• Archives of Pharmacal Research
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• v.29 no.7
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• pp.598-604
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• 2006

In many conventional drug delivery systems in vogue, failure to deliver efficient drug delivery at the target site/organs; is evident as a result, less efficacious pharmacological response is elicited. Microspheres can be derived a remedial measure which can improve site-specific drug delivery to a considerable extent. As an application, Lung-targeting Ofloxacin-loaded gelatin microspheres (GLOME) were prepared by water in oil emulsion method. The Central Composite Design (CCD) was used to optimize the process of preparation, the appearance and size distribution were examined by scanning electron microscopy, the aspects such as in vitro release characteristics, stability, drug loading, loading efficiency, pharmacokinetics and tissue distribution in albino mice were studied. The experimental results showed that the microspheres in the range of $0.32-22\;{\mu}m$. The drug loading and loading efficiency were 61.05 and 91.55% respectively. The in vitro release profile of the microspheres matched the korsmeyer’s peppas release pattern, and release at 1h was 42%, while for the original drug, ofloxacin under the same conditions 90.02% released in the first half an hour. After i.v. administration (15 min), the drug concentration of microspheres group in lung in albino mice was $1048\;{\mu}g/g$, while that of controlled group was $6.77\;{\mu}g/g$. GLOME found to release the drug to a maximum extent in the target tissue, lungs.

• Structural Engineering and Mechanics
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• v.72 no.3
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• pp.293-304
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• 2019

In this paper, a general model is developed to predict the distribution of interfacial shear and normal stresses of FG beam reinforced by porous FGM plates under mechanical loading. The beam is assumed to be isotropic with a constant Poisson's ratio and power law elastic modulus through the beam thickness. Stress distributions, depending on an inhomogeneity constant, were calculated and presented in graphicals forms. It is shown that both the normal and shear stresses at the interface are influenced by the material and geometry parameters of the composite beam, and it is shown that the inhomogeneities play an important role in the distribution of interfacial stresses. The results presented in the paper can serve as a benchmark for future analyses of functionally graded beams strengthened by imperfect varying properties plates. Numerical comparisons between the existing solutions and the present new solution enable a clear appreciation of the effects of various parameters. The results of this study indicated that the imperfect functionally graded panel strengthening systems are effective in enhancing flexural behavior of the strengthened FGM beams. This research is helpful in understanding the mechanical behaviour of the interface and design of hybrid structures.

• Steel and Composite Structures
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• v.43 no.5
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• pp.661-672
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• 2022

The solution of contact problems is extremely important as we encounter many situations involving such problems in our daily lives. One of the most important parameters effective in solving contact problems is the materials of the parts in contact. While it is relatively easy to solve the contact mechanics of the systems created with traditional materials with a homogeneous microstructure and mechanical distribution, it may be more difficult to solve the contact problem of new generation materials that do not show a homogeneous distribution. As a result of this situation, it is seen that studies on contact problems of materials that do not exhibit such a homogeneous internal structure and mechanical properties are extremely limited in the literature. In this context, in this study, analytical and numerical analyzes of a contact problem created using functionally graded materials were carried out and the results were evaluated mutually. It has been decided that the contact areas and contact pressures acquired from numerical method are reasonably appropriate with the results obtained from the analytical method.

• Steel and Composite Structures
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• v.45 no.5
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• pp.697-713
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• 2022

In the context of the finite elements method, the dynamic behavior of porous functionally graded double wishbone vehicle suspension structural system incorporating joints flexibility constraints under road bump excitation is studied and analyzed. The functionally graded material properties distribution through the thickness direction is simulated by the power law including the porosity effect. To explore the porosity effects, both classical and adopted porosity models are considered based on even porosity distribution pattern. The dynamic equations of motion are derived based on the Hamiltonian principle. Closed forms of the inertia and material stiffness components are derived. Based on the plane frame isoparametric Timoshenko beam element, the dynamic finite elements equations are developed incorporating joint flexibilities constraints. The Newmark's implicit direct integration methodology is utilized to obtain the transient vibration time response under road bump excitation. The presented procedure is validated by comparing the computational model results with the available numerical solutions and an excellent agreement is observed. Obtained results show that the decrease of porosity percentage and material graduation tends to decrease the deflection as well as the resulting stresses of the control arms thus improving the dynamic performance and increasing the service lifetime of the control arms.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.3
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• pp.272-276
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• 2005

This paper deals with the method to calculate the rotor eddy current losses of permanent magnet high-speed machines considering the effects of time/space flux harmonics. The flux harmonics caused by the slot geometry in the stator is calculated from the time variation of the magnetic field distribution obtained by the magneto-static finite element analysis and double Fast Fourier Transform. And, using the analytical approach considering the multiple flux harmonics and the Poynting vector, the rotor losses is evaluated in each rotor composite. Using this method is simple and workable for any kind of stator slot shape for rotor loss analysis.

• Earthquakes and Structures
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• v.19 no.2
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• pp.91-101
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• 2020

This work presents an efficient and original hyperbolic shear deformation theory for the bending and dynamic behavior of functionally graded (FG) beams resting on Winkler - Pasternak foundations. The theory accounts for hyperbolic distribution of the transverse shear strains and satisfies the zero traction boundary conditions on the surfaces of the beam without using shear correction factors. Based on the present theory, the equations of motion are derived from Hamilton's principle. Navier type analytical solutions are obtained for the bending and vibration problems. The accuracy of the present solutions is verified by comparing the obtained results with the existing solutions. It can be concluded that the present theory is not only accurate but also simple in predicting the bending and vibration behavior of functionally graded beams.

• Smart Structures and Systems
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• v.23 no.5
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• pp.429-447
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• 2019

The present study analyzed free vibration of the three-layered micro annular/circular plate which its core and face sheets are made of saturated porous materials and FG-CNTRCs, respectively. The structure is subjected to magneto-electric fields and magneto-electro-mechanical pre loads. Mechanical properties of the porous core and also FG-CNTRC face sheets are varied through the thickness direction. Using dynamic Hamilton's principle, the motion equations based on MCS and FSD theories are derived and solved via GDQ as an efficient numerical method. Effect of different parameters such as pores distributions, porosity coefficient, pores compressibility, CNTs distribution, elastic foundation, multi-physical pre loads, small scale parameter and aspect ratio of the plate are investigated. The findings of this study can be useful for designing smart structures such as sensor and actuator.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.5
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• pp.415-420
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• 2017

Insulation systems in Liquefied Natural Gas Carriers (LNGC) are vulnerable to sloshing impact and fatigue loads because of waves. If gas leaks into the primary barrier, the Flexible Secondary Barrier (FSB) prevents the leakage of gas in this system. Fatigue strength of the FSB largely depends on the behavior of composite materials. In this study, a new system is applied to the FSB using aramid fiber to improve the fatigue strength of the secondary barrier, with the intention of replacing conventional E-glass fibers. The manufacturing method involved varying the ratio of the aramid fiber to the E-glass fiber for optimum design of the FSB. The fatigue tests results of the secondary barrier using aramid fiber were superior to that using E-glass fiber. The statistical analysis is performed to obtain the fatigue test results and estimate the probability of failure as well as the design guideline of LNGC secondary barriers.

• Steel and Composite Structures
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• v.37 no.2
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• pp.175-191
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• 2020

In this article, for the first time, the seismic behavior of elliptic-braced moment resisting frame (ELBRF) is assessed through a laboratory program and numerical analyses of FEM specifically focused on the development of global- and local-type failure mechanisms. The ELBRF as a new lateral braced system, when installed in the middle bay of the frames in the facade of a building, not only causes no problem to the opening space of the facade, but also improves the structural behavior. Quantitative and qualitative investigations were pursued to find out how elliptic braces would affect the failure mechanism of ELBRF structures exposed to seismic action as a nonlinear process. To this aim, an experimental test of a ½ scale single-story single-bay ELBRF specimen under cyclic quasi-static loading was run and the results were compared with those for X-bracing, knee-bracing, K-bracing, and diamond-bracing systems in a story base model. Nonlinear FEM analyses were carried out to evaluate failure mechanism, yield order of components, distribution of plasticity, degradation of structural nonlinear stiffness, distribution of internal forces, and energy dissipation capacity. The test results indicated that the yield of elliptic braces would delay the failure mode of adjacent elliptic columns and thus, help tolerate a significant nonlinear deformation to the point of ultimate failure. Symmetrical behavior, high energy absorption, appropriate stiffness, and high ductility in comparison with the conventional systems are some of the advantages of the proposed system.

• Restorative Dentistry and Endodontics
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• v.32 no.1
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• pp.69-79
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• 2007

The purpose of this study was to investigate the effects of composite resin restorations on the stress distribution of notch shaped noncarious cervical lesion using three-dimensional (3D) finite element analysis (FEA). Extracted maxillary second premolar was scanned serially with Micro-CT (SkyScan1072 ; SkyScan, Aartselaar, Belgium). The 3D images were processed by 3D-DOCTOR (Able Software Co., Lexington, MA, USA). ANSYS (Swanson Analysis Systems, Inc., Houston, USA) was used to mesh and analyze 3D FE model. Notch shaped cavity was filled with hybrid or flowable resin and each restoration was simulated with adhesive layer thickness ($40{\mu}m$) A static load of 500 N was applied on a point load condition at buccal cusp (loading A) and palatal cusp (loading B). The principal stresses in the lesion apex (internal line angle of cavity) and middle vertical wall were analyzed using ANSYS. The results were as follows 1. Under loading A, compressive stress is created in the unrestored and restored cavity. Under loading B, tensile stress is created. And the peak stress concentration is seen at near mesial corner of the cavity under each load condition. 2. Compared to the unrestored cavity, the principal stresses at the cemeto-enamel junction (CEJ) and internal line angle of the cavity were more reduced in the restored cavity on both load con ditions. 3. In teeth restored with hybrid composite, the principal stresses at the CEJ and internal line angle of the cavity were more reduced than flowable resin.