• 한국콘텐츠학회논문지
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• 제11권5호
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• pp.50-56
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• 2011

본 연구는 복합지식 객체를 기반으로 다차원적인 관계를 쉽게 식별하고 검색할 수 있도록 복합지식의 3D 가시화방법을 제안한다. 이를 위해 복합지식을 네트워크 형태의 의미화된 링크와 노드로 구조화하고 3차원 형태로 보여줄 수 있도록 SOM을 이용한 가시화방법을 제안하였다. 또한, 3D 공간상에서 복합지식을 배치하고 사용자에게 제공함으로써 보다 실감적이고 직관적인 정보검색의 기회를 제공하기 위해서 객체 유사도를 이용한 복합지식의 3D 클러스터링 방법을 제안하였다. SOM을 이용한 복합지식의 3D 가시화와 클러스터링은 복합지식의 맥락과 연계성을 시공간에 가시화하는데 최적의 방법이 될 수 있다.

• 약학회지
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• 제42권4호
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• pp.395-402
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• 1998

Mori Cortex Radicis, the root bark of mulberry tree, has been used in the treatment of bronchial asthma and other lung diseases in traditional medicine. There was a recent repor t that the water soluble part with molecular weight of above 10,000 has anti-allergic activity. Therefore, we intended to isolate and purify the anti-allergic compound from hot water extract of the Mori Cortex Radicis. Crude extract of Mori Cortex Radicis was prepared by hot-water extraction, and anti-allergic compound was further purified by alcohol precipitation, successive ultrafiltration, anion exchange chromatography and gel filtration chromatography. This compound had homogeneity which was shown by the sharp single peak in HPLC chromatogram (TSK-GEL G400OPW column, RI detector). The molecular weight of the compound was estimated as 23Kda on the basis of calibration curve plotted against protein standards. This compound was identified as complex of sugar, protein and lignin (19.2: 5.9: 72.7), and proteolysis could not decrease the anti-allergic activity but mild delignification decreased the activity remarkably. Therefore, we concluded that the anti-allergic compound of Mori Cortex Radicis was a lignin-carbohydrate complex.

• International Journal of Automotive Technology
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• 제6권5호
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• pp.501-506
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• 2005

With the respective collapse characteristics of aluminum and CFRP (Carbon Fiber Reinforced Plastics) tubes in mind, axial collapse tests were performed for aluminum/CFRP compound tubes, which are composed of square or circular shaped aluminum tubes wrapped with CFRP outside. In this study, the collapse modes and the energy absorption characteristics were analyzed for aluminum/CFRP compound tubes which have different fiber orientation angle of CFRP. Fracture modes in the aluminum/CFRP compound tubes were rather stable than those in the CFRP tubes alone, probably due to the ductile nature of the inner aluminum tubes. The absorbed energy per unit volume of the aluminum or the aluminum/CFRP compound tubes was higher than that of CFRP tubes. Meanwhile, the absorbed energy per unit mass, for the light-weight design aspect was higher in the aluminum/CFRP compound tubes than in the aluminum tubes or the CFRP tubes. The energy absorption turned out to be higher in circular tubes than in square tubes. Beside the collapse modes and the energy absorption characteristics were influenced by the orientation angle, and the compound tubes took the most effective energy absorption when the fiber orientation angle of CFRP was 90 degrees.

• 스마트미디어저널
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• 제8권2호
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• pp.74-79
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• 2019

기존의 복합명사 분해 알고리즘은 미등록어 단위명사들이 포함된 복합명사를 분해할 때 미등록어를 분리하기 어려운 문제가 발생한다. 이는 현실적으로 모든 고유명사, 신조어, 외래어 등의 모든 단위 명사를 사전에 등록하는 것은 불가능하다는 한계가 존재하기 때문이다. 이 문제를 해결하기 위하여 복합명사 분해 문제를 태그 열 부착(sequence labeling) 문제로 정의하고 음절 단위 임베딩과 딥러닝 기법을 이용하는 복합명사 분해 방법을 제안한다. 단위명사 사전을 구축하지 않고 미등록 단위명사를 인식하기 위하여 복합명사를 구성하는 각 음절들을 연속적인 벡터 공간에 표현하여 LSTM과 선형체인(linear-chain) CRF를 이용하는 방식으로 복합명사를 단위명사들로 분해한다.

• 한국해양바이오학회지
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• 제14권2호
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• pp.143-154
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• 2022

We isolated marine actinomycetes, strain D-5 which produces anti-methicillin resistant Staphylococcus aureus (anti-MRSA) compound. Streptomyces sp. D-5 relatively grew well in the 20~25℃, pH 8.0, and NaCl 3.0%. The ethyl acetate extract of D-5 culture was separated by C₁₈ ODS open column and reverse phase HPLC to yield anti-MRSA compound. The molecular weight of this compound was determined to be 898 by a Liquid chromatograph-mass spectrometer (LC-MS). Compared with penicillin G, this compound showed significant anti-MRSA activity. It also exhibited an inhibition zone of 26 mm at a concentration of 64 ㎍/disk and an inhibition zone of 16 mm at a concentration of 16 ㎍/disk against the MRSA KCCM 40511. Furthermore, the co-treatment of HPLC peak 5 compound and vancomycin caused a more rapid decrease in MRSA cells than each compound alone. It showed 86.8% growth inhibition activity within 12 hours at a low concentration of 50 ㎍/mL during co-treatment, and 97.1% growth in-hibition activity within 48 hours against MRSA KCCM 40511. Taken together, our results suggest that Streptomyces sp. D-5 and its anti-MRSA compound could be employed as a potent agent in MRSA infection.

• 한국산학기술학회논문지
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• 제4권4호
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• pp.357-360
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• 2003

작약의 methanol 추출물은 혈소판 활성 실험에서 혈소판 응집에 대해 강한 억제를 보였다. 활성성분은 chromatography방법을 사용하여 정제하였고 NMR과 기존의 Data로 분석하였다. Compound 1b는 benzoyloxypaeoniflorin과 동일한 구조임을 확인하였으며. compound 2e는 작약의 주성분인 paeoniflorin과 동일한 화학구조를 가졌으며 , compound 3a의 분석결과 구조적 유사성은 있으나 동일한 구조식은 확인 할 수 없었지만 collagen에서 응집억제활성이 90％이상의 뛰어난 활성을 나타내어 benzoyloxypaeoniflorin과 유사하게 benzoyl 기가 다른 작용기로 치환되었거나 Rl group이 다른 작용기로 치환된 형태로 추측하였다. Paeoniflorin이 collagen보다 thrombin에서 강한 억제를 보이는 것은 Ca/sup 2＋/ chelate를 형성함으로 인해 calcium 대사산물이 파괴된 것으로 추측했다. Compound 3a는 paeoniflorin의 benzoyl 기에 있는 OH기나 paeoniflorin의 glycoside 5-carbon위치의 OH기 대신에 다른 작용기가 대사산물로의 역할을 수행했을 것으로 추정했다.

• 약학회지
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• 제44권5호
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• pp.478-487
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• 2000

This study was carried out to find new anti-tumor agent producing microbe and to characterize the anti-tumor agent produced from the microbe. Purified compound that has a high cytotoxicity against tumor cell-lines could be obtained from the broth culture filtrates of Streptomyces sp.409 strain isolated from soil in Korea. The in vitro cytotoxicity the in vivo evaluation of acute toxicity the safety assessment of the anti-tumor compounds and the taxonomic characteristics of the anti-tumor agent were measured. The antitumor compound 1 and 2 were obtained from the broth culture filtrates of Streptomyces sp.409 strain. The cytotoxicity of the compound 1 against tumor cell-line P388D$_1$ showed almost 4.5 times higher than that of adriamycin. However in the cytotoxicity against normal cell line Vero E6, adriamycin showed adversely 4 times higher than the compound 1 ($IC_{50}$/ value: 228.7 $\mu\textrm{g}$/$m\ell$). In comparison study with compound 1 and compound 2 in the in vitro cytotoxin productivity against tumor cell lines, $IC_{50}$/ value of the compound 1 was 0.25 $\mu\textrm{g}$/$m\ell$ in tumor cell line P388D$_1$and 0.53 $\mu\textrm{g}$/$m\ell$ in tumor cell-line L1210, and that of the compound 2 was 7.18 $\mu\textrm{g}$/$m\ell$ and 35.71 $\mu\textrm{g}$/$m\ell$, respectively; LD$_{50}$ value of the compound 1 in the in vivo acute toxicity in mice was 22.62 $\mu\textrm{g}$/kg body weight. These results suggest that compound 1 purified from Streptomyces sp. 409 has anti-tumor activity and will be developed as an anti-tumor drug.g.

• 한국응용과학기술학회지
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• 제26권1호
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• pp.18-23
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• 2009

Curing behavior and structural property of an inorganic compound added urea-formaldehyde(UF) and urea-melamine-formaldehyde(UMF) were studied. In addition, tensile strength and formaldehyde emission of plywoods made of those resin binders were studied. Curing temperature and structure were not changed, but tensile strengths of plywoods manufactured both with a UF resin and a UMF resin were decreased slightly as increased amount of inorganic compound. Formaldehyde emissions from plywoods were reduced as increased amount of inorganic compound. Wheat flour as an extender was helped to reduce of formaldehyde emission. From the result of this study it might be estimated that using appropriate amount of inorganic compound and proper resin system can be strengthened bond strength and reduced formaldehyde emission.

• Journal of Information Technology Applications and Management
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• 제11권4호
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• pp.95-102
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• 2004

This paper proposes a method of segmenting compound nouns which include unregistered nouns into a correct combination of unit nouns using characteristics of person's names, loanwords, and location names. Korean person's name is generally composed of 3 syllables, only relatively small number of syllables is used as last names, and the second and the third syllables combination is somewhat restrictive. Also many person's names appear with clue words in compound nouns. Most loanwords have one or more syllables which cannot appear in Korean words, or have sequences of syllables different from usual Korean words. Location names are generally used with clue words designating districts in compound nouns. Use of above characteristics to analyze compound nouns not only makes segmentation more accurate, helps natural language systems use semantic categories of those unregistered nouns. Experimental results show that the precision of our method is approximately 98% on average. The precision of human names and loanwords recognition is about 94% and about 92% respectively.

• Mycobiology
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• 제42권3호
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• pp.256-261
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• 2014

A ${\beta}$-glucosidase producing yeast strain was isolated from Korean traditional rice wine. Based on the sequence of the YCL008c gene and analysis of the fatty acid composition, the isolate was identified as Saccharomyces cerevisiae strain HJ-014. S. cerevisiae HJ-014 produced ginsenoside Rd, $F_2$, and compound K from the ethanol extract of red ginseng. The production was increased by shaking culture, where the bioconversion efficiency was increased 2-fold compared to standing culture. The production of ginsenoside $F_2$ and compound K was time-dependent and thought to proceed by the transformation pathway of: red ginseng extract ${\rightarrow}Rd{\rightarrow}F_2{\rightarrow}$ compound K. The optimum incubation time and concentration of red ginseng extract for the production of compound K was 96 hr and 4.5% (w/v), respectively.