• Journal of Nutrition and Health
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• 제45권4호
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• pp.303-314
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• 2012

The purpose of this study was to investigate the relationship between dietary fat intake, anthropometric data, blood lipids, C-reactive protein, and adiponectin in Korean male college students. Forty-eight subjects were divided into 2 groups based on dietary fat intake: UERF (under 30% of energy ratio for fat source), AERF (above 30% of energy ratio for fat souce). We collected dietary intake data using 24-hour dietary recall for 3 days. Anthropometric and biochemical parameters were measured by using standard methods. Segmental body composition analysis was carried out using an 8-electrode multifrequency bioelectrical impedance method of body fat estimation. There was no significant difference in anthropometric data and serum lipid profile between UERF and AERF group. Serum C-reactive protein level was significantly higher in the AERF group compared to the UERF group. Although there was no significant difference in serum adiponectin level between UERF and AERF groups, subjects had lower adiponectin levels. Correlation data show that serum adiponectin level was positively correlated with vegetable intake (p < 0.05). In addition, dietary fat intake had a positive correlation with meat (p < 0.01), whereas a negative correlation with grain (p < 0.01), vegetables (p < 0.05), and fish (p < 0.05). These results suggest that the increased fat intake of non-obese Korean male college students is associated with their increased serum C-reactive protein concentration. Therefore, proper guidelines on fat intake and nutrition education are necessary for the prevention and management of metabolic syndromes.

• 생명과학회지
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• 제14권2호
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• pp.356-361
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• 2004

폐경과 더불어 시작되는 폐경기의 에스트로겐 변화로 발생되는 건강 문제 중 심혈관계질환이 문제점으로 대두되고 있다. 그러므로 본 연구는 갱년기 장애 시 유발되는 체내 지질 함량 증가에 있어서 김 추출물이 미치는 영향을 조사하기 위해 인위적 폐경을 유발시킬 수 있는 난소 절제 쥐에서 김 추출물의 혈 중 지질 함량 변화에 미치는 영향을 검토하였다. 그 결과 난소 절제에 의한 total-cholesterol의 증가가 김 추출물을 투여함으로써 감소하는 경향을 보였다. 특히 김 추출물 50 mg/kg bw/day에서 유의적으로 감소하였다. 혈 중성 지방에서는 김 추출물 농도별 투여한 OVX-PT50, OVX-PT200 모든 군에서 난소를 절제하지 않은 Sham군과 비슷한 수준으로 감소하는 경향을 보였고, 또한 혈 중 HDL-cholesterol은 김 추출물 투여로 인해 난소 절제한 군과 비교해서 높은 경향을 나타내었다. 이상의 결과는 갱년기 장애 시 유발되는 지질 대사 이상으로 오는 심혈관계질환에 김의 섭취가 유익한 결과를 줄 것으로 사료되며, 또한 잘못된 식습관으로 오는 비만이나 심혈관계 질환에도 유익한 효과를 가져다 줄 것으로 기대된다.

• 대한한의학회지
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• 제16권2호
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• pp.337-347
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• 1995

The purpose of this study was to investigate the effect of pretreatment with Saegchinyanghyoltang(SYT) on the serum lipid composition and atherosclerotic index in streptozotocin(STZ)-induced diabetic rats. SYT pretreatment in STZ-induced diabetic rats inhibited the rise of serum glucose concentration. Serum total lipids and triglyceride levels in the STZ -induced diabetic rats were significantly higher than those in the control group. But in the group pretreated with SYT, triglyceride and lipid levels were significantly lower compared with those of STZ -induced diabetic rat group without STZ. However, the serum phospholipid levels were not statistically different among treatment groups. In the STZ-induced diabetic group, the serum total cholesterol, VLDL-, LDL-cholesterol levels and atherosclerotic index Were higher and HDL-cholesterol level was lower compared to the control group. However, these changes were prevented by SYT pretreatment Pretreatment with SYT significantly increased the activities of serum lipase compared to the STZ-treated group.

• 한국식품영양과학회지
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• 제40권10호
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• pp.1417-1422
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• 2011

본 연구는 비만중년여성 34명을 대상으로 벨리댄스와 영양교육 실시가 신체조성과 혈청지질 및 인슐린 저항성에 미치는 요인을 구명하기 위하여 벨리댄스와 영양교육을 12주간 실시한 후 운동전과 후의 신체조성, 혈청지질, 인슐린 저항성, leptin 및 adiponectin 호르몬, 그리고 항산화능을 측정하여 비교분석하였다. 벨리댄스 프로그램은 1회 1시간씩 주3회 실시하였으며, 운동 강도는 60~85% HRmax로 실시하였다. 영양교육프로그램은 영양 교육과 개별 상담으로 나누어 총 4회 실하였다. 신체조성중 체중 5.53%, 체지방률 9.51%, BMI 5.61% 유의적으로 감소하였으며, 골격근량은 0.81% 증가하였다. 혈청지질의 변화는 TG 13.50%, TC 9.51%, LDL-C 10.43% 유의적으로 감소하였으며, HDL-C는 3.24% 증가하였다. 인슐린 농도는 19.76% HOMA-IR 지수는 18.22% 유의적으로 감소였다. Leptin 호르몬의 분비는 32.35% 유의적으로 감소하였으나 adiponectin 농도는 변화가 없었다. 그러나 총 유리기 농도는 증가하는 경향을 보였고, 혈중 총 항산화능의 변화는 없었다. 본 연구의 결과를 살펴보면 보건소에서 실시하는 비만클리닉 프로그램은 비만중년 여성의 체지방률을 낮추어 혈청지질 및 인슐린 저항성을 개선함으로써 건강을 증진시키는 긍정적인 효과가 있을 것으로 사료된다.

• 대한의생명과학회지
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• 제24권4호
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• pp.380-389
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• 2018

Black vinegar has been traditionally used for supplemental flavoring on food, and commercialized beverages. Here, to investigate the effects on in vivo anti-obesity complications of black vinegar produced with herbal extracts, we evaluated on the biochemical effects of high-fat diet (HFD) induced mice compared to control fed ones. After a 84-day experiment HFD mice had higher (P < 0.05) weight gains, relative abdominal-fat pads, blood glucose level, serum/liver lipids, and serum nephron indices. Continuous oral treatment of three different concentration of herbal black vinegar (HBV; stock, 2-fold, and 4-fold diluted solution) to HFD mice showed that HBV reduced marked obesity (fat depositions, adipocyte hypertrophy), hyperglycemia, hyperlipidemia (serum total cholesterol, triglyceride, LDL-cholesterol levels), enhanced liver function (AST/ALT), and kidney function (BUN, creatine levels), respectively. Thus, HBV is expected to serve as an efficient and functional supplemental ingredients or food for the alleviation of obesity syndrome.

• Journal of Nutrition and Health
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• 제27권1호
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• pp.3-11
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• 1994

This study was carried out to examine how dietary protein and calcium levels in rats fed fat-enriched diet affect the total lipid and cholesterol contents of blood and tissues. Male Sprauge-Dawley rats weighing approximately 200g were fed six purified diets which contained 18%(w/w) beef tallow, 1% (w/w) cholesterol, two source of protein, casein or isolated soy protein (ISP) and three levels of dietary calcium, 0.1%, 0.4% and 1.0%, first, for four weeks, and second, for eight weeks. The contents of the total lipid, cholesterol and triglyceride in blood, liver, heart and feces were determined. After four weeks feeding serum lipid and cholesterol concentrations significantly decreased in rats fed 1.0% (w/w) level calcium, regardless of dietrary protein sources. After eight weeks, these concentrations were significantly lower in the rats fed soy protein than in casein-fed rats. As dietary calcium level increased serum and tissue lipid and cholesterol contents were decreased and fecal lipid excretion increased. It is concluded that hypolipidemic and/or hypocholesterolemic effects of soy protein and calcium were partly due to decrease in lipid absorption.

• 생명과학회지
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• 제8권5호
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• pp.532-536
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• 1998

식이성 고지혈증 유발 Sprague Dawley계 숫흰쥐를 사용하여 용담 열수 추출액을 급여하므로써 혈당 및 혈청의 지질 개선 효과를 규명하기 위해 4주간 실험 사육한 결과, 혈당 농도는 대조군인 1군(물)에 비해 2군(콜레스테롤+물) 및 3군(콜레스테롤+용담추출액)이 높게 나타났으며, 콜레스테롤과 용담 추출액을 급여한 3군이 2군(콜레스테롤+물)보다 다소 낮은 경향을 보였지만 혈당 저하효과는 유의성있게 관찰되지 않았다. 혈청중 총콜레스테롤 농도는 2군에 비하여 3군이 유의적으로 낮게 나타났다. LDL-콜레스테롤 농도는 2군에 비해 3군에서 유의성있게 감소하였으며, 총콜레스테롤에 대한 HDL-콜레스테롤 농도비는 용담 추출액 급여군이 높게 나타났다. 혈청 유리 콜레스테롤 및 콜레스테롤 에스테르 농도는 콜레스테롤 급여군인 2군에 비해 용담 추출액 급여군(3군)이 유의성 있게 감소하였다. 중성지질 및 인지질 농도는 3군의 농도가 낮았다. 혈청 AST 및 ALT활성은 대조군에 비하여 여타 실험군에서 증가하는 경향을 보였다. 이상의 결과에서, 용담 열수 추출액이 식이성 고지혈증 흰쥐에 대한 혈청지질 개선효과가 다소나마 있는 것으로 사료된다.

• Journal of Nutrition and Health
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• 제33권5호
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• pp.497-501
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• 2000

We investigated the effect of tea fungus/kombucha(TF) beverage on serum and liver lipid metabolism in growing male rats. The rats(Sprague-Dawley) were divided into five groups; control(TF free water), 20 or 40% TF groups(20 or 40% TF in water) and 20 or 40% TFS groups(20 or 40% TF autoclaved in water) according to the level of TF supplementation. The rats were fed ad libitum each of the experimental beverage for 7 weeks. The body weight gain of all the TF and TFS groups were similar to that of the control group. The total lipid and triglyceride concentrations of serum in the 40% TF group were increased more than those in the control group, but those in the 20% TF and 20% TFS groups were similar to that of the control group. The total cholesterol, HDL-cholesterol concentrations, HDL-cholesterol / total cholesterol ratio and atherogenic index of serum in all the TF and TFS groups were similar to those of the control group. The LDL-cholesterol concentration of serum was significantly lower in the 20% TF group than that in the control group. The LDL-cholesterol concentration of serum was significantly lower in the 20% TF group than that in the control group, but those of the 40% TF, 20% TFS and 40% TFS groups were similar to that of the control group. The liver weights of all the TF and TFS groups were heavier than that of the control group. The concentrations of hepatic triglyceride in the 20% TF and 20% TFS groups were significantly decreased, compared with that in the control group. The concentrations of hepatic total cholesterol in all the TF and TFS groups were significantly more decreased than that in the control group. These results indicated that the liver weights of tea fungus/kombucha beverage feeding rats were increased, also the serum triglyceride and total cholesterol concentrations of 40% TF feeding rats were increased. but the serum LDL-cholesterol, hepatic triglyceride and cholesterol levels of 20% TF feeding rats were decreased.

• Nutritional Sciences
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• 제8권2호
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• pp.133-139
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• 2005

Objective: The purpose of this study was to determine serum antioxidant nutrients and the relationship between serum antioxidants and risks of chronic diseases in obese Korean children Methods: Normal weight Korean school children (0=170), mean age of 11.5$\pm$1.5, and obese (body fat mass > $28\%$) children (0=176), mean age of 11.0$\pm$1.8, were recruited Fat mass ($\%$) was determnined by Bioelectrical Impedance (BEI), and body mass index (BMI) was calculated Fasting blood was collected to measure serum antioxidant nutrients, vitamin A, vitamin E and zinc. Serum lipid profiles including total cholesterol (TC), high density cholesterol (HDL) and triglyceride (TG), and blood glucose, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPI) were also determined. Differences in serum blood measurements between obese and normal children were assessed by independent t test. Pearson's correlation analysis was used to determine the relationship between variables. Results: Blood glucose, GPT, total cholesterol, and triglycerides concentrations were significantly higher among obese boys, compared to normal boys (p<005). Significantly lower concentrations of serum vitamin E, after adjustment for TG and TC, was shown in obese boys (0.26 mg/mg) and obese girls (0.31 mg/mg), compared to normal boys (0.36 mg/mg) and girls (0.38 mg/mg) (p<0.05). Fat mass ($\%$) was negatively con-elated with serum vitamin A and vitamin E. Conclusion: Obese Korean children showed insufficient serum vitamin E concentration and increased risk for diabetes, atherosclerosis, and liver disease. Since lower vitamin E concentration was negatively con-elated with atherogenic index, improved vitamin E status in children may decrease the risk of atherosclerosis later in life.

• 대한임상검사과학회지
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• 제37권3호
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• pp.185-189
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• 2005

Lipids such as total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and high sensitivity C-reactive protein (hs-CRP) are known as good risk factors for coronary artery diseases caused by arthrosclerosis. We measured the serum concentrations of hs-CRP, TC, and HDL-C of 6,128 persons who underwent medical examinations in the Health Screening Center at Kangbuk Samsung Hospital. We classified the subjects into normotensive and hypertensive groups according to the blood pressure measured. We investigated whether there was a difference of hs-CRP and lipids between the normotensive and hypertensive groups. There was significant difference of TC, TC/HDL-C ratio, and hs-CRP concentration between the normotensive and hypertensive groups in both men and women, but there was no significant difference of HDL-C concentration between two groups. Our results indicated that the concentrations of hs-CRP and lipids were higher in patients with hypertension and confirmed the usefulness of lipids and hs-CRP in predicting the risk for coronary artery diseases.