• Journal of Pharmaceutical Investigation
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• 제34권6호
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• pp.443-452
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• 2004

Habit is the description of the outer appearance of a crystal. If the environment of a growing crystal affects its external shape without changing its internal structure, a different habit results. Crystal habit and the internal structure of a drug can affect bulk and physicochemical properties, which range from flowability to chemical stability. A polymorph is a solid crystalline phase of a given compound resulting from the possibility of at least two different arrangements of the molecules of that compound in the solid state. Chemical stability and solubility changes due to polymorphism can have an impact on a drug's bioavailability and its development program. During crystallization from a solution, crystals separating may consist of a pure component or be a molecular compound. Solvates are molecular complexes that have incorporated the crystallizing solvent molecule in their lattice. When the solvent incorporated in the solvate is water, it is called a hydrate. To distinguish solvates from polymorphs, which are not molecular compounds, the term pseudopolymorph is used. Identification of possible hydrate compounds is important since their aqueous solubilities can be significantly less than their anhydrous forms. Conversion of an anhydrous compound to a hydrate within the dosage form may reduce the dissolution rate and extent of drug absorption. An amorphous solid may be treated as a supercooled liquid in which the arrangement of molecules is random. Amorphous solids lack the three-dimensional long-range order found in crystalline solids. Since amorphous forms are usually of higher thermodynamic energy than corresponding crystalline forms, solubilities as well as dissolution rates are generally greater. A study on crystal form includes characterization of (l)crystal habit, (2)polymorphism, (3)pseudopolymorphism, (4)amorphous solid.

• Imaging Science in Dentistry
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• 제51권2호
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• pp.167-174
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• 2021

Purpose: Sex determination can be done by morphological analysis of different parts of the body. The mastoid region, with its anatomical location at the skull base, is ideal for sex identification. Statistical shape analysis provides a simultaneous comparison of geometric information on different shapes in terms of size and shape features. This study aimed to investigate the geometric morphometry of the inter-mastoid triangle as a tool for sex determination in the Iranian population. Materials and Methods: The coordinates of 5 landmarks on the mastoid process on the 80 cone-beam computed tomographic images(from individuals aged 17-70 years, 52.5% female) were registered and digitalized. The Cartesian x-y coordinates were acquired for all landmarks, and the shape information was extracted from the principal component scores of generalized Procrustes fit. The t-test was used to compare centroid size. Cross-validated discriminant analysis was used for sex determination. The significance level for all tests was set at 0.05. Results: There was a significant difference in the mastoid size and shape between males and females(P<0.05). The first 2 components of the Procrustes shape coordinates explained 91.3% of the shape variation between the sexes. The accuracy of the discriminant model for sex determination was 88.8%. Conclusion: The application of morphometric geometric techniques will significantly impact forensic studies by providing a comprehensive analysis of differences in biological forms. The results demonstrated that statistical shape analysis can be used as a powerful tool for sex determination based on a morphometric analysis of the inter-mastoid triangle.

• Animal Bioscience
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• 제35권7호
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• pp.1048-1058
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• 2022

Objective: The present study was to investigate the extraction conditions of dietary fiber from dried cassava pulp (DCP) and cassava distiller's dried grains (CDG) under different NaOH concentrations, and the Fourier transform infrared (FTIR) was used to determine the dietary fiber components. Methods: The dried samples (DCP and CDG) were treated with various concentrations of NaOH at levels of 2%, 4%, 6%, and 8% using a completely randomized design with 4 replications of each. After extraction, the residual DCP and CDG dietary fiber were dried in a hot air oven at 55℃ to 60℃. Finally, the oven dried extracted dietary fiber was powdered to a particle size of 1 mm. Both extracted dietary fibers were analyzed for their chemical composition and determined by FTIR. Results: The DCP and CDG treated with NaOH linearly or quadratically or cubically (p<0.05) increased the total dietary fiber (TDF) and insoluble fiber (IDF). The optimal conditions for extracting dietary fiber from DCP and CDG were under treatment with 6% and 4% NaOH, respectively, as these conditions yielded the highest TDF and IDF contents. These results were associated with the FTIR spectra integration for a semi-quantitative analysis, which obtained the highest cellulose content in dietary fiber extracted from DCP and CDG with 6% and 4% NaOH solution, respectively. The principal component analysis illustrated clear separation of spectral distribution in cassava pulp extracted dietary fiber (DFCP) and cassava distiller's dried grains extracted dietary fiber (DFCDG) when treated with 6% and 4% NaOH, respectively. Conclusion: The optimal conditions for the extraction of dietary fiber from DCP and CDG were treatment with 6% and 4% NaOH solution, respectively. In addition, FTIR spectroscopy proved itself to be a powerful tool for fiber identification.

• Journal of Positioning, Navigation, and Timing
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• 제12권1호
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• pp.23-35
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• 2023

Korea Augmentation Satellite System (KASS) is a satellite-based augmentation system (SBAS) that provides approach procedure with vertical guidance-I (APV-I) level corrections and integrity information to Korea territory. KASS is used to monitor navigation performance in real-time, and this paper introduces the design, implementation, and verification process of mission monitoring (MIMO) in KASS. MIMO was developed in compliance with the Minimum Operational Performance Standards of the Radio Technical Commission for Aeronautics for Global Positioning System (GPS)/SBAS airborne equipment. In this study, the MIMO system was verified by comparing and analyzing the outputs of reference tools. Additionally, the definition and derivation method of accuracy, integrity, continuity, and availability subject to MIMO were examined. The internal and external interfaces and functions were then designed and implemented. The GPS data pre-processing was minimized during the implementation to evaluate the navigation performance experienced by general users. Subsequently, tests and verification methods were used to compare the obtained results based on reference tools. The test was performed using the KASS dataset, which included GPS and SBAS observations. The decoding performance of the developed MIMO was identical to that of the reference tools. Additionally, the navigation performance was verified by confirming the similarity in trends. As MIMO is a component of KASS used for real-time monitoring of the navigation performance of SBAS, the KASS operator can identify whether an abnormality exists in the navigation performance in real-time. Moreover, the preliminary identification of the abnormal point during the post-processing of data can improve operational efficiency.

• Korean Journal of Acupuncture
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• 제39권3호
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• pp.91-96
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• 2022

Objectives : The purpose of this study was to characterize the stimulation intensity in acupuncture manipulation techniques for tonification and sedation therapy. Methods : To describe the level of stimulation used in acupuncture manipulation techniques for tonification and sedation therapy, we reviewed the acupuncture manipulation techniques described in classical medical textbooks. Results : Based on the patients' conditions and pattern identification, acupuncture manipulation strategies for tonification and sedation therapy were chosen. For example, the excess condition was treated with sedative therapy, and the deficiency condition was treated with tonification therapy. For tonification therapy, weak to modest stimulation was applied in acupuncture manipulation techniques, whereas intense stimulation was applied for sedative therapy. Even though the intensity of acupuncture stimulation was chosen based on the clinical examination, deqi sensation is a crucial component of acupuncture treatment, and during acupuncture practice, the practitioner should choose the right intensity of acupuncture stimulation based on deqi response in each patient. Conclusions : We concluded that the tonifying and sedative effects of acupuncture treatment are related to the stimulation intensity of acupuncture manipulation techniques. For individualized medicine, the right amount of acupuncture stimulation should be administered based on the patients' conditions and responses, such as deqi responses.

• The Plant Pathology Journal
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• 제38권1호
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• pp.1-11
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• 2022

Fusarium culmorum is one of the most important causal agents of root rot of wheat. In this study, 10 F. culmorum isolates were collected from farms located in five agro-ecological regions of Morocco. These were used to challenge 20 durum wheat genotypes via artificial inoculation of plant roots under controlled conditions. The isolate virulence was determined by three traits (roots browning index, stem browning index, and severity of root rot). An alpha-lattice design with three replicates was used, and the resulting ANOVA revealed a significant (P < 0.01) effect of isolate (I), genotype (G), and G × I interaction. A total of four response types were observed (R, MR, MS, and S) revealing that different genes in both the pathogen and the host were activated in 53% of interactions. Most genotypes were susceptible to eight or more isolates, while the Moroccan cultivar Marouan was reported resistant to three isolates and moderately resistant to three others. Similarly, the Australian breeding line SSD1479-117 was reported resistant to two isolates and moderately resistant to four others. The ICARDA elites Icaverve, Berghisyr, Berghisyr2, Amina, and Icaverve2 were identified as moderately resistant. Principal component analysis based on the genotypes responses defined two major clusters and two sub-clusters for the 10 F. culmorum isolates. Isolate Fc9 collected in Khemis Zemamra was the most virulent while isolate Fc3 collected in Haj-Kaddour was the least virulent. This work provides initial results for the discovery of differential reactions between the durum lines and isolates and the identification of novel sources of resistance.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.369-375
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• 2004

Gas turbine engine simulation in terms of transient, steady state performance and operational characteristics is complex work at the various engineering functions of aero engine manufacturers. Especially, efficiency of control system design and development in terms of cost, development period and technical relevance implies controlling diverse simulation and identification activities. The previous engine simulation has been accomplished within a limited analysis area such as fan, compressor, combustor, turbine, controller, etc. and this has resulted in improper engine performance and control characteristics because of limited interaction between analysis areas. In this paper, we propose a new simulation methodology for gas turbine engine performance analysis as well as its digital controller to solve difficulties as mentioned above. The novel method has particularities of (ⅰ) resulting in the integrated control simulation using almost every component/module analysis, (ⅱ) providing automated math model generation process of engine itself, various engine subsystems and control compensators/regulators, (ⅲ) presenting total sophisticated output results and easy understandable graphic display for a final user. We call this simulation system GT3GS (Gas Turbine 3D Graphic Simulator). GT3GS was built on both software and hardware technology for total simulation capable of high calculation flexibility as well as interface with real engine controller. All components in the simulator were implemented using COTS (Commercial Off the Shelf) modules. In addition, described here includes GT3GS main features and future works for better gas turbine engine simulation.

• 한국자원식물학회지
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• 제35권6호
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• pp.785-795
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• 2022

Traditional germplasms are unsuitable for mechanized production, limiting adzuki bean production. The creation of cultivars that can be harvested by mechanized means is an urgent task for breeders. The bottom pod height (BPH), lodging resistance, and synchronous maturing of adzuki beans are critical factors for the reduction of losses due to mechanized harvesting. In this study, 14 traits of 806 adzuki bean accessions were analyzed. All growth stages and the yield, lodging score, and synchronous maturing correlated negatively with the BPH. These negative correlations reflect the increased difficulty of breeding to simultaneously satisfy the needs for no lodging, high synchronous maturing rates, BPHs > 10 cm, and high yield. We screened three germplasms with no lodging, high synchronous maturing rates, and BPHs > 10 cm that were used as mechanization-adapted breeding material for crossing with high-yield cultivars. Agronomic trait diversity in adzuki beans was also examined in this study. Principal component and cluster analyses were conducted for 806 germplasms resulting in three clusters with the yield and three growth stage traits serving as the main discriminating factors. Cluster 1 included high-yield germplasms with the number of pods per plant and the number of seeds per pod being the major discriminant factors. Cluster 2 included germplasms with long growth periods and large 100-seed weights while cluster 3 contained germplasms with high BPHs. In general, the characteristics that make mechanical harvesting feasible and those assessed in this study could be utilized to choose and enhance adzuki beans production.

• 한국컴퓨터정보학회논문지
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• 제14권7호
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• pp.25-32
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• 2009

논문에서는 오프라인 환경에서 패턴분석을 적용하여 두필적의 유사성을 자동으로 분석하여 필적을 검증하는 방법을 제안한다. 제안된 방법에서는 먼저 필적 문서에서 문자 영역만을 분할하고, 분할된 문자 영역에 대한 특징을 추출한다. 그리고 비선형적인 형태로 추출되는 특징으로부터 동적 타임 워핑(DTW)과 다변량 통계 분석법(PCA) 알고리즘을 이용하여 기준이 되는 특징과의 유사성을 구한다. 본 논문에서 제안된 필적 검증 방법은 효과적인 특징 추출 방법 및 기존의 짧은 패턴에서 효과적으로 수행하던 방법들을 다양한 길이를 가진 특징에 대해서도 효과적으로 필적 검증이 가능하도록 하였다. 본 논문은 실험 결과는 제안된 방법인 기존의 방법보다 우수함을 다양한 실험을 통해서 보여준다. 제안된 필적 검증 방법은 기존에 감정 전문가에 의해 수동적으로 수행되던 필적 검증 작업을 자동화하고, 기존 필적 검증 작업의 객관성을 배가할 수 있을 것으로 기대된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.162-162
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• 2022

Stormwater management is an essential component of land-use planning and development. Due to the additional challenges posed by climate change and urbanization, various stormwater management schemes have been developed to limit flood damages and ease water quality concerns. Nature-based solutions (NBS) are increasingly used as cost-effective measures to manage stormwater runoff from various land uses. Specifically, constructed wetlands were already considered as socially acceptable green stormwater infrastructures that are widely used in different countries. There is a large collection of published literature regarding the effectiveness or efficiency of constructed wetlands in treating stormwater runoff; however, metadata analyses using bibliographic information are very limited or seldomly explored. This study was conducted to determine the trends of publication regarding stormwater treatment wetlands using a bibliometric analysis approach. Moreover, the research productivity of various countries, authors, and institutions were also identified in the study. The Web of Science (WoS) database was utilized to retrieve bibliographic information. The keywords ("constructed wetland*" OR "treatment wetland*" OR "engineered wetland*" OR "artificial wetland*") AND ("stormwater*" or "storm water*") were used to retrieve pertinent information on stormwater treatment wetlands-related publication from 1990 up to 2021. The network map of keyword co-occurrence map was generated through the VOSviewer software and the contingency matrices were obtained using the Cortext platform (www.cortext.net). The results obtained from this inquiry revealed the areas of research that have been adequately explored by past studies. Furthermore, the extensive collection of published scientific literature enabled the identification of existing knowledge gaps in the field of stormwater treatment wetlands.