• Title/Summary/Keyword: Concentration boundary layer

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Characterization of valacyclovir transport mechanism across the intestinal epithelium

  • Han, H.;Covitz, M.;Surendran, N.;Stewart, B.;Amidon, G.L.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1997.04a
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    • pp.119-119
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    • 1997
  • Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

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Energy effects on MHD flow of Eyring's nanofluid containing motile microorganism

  • Sharif, Humaira;Naeem, Muhammad N.;Khadimallah, Mohamed A.;Ayed, Hamdi;Bouzgarrou, Souhail Mohamed;Al Naim, Abdullah F.;Hussain, Sajjad;Hussain, Muzamal;Iqbal, Zafar;Tounsi, Abdelouahed
    • Advances in concrete construction
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    • v.10 no.4
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    • pp.357-367
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    • 2020
  • The impulse of this paper is to examine the influence of unsteady flow comprising of Eyring-Powell nanofluid over a stretched surface. This work aims to explore efficient transfer of heat in Eyring-Powell nanofluid with bio-convection. Nanofluids possess significant features that have aroused various investigators because of their utilization in industrial and nanotechnology. The influence of including motile microorganism is to stabilize the nanoparticle suspensions develop by the mixed influence of magnetic field and buoyancy force. This research paper reveals the detailed information about the linearly compressed Magnetohydrodynamics boundary layer flux of two dimensional Eyring-Powell nanofluid through disposed surface area due to the existence of microorganism with inclusion the influence of non- linear thermal radiation, energy activation and bio-convection. The liquid is likely to allow conduction and thickness of the liquid is supposed to show variation exponentially. By using appropriate similarity type transforms, the nonlinear PDE's are converted into dimensionless ODE's. The results of ODE's are finally concluded by employing (HAM) Homotopy Analysis approach. The influence of relevant parameters on concentration, temperature, velocity and motile microorganism density are studied by the use of graphs and tables. We acquire skin friction, local Nusselt and motil microorganism number for various parameters.

Dimethylsulfide (DMS) in the Coastal Areas of the Cheju Island, Korea (제주도 연안해역을 중심으로 한 DMS 농도의 관측)

  • 김기현;이강웅;허철구;강창희
    • Journal of Korean Society for Atmospheric Environment
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    • v.13 no.2
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    • pp.161-170
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    • 1997
  • The concentrations of dimethylsulfide (DMS) were determined using samples collected from a station located at Kosan, Cheju Island during two field campaigns held in December 1996 and January 1997. The atmospheric DMS concentrations measured at 6-hr intervals during the entire campaign periods, after excluding a few extreme values, spanned in the range of 14 to 410 pptv with mean and 1 SD value of 127 $\pm$ 94 pptv (N=42). Between two month periods during which the field campaigns were conducted, a notable reduction in DMS levels was observed which was comparable to the dramatic shift in air temperature. A considerable difference was also noted in DMS levels, when data were grouped by day/night basis. The cause of unexpected, high day-to-night DMS ratios is best explained in terms of high efficiency of daytime source processes relative to low efficiency of nighttime sink processes due to the characteristics of the study location. The surface water DMS of the study site, although scarcely measured, also behaved similarly to its atmospheric counterpart with its range from 0.3 to 19 nM (N=11). When correlation analysis was conducted between the atmospheric DMS concentration and other concurrently determined parameters, significant correlations were observed from most basic meteorological parameters such as windspeed, relative humidy, and air temperature. However, the existence of "not-so-strong" correlations between air temperature and DMS concentrations relative to other ones indicated that the effect of temperature on DMS behavior must be reflected in more complicated manners at the study site. The sea-to-air flux of DMS was approximated through an application of the mass-balance flux calculation method of Wylie and de Mora (1996) under the assumption that sink mechanism within the marine boundary layer is in steady-state condition with its counterpart, source mechanism. Based on this estimation method, we reached a conclusion that oceanic DMS emitted from the southwest sea of the Korean Peninsula can amount to approximately 9 $\sim$ 36 Gg S $yr^{-1}$.$yr^{-1}$.

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A Study on the Solidification and Purification of High Purity Aluminium Alternate Stirring Method (정역 회전법에 의한 고순도 알루미늄의 응고 및 정련에 관한 연구)

  • Kim, Wook;Lee, Joung-Ki;Baik, Hong-Koo;Heo, Seong-Gang
    • Journal of Korea Foundry Society
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    • v.12 no.3
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    • pp.220-229
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    • 1992
  • The degree of purification and the macrostructure of high purity aluminium were studied through the alternate stirring method in order to improve the nonuniformity of solute concentration in the unidirectional stirring method. The $2^3$ factorial design was done to examine the effects of experimental factors more qualitatively. In the relatively low stirring speed of 1500 rpm with alternate stirring mode, the uniform solute profile and refined grain structure were obtained due to strong washing effect and turbulent fluid flow. It was induced by the transition of the momentum boundary layer by alternation of the stirrer. It was concluded from this study that the alternate stirring mode was more effective to obtain the uniformity of solute even in the stirring speed of 1500 rpm. But the degree of purification decreased below the critical alternating period. When 2N(99.8wt.%) aluminium was used as the starting material the morphology of solid-liquid showed the cellular shape and the columnar grains were inclined to the direction of rotation. This inclined grain growth resulted from the difference of relative velocities of solid and liquid. The inclined angle was increased as the stirring speed increased and solidification proceeded. In the case of 4N aluminium, there was no inclined grain growth and it was confirmed from the macrostructure and SEM work that the morphology of solid-liquid interface was planar. From the factorial design, it was found that the alternate stirring mode showed poorer purification effect than that of unidirectional stirring mode at low speed(500 rpm). In addition, the factor that had the most significant effect on the degree of purification was the stirring speed.

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Electrical, Optical, and Electrochemical Corrosion Resistance Properties of Aluminum-Doped Zinc Oxide Films Depending on the Hydrogen Content

  • Cho, Soo-Ho;Kim, Sung-Joon;Jeong, Woo-Jun;Kim, Sang-Ho
    • Journal of Surface Science and Engineering
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    • v.51 no.2
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    • pp.116-125
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    • 2018
  • Aluminum-doped zinc oxide (AZO) is a commonly used material for the front contact layer of chalcopyrite $CuInGaSe_2$ (CIGS) based thin film solar cells since it satisfies the requisite optical and electrical properties with low cost and abundant elemental availability. Low-resistivity and high-transmission front contacts have been developed for high-performance CIGS solar cells, and nearly meet the required performance. However, the durability of the cell especially for the corrosion resistance of AZO films has not been studied intensively. In this work, AZO films were prepared on Corning glass 7059 substrates by radio frequency magnetron sputtering depending on the hydrogen content. The electrical and optical properties and electrochemical corrosion resistance of the AZO films were evaluated as a function of the hydrogen content. With increasing hydrogen content to 6 wt%, the crystallinity, crystal size, and surface roughness of the films increased, and the resistivity decreased with increased carrier concentration, Hall mobility, oxygen vacancies, and $Zn(OH)_2$ binding on the AZO surface. At a hydrogen content of 6 wt%, the corrosion resistance was also relatively high with less columnar morphology, shallow pore channels, and lower grain boundary angles.

Seasonal and Diurnal Variations of Surface Ozone at Ieodo in the East China Sea (이어도 해양과학기지의 오존농도의 계절변화와 일변화 특징)

  • Shin, Beom-Cheol;Lee, Mee-Hye;Lee, Jae-Hak;Shim, Jae-Seol
    • Journal of Korean Society for Atmospheric Environment
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    • v.23 no.6
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    • pp.631-639
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    • 2007
  • We examined diurnal and seasonal variations of ozone ($O_3$) concentrations and its relation to meteorological parameters observed at the Ieodo Ocean Research Station ($32.07^{\circ}N$, $125.10^{\circ}E$, 36 m above sea level) during June 2003 and May 2005. Over the 2-year period, the mean ozone concentration was $49.5{\pm}15.5\;ppbv$. Ozone concentrations show great variability with a monthly mean up to 68.2 ppbv in May 2005 and seasonal variations with being highest in spring and fall, and lowest in summer. However, the amplitude of diurnal variation was less than ${\sim}4\;ppbv$ with a maximum at $3{\sim}4\;p.m.$ and minimum at $7{\sim}8\;a.m.$ HYSPLIT backward air trajectory indicated that the air masses with higher ozone came from the north or northwest and those with lower ozone arrived mainly via southerly or southeasterly. Ozone distributions at Ieodo Ocean Research Station were observed to be significantly impacted by long-range transport and regional scale air circulation.

Basic Study on Diffusion Branch of Tribrachial Flame with the Variation of Flammability Limits and Heat Loss Under Small Fuel Concentration Gradient (미소 농도구배 조건에서 열손실 및 가연한계가 삼지화염의 확산화염에 미치는 영향에 대한 기초 연구)

  • Cho, Sang-Moon;Lee, Min-Jung;Kim, Nam-Il
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.34 no.5
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    • pp.505-513
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    • 2010
  • The tribrachial flame has attracted interest as a basic structure of the flame edge. This flame structure helps understand stabilization of laminar flames and re-ignition of turbulent flames. A number of analytical and experimental studies have been carried out on the tribrachial flame. However, the effect of the variation of the flammability limits on the structure of the tribrachial flame has not been studied in detail. In this study, the effect of non-symmetric flammability limits on the flame structure was investigated by adopting a simple numerical scheme based on several laminar flame theories. A fixed velocity field was considered and boundary matching algorithm was used on the premixed branch. The variation of the diffusion branches under the non-symmetric flammability limits and heat loss was investigated. The formation and extinction of the diffusion branch behind the premixed branch were successfully described. This basic study can help understand the fundamental structure of the flame and can form the basis of subsequent detailed studies.

Operation of Electrodialysis at Over Limiting Current Density (한계전류밀도 이상에서 전기투석공정의 운전)

  • 박진수;최재환;문승현
    • Membrane Journal
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    • v.12 no.3
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    • pp.171-181
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    • 2002
  • The parameter which determines the plateau length of current-voltage curve for ion- exchange membranes was studied at various concentrations of NaCl and different flow rates. Moreover, the feasibility of the electrodialytic removal of 0.1 M NaCl solution at various current densities was tested by assessing the electrodialysis performance parameters such as salt removal efficiency, current efficiency, energy consumption and water dissociation. The diffusion boundary layer (DBL) thickness decreased with the NaCl concentration and flow rate of fled solution and it was observed that the plateau length of current-voltage curves was related with the DBL thickness. The removal efficiency and current efficiency were not affected significantly by the current densities even at the overlimiting current region indicating that most current were passed by electrolyte, and water dissociations are not responsible for the overlimiting current. Energy consumption increased when the current density supplied exceeded the limiting current density (LCD) values, because additional energy was necessary to overcome the plateau potential. Beyond the LCD values the energy consumption required to get a certain removal efficiency was not affected by the current density applied. The result suggests that it is allowed to operate electrodialysis processes at as high as possible current density unless water-splitting does not occur.

Development of Raman LIDAR System to Measure Vertical Water Vapor Profiles and Comparision of Raman LIDAR with GNSS and MWR Systems (수증기의 연직 분포 측정을 위한 라만 라이다 장치의 개발 및 GNSS, MWR 장비와 상호 비교연구)

  • Park, Sun-Ho;Kim, Duk-Hyeon;Kim, Yong-Gi;Yun, Mun-Sang;Cheong, Hai-Du
    • Korean Journal of Optics and Photonics
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    • v.22 no.6
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    • pp.283-290
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    • 2011
  • A Raman LIDAR system has been designed and constructed for quantitative measurement of water vapor mixing ratio. The comparison with commercial microwave radiometer and global navigation satellite system(GNSS) was performed for the precipitable water vapor(PWV) profile and total PWV. The result shows that the total GNSS-PWV and LIDAR-PWV have good correlation with each other. But, there is small difference between the two methods because of maximum measurement height in LIDAR and the GNSS method. There are some significant differences between Raman and MWR when the water vapor concentration changes quickly near the boundary layer or at the edge of a cloud. Finally we have decided that MWR cannot detect spatial changes but LIDAR can measure spatial changes.

Evaluation of Adsorption Characteristics of 2-Picoline onto Sylopute (실로퓨트에 대한 2-피콜린의 흡착 특성 평가)

  • Yang, Ji-Won;Kim, Jin-Hyun
    • Korean Chemical Engineering Research
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    • v.57 no.2
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    • pp.210-218
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    • 2019
  • Batch experiment studies were carried out on the adsorption of the major tar compound, 2-picoline, derived from the plant cell cultures of Taxus chinensis, using Sylopute while varying parameters such as initial 2-picoline concentration, contact time and adsorption temperature. The experimental data were fitted to the Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models. Comparison of results revealed that the Langmuir isotherm model could account for the adsorption isotherm data with the highest accuracy among the four isotherm models considered. From the analysis of adsorption isotherms, it was found that adsorption capacity decreased with increasing temperature and the adsorption of 2-picoline onto Sylopute was favorable. The kinetic data were well described by the pseudo-second-order kinetic model, while intraparticle diffusion and boundary layer diffusion did not play a dominated role in 2-picoline adsorption according to the intraparticle diffusion model. Thermodynamic parameters revealed the exothermic, irreversible and non-spontaneous nature of adsorption. The isosteric heat of adsorption decreased as surface loading ($q_e$) increased, indicating a heterogeneous surface.