• International Journal of Control, Automation, and Systems
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• 제2권4호
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• pp.423-434
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• 2004

In this paper, we introduce a new topology of Self-Organizing Polynomial Neural Networks (SOPNN) based on genetically optimized Multi-Layer Perceptron (MLP) and discuss its comprehensive design methodology involving mechanisms of genetic optimization. Let us recall that the design of the 'conventional' SOPNN uses the extended Group Method of Data Handling (GMDH) technique to exploit polynomials as well as to consider a fixed number of input nodes at polynomial neurons (or nodes) located in each layer. However, this design process does not guarantee that the conventional SOPNN generated through learning results in optimal network architecture. The design procedure applied in the construction of each layer of the SOPNN deals with its structural optimization involving the selection of preferred nodes (or PNs) with specific local characteristics (such as the number of input variables, the order of the polynomials, and input variables) and addresses specific aspects of parametric optimization. An aggregate performance index with a weighting factor is proposed in order to achieve a sound balance between the approximation and generalization (predictive) abilities of the model. To evaluate the performance of the GA-based SOPNN, the model is experimented using pH neutralization process data as well as sewage treatment process data. A comparative analysis indicates that the proposed SOPNN is the model having higher accuracy as well as more superb predictive capability than other intelligent models presented previously.reviously.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제13권2호
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• pp.27-36
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• 2007

Recently, hospital patients experience anxiety, confusion, and stress about wayfinding as the spacial layout and treatment circulatory system of hospitals have become complicated due to their oversized and complex structure. As part of finding a solution to the problem, this study seeks to examine what are the essential elements of the wayfinding planning of O.P.D. in general hospitals, to develop the model of wayfinding, and to suggest the methods of improving the wayfinding system. The research methods of this study adopted were literature review in wayfinding cognition, plan analysis of ten general hospitals, space analysis of these hospitals through space syntax, analysis of the system of visual-perceptual information through a field study, and analysis of surveys and follow-up surveys conducted to support the results. Based on these results, the proposals for finding decision points, providing the information, and developing a model planning are listed as follows. 1) The comprehensive understanding of O.P.D. spacial layout and the visual-perceptual information system is necessary to find the essential elements of wayfinding. 2) The decision points are found through the full understanding of spacial functions, circulation systems, and facility configuration, considering the spacial layout, the bound of the visual-perceptual information system, and the circulatory system. Furthermore, the information decision points could be confined by space syntax. 3) The checklist and color compound & color codes, developed through the planning of signage system and color system could be applied to the methods of providing the information. 4) The planning of wayfinding system according to the whole process of practices for outpatients was mentioned above. The system of visual-perceptual information developed through the process of this study should be integrated in the spacial layout of the whole O.P.D.

• 산업기술연구
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• 제20권A호
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• pp.63-71
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• 2000

A web based watershed and sewer management system was developed for the analysis of stormwater runoff and sewer flow, and for optimal operation of sewer works using ArcView and SWMM. SWMM and ArcView were dynamically linked together using Avenue and Visual Basic in order to construct user-friendly management system. The developed system was applied to Choonchun city to verify its utilities. All the relevant field data were analyzed on the basis of developed system, and the modeling of runoff and sewer flow was implemented using RUNOFF and TRANSPORT blocks in SWMM. This system was connected to the management system of surface and subsurface environment management system in order to develop an integrated environmental management system. Futhermore, this system will be a critical part of overall control system of sewer works including sewer line and wastewater treatment plant. As this system can provide comprehensive prediction of flow and pollution profiles and analytical tool equipped with Web-GIS, it could serve widely as a tool not only for optimal management, but also for decision support system to examine the efficiency of planning and implementation of sewer projects.

• Journal of Mechanical Science and Technology
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• 제20권8호
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• pp.1139-1148
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• 2006

This paper addresses the analytical modeling and dynamic response of the advanced composite rotating blade modeled as thin-walled beams and incorporating viscoelastic material. The blade model incorporates non-classical features such as anisotropy, transverse shear, rotary inertia and includes the centrifugal and coriolis force fields. The dual technology including structural tailoring and passive damping technology is implemented in order to enhance the vibrational characteristics of the blade. Whereas structural tailoring methodology uses the directionality properties of advanced composite materials, the passive material technology exploits the damping capabilities of viscoelastic material (VEM) embedded into the host structure. The VEM layer damping treatment is modeled by using the Golla-Hughes-McTavish (GHM) method, which is employed to account for the frequency-dependent characteristics of the VEM. The case of VEM spread over the entire span of the structure is considered. The displayed numerical results provide a comprehensive picture of the synergistic implications of both techniques, namely, the tailoring and damping technology on the dynamic response of a rotating thin-walled b ε am exposed to external time-dependent excitations.

• 한국보건간호학회지
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• 제37권1호
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• pp.136-146
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• 2023

This cross-sectional design study was undertaken to determine the factors associated with suicidal ideation in human immunodeficiency virus (HIV)-infected older adults. Data from a city-wide representative sample collected by the Seoul Metropolitan Government were used. The cross-sectional survey was conducted between February and March 2013. Participants selected and included in the analysis were HIV-infected adults living in Seoul, and aged 50 years and older. The overall adjusted model showed that being unemployed (adjusted odds ratio [aOR], 3.34; 95% confidence interval [CI], 1.16-9.57), a history of depression treatment (aOR, 4.61; 95% CI, 1.02-20.66), perceived belongingness (aOR, 0.63; 95% CI, 0.41-0.99), and psychological functioning (aOR, 0.85; 95% CI, 0.73-0.99) were significantly related to suicidal ideation. Psychosocial features were found to be strongly associated with suicidal ideation among HIV-infected older adults. The findings could be useful for HIV nursing consultants to identify HIV-infected older adults who are vulnerable to suicidal ideation. Comprehensive mental health services should be provided as coping resources for HIV-infected older adults who have suicidal ideation.

• Tuberculosis and Respiratory Diseases
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• 제87권4호
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• pp.451-457
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• 2024

Nontuberculous mycobacterial pulmonary disease (NTM-PD) results from the exposure of susceptible hosts to a diverse group of environmental mycobacteria. The emphasis on nonpharmacological strategies is motivated by the widespread presence of NTM in various environments, and the inconsistent success rates of pharmacological treatments. Modifiable factors contributing to NTM-PD development include impaired airway clearance, low body mass index, gastroesophageal reflux disease, and exposure to NTM habitats. This suggests that lifestyle and environmental modifications could affect disease development and progression. The review highlights several modalities that can modify the risk factors. Airway clearance techniques, informed by the "gel-on-brush" model of the bronchial epithelium, aim to enhance mucociliary clearance, and have the potential to alleviate symptoms and improve lung function. The impact of nutritional status is also examined, with a lower body mass index linked to an increased risk and progression of NTM-PD, indicating the importance of targeted nutritional support. Additionally, the theoretical and epidemiological links between gastroesophageal reflux disease and NTM-PD advocate careful management of reflux episodes. Understanding the risk of NTM transmission through environmental exposure to contaminated water and soil is also crucial. Strategies to mitigate this risk, including effective water management and minimizing soil contact, are presented as vital preventive measures. The review supports the inclusion of nonpharmacological treatments within a comprehensive NTM-PD management strategy, alongside conventional pharmacological therapies. This integrated approach seeks to improve the overall understanding and handling of NTM-PD.

• Journal of Ginseng Research
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• 제46권2호
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• pp.255-265
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• 2022

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase α (AMPKα), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

• BMB Reports
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• 제40권3호
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• pp.448-452
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• 2007

We examined the contribution of CYP2C9 and CYP2C19 genotypes and drug interactions to the phenytoin metabolism among 97 Korean epileptic patients to determine if pharmacogenetic testing could be utilized in routine clinical practice. The CYP2C9 polymorphism is a wellknown major genetic factor responsible for phenytoin metabolism. The CYP219 polymorphism, with a high incidence of variant alleles, has a minor influence on phenytoin treated Koran patients. Using a multiple regression model for evaluation of the CYP2C9 and CYP2C19 genotypes, together with other non-genetic variables, we explained 39.6% of the variance in serum phenytoin levels. Incorporation of genotyping for CYP2C9 and CYP2C19 into a clinical practice may be of some help in the determination of phenytoin dosage. However, because concurrent drug treatment is common in patients taking phenytoin and many environmental factors are likely to play a role in drug metabolism, these factors may overwhelm the relevance of CYP polymorphisms in the clinical setting. Further investigations with an approach to dose assessment that includes comprehensive interpretation of both pharmacogenetic and pharmacokinetic data along with understanding of the mechanism of drug interactions in dosage adjustment is warranted.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권4호
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• pp.311-319
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• 2021

The use of aromatherapy for the reduction of anxiety levels during dental treatment procedures has been well established in the literature; however, there is limited evidence regarding its efficacy. The present meta-analysis is an attempt to assess the association between the use of aromatherapy and anxiety levels among dental patients. A comprehensive search was conducted across Medline, Scopus, Web of Science, EBSCO host, Cochrane databases, and Google Scholar for studies evaluating aromatherapy and anxiety level among dental patients. PRISMA guidelines were followed for the meta-analysis. Randomized and cluster-randomized trials comparing aromatherapy with controls were included. The random-effects model was used to assess the mean differences in anxiety levels of patients visiting dental OPD. The significance value was set at P < 0.05. Six studies were identified that met the requirements for inclusion. Aromatherapy was significantly associated with reduction in patient anxiety levels during dental treatment (pooled mean difference: -3.36 [95% CI, -3.77 - -2.95, P = 0.00001). Low heterogeneity was noted between studies (I² = 1%, P = 0.41) analyzed in the meta-analysis. High certainty of the evidence was obtained from the association between the use of aromatherapy and dental anxiety. This meta-analysis suggests that aromatherapy is effective in reducing dental anxiety. When used judiciously, the results of this work should encourage the use of aromatherapy to reduce patient anxiety levels during dental procedures

• 대한토목학회논문집
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• 제34권1호
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• pp.195-202
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• 2014

안전한 철도운영환경을 조성하기 위해 개정된 철도안전법은 사고예방 및 사전적 철도안전관리를 위해 철도종합안전관리체계 구축 및 안전승인 심사 제도를 필요로 하고 있다. 그러나 아무리 좋은 제도와 시스템이 있어도 조직 내에 적절한 수준의 안전문화가 정착되지 않고서는 그러한 제도와 안전관리체계가 성공적으로 자리 잡기 어렵다. 국내 철도분야의 안전문화성숙을 측정할 수 있는 모델과 방법론이 부재한 상황에서 본 연구는 안전문화 성숙을 평가할 수 있는 모델과 그 절차를 검토하고 국내 철도운영환경에 적합한 안전요소 위계 설정과 적절한 설문구성 방법 및 통계적 절차를 제시 하였다. 향후 이러한 절차를 활용한 철도안전문화 성숙 평가 결과는 2014년부터 시행될 철도안전운영 사전승인제도와 결합하여 취약한 안전문화 분야와 그에 적절한 처방을 찾는데 기여할 것이다.