• 한국자원식물학회지
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• 제35권6호
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• pp.713-719
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• 2022

Platycodon grandiflorum and Glycyrrhiza uralensis contain several bioactive compounds, such as saponin, oleanolic acid, and flavone. P. grandiflorum and G. uralensis have traditionally been used to treat disorders related to blood pressure, diabetes, and counteracting poison, and they have antinociceptive and antiinflammatory properties. However, the validity of complex saponin's vasodilatory effect has not been scientifically investigated. Therefore, this study explores the vasodilatory effect of complex saponin extracted from P. grandiflorum and G. uralensis mixture extract on rabbit carotid arteries. To this end, arterial rings with intact or damaged endothelium were used in an organ bath experiment and contracted by endothelin. Complex saponins, the major active constituents of P. grandiflorum and G. uralensis mixture extract, exhibited a moderate vasodilatory effect on the rabbit's basilar arteries. Therefore, treatment with complex saponin extracted from P. grandiflorum and G. uralensis mixture extract may selectively accelerate cerebral blood flow through basilar arterial dilation. Overall, the findings suggest that the extracted complex saponins can serve as vasodilator sources.

• 대한화장품학회지
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• 제32권2호
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• pp.81-88
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• 2006

피부 각질층내의 아미노산 조성비율과 유사한 조성비로 amino acid complex을 제조하고, 제조된 amino acid complex가 피부에 미치는 영향을 알아보기 위해 세포 생존율, TIMP-1 발현 증가율, 보습 및 각질량 변화를 측정하였다. 연구 결과 amino acid complex는 독성이 없는 안전한 물질로 우수한 보습력 및 보습유지효과와 ascorbic acid와 유사한 TIMP-1 발현량 증가로 주름 예방 및 개선에 효과를 가지고 있으며, 각질량 감소 및 감소유지효과로 자극이 있는 AHA 대체 물질로의 가능성을 보였다. 따라서, amino acid complex는 다기능을 가진 노화방지 화장료 기능성분으로 유용하게 사용될 수 있음을 확인하였다.

• 한국산학기술학회논문지
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• 제8권5호
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• pp.1266-1272
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• 2007

본 연구는 육성돈에 있어 복합생균제 급여가 생산성, 영양소 소화율, 혈액성상 및 분뇨내 악취물질 발생량에 미치는 효과를 규명하고자 실시하였다. 육성돈 48두를 공시하였으며, 시험 개시시 체중은 20.12kg이었다. 시험설계는 1) CON (basal diet), 2) Pro1 (basal diet + 0.1% complex probiotics) and 3) Pro2 (basal diet + 0.2% complex probiotics)으로 총 3처리를 하여 처리당 8반복, 반복당 2두씩 완전임의 배치하였다. 사양시험은 6주간 실시하였다 전체 시험기간동안 일당증체량은 생균제 첨가 수준이 증가함에 따라 유의적으로 증가하였다(P<0.05). 그러나 생균제 급여는 일당사료섭취량 및 사료효율에 영향을 미치지 못하였다. 복합 생균제 급여는 건물 소화율을 증가시켰다(linear effect, P<.0.05). 또한 질소 소화율을 개선시켰으며, Pro 1 처리구가 가장 높게 나타났다(linear and quadratic effect, P<0.05). 생균제 급여는 혈액내 WBC, RBC, lymphocyte 및 BUN함량에 영향을 미치지 못하였다. 생균제 첨가 수준의 증가함에 따라 분뇨내 $NH_3-N$ 발생량은 감소하였으며(linear and quadratic effect, P<0.05), $H_2S$ 발생량은 감소하였다(linear and quadratic effect, P<0.05). 결론적으로 사료내 복합생균제의 첨가 급여는 생산성을 증가시켰으며, 분뇨내 악취물질 발생량을 감소 시켰다.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2006년도 하계학술발표대회 논문집
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• pp.363-368
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• 2006

The purpose of this case study is to analyze stack effect problems and to develop methods minimizing methods of stack effect in the tall complex building in cold climates. The main problems in the tall complex building occur in high-rise elevators. Such problems as elevator doors that do not close and exhaust airflows result in excessive pressure differences across elevator doors due to stack effect. Under the expected conditions causing these pressure differences, computer simulations with CONTAMW computer program and field measurements are performed in the tall complex building. The results are analyzed in architectural design aspects. With these analysis, the tall complex building design guidelines to minimize stack effect are proposed.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4045-4049
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• 2015

Objective: To investigate the effect of coenzyme complex on decreasing cardiotoxicity in elderly patients with gastrointestinal cancer who were treated by chemotherapy. Methods: From September 2011 to February 2015, we recruited 54 elderly (with more than 70 years of age) patients with gastrointestinal cancer, with advanced disease. Then treated with chemotherapy combined with or without coenzyme complex. After two cycles of treatment, the effect of coenzyme complex on decreasing cardiotoxicity were evaluated. Results: Chemotherapy was combined with coenzyme complex in 32 patients (22man, 10 woman; median age: 74 years, range: 70-87 years) without coenzyme complex in 22 patients (15man, 7 woman; median age: 73 years, range: 70-80 years) with gastrointestinal cancer. Cardiac event was significantly lower in patients treated with chemotherapy combined with coenzyme complex (p<0.01). Conclusions: Coenzyme Complex decreased cardiotoxicity when combined with chemotherapy in treating elderly patients with gastrointestinal cancer.

• 동력기계공학회지
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• 제20권5호
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• pp.72-77
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• 2016

The present study investigates noise and condensation characteristics of polyvinyl chloride (PVC), which is widely used for drainage piping materials, complex double structure by comparing to those of PVC single structure piping materials. In addition, effects of insulation on drainage noise has been measured experimentally. As the results of the experiments, noise reduction effect of PVC complex double structure is superior to that of PVC single structure in terms of elbow and vertical piping materials which are employed for drainage pipes of toilet bowls and bathtub. The insulation barely have effect on the noise reduction in case of the PVC single structure since there is almost no changes in noise occurrence even though the insulation is applied on both elbow and vertical piping materials. Temperature differences between inside and outside of the pipes have been measures for the PVC single and complex double structures as well. In consequence, outside temperature of the PVC complex double structure is higher than that of the PVC single structure. The condensation occurrence time of the PVC complex double structure shows a distinct difference from that of the PVC single structure, thus, the PVC complex double structure has outstanding effect on preventing the condensation.

• 대한의생명과학회지
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• 제12권1호
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• pp.49-52
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• 2006

To elucidate the effect of antioxidant complex containing $\beta-carotene$, vitamin E, vitamin C, Ginkgo Biloba leaf extract and selenium on oxygen :tree radical production and detoxification system, rats were fed normal diet and normal diet with antioxidant complex 0.1%, 0.3% and 0.5% for 3 weeks. Feed efficiency ratio, changes in body weight, weight gain and amounts of feces of rat are similar in four groups. Liver weight per body weight and hepatic lipid peroxide weight increased in 0.5% group. However, hepatic glutathione contents in all antioxidant complex added groups were significantly increased compare with normal control group. On the other hand, the activity of xanthine oxidase was a little increased due to the amounts of antioxidant complex. Superoxide dismutase and gutathione peroxidase activity of 0.1% antioxidant complex added group were increased about $10{\sim}20%$ in comparison to normal control group. These results suggest that the supplementation of antioxidant complex 0.1% to basal diet may reduce the hepatic damage caused by free radicals.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.39-39
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• 2023

The purpose of this study is to investigate vasodilatation effect of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract on rabbit carotid artery. In this study, to determine vasodilatation effect of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract on rabbit carotid artery, arterial rings with intact or damaged endothelium were used for experiment using organ bath, and were contracted by endothelin. complex saponin, major active constituents of Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract may selectively accelerate cerebral blood flow through dilatation of the basilar artery. Theseis result suggest a potential role of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract as source of vasodilatation agent.

• 대한의생명과학회지
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• 제7권3호
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• pp.145-149
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• 2001

The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils 1311owing dermal scald burn injury. In order to inhibit the influx of neutrophils, we induced scald burn injury on dorsal skin of rats (TBSA 15%) and spread Rhubarb (R. undulatum L.) and complex (Rhubarb+Olibanum+Myrrha) on scald skin in rats. 1. Levels of dermal KC, the indicator of skin iuflammation, caused by burn gradually increased 5 hours, 24 hours (p<0.001) and 72 hours (p<0.001) after the burn occurred. After 24 hours it occurs, KC in skin was decreased by both skin spread of Rhubarb (p<0.05) and complex (p<0.05) compared to scald bum group. After 72 hours, KC by skin sp.end of Rhubarb and complex was significantly decreased (p<0.01), and the inhibition effect of KC production by complex is higher than by Rhubarb. 2. KC content in serum was increased (p<0.01) at 24 hours after burn injury and comes down back to the normal level after 72 hours. At 24 hours postbunt both Rhubarb (p<0.05) and complex (p<0.01) skin spread decreased KC in serum. The inhibition effect of KC production by complex skin spread group is higher than by Rhubarb skin spread group. The data suggest that the KC production effects by Rhubarb skin spread group and complex skin spread group are high. Especially the endurance of the effect by complex skin spread group was longer than by Rhubarb skin spread group. The inhibition effect of KC production by complex skin spread group increases more than by Rhubarb skin spread group as time passes.

• 대기
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• 제19권4호
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• pp.345-370
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• 2009

Numerical experiments using the Weather Research and Forecasting (WRF) model were done to identify the role of the mountain ranges in the northern part of the Peninsula (referred as "the northern mountain complex"), in the occurrence of two heavy snowfall events over the Yeongdong region on 7-8 December 2002 and 20-21 January 2008. To this end, control simulations with the topography of the northern mountain complex and other simulations without the topography of the mountain complex were performed. It was revealed that the amount of snowfall over the Yeongdong region from the control simulation much more exceeded that of the simulation without the topography of the mountain complex. This increase of the snowfall amount over the Yeongdong region can be explained as follows: As the upstream flow approached the northern mountain complex, it deflected around the northern mountain complex due to the blocking effect of the mountains with a low Froude number less than ~0.16. This lead to the strengthening of northeasterly over the East Sea and over the Yeongdong region. The strong northeasterly is accompanied with much more snowfall over the Yeongdong region by intensifying air-mass modification over the sea and the orographic effect of the Taeback mountains. Thus, it was concluded that the topography of the northern mountain complex is one of the main factors in determining the distribution and amount of precipitation in the Yeongdong region when there is an expansion of the Siberian High toward the East Sea.