• Title/Summary/Keyword: Complex effect

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Inclusion Complex of Analgesic and antiinflammatory Agents with Cyclodextrins (II) : Effect of $2-Hydroxypropyl-{\beta}-cyclodextrin$ on the Release of Ibuprofen Suppository (시클로덱스트린과 소염진통제간의 포접복합체에 관한 연구 (II) : 2-히드록시프로필-${\beta}$-시클로덱스트린이 이부프로펜 좌제의 방출에 미치는 영향)

  • Oh, In-Joon;Lee, Mi-Young;Lee, Yong-Bok;Shin, Sang-Chul
    • Journal of Pharmaceutical Investigation
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    • v.27 no.3
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    • pp.165-171
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    • 1997
  • Ibuprofen, a nonsteroidal antiinflammatory, analgesic and antipyretic drug, has several limitations in clinical application because of low solubility in water and gastrointestinal irritation. Effect of ibuprofen/$2-Hydroxypropyl-{\beta}-cyclodextrin\;(HP{\beta}CD)$ inclusion compound on release of suppository was investigated. Complex formation was confirmed by $^{1}H-\;and\;^{13}C-NMR$ spectroscopy. The release of ibuprofen from suppository base in vitro was significantly increased by the complexation with $HP{\beta}CD$. The release of ibuprofen from hydrophilic base was faster than that from hydrophobic base. In vivo studies, the release rate of ibuprofen from suppository was accelerated after rectal administration in complex form. This results suggested that ibuprofen/$HP{\beta}CD$ complex can be practically used for suppository to have faster effect of ibuprofen with reduced side effect.

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EFFECT OF 17 $\beta$-ESTRADIOL ON MATING BEHAVIOR AND REPRODUCTIVITY OF MALE MEDAKA (ORYZIAS LATIPES)

  • Jisung Ryu;Lee, Chul-Woo;Park, Eung-Roh;Nam, Seong-Sook;Nam, Kyu-Chan;Rhu, Hong-Il;Jeon, Seong-Hwan;Na, Jin-Gyun;Park, Kwangsik
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.135-135
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    • 2001
  • Mating behavior and reproductivity of male fish were studied as an in vivo screening method of endocrine disruptors. Male medaka (Oryzias latipes) were exposed to 17$\beta$-estradiol at nominal concentrations of 2 and 20 $\mu\textrm{g}$/L for 14 days.(omitted)

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A Case Report on the Effect of Peripheral Body Temperature Increase and Pain Relief in a Patient with Complex Regional Pain Syndrome Type 1 Improved by Buja-tang and Aconitum ciliare Decaisne Pharmacopuncture (부자탕과 초오약침을 병행한 한방복합치료로 호전된 복합부위통증 증후군 제1형 환자의 말초체온 상승 및 통증 경감 효과에 관한 증례 보고)

  • Lee, Jung Min;Lee, Eun-Jung
    • Journal of Korean Medicine Rehabilitation
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    • v.32 no.3
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    • pp.189-196
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    • 2022
  • The aim of this study was to investigate the effect of complex Korean medicine treatment especially Buja-tang and Aconitum ciliare decaisne pharmacopuncture on patients with type 1 complex regional pain syndrome caused after a traffic accident. The patients was treated with Buja-tang, Aconitum ciliare decaisne pharmacupuncture, acupuncture and physical therapy during 20 days of hospitalization. Numerical rating scale (NRS), short form McGill pain questionnaire (SF-MPQ), body temperature measurement of the foot, manual muscle test (MMT) were used for assessment. After treatments, NRS of burning pain in the left ankle decreased from 8 to 4-5 and NRS of burning pain in the right ankle decreased from 7 to 4-5. Also, SF-MPQ results, foot temperature measurement and MMT showed improvement during hospitalization. This study shows that complex Korean medicine treatment especially Buja-tang and Aconitum ciliare decaisne pharmacopuncture are effective in alleviating symptoms in patients with type 1 complex regional pain syndrome.

Studies on the Temperature Effect to Rosin Size in Paper Making (로진 싸이즈에 미치는 溫度의 影響에 關하여)

  • Dong Bum Chi
    • Journal of the Korean Chemical Society
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    • v.7 no.2
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    • pp.133-139
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    • 1963
  • It is well-known that high temperature hurts the sizing effect of rosin size in paper making, mainly owing to the particle size of rosin-aluminium complex in paper stock. In this experiments, author find, when the temperature of stock rises up. the particle size of rosin-aluminium complex of neutral rosin size increases and the degree of sizing decreases finally. However, the behavior of Bewoid size is quite opposite to former. This result showed that, Bewoid size is suitable in hot summer and neutral rosin size in cold winter for better sizing effect.

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Prepartion and Microstructure Changes with Swelling of Polyion Complex membranes Based on the K-Carrageenan

  • Jegal, Jonggeon;Lee, Kew-Ho
    • Proceedings of the Membrane Society of Korea Conference
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    • 1994.04a
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    • pp.61-62
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    • 1994
  • In order to prepare polyion complex membranes useful for the separation of water-alcohol by pervaporation, k-carrageenan containing artionic sulfate groups in the backbone and good hydrophilicity was selected for the polyanion membrane material and poly{1,3-bis[4-butyl pyridinium] propane. bromide}, one of the polycations synthesized in our lab and containing cationic pyridinium groups., was used. The polyion complex membranes were prepared by the ion complex formation between kcarrageenan films and poly{1,3-bis[4-butyl pyridinium] propane. bromide}. On the formation process of polyion complex membranes, the way of potyion complex formation was carefully studied. In order to study the effect of the morphology on the permeation properties of the polyion complex membranes, which is one of the important factors affecting on the permeation properties of membranes but rarely studied, the microstructure behaviors of the polyion complex mem6ranes in methanol-water mixtures with different compositions Were also studied with x-ray diffractometry and polarizing microscopy.

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The Effect of Quinolate Metal Complex as an Electron Injection Layers on the Performance of Organic Light Emitting Devices (유기 전기 발광 소자의 전자 주입층)

  • Choi, Kyung-Hoon;Sohn, Byung-Chung;Kim, Young-Kwan
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.07b
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    • pp.980-983
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    • 2002
  • We investigated the effect of quinolate metal complex layer as an electron injection layer on the performance of OLEDs and optimized the device efficiency by varying from 0.5 to 10nm thickness of Liq layer. OLED with a structure of indium tin oxide/$\alpha$-napthylphenylbiphenyl(NPB,40nm)/tris-(8-hydroxyquinoline)aluminum(Alq3, 50nm)/Aluminum(150nm) were fabricated in sequence. The device with 1nm Quinolate metal complex layer showed significant enhancement of the device performance.

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The Effect of Exercise Program on pain of Patients with Chronic Low Back Pain (운동프로그램이 만성요통 환자의 통증에 미치는 효과)

  • Jang Chel;Lee Geon-Cheol;Chung Hyun-sung
    • The Journal of Korean Physical Therapy
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    • v.16 no.4
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    • pp.80-89
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    • 2004
  • To investigated the effect of the exercise program in patients with chronic low back pain, 40 patients paticipated in this experiment, who were applied for the simple exercise program and the complex exercise program respectively. The interval change of?pain?from pre-test and post-test over 7 weeks and the difference between two experimental groups are the follows : 1) There was statistically significant differences at comparison with pain in simple exercise group during weeks except first week(p<.05). 2) In complex exercise group, there was statistically significant differences at comparison with pain during each week. (p<.05) 3) There was not significant difference between simple exercise group and complex exercise group in pain by exercise period. 4) There was more significant change in complex exercise group than simple exercise group. but there was not statically significant differences between them.

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A Study on Correlation of Odorous Compounds and Odor Substance occurring in Septic Tank and Sewer Pipe (하수관거 및 정화조에서 발생하는 악취물질이 복합악취에 미치는 영향에 관한 연구)

  • Song, Homyeon;Cho, Jeongil
    • Journal of Korean Society of Water and Wastewater
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    • v.27 no.2
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    • pp.165-175
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    • 2013
  • This study aims to analysis correlation in septic tank and sewer pipe between odor substances and complex odor. For the analysis, convert odor substances to odor intensity, and estimate the effect of odor substances on complex odor. As a result, both Hydrogen sulfide and Methyl mercaptane of specified offensive odor substances accounted for 29 percent of the effect of odor substances on complex odor. Hydrogen sulfide and Methyl mercaptane are major cause of odor from septic tank and sewer pipe. The result of this study is suggested to be used as a preliminary data for research on analysis complex odor and odor substances.

Effects of Annealing on the Structural Deformation of Polyelectrolyte Complexes based on Two Anionic Polysaccharides

  • Kim, Sang-Gyun;Lee, Kew-Ho
    • Korean Membrane Journal
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    • v.10 no.1
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    • pp.39-45
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    • 2008
  • Polyelectrolyte complex based on two anionic polysaccharides, composed of sodium alginate and carrageenan, were prepared by interacting with divalent calcium ions in solution. The effects of annealing on the structural deformation of polyelectrolyte complex and on their characteristics at removing water from a methanol mixture from the point of molecular sieve were investigated and discussed. The result showed that the structural deformation of the annealed polyelectrolyte complex has an effect on the free volume between these polymer chains and the chelate segments such a shrinking of the overall morphology, which act as a molecular sieve in the separation of methanol and water mixtures.

Effects of Temperature and UV Irradiation on Stability of Anthocyanin-Polyphenol Copigment Complex in Mulberry Fruits (오디에서 열처리와 자외선 조사가 Anthocyanin-Polyphenol Copigment Complex의 안전성에 미치는 효과)

  • Bang, In-Soo;Yu, Chang-Yeon;Lim, Jung-Dae
    • Korean Journal of Medicinal Crop Science
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    • v.18 no.3
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    • pp.191-200
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    • 2010
  • Anthocyanin and polyphenolic compounds present in fruits of mulberry (Morus alba L.) were determined and the influence of temperature and UV irradiation on stability of the anthocyanin-copigment complex were investigated. The copigmentation substance selected in non-anthocyanin fraction from mulberry for the study included: phenolic acid (hydroxybenzoic acid) and flavonoid (quercetin-3-O-$\beta$-D-glucopyranoside). The copigmentation effect increased with the copigment content. UV irradiation had a stronger degradation effect on the copigmentation complex than heating at $80^{\circ}C$. The non-anthocyanin fraction of mulberry and isolated flavonoid (quercetin-3-O-$\beta$-D-glucopyranoside) from mulberry fruit predominated over other copigment substances.