• Journal of Genetic Medicine
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• 제13권2호
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• pp.65-71
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• 2016

Cell-free nucleic acids (cf-NAs) originate in trophoblasts and are detected in the maternal plasma. Using innovative bioinformatic technologies such as next-generation sequencing, cf-NAs in the maternal plasma have been rapidly applied in prenatal genetic screening for fetal aneuploidy. Amniotic fluid is a complex and dynamic fluid that provides growth factors and protection to the fetus. In 2001, the presence of cf-NA in amniotic fluid was reported. Amniotic fluid is in direct contact with the fetus and is derived from fetal urine and maternal and fetal plasma. Therefore, these genetic materials have been suggested to reflect fetal health and provide real-time genetic information regarding fetal development. Recently, several studies evaluated the global gene expression changes of amniotic fluid cell-free RNA according to gestational age. In addition, by analyzing the transcriptome in the amniotic fluid of fetal aneuploidy, potential key pathways and novel biomarkers for fetal chromosomal aneuploidy were identified. Here, we review the current knowledge of cell-free RNA in amniotic fluid and suggest future research directions.

• 한국정밀공학회지
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• 제11권2호
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• pp.50-64
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• 1994

Cutter deflections in the ball-end milling process is one of the main causes of the machining errors on a free-form surface. In order to avoid machining errors in this process, a methodology avoiding these machining errors on the free-form surfaces has been developed. In this method, feedrates in the finish cuts are adjusted for the prevention of machining errors. A model for the prediction of machining errors on the free-form surface is analytically derived as a function of feed and normal vector at the surface of contact point by the cutter. This model is applied to the dertermination of the adjusted feedrates which satisfy the machining tolerance of the surface. In the finish cuts of a simple curved surface, the suggested model is examined by the measurements of the generated machining error on this surface. And also, this surface is machined with the adjusted feedrates for the given machining tolerance. The measured machining errors on this surface are compared with the given tolerance. In this comparisons, it is shown that the predicted errors are fairly good agreement with the test results.

• Steel and Composite Structures
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• 제52권4호
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• pp.487-499
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• 2024

The primary objective of this study is to analyze the free vibration behavior of a sandwich cylindrical shell with a defective core and wavy carbon nanotube (CNT)-enhanced face sheets, utilizing the three-dimensional theory of elasticity. The intricate equations of motion for the structure are solved semi-analytically using the generalized differential quadrature method. The shell structure consists of a damaged isotropic core and two external face sheets. The distributions of CNTs are either functionally graded (FG) or uniform across the thickness, with their mechanical properties determined through an extended rule of mixture. In this research, the conventional theory regarding the mechanical effectiveness of a matrix embedding finite-length fibers has been enhanced by introducing tube-to-tube random contact. This enhancement explicitly addresses the progressive reduction in the tubes' effective aspect ratio as the filler content increases. The study investigates the influence of a damaged matrix, CNT distribution, volume fraction, aspect ratio, and waviness on the free vibration characteristics of the sandwich cylindrical shell with wavy CNT-reinforced face sheets. Unlike two-dimensional theories such as classical and the first shear deformation plate theories, this inquiry is grounded in the three-dimensional theory of elasticity, which comprehensively accounts for transverse normal deformations.

• 한국전기전자재료학회논문지
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• 제35권4호
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• pp.412-417
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• 2022

Capacitive-type humidity sensors with a high sensitivity and fast response/recovery times have attracted a great attention in non-contact respiration biological signal monitoring applications. However, complicated fabrication processes involving high-temperature heat treatment for the hygroscopic film is essential in the conventional ceramic-based humidity sensors. In this study, a non-toxic ceramic/metal halide (BaTiO₃(BT)/NaCl) humidity sensor was prepared at room temperature using a solvent-free aerosol deposition process (AD) without any additional process. Currently prepared BT/NaCl humidity sensor shows an excellent sensitivity (245 pF/RH%) and superior response/recovery times (3s/4s) due to the NaCl ionization effect resulting in an immense interfacial polarization. Furthermore, the non-contact respiration signal variation using the BT/NaCl sensor was determined to be over 700% by maintaining the distance of 20 cm between the individual and the sensor. Through the AD-fabricated sensor in this study, we expect to develop a non-contact biological signal monitoring system that can be applied to various fields such as respiratory disease detection and management, infant respiratory signal observation, and touchless skin moisture sensing button.

• Structural Engineering and Mechanics
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• 제25권5호
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• pp.501-518
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• 2007

In this work, a new approach is developed for dynamic analysis of a composite beam with an interply crack, based on finite element solution of partial differential equations with the use of the COMSOL Multiphysics package, allowing for fast and simple change of geometric characteristics of the delaminated area. The use of COMSOL Multiphysics package facilitates automatic mesh generation, which is needed if the problem has to be solved many times with different crack lengths. In the model, a physically impossible interpenetration of the crack faces is prevented by imposing a special constraint, leading to taking account of a force of contact interaction of the crack faces and to nonlinearity of the formulated boundary value problem. The model is based on the first order shear deformation theory, i.e., the longitudinal displacement is assumed to vary linearly through the beam's thickness. The shear deformation and rotary inertia terms are included into the formulation, to achieve better accuracy. Nonlinear partial differential equations of motion with boundary conditions are developed and written in the format acceptable by the COMSOL Multiphysics package. An example problem of a clamped-free beam with a piezoelectric actuator is considered, and its finite element solution is obtained. A noticeable difference of forced vibrations of the delaminated and undelaminated beams due to the contact interaction of the crack's faces is predicted by the developed model.

• 한국운동역학회지
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• 제13권3호
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• pp.15-26
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• 2003

This study was conducted to investigate the performance times, CM position and CM speed, pole chord length and pole chord angle, whole body angular momentum(X axis), and grip width in pole vault event according to the event and phase; touch down, pole plant, take-off, maximum pole bending pole straight, pole release, peak height, and foot contact, pole contact, free flight. The pole vaulting of four male elite vaulters including six trial were filmed using two video digital cameras at 60 Hz at 56th national athletic match, and data were collected through the DLT method of three dimensional cinematography. In general the better jumper is, the longer the performance time is. And the greater CM speed is, and the better his transformation ability of CM horizontal speed into vertical speed is. As he uses a longer pole, his grip is higher, and it is a enough for him to rock back his body, so that he pulls and pushes the pole well keeping his hips close to. An greater maximum angular momentum and early positioning of the hips parallel to the bar makes his body far side of the bar and his bar clearance easier. Specially our national jumper needs to have more powerful braking force during foot contact phase, and take his body on the pole after maximum pole bending, and pull and push the pole strongly keeping his hips close to. Also he needs to have stronger muscular strength in order to control the longer pole and use the pole of proper tension more efficiently.

• 한국정밀공학회지
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• 제18권9호
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• pp.61-70
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• 2001

This paper introduces a new digitization method with sensor fusion for shape measurement in reverse engineering. Digitization can be classified into contact and non-contact type according to the measurement devices. Important thing in digitization is speed and accuracy. The former is excellent in speed and the latter is good for accuracy. Sensor fusion in digitization intends to incorporate the merits of both types so that the system can be automatized. Firstly, non-contact sensor with vision system acquires coarse 3D point data rapidly. This process is needed to identify and loco]ice the object located at unknown position on the table. Secondly, accurate 3D point data can be automatically obtained using scanning probe based on the previously measured coarse 3D point data. In the research, a great number of measuring points of equi-distance were instructed along the line acquired by the vision system. Finally, the digitized 3D point data are approximated to the rational B-spline surface equation, and the free-formed surface information can be transferred to a commercial CAD/CAM system via IGES translation in order to machine the modeled geometric shape.

• 대한기계학회논문집A
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• 제25권11호
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• pp.1863-1872
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• 2001

In this Paper, we suggest the precision stage using a novel non-contact planar actuator that utilizes an interaction between an array type of air-core solenoids and permanent magnets. The former with axes arranged in the mutually orthogonal direction is fixed on the stator and the latter with the same polar direction is attached below the stage. The promising magnetic structure has little uncertainty such as hysteresis loss caused by ferromagnetic material, then it is simple to quantify the magnetic phenomenon. And all the magnetic forces are transmitted through narrow air-gap between the coil and the permanent magnet, therefore the structure can be highly compacted. Furthermore, the stage or plate can be perfectly isolated from the stator without any wire connection, leading to diminish the generating possibility of wear particles due to mechanical contact. Then. it is estimated that the proposed operating principle is very suitable for work requiring high accuracy and cleanness. or general-purpose nano stage. The main issues rebated to the plate driving are discussed here.

• 대한조선학회논문집
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• 제40권6호
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• pp.80-87
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• 2003

Tank structures in ships are in contact with various fluid. The vibration characteristics of those structures are strongly affected by the added mass due to containing fluid. It is important to predict vibration characteristics of tank structures, but it is difficult to do. That's because the interaction problem concerned with the free surface, the variation of water depth and stiffener is to be considered between the fluid and the structure. Many authors have studied vibration of rectangular tank structures containing water. Kito studied added mass effect of water in contact with thin elastic flat plates. Kim et al. studied flexural vibration of stiffened plates in contact with water. However, few researches on dynamic interaction tank walls with water are reported in the vibration of rectangular tanks recently. in the present report, the coupling effect of added mass of fluid and structural constraint between panels on each vibration mode changing breadth of elastic plate, and dynamic pressure distribution have investigated numerically and discussed.

• Journal of Preventive Medicine and Public Health
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• 제54권4호
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• pp.245-250
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• 2021

Objectives: Jeju Province in Korea reported 627 coronavirus disease 2019 (COVID-19) cases between January 20, 2020, and March 31, 2021. This study analyzed the sources of infection among confirmed cases in Jeju Province, a self-governed island. Methods: The sources of infection were broadly categorized as follows: (1) infections from overseas (confirmed patients who reported travel overseas or contact with overseas travelers); (2) infections from outside Jeju Province (confirmed patients who had visited other provinces or had contact with individuals who had traveled to other provinces in Korea); and (3) unknown sources of infection (confirmed patients who were infected following contact with an infected person whose source of infection was unknown). The chi-square test was used to analyze the differences in the distributions of related variables for each source of infection. Results: Of the 627 confirmed cases, 38 (6.1%) were infections from overseas sources, 199 (31.7%) were from outside of Jeju Province, and 390 (62.2%) were from unknown sources. Jeju Province had no cases with an unknown source of infection during the first and second waves of the nationwide outbreak. Conclusions: Infections from overseas sources could be blocked from spreading to local communities in Jeju Province by conducting screening at the airport, along with the preemptive suspension of visa-free entry. In addition, considering the scale of the nationwide outbreak, measures must be established to delay outbreaks from unknown sources of infection caused by sources outside Jeju Province.