• The Journal of the Korean Society for Microbiology
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• v.35 no.1
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• pp.9-18
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• 2000

Immunological mechanisms involving the release of inflammatory factors by HIV-1 infected microglia in the brain have been implicated in the pathogenesis of HIV dementia (HIVD). Since the regulation of matrix metalloproteinases (MMPs) activity can be influenced by variety of inflammatory mediators, this study was undertaken to look for a correlation between the MMP-9 release and the production of TNF-${\alpha}$ in response to HIV-1 p24 in the human monocyte cell line THP-1 as a model for microglia. First, it was shown that HIV-l core p24 antigen induced THP-1 to secrete MMP-9 in a dose response manner while it elicited a little effect on MMP-2 release in human astroglial cell line T98G. Next, it was found that p24 induced THP-1 to secrete TNF-${\alpha}$ without prior differentiation into macrophages by phorbol myristate acetate (PMA) treatment. Furthermore, anti-TNF-${\alpha}$ neutralizing antibodies significantly blocked p24-induced MMP-9 release in a dose dependent manner. Our data indicate that p24 antigen induces monocytic MMP-9 release by triggering up-regulation of TNF-${\alpha}$ secretion.

• Journal of Korean Society of Transportation
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• v.35 no.5
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• pp.409-422
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• 2017

TOD (Transit-Oriented Development) is one of the urban structure concentrated on the multifunctional space/district with public transportation system, which is introduced for maintaining sustainable future cities. With such trends, the project of building complex transferring centers located at a urban railway station has widely been spreaded and a comprehensive and systematic analytical framework is required to clarify and readily understand the complicated procedure of estimation with the large scale of the project. By doing so, this study is to develop a comprehensive analytical framework for estimating a pedestrian OD matrix using a spatial information and an integrated smart card data, which is so called a data depository and it has been applied to the Samseong station for the model validation. The proposed analytical framework contributes on providing a chance to possibly extend with digitalized and automated data collection technologies and a BigData mining methods.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.41 no.2
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• pp.41-50
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• 2004

Since the MPEG-4 visual standard enables content-based functionalities, it is necessary to extract video objects from video sequences. Segmentation algorithms can largely be classified into two different categories: automatic segmentation and user-assisted segmentation. In this paper, we propose a new user-assisted image segmentation method based on the active contour. If we define a shape space as a set of all possible variations from the initial curve and we assume that the shape space is linear, it can be decomposed into the column space and the left null space of the shape matrix. In the proposed method, the shape space vector in the column space describes changes from the initial curve to the imaginary feature curve, and a dynamic graph search algorithm describes the detailed shape of the object in the left null space. Since we employ the shape matrix and the SUSAN operator to outline object boundaries, the proposed algorithm can ignore unwanted feature points generated by low-level image processing operations and is, therefore, applicable to images of complex background. We can also compensate for limitations of the shape matrix with a dynamic graph search algorithm.

• Interaction and multiscale mechanics
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• v.5 no.1
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• pp.27-40
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• 2012

The two-dimensional incompressible flow of a linear viscoelastic fluid we considered in this research has rapidly oscillating initial conditions which contain both the large scale and small scale information. In order to grasp this double-scale phenomenon of the complex flow, a multiscale analysis method is developed based on the mathematical homogenization theory. For the incompressible flow of a linear viscoelastic Maxwell fluid, a well-posed multiscale system, including averaged equations and cell problems, is derived by employing the appropriate multiple scale asymptotic expansions to approximate the velocity, pressure and stress fields. And then, this multiscale system is solved numerically using the pseudospectral algorithm based on a time-splitting semi-implicit influence matrix method. The comparisons between the multiscale solutions and the direct numerical simulations demonstrate that the multiscale model not only captures large scale features accurately, but also reflects kinetic interactions between the large and small scale of the incompressible flow of a linear viscoelastic fluid.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.3
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• pp.653-661
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• 1994

In this paper the CSCM type upwind flux difference splitting Navier-Stokes method has been applied to study the ARL-SL19 supersonic/transonic compressor cascade flow. H-type grid was chosen for its simplicity in applying cyclic tridiagonal matrix algorithm along with conventional slip/no-slip boundary conditions. The thin-layer algebraic model of Baldwin-Lomax was employed for the calculation of turbulent flows. The test case inlet Mach No. was 1.612 and inlet/exit pressure ratio($P_2/P_1$) was 2.15. The results were compared with experimental results from current method were compared well in suction surface with the experiments and other computational results; however, not well in pressure surface. It might be due to the complex flowfields such as shock/boundary layer interaction, turbulence, and flow separation, etc. In the future, a proper turbulence modelling and adaptive grid system will be studied to improve the solution quality.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.200-205
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• 1998

Although discretization methods such as the transfer matrix method (TMM) and the finite element method (FEM) have played an important role in the design or analysis of rotor-bearing systems, continuous system modeling and analysis are often desirable especially for sensitivity analysis or design. The present paper proposes a comprehensive modeling procedure to obtain exact solution of general rotor-bearing systems. The proposed method considers a Timoshenko beam model and makes use of complex coordinate in the formulation. The proposed method provides exact eigensolutions and frequency response functions (FRFS) of general multi-stepped rotor-bearing systems. The first numerical example compares the proposed method with FEM. The numerical study proves that the proposed method is very efficient and useful for the analysis of rotor-bearing systems.

• Water for future
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• v.29 no.6
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• pp.217-224
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• 1996

In this paper, the evaluation of diameter, global velocity, global roughness coefficients of the water distribution pipes are examined by using pressure and flowrate measurements in selected points of the network. The selected pipe network parameters are determined through reformulation of the continuity and energy equation. Additional energy equation is considered to analyze the coefficient matrix. The resulting nonlinear equations are solved by using Newton Raphson method. Three computer models with complex pipe system are used to demonstrate these procedures. The computed results of hydraulic parameters show good agreements with KYPIPE2 flow analysis model.

• Computational Structural Engineering
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• v.9 no.1
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• pp.77-83
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• 1996

The overall stress intensity factor for edge crack located at the interface between fiber and matrix of a unidirectional graphite/epoxy laminate model subjected to a transverse tensile strain have been computed using the boundary element method. Such crack might be generated due to a stress singularity in the vicinity of the free surface. The amplitude of complex stress intensity factor has the constant value at large crack lengths.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.9
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• pp.71-81
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• 2001

This paper analyzes the effectiveness of minimizing vibration and sound transmission on/through a thin rectangular plate by both feedback control and hybrid control which combines adaptive feedforward control with a feedback loop. An experimental system identification technique using the matrix-fractional curve-fitting of the frequency response data is introduced for complex shaped structures. This identification technique reduces the model order o the MIMO(Multi-Input Multi-Output) system which simplifies the practical implementation. The adaptive feedforward control uses a Multiple filtered-x LMS(Least Mean Square) algorithm and the feedback control uses a multivariable digital LQG(Linear Quadratic Gaussian) algorithm. Experimental results show that an effective reduction of sound transmission is achieved by the hybrid control scheme when both vibration and noise measurement signals are incorporated in the controller.

• Korean Journal of Computational Design and Engineering
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• v.4 no.1
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• pp.43-51
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• 1999

Producing the relevant information (features) from the CAD models of CAM, called feature recognition or extraction, is the essential stage for the integration of CAD and CAM. Most feature recognition methods, however, have problems in the recognition of intersecting features because they do not handle the intersection geometry properly. In this paper, we propose a machining feature recognition algorithm, which has a solid model consisting of orthogonal primitives as input. The algorithm calculates candidate features and constitutes the Intersection Geometry Matrix which is necessary to represent the spatial relation of candidate features. Finally, it recognizes machining features from the proposed candidate features dividing and growing systems using half space and Boolean operation. The algorithm has the following characteristics: Though the geometry of part is complex due to the intersections of design primitives, it can recognize the necessary machining features. In addition, it creates the Maximal Feature Volumes independent of the machining sequences at the feature recognition stage so that it can easily accommodate the change of decision criteria of machining orders.