• 대한의생명과학회지
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• 제19권3호
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• pp.266-269
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• 2013

Hox genes encode transcription factors important for anterior-posterior body patterning at early stages of embryonic development. However, the precise mechanisms by which signal pathways are stimulated to regulate Hox gene expression are not clear. In the previous study, protein kinase B alpha (Akt1) has been identified as a putative upstream regulator of Hox genes, and Akt1 has shown to regulate Gcn5, a prototypical histone acetyltransferase (HAT), in a negative way in mouse embryonic fibroblast (MEF) cells. Since the activity of HAT such as the CBP/p300, and PCAF (a Gcn5 homolog), was down-regulated by Akt through a phosphorylation at the Akt consensus substrate motif (RXRXXS/T), the amino acid sequence of Gcn5 protein was analyzed. Mouse Gcn5 contains an Akt consensus substrate motif as RQRSQS sequence while human Gcn5 does not have it. In order to see whether Akt1 directly binds to Gcn5, immunoprecipitation with anti-Akt1 antibody was carried out in wild-type (WT) mouse embryonic fibroblast (MEF) cells, and then western blot analysis was performed with anti-Akt1 and anti-Gcn5 antibodies. Gcn5 protein was detected in the Akt1 immunoprecipitated samples of MEFs. This result demonstrates that Akt1 directly binds to Gcn5, which might have contributed the down regulation of the 5' Hoxc gene expressions in wild type MEF cells.

• Archives of Plastic Surgery
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• 제38권4호
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• pp.391-397
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• 2011

Purpose: The injection of various materials, including medical fillers and unregulated products, is widespread, potentially causing the development of foreign body granulomas. Should this occur on the nose, the contour deformity and inflammatory signs that result from these granulomas are aesthetically undesirable to patients. The purpose of our study is to share our experiences using different surgical approaches, depending on the affected portion of the nose, to optimize management of this challenging problem and to evaluate patient's satisfaction using our in-house questionnaire along with degree of improvement by two independent plastic surgeons. Methods: We treated 18 patients who underwent surgical excision of nasal foreign body granulomas via a perilesional approach to the lesion (n=12) or by transcolumellar incision (n=6) at our hospital over a period of seven years from March 2003 to October 2010. Nonparametric statistics were used and are presented as medians (25th-75th). Patient satisfaction was evaluated on a scale of 1 to 5 using an in-house questionnaire. All pre-and post-operative photographs were analyzed by two independent plastic surgeons. Post-operative outcomes were evaluated based on the surgeons' consensus ratings. Results: All patients receiving the transcolumellar approach reported a high level of satisfaction with the results. All but two patients who received the perilesional approach were satisfied with the outcome. No outcomes were rated as no change or worse by the consensus ratings. Conclusion: For the upper two-thirds of the nose, perilesional surgical excision can lead to substantial patient satisfaction with modified contour deformity and infection control. The transcolumellar approach resulted in better outcomes and patient satisfaction for the lower one-third of the nose.

• 동남아시아연구
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• 제28권1호
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• pp.1-20
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• 2018

2017년 동남아의 정치경제는 대미의존적 안보질서와 대중의존적 경제질서가 중첩하는 역설적 '이중질서'로 요약되는 동아시아의 지정학적 지경학적 조건에서 전개된다. 경제발전의 지속적 진전과 정치발전의 만성적 부진이 날카롭게 엇갈리는 동남아의 두 얼굴은 동남아와 동북아를 포괄하는 동아시아의 두 얼굴을 충실하게 반영한다. 정치적 차원에서, 전체주의의 향수를 떨쳐내기 어려운 베트남, 라오스, 캄보디아, 미얀마 등 구사회주의권은 전체주의와 권위주의 사이의 완충지대에 서식하고, 민주주의의 명분을 저버리기 어려운 필리핀, 태국, 인도네시아, 말레이시아, 싱가포르 등 원자본주의권은 권위주의와 민주주의 사이의 회색지대를 전전한다. 경제적 차원에서, 계획경제의 거대한 유산을 포기하기 어려운 구사회주의권은 신국가주의적 '베이징 콘센서스'로 분장되는 중국형 국가자본주의의 은밀한 유혹과 타협하고, 시장경제의 화려한 신화를 외면하기 어려운 원자본주의권은 신자유주의적 '워싱턴 콘센서스'로 포장되는 미국형 자유자본주의의 오만한 압력에 노출된다. 그에 따라 동남아의 지역통합을 대변하는 아세안 공동체는 대륙세력과 해양세력의 경쟁적 협공에 따라 '신냉전'의 부상이 예감되는 전략적 곤경에서 끊임없이 부침한다.

• 지식경영연구
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• 제24권3호
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• pp.1-15
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• 2023

본 논문은 최근 큰 반향을 일으키고 있는 생성형 인공지능 ChatGPT를 연구용으로 사용할 때 고려해야 할 연구윤리의 내용을 살펴본다. ChatGPT와 연구윤리를 직접 연결하는 논의가 많지 않기 때문에, 먼저 연구윤리의 전통적인 주제인 인용과 표절, 위조와 변조, 정당한 저자표기, 연구자 공동체, 연구자의 사회적 책임 등을 차례로 ChatGPT 사용과 연결하여 검토할 것이다. 연구윤리에서 인용이나 정당한 저자 표기를 강조하고 표절이 문제가 되는 원리를 고려할 때, ChatGPT 관련 논의를 허용과 불허, 적발과 처벌의 관점에서만 보는 것은 부적절하고, 기존의 규칙들이 ChatGPT의 작동 방식에 제기하는 근본문제를 직시해야 한다. 이에 따라 연구 목적을 위해서 ChatGPT를 쓸 때에는 일단 그 사실을 최대한 밝히고, 그럼에도 불구하고 해결할 수 없는 문제가 있음을 인식해야 한다. ChatGPT의 장기적인 사용이 연구자 공동체에 미칠 영향과 연구자의 사회적 책임에 대해서도 고민해야 할 부분이 많다. 물론 ChatGPT를 비롯한 생성형 인공지능 기술이 아직 개발 초기 단계에 있는 만큼, 섣부른 결론을 내리는 것은 적절하지 않다. 그러나 신기술과 관련한 연구윤리에 대한 관심이 절실하고, 동시에 ChatGPT와 인공지능 기술의 도래로 근본적인 도전에 직면한 연구의 정의에 대한 연구자들의 논의와 합의가 시도되어야 한다.

• Korean Journal of Radiology
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• 제22권1호
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• pp.41-62
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• 2021

Radiologic imaging is important for evaluating extrahepatic bile duct (EHD) cancers; it is used for staging tumors and evaluating the suitability of surgical resection, as surgery may be contraindicated in some cases regardless of tumor stage. However, the published general recommendations for EHD cancer and recommendations guided by the perspectives of radiologists are limited. The Korean Society of Abdominal Radiology (KSAR) study group for EHD cancer developed key questions and corresponding recommendations for the radiologic evaluation of EHD cancer and organized them into 4 sections: nomenclature and definition, imaging technique, cancer evaluation, and tumor response. A structured reporting form was also developed to allow the progressive accumulation of standardized data, which will facilitate multicenter studies and contribute more evidence for the development of recommendations.

• 동의신경정신과학회지
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• 제33권3호
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• pp.227-239
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• 2022

Objectives: The purpose of this study was to develop a standardization manual for Emotion To Emotion therapy. In this study, the processes and categories derived through literature search related to the Emotion To Emotion treatments, were revised and supplemented by the expert FGI (Focus Group Interview). Afterwards, the expert Delphi was conducted, to develop a standard manual for the disease types, purpose, and method of Emotion To Emotion therapy. Methods: In this study, literature analysis and expert Delphi, as a quantitative research method, were conducted, and the expert Focus Group Interview (FGI) was conducted as a qualitative study. The manual was completed by leading the consensus, on the standardization manual for Emotion To Emotion therapy. After that, a clinical expert Delphi was conducted to test the reliability as well as validity of the manual, through quantitative consensus on the manual of the Emotion To Emotion therapy. Results: First, as a result of literature studies, to date, studies related to Emotion To Emotion therapy have been qualitatively and quantitatively limited, as comparative literature related to clinical cases. Second, through expert FGI, the manual was structured with eight sub-factors for the indication diagnosis, six sub-factors for the implementation method, and 13 detailed factors. Third, through an expert Delphi, the consensus did the factor of indication, implementation methods, and implementation process, and developed a standardization manual for Emotion To Emotion therapy ver 1.0. Conclusions: Through literature analysis, expert FGI, and expert Delphi, the Emotion To Emotion therapy standardization manual ver 1.0 was completed, and will proceed with the revision and improvement report.

• 인간식물환경학회지
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• 제23권6호
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• pp.589-602
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• 2020

Background and objective: There are many theories related to the development of agrotourism, and each stakeholder has its own role and function. If it is based on organizational functions, stakeholders need to be coordinated, and the state plays a major administrative role. But in the successful case of Yeongdong County, Chungcheongbuk province, the Republic of Korea, the government played an important role in the development of tourism, which grants us another perspective on the role of the government in promotion and development agrotourism activities. Methods: This article aims to examine the development of agrotourism through a cooperative approach, by clarifying the role of the local authorities in the Yeongdong region in the management and operation of the local agrotourism activities. The qualitative research method is based on a field survey conducted in Yeongdong County in 2019. Results: The study's findings show that in situations where conflicts of interest among stakeholders are prone to occur, the development of local tourism has a limited impact on the cooperative culture, and local governments play an important role. Accordingly, the local governments must actively formulate strategies to maintain and develop traditional agricultural industries and at the same time develop agrotourism activities. The government's ability to coordinate, cooperate, and participate reasonably is a key factor for the success of the sustainable development of the tourism industry. Conclusion: Based on coordination between stakeholders and a reasonable strategic direction, Yeongdong's agrotourism is being effectively deployed. The development of Yeongdong's agrotourism industry has achieved impressive results through an effective strategy, highlighting the important role of localgovernment in the consensus of local communities and collaboration with stakeholders. The role of outstanding local governments has been clearly demonstrated, especially in promoting, establishing, and contacting different organizations to effectively deploy agrotourism in the region.

• 한국의료질향상학회지
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• 제3권2호
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• pp.36-51
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• 1997

Background : Clinical practice guidelines define "systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances" and help to improve patient care. The purpose of this study is to develop a clinical practice guideline for the most effective diagnoses and treatments of benign prostatic hyperplasia based on patient preference and clinical need. Methods : For this research project, extensive literature searches (208 articles) were conducted. As well, critical reviews and syntheses (meta-analysis) were used to evaluate empirical evidence and significant outcomes of the BPH literature. Questionnaires about clinical practice for BPH patients were distributed and consensus meetings were undertaken to grasp variations in clinical practice and to reach agreement on the guideline's development. The guideline was promoted under the sponsorship of the Korean Medical Association and the Korean urological Cancer. Society. For the task, the Benign Prostatic Hyperplasia Guideline Panel was composed of multidisciplinary experts in the field. Results : BPH is a disease that affects a patient's quality of life. This Clinical Practice Guideline was developed for the typical man over age 50 with symptoms of prostatism, but with no significant medical morbidities such as diabetes or other known causes of voiding dysfunction, such as urethral stricture or neurogenic bladder. The guidelines detail the relative benefits and obstacles associated with all diagnostic and treatment approaches, including watchful waiting. Conclusion : This guideline provides a cornerstone for our medical association. It represents the most current scientific knowledge regarding the development, diagnosis, and treatment of BPH. It will be revised and updated as needed.

• 한국경제지리학회지
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• 제17권2호
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• pp.249-263
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• 2014

1950년대에 조성된 RTP는 계획적으로 조성된 첨단 산-학 복합단지임과 동시에 외생적 발전 전략으로 클러스터 기반을 구축한 후, 성장 과정에서 내생적 발전 역량을 갖추게 된 흥미로운 사례이다. 본 논문에서는 외생적 발전 전략에 의해 계획적으로 조성된 RTP가 어떻게 성공적인 진화 경로를 밟게 되었는지, 그 과정과 요인을 트리플 힐릭스 공간의 구축 과정을 통해 분석하였다. RTP의 클러스터 형성 초기에는 지식 공간의 존재와 역할이 중요했으나, RTP의 고도성장기에 지식 공간이 미친 영향은 상대적으로 미흡했다. 반면에, NC 과학기술위원회는 트리플 힐릭스 합의 공간으로서, RTP의 조성단계에서부터 지금까지 클러스터의 경로파괴적 진화를 견인한 핵심 주체라고 할 수 있다. 그리고 RTP의 지속적 진화 과정에는 노스캐롤라이나 생명공학연구센터(NCBC)와 노스캐롤라이나 마이크로일렉트릭센터(MCNC) 등과 같은 혁신 공간은 클러스터의 트리플 힐릭스 상호작용을 유발하는 핵심 중개기관의 역할을 수행했다. 오늘날, RTP에는 합의 공간을 중심으로 지식 공간과 혁신 공간이 연계되는 구조를 통해 트리플 힐릭스 공간이 구축되어 있으며, 이를 통해 기존 산업 생태계의 역동성을 유지하면서도 새로운 산업 생태계가 성장하는 이른바 역동적 진화 구조를 나타내고 있다.

• 대한치과의사협회지
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• 제57권8호
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• pp.437-447
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• 2019

Purpose: In recent years, efforts to improve the dental curriculum in South Korea have focused on a shift to outcome-based dental education based on core competencies in dentistry. So far, the field has seen various studies on the development of competencies, performance evaluation, and the importance of outcome-based education, but few studies have documented the development of such an education model. Therefore, this study develops an OBE curriculum for dentistry education and describes the development procedures and then finally this study intends to share our experience to other dental schools. Methods: This study introduces the development procedure and details of an outcome-based education model for dental education and presents the five stages of an outcome-based education model. In this study, 3 educational experts and 2 dental professor composed the TFT and developed the research method according to the ADDIE model. Step 1 is to conduct quantitative / qualitative research analysis through some survey and interview, Step 2 is to do a survey to revise competency, Step 3 is to develop a materials through consensus and participation of our professors of the dental school, Step 4 is to do some workshops, Step 5 is to prepare and conduct a outcome evaluation. Results: Step 1 is a required process for developing an educational model: the Job Analysis & Need Analysis stage. Step 2 is the Development of Outcome and Competency stage, which involves revising the competencies that are the basis of the curriculum. Step 3 is developing competency descriptions, competency levels, and evaluation criteria?the Development of Outcomes and Evaluation Standards. Step 4 is the Development of Milestones for Curriculum and Instructional Strategy, which examines the curriculum's problems and analyzes the improvements of each course. Step 5 is the Evaluating Outcomes stage, conducted based on the competencies specified by the target dental school. Conclustion: The model presented here can serve as a foundation for outcome-based education in other dental schools.