• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.289-298
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• 2023

Complex diseases including cardiovascular disease are caused by a combination of the alternation of many genes and the influence of environments. Recently, non-coding RNAs (ncRNAs) have been shown to be involved in diverse diseases, and the functions of various ncRNAs have been reported. Many researchers have elucidated the mechanisms of action of these ncRNAs at the cellular level prior to in vivo and clinical studies of the diseases. Due to the characteristics of complex diseases involving intercellular crosstalk, it is important to study communication between multiple cells. However, there is a lack of literature summarizing and discussing studies of ncRNAs involved in intercellular crosstalk in cardiovascular diseases. Therefore, this review summarizes recent discoveries in the functional mechanisms of intercellular crosstalk involving ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs. In addition, the pathophysiological role of ncRNAs in this communication is extensively discussed in various cardiovascular diseases.

• 한국음향학회지
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• 제23권5호
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• pp.420-427
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• 2004

본 논문에서는 선형예측 잔여신호에 대한 하모닉 벡터 여기 코딩과 시간 대역 분리 혼합 코딩을 결합한 4kbps EHSX (Enhanced Harmonic Stochastic Excitation) 음성부호화기 실시간 구현한 내용을 기술한다. 유성음 구간에서는 하모닉 여기 코딩에 무성음 구간에 대해서는 분석-합성 구조의 벡터 여기 코딩을 사용하였으며, 유/무성음이 혼재하는 전이구간에서는 시간 분리 전이 코딩을 사용하였다. 이 음성부호화기 구현을 위해 부동소수점과 고정소수점을 모두 지원하는 DSP인 TMS320C6701을 사용하였고, 연산량을 줄이기 위해 IFFT를 사용한 저 복잡도 정현파 합성법을 사용하여 알고리즘의 최적화를 이루었으며, 복잡도의 문제가 되는 부분을 고정소수점으로 변환한 후 파이프라인을 적용한 핸드 어셈블리 코딩을 하여 구현에서의 최적화를 이루었다. 또한, 메모리의 효율성을 극대화하기 위해 캐쉬 메모리 할당과 데이터를 내부 메모리에 할당하였고 수학 연산의 최적화를 위해 FastRTS67x 라이브러리를 사용하였다. 개발 환경은 DSP EVM 보드를 사용하였으며 음성 신호의 입·출력 확인으로 동작 및 기능을 검증하여 실시간 구현하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 추계학술대회 논문집 학회본부 B
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• pp.524-526
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• 1999

In the construction of successful fuzzy models and/or controllers for nonlinear systems, the identification of a good fuzzy inference system is an important yet difficult problem, which is traditionally accomplished by a time-consuming trial-and-error process. In this paper, we propose a systematic identification procedure for complex multi-input single-output nonlinear systems with DNA coding method. A DNA coding method is optimization algorithm based on biological DNA as conventional genetic algorithms(GAs) are. The strings in the DNA coding method are variable-length strings, while standard GAs work with a fixed-length coding scheme. the DNA coding method is well suited to learning because it allows a flexible representation of a fuzzy inference system. We also propose a new coding method fur applying the DNA coding method to the identification of fuzzy models. This coding scheme can effectively represent the zero-order Takagi-Sugeno(TS) fuzzy model. To acquire optimal TS fuzzy model with higher accuracy and economical size, we use the DNA coding method to optimize the parameters and the number of fuzzy inference system. In order to demonstrate the superiority and efficiency of the proposed scheme, we finally show its application to a Duffing-forced oscillation system.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 학술대회 논문집 정보 및 제어부문
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• pp.298-300
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• 2004

In the decoding process of interframe wavelet coding, the inverse wavelet transform requires huge computational complexity. However, the decoder may need to be used in various devices such as PDAs, notebooks, PCs or set-top Boxes. Therefore, the decoder's complexity should be adapted to the processor's computational power. A decoder designed in accordance with the processor's computational power would provide optimal services for such devices. So, it is natural that the complexity scalability and the low complexity codec are also listed in the requirements for scalable video coding. In this contribution, we develop a method of controlling and lowering the complexity of the spatial wavelet transform while sustaining almost the same coding efficiency as the conventional spatial wavelet transform. In addition, the proposed method may alleviate the ringing effect for certain video data.

• ETRI Journal
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• 제28권2호
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• pp.145-154
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• 2006

In the decoding process associated with interframe wavelet coding, the inverse wavelet transform requires high computational complexity. However, as video technology starts to pervade all aspects of our lives, decoders are becoming required in various devices such as PDAs, notebooks, PCs, and set-top boxes. Therefore, a decoder's complexity needs to be adapted to the processor's computational power, and consequently a low-complexity codec is also required for scalable video coding. In this paper, we propose a method of controlling and lowering the complexity of the spatial wavelet transform while sustaining the same coding efficiency as that currently afforded. In addition, the proposed method may alleviate the ringing effect for slowly changing image sequences.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 하계학술대회 논문집 D
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• pp.2314-2316
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• 2000

In the construction of successful fuzzy models and/or controllers for nonlinear systems, identification of a good fuzzy Neural inference system is an important yet difficult problem, which is traditionally accomplished by trial and error process. In this paper, we propose a systematic identification procedure for complex multi-input single- output nonlinear systems with DNA coding method.DNA coding method is optimization algorithm based on biological DNA as are conventional genetic algothms (GAs). We also propose a new coding method for applying the DNA coding method to the identification of fuzzy Neural models. To acquire optimal TS fuzzy model with higher accuracy and economical size, we use the DNA coding method to optimize the parameters and the number of fuzzy inference system.

• 한국통신학회논문지
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• 제22권3호
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• pp.469-480
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• 1997

For moving image coding, the variable size of region coding based on local motion is more efficient than fixed size of region coding. It can be applied well to complex motions and is more stable for wide motions because images are segmented according to local motions. In this paper, new image coding method using the segmentation of motion vectors is proposed. First, motion vector field is smoothed by filtering and segmented by smoothed motion vectors. The region growing method is used for decomposition of regions, and merging of regions is decided by motion vector and prediction errors of the region. Edge of regions is excluded because of the correlation of image, and neighbor motion vectors are used evaluation of current block and construction of region. The results of computer simulation show the proposed method is superior than the existing methods in aspect of coding efficiency.

• Journal of Animal Science and Technology
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• 제50권2호
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• pp.177-184
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• 2008

Acid-labile subunit(ALS)는 85-kDa 크기의 당단백질로서 7.5-kDa의 insulin-like growth factor(IGF) 및 40~45-kDa IGF-binding protein-3와 결합하여 150-kDa ternary complex를 형성하는 혈장단백질이다. 선행연구에서 본 연구진은 reverse transcription-polymerase chain reaction(RT-PCR) 방법으로 돼지(porcine) ALS(pALS)의 coding sequence를 합성하여 plasmid vector에 삽입시켜 ‘expression construct’를 제작한 바 있다. 그러나 본 expression construct의 pALS coding sequence에는 PCR error로 추정되는 원인으로 말미암아 2개의 bases에서 mis-sense mutation이 일어난 것이 발견되었다. 본 연구에서는 ‘site-directed mutagenesis’ 방법으로 pALS의 올바른 coding sequence를 합성하여 ‘insert DNA’의 마지막 codon 다음에 ‘His-tag’ sequence가 위치한 pET- 28a(+) plasmid expression vector에 삽입하였다. 본 expression construct는 E. coli BL21(DE3) 세포에서 ‘induction’ 시켰고, 발현된 유전자재조합(recombinant) peptide는 Ni-affinity chromato- graphy로 정제하였다. 이렇게 affinity chro- matography로 정제된 peptide는 SDS-PAGE에서 66kDa 위치에 single band를 나타냄으로써 recombinant pALS의 예상된 질량과 일치하였다. 이상의 결과는 본 연구에서 recombinant pALS peptide가 성공적으로 발현정제되었음을 시사한다.

• 전자공학회논문지T
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• 제35T권3호
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• pp.15-24
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• 1998

본 논문에서는 Barnsley가 제안한 반복 함수 체계(IFS)에 근거한 새로운 영상 압축 기술인 프랙탈 영상 부호화의 성능 개선 방법을 제시한다. 기존의 완전 탐색을 이용한 프랙탈 부호화 방법은 영상의 복원 화질이 다른 프랙탈 기법에 비해 좋은 결과를 얻을 수 있지만 탐색시간이 지나치게 오래 걸리고, 선형 유사 변환을 통하여 블록의 근사화를 수행하므로 복잡한 블록의 근사화가 어렵다는 단점이 있다. 따라서 본 논문에서는 쿼드 트리 분할을 사용하여 코딩 블록의 크기를 가변적으로 설정하도록 하여 복잡한 블록은 크기가 작은 블록으로 단순한 블록은 큰 블록으로 분할되도록 하였다. 이렇게 함으로써 블록의 근사화 정도도 높이고 변환의 수도 줄여 압축률의 개선을 가져왔다. 또한, 탐색 영역을 제한하여 부호화 시간이 짧으면서도 기존의 완전 탐색(full searching) 방법에 비하여 탐색 시간을 줄였으며 복원 영상의 주관적 평가의 화질은 더 우수했다. 그리고 매칭 블록의 탐색이 필요 없는 Monro 방법에 비해 부호화 시간이 다소 느리기는 하지만 화질 면에서 월등한 성능을 보였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.39-42
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• 2005

H.264, a recently proposed international video coding standard, has adopted context-based adaptive variable length coding (CAVLC) as the entropy coding tool in the baseline profile. By combining an adaptive variable length coding technique with context modeling, we can achieve a high degree of redundancy reduction. However, CAVLC in H.264 has weakness that the correct prediction rate of the variable length coding (VLC) table is low in a complex area, such as the boundary of an object. In this paper, we propose a VLC table prediction scheme considering multiple reference blocks; the same position block of the previous frame and the neighboring blocks of the current frame. The proposed algorithm obtains the new weighting values considering correctness of the VLC table for each reference block. Using this method, we can enhance the prediction rate of the VLC table and reduce the bit-rate.