• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.4
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• pp.442-450
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• 2009

Piperine is an alkaloid-amine found in pepper and has been reported to have anticarcinogenic properties. To explore the possibility that piperine has cancer chemopreventive and chemotherapeutic effects in colon cancer, we examined whether piperine inhibits the growth of HT-29 human colon cancer cells and investigated the mechanisms for this effect. Cells were cultured with various concentrations ($0{\sim}40{\mu}M$) of piperine. Piperine decreased the cell viability and induced apoptosis of HT-29 cells. Western blot analysis of total cell lysates revealed that piperine decreases the protein levels of Bcl-2, Mcl-1, and intact Bid but increases Bik levels. Piperine increased the percentage of cells with depolarized mitochondrial membrane, and the release of cytochrome c into cytoplasm. Piperine induced the cleavage of poly (ADP-ribose) polymerase and caspases 8, 9, 7, and 3 and increased the Fas levels. In addition, piperine significantly decreased the protein levels of survivin. The present results indicate that piperine inhibits the growth of HT-29 colon cancer cells by the induction of apoptosis, which may be mediated by its ability to change the Bcl-2 family proteins, increase the activation of caspases, and decrease survivin levels. Overall, our findings suggest that piperine has cancer chemotherapeutic effects in colon cancer.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.41 no.4
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• pp.293-301
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• 2017

A Sub-kWe small-scale experimental test loop was manufactured to investigate characteristics of the supercritical carbon dioxide power cycle. A high-speed turbo-generator was also designed and manufactured. The designed rotational speed of this turbo-generator was 200,000 rpm. Because of the low expansion ratio through the turbine and low mass flowrate, the rotational speed of the turbo-generator was high. Therefore, it was difficult to select the rotating parts and design the turbine wheel, axial force balance and rotor dynamics in the lab-scale experimental test loop. Using only one channel of the nozzle, the partial admission method was adapted to reduce the rotational speed of the rotor. This was the world's first approach to the supercritical carbon dioxide turbo-generator. A cold-run test using nitrogen gas under an atmospheric condition was conducted to observe the effect of the partial admission nozzle on the rotor dynamics. The vibration level of the rotor was obtained using a gap sensor, and the results showed that the effect of the partial admission nozzle on the rotor dynamics was allowable.

• Journal of the Microelectronics and Packaging Society
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• v.16 no.1
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• pp.13-19
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• 2009

A 440MHz wireless and passive surface acoustic wave (SAW) based chemical sensor was developed on a $41^{\circ}YX\;LiNbO_3$ piezoelectric substrate for simultaneous measurement of $CO_2$ gas and relative humidity (RH) using a reflective delay line pattern as the sensor element. The reflective delay line is composed of an interdigital transducer (IDT) and several shorted grating reflectors. A Teflon AF 2400 and a hydrophilic $SiO_2$ layer were used as $CO_2$ and water vapor sensitive films. The coupling of mode (COM) modeling was conducted to determine optimal device parameters prior to fabrication. According to simulation results, the device was fabricated and then wirelessly measured using the network analyzer. The measured reflective coefficient $S_{11}$ in the time domain showed high signal/noise (S/N) ratio, small signal attenuation, and few spurious peaks. In the $CO_2$ and humidity testing, high sensitivity ($2^{\circ}/ppm$ for $CO_2$ detection and $7.45^{\circ}/%$RH for humidity sensing), good linearity and repeatability were observed in the $CO_2$ concentration ranges of $75{\sim}375ppm$ and humidity levels of $20{\sim}80%$RH. Temperature and humidity compensations were also investigated during the sensitivity evaluation process.

• Journal of Intelligence and Information Systems
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• v.16 no.2
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• pp.33-54
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• 2010

The World Wide Web is transitioning from being a mere collection of documents that contain useful information toward providing a collection of services that perform useful tasks. The emerging Web service technology has been envisioned as the next technological wave and is expected to play an important role in this recent transformation of the Web. By providing interoperable interface standards for application-to-application communication, Web services can be combined with component based software development to promote application interaction both within and across enterprises. To make Web services for service-oriented computing operational, it is important that Web service repositories not only be well-structured but also provide efficient tools for developers to find reusable Web service components that meet their needs. As the potential of Web services for service-oriented computing is being widely recognized, the demand for effective Web service discovery mechanisms is concomitantly growing. A number of public Web service repositories have been proposed, but the Web service taxonomy generation has not been satisfactorily addressed. Unfortunately, most existing Web service taxonomies are either too rudimentary to be useful or too hard to be maintained. In this paper, we propose a Web service taxonomy generation framework that combines an artificial neural network based clustering techniques with descriptive label generating and leverages the semantics of the XML-based service specification in WSDL documents. We believe that this is one of the first attempts at applying data mining techniques in the Web service discovery domain. We have developed a prototype system based on the proposed framework using an unsupervised artificial neural network and empirically evaluated the proposed approach and tool using real Web service descriptions drawn from operational Web service repositories. We report on some preliminary results demonstrating the efficacy of the proposed approach.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.171-174
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• 2005

According as marine leisure industry has developed and the demand of leisure culture has increased rapidly, a desire about service which supply marine safety and connect marine information is enlarging. The performance of personal mobile device has improved and been evolved by composition terminal. So, it became possible that storage and expression of multimedia information as well as simple communication facility. Domestic wireless internet has given development strain to developer and contents Provider(CP) because of different platform. And this has become hindrance factor of wireless internet activation. But, recently, the use of WIPI(Wireless Internet Platform for Interoperability), the wireless internet standard platform, could use different wireless application programs and also guarantee the independency for hardware. We wish to develop contents of download form that supply geographic information of Electronic Navigational Chart(ENC) in the marine that is digitalized to carrying along terminal of WIPI base and various informations for marine leisure. For this, DB that offer ENC and additional information should be constructed. Also, we need server (CPS; Contents provider Server) that offer required contents. In this paper, we design web retrieval agent which store request information to database. When consumer required necessary information through personal mobile device, CPS can inform that by real time. So, we wish to develop agent component that parse informations in various World Wide Webs, and store to database.

• The Korean Journal of Physiology
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• v.22 no.1
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• pp.13-29
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• 1988

In order to elucidate the regulatory mechanism of intracellular calcium ion concentrations, contractions or contractures induced by $Na^{+}-removal$, calcium-application or ouabain-treatment as an index of $Na^+/Ca^{2+}$ exchange activity were studied in atrial muscle or vascular smooth muscle (aorta and renal artery) of the rabbit. The magnitude of low sodium contractures in atrial trabeculae increased with sigmoid shape when external sodium concentrations were reduced to sodium-free condition, whereas that of calcium contracture intensified in a parabolic pattern when external calcium concentrations were elevated to 8 mM. $Na^{+}-removal$ contractures were induced in a duration-dependent manner to $K^{+}-free$ exposure and same findings were observed with ouabain treatment. $Na^{+}-free$ contractures were not affected by verapamil treatment, but stimulated by $100{\mu}M\;Mn^{2+}$ and inhibited by high concentrations of $Mn^{2+}\;(2{\sim}8mM)$ in a dose-dependent manner. Ryanodine which is known to suppress the release of calcium from internal store abolished spontaneous twitch contractions induced by $K^{+}-free$ solution, but had no effect on the development $Na^{+}-free$ contractures. Na-free contractures were not always induced in vascular smooth muscle preparations. Contractures by $O\;mM\;Na^+$ were usually seen in aorta, but not often in renal artery.$50\;mM\;K^+$, noradrenaline (NA) and angiotensin II (AII) always evoked very large contraction in all preparations of vascular smooth muscle. Contractures developed by $O\;mM\;Na^+$ were not sensitive to verapamil treatment as in atrial trabeculae, but were abolished by $100{\mu}M\;Mn^{2+}$. In contrast to $Na^{+}-free$ contractures, $Mn^{2+}(100{\mu}M)$ had no effect on the contractures induced by NA or 50 mM$K^+$. Caffeine in the concentration of 10 mM evoked transient contracture in the distal renal artery. The rate of spontaneous relaxation in caffeine contracture was dependent upon the concentrations of external sodium, and had double component of relaxation when the rate of relaxation was plotted in the semilogarithmic scale of relative tension versus time. Especially late components of relaxation had more direct relation to $Na^+$ concentrations. It could be concluded that $Na^+/Ca^{2+}$ exchange mechanism in the heart has a large capacity, inhibited by $Mn^{2+}$ but not by verapamil and ryanodine, while $Na^+/Ca^{2+}$ exchange system in vascular smooth muscle has a very low capacity especially in small artery, inhibited by low concentration of $Mn^{2+}\;(100{\mu}M)$ but not affected by verapamil and ryanodine.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.11 no.1
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• pp.56-67
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• 1999

It is desired to use a domestically manufactured ocean data buoy for the long-term operational ocean monitoring. The ocean data buoy manufacturing technology was introduced through the research cooperation with the Qingkong University of Taiwan. The introduced ocean data buoy system was further expanded and improved for more efficient application for the marine environmental monitoring in Korea. The size of the ocean data buoy is 2.5 m in diameter, which is smaller compared to the NOAA's 3.0 m discus buoy to allow easy land transportation and ocean deployment as well. From the dynamic response test of the buoy carried out numerically, it was shown that the measurement of waves with period greater than 4 seconds is acceptable. The measurement and control system of the data buoy were improved to increase the number of measuring parameters, to reduce power consumption and to enhance better data analysis and management. Each component of the improved data buoy system was described in detail in this paper. Water quality sensors of water temperature, salinity, DO, pH and turbidity were added to the system in addition to the marine meteorological sensors of wind speed and direction, air temperature, humidity, air pressure and wave. Inmarsat satellite communication system is used for the real-time data telemetry from the buoy deployed offshore. A field performance test of the improved and domestically manufactured buoy was carried out for a month at the open sea off Pohang together with DatawelI's Wave-rider buoy to compare the wave data. The results of the test were satisfactory.

• Korean Journal of Environmental Biology
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• v.31 no.4
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• pp.243-274
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• 2013

To investigate the research state and characteristics of dinoflagellate cyst along the Korean coastal waters, this work analyzed 45 studies conducted in the Korean coasts and basin, the south of Jeju, East China Sea including some part of the Yellow Sea. It was found that the research on dinoflagellate cyst began in the later half of the 1980s in Korea, and that the research areas focused on eutrophied regions where a red tide occurred or on the seas where coastal development occurred. In other words, no research on the East Sea was found. In terms of research contents, there were various studies on analysis of cyst assemblage, tracking of the changes in marine environment like process of eutrophication, roles as a seed population in occurrence of a red tide, creation of cyst by use of sediment trip and tracking of its changes, morphological changes by the change of pH concentration in the hypoxia zone of eutrophied region, germination of a specific species, and other international-level studies. Species composition and cell density also varied in the Korean coastal waters. However, much research on dinoflagellate cyst in Korea is not systematic, and is fragmentary and individual and hencesuffers from great limitations. The research results so far have focused only on specific regions, and sporadic research had been conducted by specific research groups. Dinoflagellate cyst of surface sediments represents the accumulation index of pelagic environment in the sea and is a useful index to understand the marine environment efficiently. In conclusion, Korea requires organized human resources and collaborative research on dinoflagellate cyst which in turn should be considered as a component of marine ecosystem and as an essential aspect of marine biology.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2016.05a
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• pp.404-430
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• 2016

This study started from the awareness of the issue if the citation index newly introduced to evaluate the quality of papers satisfies the proper timing matter, which is a component of performance indicators for the evaluation of government-funded R&D institutes. Accordingly, the study will propose improvement ways to shift the previous evaluation system to quality evaluation for mission-oriented R&D institutes by analysing and using the periodical characteristics such as citation half-life and immediacy index of papers. As a result, it turned out that the speed of academic change is getting faster in proportion to the dependency on the technological development but that the citation speed in the field of public technology is relatively slower and the speed of knowledge transfer in the fields related to industry is faster. In addition, the citation index among the R&D fields showed no differences, and the minimum period for citation index measurement with validity should be over 6 years. The problems of evaluation for mission-oriented R&D institutes were deducted based on the technical and statistical analysis results of the temporal characteristic of citation necessary for quality evaluation of performance among R&D fields. To solve the problems, policy alternatives for object and valid quality evaluation were proposed from the points of evaluation period, evaluation criteria, and evaluation management.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.2
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• pp.261-270
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• 2018

In this study, to replace the 'J-slot joint', a joint device between a disposal canister and an emplacement jig in Deep Borehole Disposal process, a novel joint device was designed and tested. The novel joint device was composed of a wedge on top of a disposal canister and a hook box at the end of a winch system. The designed joint device had merits in that it can recombine an emplaced canister freely without the replacement of the joint component. Moreover, it can be applied to various emplacement jigs such as drill pipes, wire-lines, and coiled tubing. To demonstrate the designed joint device, the joint device (${\Phi}110mm$, H 148 mm), a twin canister string (${\Phi}140mm$, H 1,105 mm), and a water tube (${\Phi}150mm$, H 1,500 mm) as a borehole model were manufactured at 1/3 scale. As deployment muds, Na-type bentonite (MX-80) and Ca-type (GJ II) bentonite muds were prepared at solid contents of 7wt% and 28wt%, respectively. The manufactured joint device showed good performance in pure water and viscous muds, with an operation speed of $10m{\cdot}min^{-1}$. It was concluded that the newly developed joint device can be used for the emplacement and retrieval of a deep disposal canister, below 3~5 km, in the future.