• Economic and Environmental Geology
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• v.30 no.3
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• pp.263-275
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• 1997

Compound calcrete deposits are recognized from the Dadaepo Formation in Dusong peninsula, Pusan, and their textures, structures, morphology, and stratigraphic distribution are examined. The Dadaepo Formation in study area consists of fluvial plain deposits including floodplain-lake deposits, and the compound calcrete deposits occur above floodplain deposits and below lacustrine deposits. The compound calcrete deposits are composed of nodular to massive (micritic), laminar, nodular, nodular to massive (marly), and marly calcrete deposits. In these calcretes, circumgranular and curved cracks, alveolar structures, fitted peloids, tubular fenestrae with laminar micrite wall (rootlet casts), microstalactic calcite, and tepee structures are observed, which indicates that they are calcic paleosols. Considering their stratigraphic occurrences and pedogenic origin, compound calcrete deposits are interpreted to have formed on distal fluvial plain to palustrine environment by the repetetion of deposition and subsequent calcification due to alternation of lake expansion and contraction. The repetetion of calcrete formation suggests that arid climatic condition was alternated with humid condition in short-term period. Such alternated paleoclimatic condition is similar to those of the Sindong and Hayang groups, and indicates that short-term fluctuations from arid to humid climate were prevailing in overall Gyeongsang Basin. In stratigraphic sense, the compound calcrete deposits can be used as a marker deposit for the correlation of the Dadaepo Formation.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.1
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• pp.7-12
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• 2006

Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the $G_1$ phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.1
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• pp.97-102
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• 2012

Odontoma is a mixed tumor formed by the overgrowth of ectodermal epithelial cells and mesodermal cells. It arises during normal tooth development and only grows to a certain level. It is not a true neoplasm and therefore it is considered as hamartomas. Odontomas are classified into compound and complex types based on morphology. Compound odontoma is commonly found in the anterior region of the maxilla, and has a radiopaque lesion that resembles small teeth. Usually, odontoma is treated by conservative surgical removal and there is little probability of recurrence. This paper describes three cases of compound odontoma diagnosed in children with 1 year of follow-up. These case reports present patients having eruption disturbance of primary and permanent teeth due to the presence of compound odontoma. In order to induce spontaneous eruption, conservative surgical removal was performed showing favorable results.

• YAKHAK HOEJI
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• v.60 no.3
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• pp.101-106
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• 2016

Allylthiopyridazine derivatives were synthesized and evaluated for anti-proliferative activities in the previous study. In this study, selected two allylthiopyridazine derivatives (compound I, 3-heptylamino-6-allylthiopyridazine and compound II, 3-dipentylamino-6-allylthiopyridazine) were assessed for cytotoxicity and chronic proliferation in human colon carcinoma RKO cells. Two derivatives dose-dependently inhibited cell viability and proliferation. To elucidate the anticancer mechanism of two derivatives, we investigated the expression level of apoptosis-related proteins in RKO cells. Compound I induced the activation of JNK and expression of p53 and p21. On the other hand, compound II showed no change of p53 level. Interestingly, compound II inhibited the nuclear translocation of NF-${\kappa}B$. This result suggested that compound II suppressed cell proliferation. These different mechanisms of these compounds might have occurred through different steric conformation.

• Journal of Ginseng Research
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• v.34 no.4
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• pp.288-295
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• 2010

Ginsenosides are the principal components responsible for the pharmacological and biological activities of ginseng. Ginsenoside Rd was transformed into compound K using cell-free extracts of food microorganisms, with Lactobacillus pentosus DC101 isolated from kimchi (traditional Korean fermented food) used for this conversion. The optimum time for the conversion was about 72 h at a constant pH of 7.0 and an optimum temperature of about $30^{\circ}C$. The transformation products were identified by thin-layer chromatography and high-performance liquid chromatography, and their structures were assigned using nuclear magnetic resonance analysis. Generally, ginsenoside Rd was converted into ginsenoside F2 by 36 h post-reaction. Consequently, over 97% of ginsenoside Rd was decomposed and converted into compound K by 72 h post-reaction. The bioconversion pathway to produce compound K is as follows: ginsenoside Rd$\rightarrow$ginsenoside F2$\rightarrow$compound K.

• Nuclear Engineering and Technology
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• v.50 no.1
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• pp.18-24
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• 2018

This study proposes a new method of analyzing the burnup credit in boiling water reactor spent fuel assemblies against various operating parameters. The operating parameters under investigation include fuel temperature, axial burnup profile, axial moderator density profile, and control blade usage. In particular, the effects of variations in one and two operating parameters on the curve of effective multiplication factor ($k_{eff}$) versus burnup (B) are, respectively, the so-called single and compound effects. All the calculations were performed using SCALE 6.1 together with the Evaluated Nuclear Data Files, part B (ENDF/B)-VII238-neutron energy group data library. Furthermore, two geometrical models were established based on the General Electric (GE)14 $10{\times}10$ boiling water reactor fuel assembly and the Generic Burnup-Credit (GBC)-68 storage cask. The results revealed that the curves of $k_{eff}$ versus B, due to single and compound effects, can be approximated using a first degree polynomial of B. However, the reactivity deviation (or changes of $k_{eff}$, ${\Delta}k$) in some compound effects was not a summation of the all ${\Delta}k$ resulting from the two associated single effects. This phenomenon is undesirable because it may to some extent affect the precise assessment of burnup credit. In this study, a general formula was thus proposed to express the curves of $k_{eff}$ versus B for both single and compound effects.

• Polymer(Korea)
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• v.39 no.2
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• pp.240-246
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• 2015

Formation of a strong 3-dimensional interfacial network structure via chemical reaction between hydroxyl group on silica surface and NR chain by the addition of bis(triethoxysilylpropyl)tetrasulfide (TESPT) into silica-filled NR compound was observed by using Py-GC/MS and SEM. Addition of TESPT into silica-filled NR compound decreased scorch time ($t_{10}$) due to increased sulfur content, and reduced cure rate index (CRI) via continuous reaction between sulfur atoms in TESPT, which acted as a sulfur donor, and activators and/or accelerators. Addition of TESPT in the compound improved processability and mechanical properties of the compound. Overall, we observed that the addition of TESPT into the silica-filled NR compound formed a silica-TESPT-NR network, and thus the degree of crosslinking was increased resulting in improved mechanical properties.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.10 s.241
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• pp.1329-1335
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• 2005

An aluminum or CFRP (Carbon Fiber ReinfDrced Plastics)is representative one of light-weight materials but its axial collapse mechanism is different from each other. The aluminum member absorbs energy by stable plastic deformation, while the CFRP member absorbs energy by unstable brittle failure with higher specific strength and stiffness than those in the aluminum member. In an attempt to achieve a synergy effect by combining the two members, aluminum CFRP compound square members were manufactured, which are composed of aluminum members wrapped with CFRP outside aluminum square members with different fiber orientation angle and thickness of CFRP, and axial collapse tests were performed fur the members. The axial collapse characteristics of the compound members were analyzed and compared with those of the respective aluminum members and CFRP members. Test results showed that the collapse of the aluminum CFRP compound member complemented unstable brittle failure of the CFRP member due to ductile characteristics of the inner aluminum member. The collapse modes were categorized into four modes under the iuluence of the fiber orientation angle and thickness of CFRP. The absorbed energy Per unit mass, which is in the light-weight aspect was higher in the aluminum CFRP compound member than that in the aluminum member and the CFRP member alone.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.55-63
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• 2010

Objectives : In this study, we investigated anti-allergic effect of Okbyeongpungsan-Hap-Changijasan (KOB01) in allergic rhinitis(AR) experimental animals and mast cells. Methods : The potential anti-allergic effect of KOB01 was investigated in a rat model of compound 48/80-induced systemic anaphylactic shock and a mouse of ovalbumin(OVA)-induced AR, and human mast cell line, HMC-1 culture. Each animals were divided into four groups: normal, control, KOB01-treated(100 and 200 mg/kg) and anti-histamine drug, dosodium cromoglycate (DSCG)-treated(50 mg/kg). Animals were orally treated with KOB01 and DSCG and intraperitoneally injected with compound 48/80($10\;{\mu}g/kg$) or sensitized with 0.1% OVA. The mortality and serum histamine levels were measured in compound 48/80-induced anaphylatic rats. The histological changes in nasal mucosa were investigated in OVA-induced AR mice. Also, mast cell degranulation was observed in compound 48/80-stimulated HMC-1 cells. Results : KOB01 increased mortality and significantly decreased serum histamine levels in compound 48/80-induced anaphylatic rats. The abnormal histological changes such as expansion of grandular cells and hypertrophy of epithelium in nasal mucosa of OVA-induced AR mice was improved by KOB01 treatment nearby a normal group. Therefore, KOB01 inhibited compound 48/80-induced degranulation in HMC-1 cells. Conclusions : These results indicate that KOB01 decrease allergic response through suppressing the mast cell activation in AR and suggest a potential role for KOB01 as a source of anti-allergic agents for use in allergic disorders including of AR.

• Journal of Pharmacopuncture
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• v.19 no.3
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• pp.246-252
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• 2016

Objectives: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. Methods: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer. The combinations were screened by using a well-diffusion assay with cloxacillin as a control. Pseudomonas spp. was tested with our novel antimicrobial compound. The zones of inhibition in agar culture were measured for each individual component and for the compound, and the results were compared with those of the control group which had been treated with cloxacillin. Data were expressed as means ${\pm}$ standard deviations. Quantitative analyses were performed using the paired t-test. Results: The antibiotic effect of the Phenol-rich compound sweet gel was statistically shown to be more significant than that of cloxacillin against Pseudomonas aeruginosa (P < 0.05). Conclusion: Our novel approach to fighting the antibiotic resistance of Pseudomonas proved to be successful. The Phenol-rich compound sweet gel was found to be suitable for use as an alternative medicine and bioactive dressing material, for the treatment of patients with various types of wounds, including burns, venous leg ulcers, ulcers of various etiologies, leg ulcers on the feet of diabetic, unhealed graft sampling sites, abscesses, boils, surgical wounds, necrotic process, post-operative and neonatal wound infection, and should be considered as an alternative to the usual methods of cure.