present in the past 7 days as well as on the day of test. Outcomes were assessed by meridian-electromyography(MEMG), Neck Disability Index(NDI), Visual Analog Scale(VAS), Beck Depression Inventory(BDI), Stress Reaction Inventory(SRI), Holmes & Rahe Social Readjustment Rating Scale(SRRS). Results : The NDI score and BDI score had a correlationship(r=0.48), and the NDI score and SRI score also had a correlationship(r=0.48), significantly. The NDI score and contraction power of upper trapezius by MEMG had a correlationship significantly, but with the other muscles the NDI score didn't have correlationships. The NDI score and the SRI score were significantly higher in depression group(BDI score ${\circ}{\surd}$14). The contraction power of trapezius by MEMG was significantly lower in depression group. Conclusions : The results suggest that mental stress can be a major risk factor of neck pain in female office workers.

• 대한통합의학회지
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• 제8권2호
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• pp.75-88
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• 2020

Purpose : Dysmenorrhea can be caused by misalignment of the pelvis. Since pilates stabilization exercise is a methods that affects pelvic alignment by inducing contraction of abdominal muscles, the purpose of this study is to determine whether dysmenorrhea is reduced when pilates stabilization exercise is applied. Methods : 47 dysmenorrhea patients were randomly divided into experimental (n=23) and control (n=24) groups. The experimental group performed pilates stabilization exercise three times a week for 12 weeks, and the control group did not perform any intervention. Abdominal muscle thickness, lumbar pelvic alignment, and dysmenorrhea were measured before intervention, 6 weeks, and 12 weeks after intervention to determine the mean change over time and the effect of group and factor interactions (repeated measured ANOVA and contrast test for each period). Results : In the experimental group, the thickness of the transverse abdominis, internal oblique, and external oblique muscles were increased significantly by group and period (p<.05). The pelvic torsion, lordosis and dysmenorrhea were also significantly decreased by group and period. But the control group did not change significantly in any of the variables. Conclusion : Applying pilates stabilization exercise to women with dysmenorrhea may be an effective intervention that contributes to relieving dysmenorrhea by correcting the stability and alignment of the lumbar pelvis.

• 한국산학기술학회논문지
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• 제7권6호
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• pp.1040-1046
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• 2006

본 논문에서는 다양한 곡률반경의 연속에 의하여 살 두께 차가 큰 사출성형품이 불균일한 수축에 의한 변형 발생에 대하여 연구하였다. SAN 및 PMMA 재질의 Jar에 대한 균일냉각구조와 최적성형조건을 CAE 해석에서 구하여 금형설계에 적용하고자 사출성형의 중요인자인 사출압력, 수지온도, 금형온도, 냉각조건 등을 Moldflow 프로그램에서 사출압력, 수지온도, 냉각속도 등에 의한 변형 및 불량현상을 분석하였고 이들을 극소화시킬 수 있는 냉각구조와 사이클 시간을 단축시킬 수 있는 사출성형조건을 제시하였다.

• Physical Therapy Rehabilitation Science
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• 제10권4호
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• pp.398-405
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• 2021

Objective: The interest of clinicians is increasing due to the newly established medical insurance for pulmonary rehabilitation. Improvement of respiratory muscle strength and pulmonary function is an important factor in pulmonary rehabilitation, and this study aims to investigate the correlation between changes in respiratory muscle contraction thickness that can affect respiratory muscle strength and pulmonary function. Design: Cross-sectional observational study. Methods: Thirty-one subjects (male=13, female=18) participated in this study. The respiratory muscle strength was measured by dividing it into inspiratory/forced expiratory muscles, and the pulmonary function was measured by forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC. To evaluate the respiratory muscle length increase, in resting and concentric contraction thickness of diaphragm, external/internal oblique, transverse abdominis, and rectus abdominis were measured by using ultrasonography. Results: Inspiratory muscle strength showed a significant correlation with the length increase of the inspiratory muscle (r=0.368~0.521, p<0.05), and forced expiratory muscle strength showed a significant correlation with length increase of forced expiratory muscle (r=0.356~0.455, p<0.05). However, pulmonary function was not correlated with the length increase of the respiratory muscle. Conclusions: In this study, a correlation between respiratory muscle strength and respiratory muscle length increase was confirmed, but no correlation with the pulmonary function was found. It is considered that the respiratory muscle strength can be improved by increasing the respiratory muscle thickness through appropriate respiratory muscle training.

• 동의생리병리학회지
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• 제25권5호
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• pp.887-893
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• 2011

The purpose of this study was to investigate the wound healing effects of Danggwieumja (DG), which is commonly used for skin inflammation, skin wound, skin pruritus, and chronic hives etc. The 1.5 cm ${\times}$ 1.5 cm full-thickness skin wound was induced to two groups, DG (n=16) and Saline (n=16) group. The DG extract and Saline were orally administrated daily for 15 days after skin wound induction. Then, the body weight of rats and the congestion indices were daily measured for 15 days after skin wound induction. The wound contractions and epithelizations were also measured. The wound contractions were daily measured for 15 days after wound induction and wound epithelizations were measured for 8 days from day 7 after wound induction. For evaluating angiogenesis, the immunoreactivities of vWF and VEGF protein were measured immunohistochemistrically on day 15. In results, although the percentage increases in mean body weight of rats in the DG and Saline groups hve no significant differences, DG extract decreased the time of wound healing and congestion around wound, and improved wound contraction and epithelization. The contraction percentage of DG group was significantly increased on day 5 (P<0.05) and day 7 (P<0.01) than that of Saline group. DG group showed significant increase of wound epithelization on day 7 (P<0.05) as compared to Saline group. Moreover, DG extract reduced the inflammation of skin dermis and promoted the growth of vascular vessels of dermis by accelerating vascular endothelial growth factor (VEGF) protein. These results suggest that DG has the beneficial effects on skin incision wound and can be the suitable wound healing agent for various surgical wounds.

• 한국운동역학회지
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• 제15권3호
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• pp.9-19
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• 2005

The purpose of this study was to analyze the effects of three different types of preparatory movement(squat, countermovement and hopping) in sideward responsive propulsion movement. 7 healthy subjects performed left and right side movement task by external output signal. 3D kinematics were analyzed The results were followed First, performance time in the countermovement and hopping conditions was shorter(10-20%) than that in the squat condition. The hopping condition that is more related to pre-stretch showed excellent performance. Second, time difference between after turned on the external signal and until take off was the primary factor in performance results among movement conditions. The preparatory phase before the propulsive phase in the squat condition produced more time than that in other conditions. The hopping condition showed the most short time in both the preparatory and the propulsive phase, therefore it was advantage for performance result Third, significant difference was not found in take-off velocity among movement conditions although there was difference of the time required in the propulsive phase. The maximum acceleration in the propulsive phase was larger in order of the hopping. countermovement, and squat condition. The countermovement and hopping conditions showed high take-off velocity although the propulsive phase in those conditions was shorter than that in squat condition. The pre-stretch by preparatory countermovement was considered as the positive factor of producing power in concentric contraction. Fourth, the hopping condition produced large angular velocity of joints. In hopping condition, large amount of moment for rotation movement was revealed in relatively short time and it was considered to cause powerful joint movements. In conclusion, the hopping movement using countermovement is advantage of responsive propulsion movement. It is resulted from short duration until take off and large amount of joint moment and joint power in concentric contraction by pre-stretch.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권5호
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• pp.253-260
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• 2019

Background: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that can cause inflammation. Inflammatory responses are a well-known major cause of preterm labor and preterm birth. Here we demonstrate the effects of remifentanil on the factors related to preterm labor and its mechanism of action on amniotic-derived epithelial cells (WISH cells). Methods: WISH cells were exposed to lipopolysaccharide (LPS) for 24 h and co-treated with various concentrations of remifentanil. MTT assays were performed to measure cell viability. To explain the effects of remifentanil on the factors related to inflammation in WISH cells, activation of nuclear factor kappa B ($NF-{\kappa}B$) and p38 and the expression of interleukin $(IL)-1{\beta}$, tumor necrosis factor $(TNF)-{\alpha}$, cyclooxygenase (COX)2, and prostaglandin E $(PGE)_2$ were quantified using western blotting and RT-PCR, respectively. Results: Remifentanil did not affect WISH cell viability. In western blot analysis, co-treatment with remifentanil resulted in decreased phosphorylation of $NF-{\kappa}B$, and expression of COX2 and $PGE_2$ in LPS-induced inflammation, but the results were statistically significant only at low concentrations. Reduction of $IL-1{\beta}$ and $TNF-{\alpha}$ expression was also observed with RT-PCR. Conclusion: Co-treatment with remifentanil does not affect the viability of WISH cells, but reduces the expression of the factors related to inflammation, which can induce uterine contraction and preterm labor. These findings provide evidence that remifentanil may inhibit uterine contraction and preterm labor in clinical settings.

• Structural Monitoring and Maintenance
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• 제7권4호
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• pp.295-317
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• 2020

Investigation of the stability of arch dam abutments is one of the most important aspects in the analysis of this type of dams. To this end, the Bakhtiari dam, a doubly curved arch dam having six wedges at each of its abutments, is selected. The seismic safety of dam abutments is studied through time history analysis using the design-based earthquake (DBE) and maximum credible earthquake (MCE) hazard levels. Londe limit equilibrium method is used to calculate the stability of wedges in abutments. The thrust forces are obtained using ABAQUS, and stability of wedges is calculated using the code written within MATLAB. Effects of foundation flexibility, grout curtain performance, vertical component of earthquake, nonlinear behavior of materials, and geometrical nonlinearity on the safety factor of the abutments are scrutinized. The results show that the grout curtain performance is the main affecting factor on the stability of the abutments, while nonlinear behavior of the materials is the least affecting factor amongst others. Also, it is resulted that increasing number of the contraction joints can improve the seismic stability of dam. A cap is observed on the number of joints, above which the safety factor does not change incredibly.