• Journal of Biomedical Engineering Research
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• v.23 no.5
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• pp.341-349
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• 2002

The target controlled infusion(TCI) pump system is a logical approach to the development of improved administration techniques of an intravenous anaesthetic agent. The principle of TCI system is based on an understanding of the pharmacokinetic properties, three or four compartment model. The TCI system is optimal and flexible control of the plasma drug concentration. But the clinical goal is always to achieve a therapeutic drug effect, not a therapeutic concentration. So we developed the algorithm to target the concentration at the site of drug effect rather than the concentration in the plasma. If impulse drug is inputted into body, the decline of plasma concentration with time is shown, resulting in the expression of the differential equation. Therefore, we must reformulate our three-compartment model as four-compartment model with the effect compartment. And we tested plasma targeting and effect targeting algorithm by computer simulation using four-compartment model. So we developed the TCI capable of applying all intravenous drugs by adjusting individual pharmacokinetic parameters independently.

• Korean Journal of Food Science and Technology
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• v.20 no.6
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• pp.812-819
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• 1988

Rheological properties of rehydrated suspensions of freeze dried tomato ketchup were measured by Brabender Viscotron at the temperature range of $30-90^{\circ}C$, at the concentration of 15-50%, and at the shear rate of $0-250sec^{-1}$. At the shear rate of $0-210sec^{-1}$, tomato ketchup was found to be a thixotropic food product. The values of flow behavior index, consistency index and yield stress at the shear rate of $0-210sec^{-1}$, at the temperature of $30^{\circ}C$ and at the concentration of 33% , were 0.2131, 22.5047 $Pa\;sec^{-n}$, and 8.544 Pa, respectively. It was found that the apparent viscosity model for temperature was expressed by Andrade model and the model for concentration was expressed by Power model, and the model for both temperature and concentration was described by exponential and power models. The activation energies at the concentrations of 15, 20, 30, 33, 40, and 50% were 3.973, 4.985. 5.078, 5.226, 5.357, and 7.655 $kcal/g{\cdot}mole$, respectively.

• Asian Journal of Atmospheric Environment
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• v.12 no.1
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• pp.59-66
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• 2018

This study aims to evaluate the performance of the Air Quality Model (AQM) for the seasonal and spatial distribution of the $NH_3$ concentration in the atmosphere. To obtain observational data for the model validation, observations based on biweekly sampling have been conducted using passive samplers since April 2015 at multiple monitoring sites in the Tokyo metropolitan area. AQM, built based on WRF/CMAQ, was applied to predict the $NH_3$ concentration observed from April 2015 to March 2016. The simulation domain includes the Kanto region, which is the most densely populated area in Japan. Because the area also contains large amount of livestock, especially in its northern part, the density of the $NH_3$ emissions derived from human activities and agriculture there are estimated to be the highest in Japan. In the model validation, the model overestimated the observed $NH_3$ concentration in the summer season and underestimated it in the winter season. In particular, the overestimation in the summer was remarkable at a rural site (Komae) in Tokyo. It was found that the overestimation at Komae was caused by the transportation of $NH_3$ emitted in the northern part of the Kanto region during the night. It is suggested that the emission input used in this study overestimated the $NH_3$ emission from human sources around the Tokyo suburbs and agricultural sources in the northern part of the Kanto region in the summer season. In addition, the current emission inventories might overestimate the difference of the agricultural $NH_3$ emissions among seasons. Because the overestimation of $NH_3$ in the summer causes an overestimation of $NO_3{^-}$ in $PM_{2.5}$ in the AQM simulation, further investigation is necessary for the seasonal variation in the $NH_3$ emissions.

• Journal of Korean Society of Water and Wastewater
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• v.20 no.3
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• pp.443-450
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• 2006

For understanding sludge concentration profile as a function of time, sludge was sampled at each sampling port. When sludge concentration was 3g/L, the vertical sludge concentration distribution was similar to that of 2g/L of sludge concentration. During the early stage of sludge settling, sludge concentration increased remarkably as the sludge interface height in batch column became lower. The higher sludge concentration became, the worse sludge setteability became. Also, the type of sludge settling was influenced with sludge concentration gradient in batch column. In the same concentration, the greater sludge concentration gradient was, the faster sludge interface settled down. And the changing sludge concentrations in a batch settling or a continuous settling were simulated by using the equation of sludge interface height change model.

• Journal of Industrial Technology
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• v.22 no.A
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• pp.145-151
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• 2002

This paper is results of extensive centrifuge model experiments about design factors influencing the bearing capacity and the settlement behaviors of SCP (Sand Compaction Pile). Centrifuge model tests were carried out changing design factors for SCP method such as replacement area ratio (as= 20, 40, 70%), Improvement ratio to footing width (W/B = 1, 2, 3), and amount of fines m sand pile (#200 = 5, 10, 15). Therefore, the effects of these design factors on the bearing capacity and the settlement behavior of SCP were investigated and changes of stress concentratio rato due to such an design factors were also investigated. Centrifuge model testing technique for preparing and installing centrifuge model of sand compaction pile, using freezing them, was also developed. As results of centrifuge model tests, more fines in sand compaction pile increases the bearing capacity of SCP. Optimum improvement ratio to footing width was found to be 2. Values of stress concentration ratio was in the ranges of 1.5 - 3.5. The depth of bulging in sand plies was found in the range of 2.0 - 2.5 times of pile diameter.

• Computers and Concrete
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• v.7 no.5
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• pp.421-435
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• 2010

This paper utilizes the modified Davis model and the mode coupling theory, as parts of the electrolyte solution theory, to investigate the diffusivity of the ion in concrete. Firstly, a computational model of the ion diffusion coefficient, which is associated with ion species, pore solution concentration, concrete mix parameters including water-cement ratio and cement volume fraction, and microstructure parameters such as the porosity and tortuosity, is proposed in the saturated concrete. Secondly, the experiments, on which the chloride diffusion coefficient is measured by the rapid chloride penetration test, have been carried out to investigate the validity of the proposed model. The results indicate that the chloride diffusion coefficient obtained by the proposed model is in agreement with the experimental result. Finally, numerical simulation has been completed to investigate the effects of the porosity, tortuosity, water-cement ratio, cement volume fraction and ion concentration in the pore solution on the ion diffusion coefficients. The results show that the ion diffusion coefficient in concrete increases with the porosity, water-cement ratio and cement volume fraction, while we see a decrease with the increasing of tortuosity. Meanwhile, the ion concentration produces more obvious effects on the diffusivity itself, but has almost no effects on the other ions.

• Journal of Microbiology and Biotechnology
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• v.18 no.7
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• pp.1298-1307
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• 2008

In this study, we investigated the inhibition effects of single and mixed heavy metal ions ($Zn^{2+},\;Ni^{2+},\;Cu^{2+},\;and\;Cd^{2+}$) on iron oxidation by Acidithiobacillus ferrooxidans. Effects of metals on the iron oxidation activity of A. ferrooxidans are categorized into four types of patterns according to its oxidation behavior. The results indicated that the inhibition effects of the metals on the iron oxidation activity were noncompetitive inhibitions. We proposed a reduced inhibition model, along with the reduced inhibition constant ($\alpha_i$), which was derived from the inhibition constant ($K_I$) of individual metals and represented the tolerance of a given inhibitor relative to that of a reference inhibitor. This model was used to evaluate the toxicity effect (inhibition effect) of metals on the iron oxidation activity of A. ferrooxidans. The model revealed that the iron oxidation behavior of the metals, regardless of metal systems (single, binary, ternary, or quaternary), is closely matched to that of any reference inhibitor at the same reduced inhibition concentration, $[I]_{reduced}$, which defines the ratio of the inhibitor concentration to the reduced inhibition constant. The model demonstrated that single metal systems and mixed metal systems with the same reduced inhibitor concentrations have similar toxic effects on microbial activity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.10
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• pp.1840-1844
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• 2008

In this paper, the influence of channel doping concentration, which the most important factor is as double gate MOSFET is fabricated, on transport characteristics has been analyzed in the subthreshold region. The analytical model is used to derive transport model based on Poisson equation. The thermionic omission and tunneling current to have an influence on subthreshold current conduction are analyzed, and the relationship of doping concentration and subthreshold swings of this paper are compared with those of Medici two dimensional simulation, to verify this model. As a result, transport model presented in this paper is good agreement with two dimensional simulation model, and the transport characteristics have been considered according to the dimensional parameters of double gate MOSFET.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.414-427
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• 2020

The finite element method is used to simulate the navigation of an ice-area bulk carrier in broken ice fields. The ice material is defined as elastic, and the simulations are accomplished at four model speeds and three ice concentrations. The movements of ice floes in the simulation are consistent with those in the model test, and the percentage deviation of the numerical ice resistance from the ice resistance in the model test can be controlled to be less than 15 %. The key characteristics of ice loads, including the average ice loads, extreme ice loads, and characteristic frequency, are analyzed thoroughly in a comprehensive manner. Moreover, the effects of sailing speed and ice concentration on the ice loads are analyzed. In particular, the stress distribution of ice floes is presented to help understand how model speed and concentration affect the ice loads. The "ice pressure" phenomenon is observed at 90 % ice concentration, and it is realistically reflected both in the time―and frequency―domain ice force curves.

• The Journal of Korean Academy of Prosthodontics
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• v.18 no.1
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• pp.37-47
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• 1980

The purpose of this study was to investigate the stresses in different proximal margins and to measure, quantitatively, the effect of different modifications in the design of preparations on the stresses using two-dimensional photoelasticity. Photoelastic stress analysis is based on the phenomenon, exhibited by most transparent solids, of becoming birefringent, or doubly refracting, when strained. Two birefringent materials were used in this study, PSM-1 and PSM-5 in .standard sheet ($10'{\times}10'{\times}\frac{1}{4}'$ thickness), PSM-1(polyester) was used for constructing the substructure, and PSM-5(epoxy resin) was used in making the restorations to be investigated. Two birefringent materials were used in the construction of composite photoelastic model. Seven variable models were constructed. The peripheral dimensions of all model were constant and the models represent an occlusomesial section of a lower posterior molar. Model 1 represents the knife edge margin (shoulderless), Model 2 represents the chamfer, Model 3 represents a rounded shoulder(no sharp angle between the axial wall and gingival floor), Model 4 represents a flat shoulder (axial wall is a $90^{\circ}$ angle to the gingival wall), Model 5 represents $+15^{\circ}$ angulation, Model 6 has a $-15^{\circ}$ angulation, and Model 7 is the same as Model 4 except that it has a $45^{\circ}$ bevel. Improved artificial stone was used to represent dental cement in luting the composite photoelastic model. Static loading procedures(100 pounds) were used at preplanned sites. The results were as follows; 1. The stresses in the proximal portion of all tested models were compressive in nature when the proximal shoulders were loaded vertically on the same proximal marginal ridge. 2. The round and chamfered preparations were the optimum designs in proximoocclusal restorations. They showed the lowest stress concentration factor, i.e. 2.16 and 2.23, respectively. The knife edged shoulder had the highest value, K=5.39. Round type shoulder geometry experiments reduced the stress concentration factor (S.C.F.) 3. The gingival portion of proximal shoulder geometry was a critical location for stress concentration.