• Journal of Pharmaceutical Investigation
• /
• 제14권1호
• /
• pp.19-30
• /
• 1984

The pharmaceutical characteristics of solid indoprofen inclusion complex such as dissolution, permeation through a cellophane membrane, model analysis of interfacial tranesfer, absorption behaviors in rat intestine, and the plasma concentration of indoprofen after oral administrations to rabbits were examined in comparison with those indoprofen alone. The inclusion complex obtained by freeze-drying method showed the higher dissolution rate and membrane permeability among the test powders, and increased significantly the amont of indoprofen absorbed in rat intestine and the levels of plasma concentration of indoprofen after oral adminstrations to rabbits. The increase of bioavailability of $indoprofen-{\beta}-cyclodextrin$ complex was considered due to the increased solubility and dissolution rate of solid powder form.

• Journal of electromagnetic engineering and science
• /
• 제12권1호
• /
• pp.20-25
• /
• 2012

In this paper, the EM wave absorber for ETC system was designed and fabricated. We fabricated several samples in different composition ratios of flaked sendust and CPE(Chlorinated Polyethylene). Absorption abilities were simulated in accordance with different thicknesses of the prepared absorbers and changed complex relative permittivity and permeability according to composition ratio. The optimized mixing ratio of flaked sendust and CPE was found as 60 : 40 wt.% by experiments and simulation. Then the EM wave absorber was fabricated and tested using the simulated data. As a result, the developed EM wave absorber has the thickness of 2.75 mm and absorption ability was 22.5 dB in the case of normal incidence at 5.8 GHz. Therefore, it was confirmed that the newly developed absorber can be used for ETC system.

• 한국세라믹학회지
• /
• 제29권3호
• /
• pp.177-182
• /
• 1992

The effect of heat-treatment temperature on the microwave absorbing properties was investigated in Ni0.8Zn0.2Fe2O4 specimens. The composite specimens were prepared by modling and curing the mixture of prereacted ferrite powder and silicone rubber. The measurement of complex permeability and permittivity was made by the reflection/transmission method. The most sensitive material constants with heat-treatment temperature is the imaginary (loss) component of permeability. The higher the heat-treatment temperature, the greater the magnetic loss. The composite specimens with high magnetic loss exhibited superior microwave absorbing properties. The quantitative estimation of microwave absorbing properties were made by plotting the observed material constants on the calculated solution map of impedance-matching.

• BMB Reports
• /
• 제49권5호
• /
• pp.255-262
• /
• 2016

The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified 'loss of function' mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research.

• Journal of information and communication convergence engineering
• /
• 제4권3호
• /
• pp.114-117
• /
• 2006

In this paper, we fabricated the EM wave absorber for 94 GHz radar sensors using Permalloy of magnetic material with chlorinated polyethylene (CPE), and S-parameter was measured. The complex relative permittivity and permeability are calculated by the measured data. Absorption abilities are simulated according to different thickness of the EM wave absorbers, and the EM wave absorber was manufactured based on the simulated design. Simulated and measured results agree very well. As a result, we developed the EM wave absorber with the thickness of 1.15 mm which has an absorption ability of 18 dB at 94 GHz.

• 한국항해항만학회지
• /
• 제31권8호
• /
• pp.671-674
• /
• 2007

본 논문에서는 ETC 시스템에서 다중반사로 인한 오신호 또는 시스템간의 간섭을 방지하기 위하여 사용될 전파흡수체를 설계 및 제작하였다. 자성손실 재료인 MnZn-ferrite, 도전손실 재료인 Carbon과 지지재인 CPE를 사용하여 조성비별로 전파흡수체 샘플을 제작하고, 측정된 샘플의 데이터로부터 최적의 조성비가 MnZn-ferrite : Carbon : CPE = 40 : 15 : 45 wt% 임이 확인되었다. 확인된 샘플로부터 재료정수 복소비유전율과 복소비투자율을 계산하여 시뮬레이션 하였으며, 이 결과를 토대로 전파흡수체를 실제 제작하여 전파흡수능을 분석한 결과 시뮬레이션과 실제측정 값이 거의 일치하는 것을 볼 수 있었다. 결과적으로 전파흡수체의 조성비 MnZn-ferrite : Carbon : CPE = 40 : 15 : 45 wt% 로 두께 3.38 mm, 주파수 5.8 GHz대에서 전파흡수능 20 dB 이상의 전파흡수체를 개발하였다.

• Geomechanics and Engineering
• /
• 제29권2호
• /
• pp.145-154
• /
• 2022

Complex geological conditions have a great influence on the mining of coalbed methane (CBM), which affects the extraction efficiency of CBM. This investigation analyzed the complicated geological conditions in the Liujia CBM block of Fuxin. A geological model of heterogeneities CBM reservoirs was established to study the influence of strike direction of igneous rocks and fault structures on horizontal well layout. Subsequently, the dual-porosity and dual-permeability mathematical model was established, which considers the dynamic changes of porosity and permeability caused by gas adsorption, desorption, pressure change. The results show that the production curve is in good agreement with the actual by considering gas seepage in matrix pores in the model. Complicated geological structures affect the pressure expansion of horizontal wells, especially, the closer to the fault structure, the more significant the effect, the slower the pressure drop, and the smaller the desorption area. When the wellbore extends to the fault, the pressure expansion is blocked by the fault and the productivity is reduced. In the study area, the optimal distance to the fault is 70 m. When the horizontal wellbore is perpendicular to the direction of coal seam igneous rock, the productivity is higher than that of parallel igneous rock, and the horizontal well bore should be perpendicular to the cleat direction. However, the well length is limited due to the dense distribution of igneous rocks in the Liujia CBM block. Therefore, the horizontal well pumping in the study area should be arranged along the direction of igneous rock and parallel plane cleats. It is found that the larger the area surrounded by igneous rock, the more favorable the productivity. In summary, the reasonable layout of horizontal wells should make full use of the advantages of igneous rock, faults and other complex geological conditions to achieve the goal of high and stable production.

• Journal of Korean Neurosurgical Society
• /
• 제40권2호
• /
• pp.103-109
• /
• 2006

Objective : Activated endothelial cells mediate the cascade of reactions in response to hypoxia for adaptation to the stress. It has been suggested that hypoxia, by itself, without reperfusion, can activate the endothelial cells and initiate complex responses. In this study, we investigated whether hypoxia-induced endothelial products alter the endothelial permeability and have a direct cytotoxic effect on nerve cells. Methods : Hypoxic condition of primary human umbilical vein endothelial cells[HUVEC] was induced by $CoCl_2$ treatment in culture medium. Cell growth was evaluated by 3,4,5-dimethyl thiazole-3,5-diphenyl tetrazolium bromide [MTT] assay Hypoxia-induced products [$IL-1{\beta},\;TGF-{\beta}1,\;IFN-{\gamma},\;TNF-{\alpha}$, IL-10, IL-6, IL-8, MCP-l and VEGF] were assessed by enzyme-linked immunosorbent assay. Endothelial permeability was evaluated by Western blotting. Results : Prolonged hypoxia caused endothelial cells to secrete IL -6, IL -8, MCP-1 and VEGF. However, the levels of IL -1, IL -10, $TNF-{\alpha},\;TGF-{\beta},\;IFN-{\gamma}$ and nitric oxide remained unchanged over 48 h hypoxia. Hypoxic exposure to endothelial cells induced the time-dependent down regulation of the expression of cadherin and catenin protein. The conditioned medium taken from hypoxic HUVECs had the cytotoxic effect selectively on neuroblastoma cells, but not on astroglioma cells. Conclusion : These results suggest the possibility that endothelial cell derived cytokines or other secreted products with the increased endothelial permeability might directly contribute to nerve cell injury followed by hypoxia.

• 한국재료학회지
• /
• 제10권6호
• /
• pp.430-436
• /
• 2000

본 연구에서는 hexagonal-ferrite에서 NiO, CuO의 몰비와 B-Bi-Zn 첨가제에 따른 미세구조, 밀도 흡수율, 수축율, 주파수에 따른 투자율 등의 특성을 관찰하여 수 GHz대역의 고주파 침 인덕터용 재료로서의 가능성을 확인하고자 하였다. 투자율의 측정은 impedance analyzer 와 network analyzer를 이용하여 100kHz∼3GHz 대역까지 실시하였다. 특성의변화를 살펴본 결과 사용된 B-Bi-Zn 유리분말은 전극돠의 동시소결이 가능하게 보였으며, 복수투자율의 결과에 의하며, 1.8GHz까지는 그 값이 변화를 보이지 않고 일정하였고, 복소투자율의 허수값이 최고값에서 나타나는 공진주파수는 2 GHz 부근에서 관찰되었다.

• 대한전자공학회논문지TC
• /
• 제45권8호
• /
• pp.60-68
• /
• 2008

구형 도파관 기법을 이용하여 다양한 모양을 가진 주기적인 metamaterial (MTM) 셀의 복소 유전율과 투자율을 시뮬레이션으로 추출하였다. 이 도파관은 PEC 벽과 PMC 벽으로 구성된 가상적인 것이고, 고려된 MTM 셀의 모양은 thin wire (TW), single split-ring resonator (SSRR), double SRR (DSRR), modified SRR, 그리고 TW와 DSRR이 결합된 구조이다. TW는 음의 유전율/양의 투자율, SRR은 양의 유전율/음의 투자율, 그리고 TW와 DSRR을 합친 구조는 유전율과 투자율이 동시에 음이 되는 영역이 나타남을 확인하였다. 각 셀의 파라미터에 따른 유전율과 투자율의 변화를 살펴보았다. 추가적인 연구로서 상기 도파관 기법의 단점을 보완하는 시 영역 신호를 이용한 추출 방법을 소개했다.