• Journal of Environmental Health Sciences
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• v.33 no.4
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• pp.235-241
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• 2007

The National Institute of Environmental Research(NIER) launched a research about Framework of Environmental Health Information System for Industrial Complex in 2001, with the goal of finding out measures to establish an integrated management system(IMS) for environmental health information. Based on the research results, NIER started to build integrated information system. The process will continue from 2006 to 2008. As the first step, in 2006, NIER outsourced the job of setting up the specific plan. In 2007, based on the plan created in the previous year, computerization work began. During 2008, the $3^{rd}$ year of the process, the integrated system will be compatible to conventional GIS system and statistics analysis system to deliver funker efficient and useful services. In this vein, the objective of the study is to identify data collection procedure, data utilization, and overall goal of the system. In addition, It will illustrate digitalization process and recommendation about how to utilize the system.

• Ocean and Polar Research
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• v.33 no.4
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• pp.497-506
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• 2011

The rapid industrial and technological development has made the human activities for the utilization of marine resources more complex. Marine spatial management is a space-based approach. It is a comprehensive and integrated management approach. The ultimate goal of marine spatial management is the "sustainable use" of marine resources. The partial approach is applied in the existing marine spatial management, mainly coastal zones which involves integrated approach. Also this showed various limitations including restricted mostly to coastal zones, and limitation to implementation tools. However, for marine spatial management to have a reasonable approach that attaches importance to the relationship between humans and the holistic ecosystem, it is important to internalize a central principle in marine spatial management that focuses on the sustainable use of marine resources. In the present study, four central principles are proposed that will eventually be applied through marine spatial management planning tools. These principles are 1) the establishment of a cooperative decision making and planning system that is based on stakeholder participation; 2) scientific assessment of the current status and impact on the basis of ecology, sociology, and economics; 3) reasonable and optimal spatial assignment based on the forecasting of future-use characteristics and environmental changes; and 4) ascribing importance to the implementation of the results of rational planning processes.

• Tunnel and Underground Space
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• v.5 no.4
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• pp.336-346
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• 1995

Geotechnical Information System (GTIS) for efficient management of three dimensional borehole data has been developed. Some problems were raised during the input process of borehole data, and alternative solutions were sought. According to the previous geotechnical reports, there is no unified weathering classification scheme. A criterion, 100 times/30cm from SPT, was turned out inappropriate to the discrimination of weathered rock from weathered soil. It has also been suggested that weathered soil, weathered rock, soft rock, and hard rock should be defined as CW, HW, MW, and SW~fresh condition. For better comparison of RQD, the use of NX size coring is recommended for the whole area although BX size coring has been used in excavated area. The limit of drilling depth up to 1 m from the top of surface of hard rock should be extended to avoid possible wrong interpretation of rock head due to the existence of corestone. The input data were analysed by geostatistical methods. It is found that the range in semivariogram is about 300m, and the variance of gneiss is greater than that of granite. It is because the granite data analysed came from almost single uniform rock mass(i.e.Seoul granite), but gneiss data came from the rock mass(i.e. Gyeonggi gneiss complex experienced several metamorphic metamorphic processes.

• Journal of the Korean Society for information Management
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• v.30 no.2
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• pp.143-167
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• 2013

There are increasing needs for complex information services for user of cultural heritage institution recently. And the concept of "Larchiveum", merging of functions of libraries, archives and museums, is suggested in United States and researches associated with this concept are progressed on Korean information science. At present, however, the larchiveum has not been materialized, and hence researches focus on theoretical frameworks. Therefore, this study establishes plans for an analysis with planning of institutions that libraries, archives and museums are remodeled into larchiveum. Methodologically, the research processes of existing larchiveum spatial planning are specified. More realistic implementing measures for larchiveum spatial planning are suggested through utilization of related law & guidelines as analysis tools.

• Journal of Microbiology and Biotechnology
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• v.13 no.4
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• pp.517-521
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• 2003

Telomerase is a ribonucleoprotein complex whose function is to add telomeric repeats to chromosomal ends. Telomerase consists of two essential components, telomerase RNA template (hTR) and catalytic subunit (hTERT). hTERT is expressed only in cells and tissues positive for telomerase activity, i.e., tumor and fetal cells. In this report, the possibility of utilization of the hTERT promoter in targeted cancer gene therapy was tested. The hTERT promoter was cloned in the replacement of the CMV promoter, and the HSV-TK gene was subcloned to be controlled by the hTERT gene promoter in the adenovirus shuttle plasmid. Then, the recombinant adenovirus Ad-hT-TK was constructed and was infected into normal and human gynecological cancer cell lines. The selective tumor specific cell death by Ad-hT-TK was identified through these experiments, showing that Ad-hT-TK could be used for targeted cancer gene therapy.

• Journal of Biosystems Engineering
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• v.20 no.3
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• pp.250-261
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• 1995

This study has been performed to develop an agricultural waste incinerator to combust the rice hull originated from RPC with the typical disposal treatment capacity of 30kg/h and to test performance of the developed incinerator. Experimental results are summarized as following. 1. The optimum feed rate of rice hull of the incinerator is 30kg/h with air ratio of 1.5. 2. The contents of $SO_2$ in flue gas is maximum 18ppm(when rice hull feed rate was 20kg/h and air ratio of 1.5), minimum 7ppm(when rice hull feed rate was 30kg/h and air ratio of 1.5) and average 11ppm. So there is no environmental pollution problem for the incinerating treatment of rice hull of the RPC. 3. The temperature of water of heat exchanger are $53^{circ} C$ and $62^{circ} C$ with water flow rate $3{ell}/min$ and $1.5{ell}/min$ at the optimum combustion condition, respectively. 4. According to theoretical energy calculation, the energy from rice hull combustion may be amounted as much as 80%~190% of energy supplied by kerosene required by RPC.

• Journal of Microbiology and Biotechnology
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• v.25 no.7
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• pp.963-977
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• 2015

The well-characterized gram-positive bacterium Bacillus subtilis is an outstanding industrial candidate for protein expression owing to its single membrane and high capacity of secretion, simplifying the downstream processing of secretory proteins. During the last few years, there has been continuous progress in the illustration of secretion mechanisms and application of this robust host in various fields of life science, such as enzyme production, feed additives, and food and pharmaceutical industries. Here, we review the developments of Bacillus subtilis as a highly promising expression system illuminating strong chemical- and temperatureinducible and other types of promoters, strategies for ribosome-binding-site utilization, and the novel approach of signal peptide selection. Furthermore, we outline the main steps of the Sec pathway and the relevant elements as well as their interactions. In addition, we introduce the latest discoveries of Tat-related complex structures and functions and the countless applications of this full-folded protein secretion pathway. This review also lists some of the current understandings of ATP-binding cassette transporters. According to the extensive knowledge on the genetic modification strategies and molecular biology of Bacillus subtilis, we propose some suggestions and strategies for improving the yield of intended productions. We expect this to promote striking future developments in the optimization and application of this bacterium.

• Journal of Microbiology and Biotechnology
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• v.28 no.4
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• pp.571-578
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• 2018

Biofuel production using lignocellulosic biomass is gaining attention because it can be substituted for fossil fuels without competing with edible resources. However, because Saccharomyces cerevisiae does not have a ${\text\tiny{D}}$-xylose metabolic pathway, oxidoreductase or isomerase pathways must be introduced to utilize ${\text\tiny{D}}$-xylose from lignocellulosic biomass in S. cerevisiae. To elucidate the biochemical properties of xylose isomerase (XI) from Piromyces sp. E2 (PsXI), we determine its crystal structure in complex with substrate mimic glycerol. An amino-acid sequence comparison with other reported XIs and relative activity measurements using five kinds of divalent metal ions confirmed that PsXI belongs to class II XIs. Moreover kinetic analysis of PsXI was also performed using $Mn^{2+}$, the preferred divalent metal ion for PsXI. In addition, the substrate-binding mode of PsXI could be predicted with the substrate mimic glycerol bound to the active site. These studies may provide structural information to enhance ${\text\tiny{D}}$-xylose utilization for biofuel production.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.3
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• pp.40-48
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• 2009

In this article, scheduling of a casting sequence is studied in a casting foundry which must deliver products according to the Just-in-time(JIT) production policy of a customer. When a foundry manufactures a variety of casts with an identical alloy simultaneously, it frequently faces the task of production scheduling. An optimal casting schedule should be emphasized in order to maximize the production rate and raw material efficiency under the constraints of limited resources; melting furnaces and operation time for a casting machine. To solve this practical problem-fulfilling the objectives of casting the assigned mixed orders for the highest raw material efficiency in a way specified by the customer's JIT schedule, we implement simple integer programming. A simulation to solve a real production problem in a typical casting plant proves that the proposed method provides a feasible solution with a high accuracy for a complex, multi-variable and multi-constraint optimization problem. Employing this simple methodology, a casting foundry having an automated casting machine can produce a mixed order of casts with a maximum furnace utilization within the due date, and provide them according to their customer's JIT inventory policy.

• Journal of Mechanical Science and Technology
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• v.19 no.11
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• pp.2007-2015
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• 2005

A large-scale analysis to evaluate complex material and structural behaviors is one of interesting topic in diverse engineering and scientific fields. Also, the utilization of massively parallel processors has been a recent trend of high performance computing. The objective of this paper is to introduce a parallel process system which consists of general purpose finite element analysis solver as well as parallelized PC cluster. The later was constructed using eight processing elements and the former was developed adopting both hierarchical domain decomposition method and balancing domain decomposition method. Then, to verify the efficiency of the established system, it was applied for structural analysis of steam generator in nuclear power plant. Since the prototypal evaluation results agreed well to the corresponding reference solutions it is believed that, after reinforcement of PC cluster by increasing number of processing elements, the promising parallel process system can be utilized as a useful tool for advanced structural integrity evaluation.