• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.295-303
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• 2014

Purpose: This study aims to observe bleaching resulted from multipurpose contact lens solutions used to manage lenses with the subjects of colored contact lenses being distributed in Korea. Methods: The lenses have been worn for six months, and their refraction is 0.00D. Three types of colored contact lenses of which margin has been colored with a different manufacturing method have been adopted (type 1: pigment application method, type 2: chemical bonding process, type 3: sandwich method), and multipurpose solutions used were two types containing different components. Each of the colored contact lenses was stored in the multipurpose solutions for 20 days and went through vortexing for 15 seconds per day. Their fluorescence absorbance, surface roughness, brightness index, and color coordinate index were measured before and after the vortexing to see the degree of bleaching. Results: In the two types of multipurpose solutions, every type of the color contact lenses showed no statistically significant difference in their fluorescence absorbance value before and after the vortexing. Regarding surface image, the front surface of the lenses was smooth in every type, and about the back surface, type 3 indicated less protrusion than type 1 and 2. About the difference of color on the lens surface before and after the vortexing, type 3 showed significantly less difference than type 1 and 2; however, all fell into the permissible error. Conclusions: About the bleaching of colored contact lenses resulted from multipurpose solutions for soft contact lenses, there was no difference observed in terms of fluorescence absorbance and color. According to the methods of manufacturing dyes, however, there was difference in the protrusion of the posterior surface image.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.339-346
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• 2010

Purpose: The study was performed to compare the difference of non-invasive tear break-up time (NIBUT) with alignment or steep fitting of soft contact lens in normal and dry eyes. Methods: Total 40 eyes (aged 20~30 years) were classified to the normal (n=20) or dry eye group (n=20) by the diagnosis methods for dry eyes and worn soft contact lens (polymacon material) with alignment or steep fitting. NIBUTs of lens wearers were separately measured at the points of before wearing, immediately after wearing and after stabilization of tear film. Results: With alignment fitting, averaged NIBUT in the dry eye group after stabilization of tear film was not significantly different from that of the normal eye group. However, averaged NIBUTs in the normal and dry eyes had significant difference when measured immediately after lens wearing. However, the number of eyes having NIBUT less than 4.0 second was 30% higher compared to the number of normal eyes with steep fitting when measured immediately after wearing. Some shorten NIBUT in dry eyes with steep fitting was also shown after stabilization of tear film. Conclusions: These results suggest that wearing soft contact lens in dry eyes differently affect tear film compared to normal eyes. Thus, dry eyes need more advertent fitting for contact lens wearing because of unstable tear film.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.3
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• pp.279-289
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• 2013

Purpose: To evaluate the changes of refractive power when worn soft contact lenses were temporarily removed. Methods: 91 soft contact lens wearers (15 males and 76 females; total 182 eyes) from 17 to 39 years of age (average: $24{\pm}4.8$ years) were participated. Objective and subjective refraction, and corneal radius were measured at 0, 30, 60 and 90 min after lens removal. The changes in refractive power were evaluated between measurements over time. The other parameters such as types of lenses, fitting and wearing conditions were also assessed. Results: Objective refraction, subjective refraction and corneal radius were significantly changed according to measured time (p<0.0001). A moderate myopic shifts was observed at the beginning (30 min after lens removal) and a slight myopic shift at the late of measurement (60 min to 90 min after lens removal). There are no significant differences between lens types, fitting states, wearing time, wearing days and sleeping time in the previous day. However, there was significant interaction in changes for corneal radius between measuring time and lens type (p=0.017), fitting state (p=0.019), and sleeping time prior to the test (p=0.010). Conclusions: Time to reach refractive and corneal radius stability after contact lens removal revealed at least more than 60 min, regardless of types of lenses, fitting and wearing conditions. Therefore, refraction for correction should be performed after waiting for more than that time as possible.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.65-69
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• 2003

The effects of grapefruit seed extract and $H_2O_2$ disinfectants on Pseudomonas aeruginosa were investigated by antimicrobial assay and scanning electron microscopy. Pseudomonas aeruginosa is a Gram negative bacteria and a common causative microorganism of bacterial keratitis. After incubation of soft contact lens in Pseudomonas aeruginosa suspension for 120 minutes containing the disinfectants, the grapefruit seed extract showed antimicrobial activity as good as the chemical disinfectant. The living rates of Pseudomonas aeruginosa in grapefruit seed extract and $H_2O_2$ disinfectants were $1{\times10^3CFU/m{\ell}$ and $0.5{\times}10^3CFU/m{\ell}$, respectively showing no major difference in the killing activity. However, the mechanisms of the antimicrobial activity were quite different as indicated by scanning electron microscopy of the bacterial surface morphology. Considering chemically or other toxins induced keratitis, the natural disinfectant isolated from grapefruit seed extract shows promising results as a soft contact lens disinfectant.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.3
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• pp.259-265
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• 2006

We polymerized material of AA(Acrylic acid) and BMA(butyl methacrylate) to make up for the weak points of hydrogel contact lens. The synthesis process of silicone synthesis is as follows. Acrylate-PDMS(Polydimethylsiloxane)-Urethane prepolymer was composed after Diisocynate reacted with HEMA(2-hydroxyethylmethacrylate) under the catalyst and it reacted again with bis(hydroxyalkyl) terminated poly(dimethylsiloxane) with high oxygen transmissibility characteristics. HEMA(2-hydroxyethylmethacrylate) was used to make prepolymer that can be polymerized and the urethane was used to improve elasticity and oxygen transmissibility, copolymerization was performed with conventional hydrogel contact lens materials to make silicone hydrogel contact lens with higher oxygen transmissibility. For manufacturing of contact lens, We added BMA(Butyl methacrylate) with better elasticity and flexibility, and AA(Acrylic acid) with higher moisturizing to used contact lens materials. AIBN (Azobis2-methylpropionitrile) as initiator and EGDMA(Ethylene Glycol Dimethacrylat) as crosslinking agent were used and the lens with higher oxygen transmissibility and better moisturizing were manufactured complying with basic contact lens properties, which have several combination trial of each monomer characteristics. Compounding SN which included SILICONE, HEMA, NVP and EGDMA etc was showed by swelling ratio of 9.38% and water content of 23.7%. SN was showed by swelling ratio of 9.38%, water content of 23.7% and a visible ray transmissibility of 89%. SB which added BMA in the SN was showed by swelling ratio of 12.50%, water content of 18.56% and a visible ray transmissibility of 88%. SAB which added both AA and BMA in the SN was showed by swelling ratio of 8.33%, water content of 12.93% and a visible ray transmissibility of 88%.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.315-322
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• 2014

Purpose: The physical and optical characteristics of hydrophilic tinted contact lens containing titanium silicon oxide nanoparticles and the basic hydrogel contact lens material containing 4-iodoaniline were examined. In this study, the utility of titanium silicon oxide nanoparticles as a UV-blocking material for ophthalmologic devices were investigated by measuring the UV transmittance of the produced polymer. Also, titanium silicon oxide nanoparticles only without the addition of 4-iodoaniline in primary contact lens materials by copolymerizing two groups were compared. Methods: For manufacturing hydrogel lens, HEMA, MA, MMA, 4-iodoaniline and a cross-linker EGDMA were copolymerized in the presence of AIBN as an initiator. Also, the titanium silicon oxide nanoparticles was used as additive. After polymerization the physical properties such as water content, refractive index, contact angle and spectral transmittance of produced contact lenses were measured. Results: Measurement of the physical properties of the copolymerized material showed that the water content, refractive index, UV-B transmittance and contact angle were in the range of 35.01~38.60%, 1.4350~1.4418, $34.15{\sim}57.25^{\circ}$ and 1.0~10.0%, respectively. Titanium silicon oxide nanoparticles is not used as an additive in the experimental group, the results of the measurement showed that the water content, refractive index, contan angle and UV-B transmittance of the hydrogel lens polymer was 34.00~36.80%, 1.4378~1.4420, $40.15{\sim}60.16^{\circ}$ and 1.8~25.0%, respectively. Conclusions: Also, the transmittance for UV light was reduced significantly in combinations containing titanium oxide nanoparticles.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.277-284
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• 2015

Purpose: The study aimed to evaluate the effect of circle contact lens wearing on visual quality of the eyes after a refractive surgery. Methods: The objective visual quality was evaluated for 40 eyes who did not get refractive surgery and 30 eyes who got a refractive surgery after applying plano circle contact lenses on their eyes, respectively. Modulation transfer function (MTF), objective scatter index (OSI) and the focusing ratio on retina (Strehl ratio) were measured by using optical quality analysis system (OQAS) and the correlation between pupil size and objective visual quality was analyzed by measuring the pupil size. Results: When wearing circle contact lens on the eyes after refractive surgery, MTF and Strehl ratio were reduced and OSI was increased compared with the eyes without refractive surgery. The eyes after a refractive surgery showed more significant difference changes in MTF, OSI and Strehl ratio according to the pupil size compared with those without refractive surgery. Conclusions: The results showed that wearing of circle contact lens after the refractive surgery has deteriorated the objective visual quality based on the quality of focused image on the retina. Therefore, we suggest that sufficient understanding and consideration about the deterioration of visual quality is necessary in the case of circle contact lens wearing after refractive surgery.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.455-462
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• 2015

Purpose: To develop more accurate wet measuring system combining the wet cell, automatic lensmeter and the related software for hydrophilic contact lenses and to verify the accuracy of those measuring holder system already available in the market. Methods: Refractive power measurement were done in both a conventional method which has been commonly used in optical shops and a new method which is recently developed in korea. Hydrophilic contact lens of korean brand was chosen as a test material and was tested by water content ratio and by spherical refractive power. Results: When spherical power of -3.00 D contact lens is measured in the newly developed wet cell measurement holder with automatic lensmeter, it reads -3.01 D at water content ratio of 38%. -3.00 D at 45% and -2.98 D at 58%. The same experiment with the Poster soft contact lens wet cell measurement holder maintaining other conditions same resulted in -3.60 D at the water content ratio of 38%, -3.06 D at 45% and -2.46 D at 58%. Conclusions: At the higher water content, the refractive power values measured by both of the wet cell measuring holders are shown lower, and additionally, the new method using the wet cell holder and new software program in a automatic lensmeter showed more accurate readings than conventional Poster soft contact lens wet cell measuring system.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.437-443
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• 2015

Purpose: This study evaluated the optical and physical and characteristics of soft contact lens polymerized with addition of 3-chloropyridine-4-carboxylic acid and 3-fluoropyridine-4-carboxylic acid in the basic hydrogel contact lens material. In particular, the utility of 3-chloropyridine-4-carboxylic acid and 3-fluoropyridine- 4-carboxylic acid as a hydrogel contact lens material was investigated. Methods: In this study, 3-chloropyridine-4-carboxylic acid and 3-fluoropyridine-4-carboxylic acid were used as additives. Also, 2-hydroxyethyl methacrylate, acrylic acid, methyl methacrylate and a cross-linker EGDMA were co-polymerized in the presence of AIBN as an initiator. Results: The physical properties of the produced polymers were measured as followings. The water content of 34.54~37.15%, refractive index of 1.4320~1.4342, tensile strength of 0.2872~0.3608 kgf and contact angle of $57.82{\sim}79.57^{\circ}$, UV-B transmittance of 76.8~82.4% and UV-A transmittance of 84.6~86.6% were obtained respectively. Conclusions: Based on the results of this study, contact lens material containing 3-chloropyridine-4-carboxylic acid and 3-fluoropyridine-4-carboxylic acid is expected to be able to used as a material for high wettability and UV-block hydrogel contact lens.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.4
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• pp.261-266
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• 2005

Quaternary ammonium compounds(QACs) are some of the most commonly used antimicrobials. Antimicrobial polymers have been used as biomedical devices. In this Study, We synthesized new methacrylate monomers including quaternary ammonium moieties for preparation of contact lens, And also, we tested for antimicrobial activities against S. aureus, E. coli and P. aeruginosa. They showed much higher antimicrobial activities against all than the polymers of no including quaternary ammonium.