• Journal of Integrative Natural Science
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• v.8 no.3
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• pp.176-183
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• 2015

Corticotropin-releasing actor receptors (CRFRs) activates the hypothalamic pituitary adrenal axis, one of the 2 parts of the fight or flight response to stress. Increased CRH production has is associated with Alzheimer's disease and major depression and hypoglycemia. In this study, we report the important structural and chemical parameters for CRFR inhibitors using the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolines. A 3D QSAR study, Comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with a $q^2$ of 0.607 with 6 components and $r^2$ of 0.991. The statistical parameters from the generated CoMFA models indicated that the data are well fitted and have high predictive ability. The contour map resulted from the CoMFA models might be helpful in the future designing of novel and more potent CRFR derivatives.

• Journal of Integrative Natural Science
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• v.4 no.3
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• pp.216-221
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• 2011

c-Jun N-terminal kinase-3 (JNK-3) has been shown to mediate neuronal apoptosis and make the promising therapeutic target for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and other CNS disorders. In order to better understand the structural and chemical features of JNK-3, comparative molecular field analysis (CoMFA) was performed on a series of 3,5-disubstituted quinolines derivatives. The best predictions were obtained CoMFA model ($q^2$=0.707, $r^2$=0.972) and the statistical parameters from the generated 3D-QSAR models were indicated that the data are well fitted and have high predictive ability. The resulting contour map from 3D-QSAR models might be helpful to design novel and more potent JNK3 derivatives.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.2028-2032
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• 2008

DEM은 도시계획, 도로건설 계획, 수해지역 예측 등의 많은 분야에서 다양하게 활용되고 있다. 특히 홍수와 같은 하천재해를 분석, 관리하기 위한 유출모형 적용 때 중요한 입력 자료로 사용되고 있다. 그러나 현재 우리나라에서 사용되는 DEM 제작방법은 과정이 복잡하고 자료 전환이 불가피하며 적용범위에 있어서도 제약이 따른다. 따라서 기존에 사용되던 방법들의 한계를 극복할 수 있는 정확한 DEM 생성 방법으로 위성영상을 이용하는 연구 및 기술개발이 진행되어 왔다. 본 연구에서는 현재 널리 사용되고 있는 DEM 생성 알고리즘을 ASTER 위성 영상에 적용하여 추출한 DEM의 정확도를 평가하고자 하였다. 정확도 평가는 USGS DEM을 사용하였으며, 그 결과 정사보정의 RMSE는 6개의 GCP에서 2 화소에 수렴하였고, 구름영역에서 고도값이 실제 지형보다 높게 나타났다. 또한, 금강 유역의 북동쪽으로 발달된 능선의 고도값은 ASTER DEM이 USGS DEM에 비해 과소평가 되었지만 영상 왼쪽에 위치한 분지는 평활한 지역으로 ASTER DEM과 USGS EM과의 차이가 거의 없는 것으로 나타났다. 또한, 산림 지역 등 능선의 고도값은 ASTER DEM이 USGS DEM에 비해 과소평가 되었지만, 분지 등 평탄 지역의 DEM은 차이가 거의 없는 것으로 나타났다.

• Wind and Structures
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• v.20 no.4
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• pp.565-578
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• 2015

A wind energy assessment is an integrated analysis of the potential of wind energy resources of a particular area. In this work, the wind energy potentials for Mauritius have been assessed using a Computational Fluid Dynamics (CFD) model. The approach employed in this work aims to enhance the assessment of wind energy potentials for the siting of large-scale wind farms in the island. Validation of the model is done by comparing simulated wind speed data to experimental ones measured at specific locations over the island. The local wind velocity resulting from the CFD simulations are used to compute the weighted-sum power density including annual directional inflow variations determined by wind roses. The model is used to generate contour maps of velocity and power, for Mauritius at a resolution of 500 m.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.1226-1231
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• 2009

This paper presents operating characteristics of internal heat exchanger(IHX) for $CO_2$ geothermal heat pump in the heating mode. Mass flow rate of $CO_2$, inlet temperatures of $CO_2$ at high and low pressure side were selected as main effect factors by using fractional factorial DOE(Design of Experiments). And RSM(Response Surface Method) was used in optimization phase. The results show that heat transfer rate of IHX increases when either inlet temperature of low pressure side decreases or inlet temperature of high pressure side increases. Effectiveness of IHX increases with increasing of inlet temperature of either high pressure side or low pressure side. Finally, performance contour map was provided over the operation ranges of the main design factors.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.07a
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• pp.267-269
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• 2003

반도체 웨이퍼 및 각종 박막의 면/비저항(sheet/resistivity resistance)의 측정에 비교적 간단히 측정할 수 있고 측정정확도가 높은 4탐침(four-point probe)방법이 널리 사용되고 있다 또한 4탐침 측정방법은 높은 분해능의 contour map작성과 ion implantation의 doping accuracy 및 doping uniformity의 측정에도 사용된다. 최근 재료의 소형, 박막화 경향으로 볼 때 정확한 비저항 측정의 필요성이 요구되고 있으며 이에 따라 4탐침 측정기술인 single 및 dual configuration method로 실리콘 웨이퍼에 대한 비저항의 측정 정확도를 고찰한 결과 dual configuration 측정방법이 single configuration측정 방법에 비하여 정밀 정확도가 더 좋은 것으로 고찰되었다.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10c
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• pp.653-655
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• 1998

본 논문은 3차원 지형을 현실감 있고 효율적으로 구축하기 위하여, 등고선 데이터로부터 지형의 특징점을 추출하고 이를 이용하여 3차원 지형 데이터를 복원하는 방법을 제안한다. 래스터 기반의 거리변환기법 알고리즘을 사용하여 2차원의 등고선 데이터로부터 3차원 지형을 생성하며, 생성된 3차원 지형정보로부터 지형의 특징점을 추출한다. 복원된 3차원 지형을 격자망 형태로 시각화하는데, 이때 특징점의 높이정보를 이용함으로써 지형을 표시하는데 요구되는 정보의 크기를 감소시킨다. 제안한 방법은 사용자가 상호대화식으로 수행할 수 있는 프로그램으로 윈도우 환경의 PC상에서 구현되었다. 이 프로그램의 실험결과는, 기존의 방법보다 적은 데이터양으로 3차원 지형을 시각화할 수 있음을 보여준다.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2006.04a
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• pp.383-386
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• 2006

Subsurface temperature is affected by heat advection due to groundwater advection. Temperature-depth profile can be perturbed especially when there are significant vertical groundwater flux caused by external force such as injection or extraction. This research is to clarify the change of subsurface temperature distribution when the 40m x l0m sandy aquifer is stimulated by two different vertical flux($case1:\;{\pm}10^{-5}m^3/s,\;case2:\;{\pm}4{\times}10^{-5}m^3/s$) using a program called HydroGeoSphere. The resulting temperature distribution contour map shows pumping causes vertical attraction of water from deeper and warmer place which result in rising up isotherm. Additionally more injection/extraction rate, more vertical groundwater flux leads to faster Increase in temperature near the pumping well.

• Journal of Integrative Natural Science
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• v.4 no.4
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• pp.266-272
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• 2011

Focal adhesion kinase (FAK) is a potential target for the treatment of primary cancers as well as prevention of tumor metastasis. To understand the structural and chemical features of FAK inhibitors, we report comparative molecular field analysis (CoMFA) for the series of 7H-pyrrolo(2,3-d)pyrimidines. The CoMFA models showed good correlation between the actual and predicted values for training set molecules. Our results indicated the ligand-based alignment has produced better statistical results for CoMFA ($q^2$ = 0.505, $r^2$ = 0.950). Both models were validated using test set compounds, and gave good predictive values of 0.537. The statistical parameters from the generated 3D-QSAR models were indicated that the data are well fitted and have high predictive ability. The contour map from 3D-QSAR models explains nicely the structure-activity relationships of FAK inhibitors and our results would give proper guidelines to further enhance the activity of novel inhibitors.

• 한국태양에너지학회:학술대회논문집
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• 2011.11a
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• pp.124-129
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• 2011

Since the horizontal global radiation and cloud cover are a main factor for designing any solar energy system, it is necessary to evaluate its characteristics all over the country. The work presented here are the investigation of horizontal global radiation and cloud cover in Korea. The data utilized in the investigation consist of horizontal global radiation and cloud cover collected for 27 years(1982.12~2008.12) at measuring stations across the country. The analysis shows that the annual-average daily horizontal global radiation is $3.61kWh/m^2$ and the annual-average daily cloud cover is 5.1 in Korea. We also constructed the contour map of cloud cover in Korea by interpolating actually measured data across the country.