• Journal of Korean Society for Geospatial Information Science
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• v.22 no.4
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• pp.63-69
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• 2014

Due to population growth and urban development in construction technology has expanded living space, underground construction as public transport as has been extended to the ground and underground urban traffic congestion increases. This underpass Stations sphere of influence this development was the center of the living space, space-time became a cultural space. However underpass ground space and time and space are enormous difficulties in contrast visibility due to smoke when light levels are low fire occurs, momentary loss of judgment errors due to a sense of orientation, rapid diffusion and ambient oxygen deficiency due to acquisition limitations, such as the Open resulting in property damage and personal injury. The purpose of this study is to analyze the existing system with respect to the address of the underground shopping center and system for presenting an address to the underground shopping mall in the basement of the straight and circular in connection with the street name address. Also can be known only to evacuate their citizens to address the position in the event of a fire inside the basement through the underground shopping mall address standardization system, the fire department only address exact location is being judged will be identified.

• Journal of Life Science
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• v.16 no.2 s.75
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• pp.186-191
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• 2006

This study was carried out to investigate the effects of Rhynchosia molubilis saponin on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity. Sprague-Dawley rats were intraperitoneally administered the Rhynchosia molubilis saponin at 100 mg/kg every day for two weeks, then $CCl_4$ (3.3 ml/kg) was injected into rats. 12 hours later, they were anesthesized with ether and dissected. Rhynchosia molubilis saponin-administered group showed 59.92% and 62.28% of inhibitory effects on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities compared to $CCl_4$-treated group (p<0.05). Malonedialdehyde (MDA) levels of Rhynchosia molubilis Saponin-administered and $CCl_4$-treated (RSC) group in liver homogenate and mitochondria were significantly inhibited to 61.83%, 81.11 %, respectively, compared to $CCl_4$-treated group (p<0.05). Superoxide dismutase (SOD) activities of RSC group in liver homogenate and mitochondria were significantly inhibited to 66.53%, 31.04%, respectively, compared to $CCl_4$-treated group (p<0.05). GPx activities of RSC group in liver homogenate and mitochondria were significantly inhibited to 72.74%, 72.68%, respectively, compared to $CCl_4$-treated group (p<0.05). The histological examinations showed that the liver cell necrosis and centrilobular congestion aggregation induced by $CCl_4$ were dearly eliminated by the administration of Rhynchosia molubilis saponin. These results suggest that Rhynchosia molubilis saponin could have the protective effects against hepatotoxicity.

• Journal of Life Science
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• v.27 no.8
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• pp.896-901
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• 2017

This study was performed to investigate the protective effects of succinic acid of Succiniter against carbon tetrachloride ($CCl_4$)-induced hepatotoxicity in rats. After an adaptation period of one week, Sprague-Dawley rats were administered succinic acid of Succiniter at 200 mg/kg every day for 21 days. Then $CCl_4$ (3.3 ml/kg) was intraperitoneally injected into rats of the other groups except the normal group, five hours after the last treatment of succinic acid of Succiniter on day 21. The succinic acid-treated group showed 93.20% and 88.76% of inhibitory effects in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, respectively, compared with the $CCl_4-treated$ group. The succinic acid-treated group showed inhibition of malonedialdehyde (MDA) by 85.17% compared with the $CCl_4-treated$ group. The succinic acid-treated group in liver homogenate promoted effects of 38.65% and 47.99% in superoxide dismutase (SOD) and catalase (CAT), respectively, compared with the $CCl_4-treated$ group. In conclusion, the AST and ALT activities of the succinic acid-treated group were both decreased compared with the $CCl_4-treated$ group. The MDA level of the succinic acid-treated group was decreased compared with the $CCl_4-treated$ group. However, the SOD and CAT levels of the succinic acid-treated group in liver homogenate were both increased compared with the $CCl_4-treated$ group. Also, histological examinations showed that the liver cell necrosis and centrilobular congestion aggregation induced by $CCl_4$ were clearly eliminated by treatment with succinic acid of Succiniter. These results suggest that succinic acid of Succiniter has a protective effect against liver damage and could be used in the development of the appropriate drug.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.1
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• pp.105-114
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• 2016

With approximately 20 million transportation card data entries of the metropolitan districts being generated per day, application of the data to management and policy interventions is becoming an issue of interest. The research herein attempts a model of the possibility of dynamic demand change predictions and its purpose is thereby to construct a Dynamic Passengers Trip Assignment Model. The model and algorithm created are targeted at city rail lines operated by seven different transport facilities with the exclusion of travel by bus, as passenger movements by this mode can be minutely disaggregated through card tagging. The model created has been constructed in continuous time as is fitting to the big data characteristic of transport card data, while passenger path choice behavior is effectively represented using a perception parameter as a function of increasing number of transfers. Running the model on 800 pairs of metropolitan city rail data has proven its capability in determining dynamic demand at any moment in time, in line with the typical advantages expected of a continuous time-based model. Comparison against data measured by the eye of existing rail operating facilities to assess changes in congestion intensity shows that the model closely approximates the values and trends of the existing data with high levels of confidence. Future research efforts should be directed toward continued examination into construction of an integrated bus-city rail system model.

• Journal of Korean Society of Transportation
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• v.33 no.2
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• pp.214-222
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• 2015

Jeju International Airport has become the most delayed airport in Korea, due to increased demand in air passengers and unexpected local weather condition. Observing the demands continuously grow for a decade, the airport is expected to be saturated in the near future. As a part of effort to prepare effective and timely measure for this expected situation, airport planners seeks the annual runway capacity, i.e., the appropriate number of flight operations in a given year with tolerable delay. In practice, the FAA formula is frequently adopted for the capacity estimation. The method, however, has intrinsic issues: 1) the hourly capacity imbedded in the formula is not clearly defined and thus the estimated value is vulnerable to be subjective judgement, and 2) the formula doesn't consider aircraft delay resulted from runway congestion. In this paper, we explain a novel method for estimating the daily runway capacity and then converting to the annual capacity taking into account the aircraft delay. In this paper, average delay of aircraft was measured using microscopic air traffic simulation model. Daily capacity of the runways were analyzed based on the simulation outputs and the method to assess the yearly capacity is introduced. Using a microscopic simulation model named TAAM, we measure the average aircraft delay at various levels of flight demand, and then estimate the practical daily runway capacity. The estimated daily and annual runway capacities of Jeju airport are about 460 operations a day which is equal to 169,000 operations year. The paper discusses how to verify the simulation model, and also suggests potential enhancement of the method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.513-522
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• 2017

Rapid urbanization is being portrayed around the world au causing difficulty to manage public hygiene and maintain public order. Common problems often detected in urban areas including traffic congestion and the deterioration of the ecological environment are also being exacerbated. Despite all the effort being made by the government and local governments to manage urban facilities, urban residents are subjected to various levels of difficulty, due to the number of facilities to be managed exceeding the number of management personnel and the lack of an adequate management system. The aim of this study is to propose a management method using smart phones to improve the maintenance efficiency of urban facilities. First, the one-stop maintenance of urban facilities, including facilities information management, maintenance management and history management, is made possible by using smart phones to collect and transfer pictures and the locations of the urban facilities. Second, maintenance management is based on the location and picture information of the subject, not the location of the smart phones, which enables a prompt understanding of and actions to be taken for the facility. This method is especially effective as the smart phone application sends the facility status information directly to the maintenance personnel. Third, all of the information and figures relating to the facilities is managed using a database, resulting in the easy utilization of the history management and data. Fourth, all of the urban residents have access to this information via smart phone applications and, therefore, expanding the role of the facility maintenance personnel is made possible without any additional investment in infrastructure. Lastly, the location-based information enables the management of roads, trees and trails.

• International Commerce and Information Review
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• v.15 no.2
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• pp.3-23
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• 2013

In 1997, 180 countries signed the Kyoto Protocol in Kyoto, Japan. The Kyoto Protocol came into force in February 2005. The agreement calls for industrialized nations to cut greenhouse gas emissions by 5 percent from 1990 levels by 2008 to 2012. One of those polices is a modal shift that change from road freight to sea, inland waterway and railroad transportation that is eco-friendly. The increase of road freight brings road congestion, accidents, logistic costs, air pollution and greenhouse gases. Railroads are superior than the other modes of transportation in mass transportability, high speed, timeliness, safety and environmental-friendliness, but the railway industry has been pushed behind in competition. Korean railroads were used by passengers and freight transport popularly until the middle of 20th century, however, by the sudden change of logistics environments, a shaving time efficiency being most important, railroad logistic lost its competitive power against the transportation by truck. From the research which sees consequently investigated a various policy, a system and a law about Chinese logistics industry and present condition of the Chinese goods enterprise and instance analysis of the large Chinese corporation that branch out to undeveloped markets led and a Chinese logistics industry and problem point escape hereafter the heightening of competitiveness plan which is rational under prsenting boil.

• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.145-159
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• 2012

Objectives : The object of this study was to obtain acute toxicity information (single oral dose toxicity) of Armeniacae Semen (AS), a medicinal herb used for treating constipation and various respiratory diseases, in rats. Methods : In order to observe the $LD_{50}$ (50% lethal dose), approximate lethal dosage (ALD) and target organs, AS aqueous extracts were orally administered once to female and male Sprague Dawley rats at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight). The mortality, changes in the body weight, clinical signs and gross observation were monitored for 14 days after single oral treatment of AS extracts, and the organ weights and histopathological findings of principle organs were observed after sacrifice. Results : After single oral treatment of AS 2,000 and 1,000 mg/kg, all (5/5; 100%) female and male rats died within 30 minutes after treatment, while no mortalities were observed in the female and male rats treated with 500 mg/kg of AS extract. Therefore, $LD_{50}$ in female and male rats was calculated as 741.95 mg/kg. Seizure, loss of locomotion, salivation, increases of respiration and heart-beat were observed after AS extract treatment, which were observed in all rats including the lowest dosage group, 500 mg/kg in the present study. In addition, lung congestion was visible in all mortal rats with AS 2,000 and 1,000 mg/kg, respectively. Conclusions : The results obtained in this study suggest that AS extract ranges in Class III, because the $LD_{50}$ and ALD in both female and male rats were calculated as 741.95 mg/kg and 500~1,000 mg/kg, respectively. However, AS extract should be carefully treated at clinical applications, because salivation, increase of respiration and heart-beat were also observed in the lowest dosage group, 500 mg/kg in the present study.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.2D
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• pp.121-127
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• 2012

One of the traffic problems has been caused by the illegal parking because of the lack of parking space. Especially, the illegal occupancy of the road near an intersection makes an serious reduction of road capacity. The current illegal parking and stop-prohibited areas have been designated for less than 5 meters from the edge or the corner of the 4-leg intersection. However, in reality, the cars parked at the place over 5 meters have had a significant impact on the intersection traffic. In addition, many variables such as intersection type, size, and service levels should be considered as factors which influence on the traffic condition at the intersection. It was assumed that through and right-turn traffic rate have a significant impact on the 4-leg intersection with the illegal parking or stop near it. This study tried to verify the impact through the simulation implementation with MOE and LOS. It shows a guideline to designate the parking or stop-prohibited area near the 4-leg intersection under various traffic conditions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.134-142
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• 2010

Although BinSo-San(BSS), a mixed herbal formula consisted of 11 types of medicinal herbs and have been used as anti-inflammatory agent, In the present study, the acute toxicity (single oral dose toxicity) of lyophilized BSS aqueous extracts was monitored in male and female mice after oral administration according to Korea Food and Drug Administration (KFDA) Guidelines (2005-60, 2005). In order to observe the 50% lethal dose ($LD_{50}$), approximate lethal dosage (ALD), maximum tolerance dosage (MTD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2000, 1000, 500, 250 and 0 (control) mg/kg (body wt.) according to the recommendation of KFDA Guidelines (2005-60, 2005). The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines (2005-60, 2005) with organ weight and histopathology of 12 types of principle organs. We could not find any mortality, clinical signs and changes in the body weights except for dose-independent increases of body weight and gains restricted in 1000 mg/kg of BSS extracts-dosing female group. Hypertrophic changes of lymphoid organs.thymus, spleen and popliteal lymph nodes were detectedat postmortem observation with BSS extracts dose-dependent increases of lymphoid organ weights, and hyperplasia of lymphoid cells in these all three lymphoid organs at histopathological observations. These changes are considered as results of pharmacological effects of BSS extracts or their components, immunomodulating effects, not toxicological signs. In addition, some sporadic accidental findings such as congestion spots, cyst formation in kidney, atrophy of thymus and spleen with depletion of lymphoid cells, and edematous changes of uterus with desquamation of uterus mucosa as estrus cycles were detected throughout the whole experimental groups including both male and female vehicle controls. The significant (p<0.01) increases of absolute weights of kidney and pancreas detected in BSS extracts 1000 mg/kg-treated female group are considered as secondary changes from increases of body weights. The results obtained in this study suggest that the BSS extract is non-toxic in mice and is therefore likely to be safe for clinical use. The LD50 and ALD of BSS aqueous extracts in both female and male mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. In addition, the MTD of BSS extracts was also considered as over 2000 mg/kg because no BSS extracts-treatment related toxicological signs were detected at histopathological observation except for BSS or their component-related pharmacological effects, the immunomodulating effects detected in the present study.