• 한국강구조학회 논문집
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• 제10권3호통권36호
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• pp.451-461
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• 1998

1차전단변형 판이론에 의한 비등방성 복합적층판의 임계좌굴하중 및 좌굴모드는 기존의 해석적인 방법으로는 다양한 조건에 대하여 해를 제공할 수 없다는 단점을 가지고 있다. 따라서 근사해법인 수치해석을 이용하게 되는데, 이러한 수치해석기법으로 기존 상용프로그램에서는 유한요소법이 널리 사용되었다. 그러나 least upper bound 특성을 가지고 있는 유한요소법을 이용한 적층판의 좌굴해는 구조적인 안정성을 보장하지 못하는 경우도 있다. 따라서 본 논문에서는 유한차분법에 의한 좌굴해석을 수행하여 유한요소법과 상호 비교함으로서 각 경우에 관한 두 가지 수치해석기법의 장단점을 규명하고 효과적으로 적용할 수 있는 기법을 제시하는 것을 목적으로 하였다. 수치해석 결과, 유한차분법에 의한 좌굴하중 및 좌굴모드는 신소재를 사용하는 적층 구조물의 실용화에 앞서 다양한 기준을 제시할 수 있을 것으로 판단된다.

• Genomics & Informatics
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• 제13권1호
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• pp.15-24
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• 2015

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an attractive pharmacological target. Here, we have attempted to predict the theoretical models for the human enoyl reductase (ER) and ${\beta}$-ketoacyl reductase (KR) domains based on the porcine FASN crystal structure, which was the structurally closest template available at the time of this study. Comparative modeling methods were used for studying the structure-function relationships. Different validation studies revealed the predicted structures to be highly plausible. The respective substrates of ER and KR domains-namely, trans-butenoyl and ${\beta}$-ketobutyryl-were computationally docked into active sites using Glide in order to understand the probable binding mode. The molecular dynamics simulations of the apo and holo states of ER and KR showed stable backbone root mean square deviation trajectories with minimal deviation. Ramachandran plot analysis showed 96.0% of residues in the most favorable region for ER and 90.3% for the KR domain, respectively. Thus, the predicted models yielded significant insights into the substrate binding modes of the ER and KR catalytic domains and will aid in identifying novel chemical inhibitors of human FASN that target these domains.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.98-98
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• 2003

Direct gene transfer to mammalian tissues has significant potential for gene therapy and transgenesis. Liposome-mediated in vivo transfection has begun to gain attention as an alternative to viral vectors, and may also be a good mode of transfection in gene transfer. Interestingly, polymerized cationic liposomes are reported to be very stable in the bloods and efficient for in vivo gene transfer. To examine a possible gene delivery in vivo, we investigated the efficacy and safety of the liposome-mediated gene transfer using vein injection in chick or mouse as model animals. The number of injected pGFP-LacZ using either a commercial or home-made liposomes was 8 and 19 at 16 and 7 day of hatch, respectively. One of injected chick of each experiments was analyzed and the rest is being bred. In mouse, 4/22 showed expression of pGFP-LacZ but 8/22 showed no expression and the remaining animals are also being bred. After injection of liposome/pGFP-LacZ complex into wing vein of 7 or 16 day-old chick, pGFP-LacZ was detected in various tissues isolated from not only young chick but also old chick were turned out to possess. exogenous DNA. Transcripts and proteins of the transgene were also detected by RT-PCR or histochemical analysis, respectively. These results suggest that injected DNA were inserted to genome and produced mRNA and proteins in various tissues and may give an important tools for effective gene delivery in gene therapy or transgenesis.

• Coupled systems mechanics
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• 제1권4호
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• pp.381-395
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• 2012

Dynamic response of Pile Supported Structures is highly depended on Soil Pile Structure Interaction. In this paper, by comparison of experimental and numerical dynamic responses of a prototype jacket offshore platform for both hinge based and pile supported boundary conditions, effect of soil-pile-structure interaction on dynamic characteristics of this platform is studied. Jacket and deck of a prototype platform is installed on a hinge-based case first and then platform is installed on eight skirt piles embedded on continuum monolayer sand. Dynamic characteristics of platform in term of natural frequencies, mode shapes and modal damping are compared for both cases. Effects of adding and removing vertical bracing members in top bay of jacket on dynamic characteristics of platform for both boundary conditions are also studied. Numerical simulation of responses for the studied platform is also performed for both mentioned cases using capability of ABAQUS and SACS software. The 3D model using ABAQUS software is created using solid elements for soil and beam elements for jacket, deck and pile members. Mohr-Coulomb failure criterion and pile-soil interface element are used for considering nonlinear pile soil structure interaction. Simplified modeling of soil-pile-structure interaction effect is also studied using SACS software. It is observed that dynamic characteristics of the system changes significantly due to soil-pile-structure interaction. Meanwhile, both of complex and simplified (ABAQUS and SACS, respectively) models can predict this effect accurately for such platforms subjected to dynamic loading in small range of deformation.

• 한국추진공학회지
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• 제8권2호
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• pp.102-114
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• 2004

리치컷형 폭발볼트 모델에서, 3차원 솔리드 모델링을 통한 형상모델의 작성, 요소분할 방법, 경계조건의 부과 및 해석방법. 계산결과의 처리 등 폭발볼트의 수치해석에 필요한 모든 과정을 정립하고, 해석결과와 이미 수행된 시험결과의 비교를 통하여 볼트의 파손해석에 사용될 수 있는 파손모델과 파손응력을 선정하였다. 해석에는 볼트의 파손응력을 결정할 때 사용한 모델과, 시험결과와 해석결과로부터 설정된 파손모델의 타당성 평가를 위한 추가 모델들을 사용하였으며, 정립된 해석 프로시져의 적용으로 기존에 의존하였던 성능시험 평가 횟수를 대폭 줄일 수 있을 것으로 생각되며. 이에 따른 개발기간의 단축도 함에 고려할 수 있다. 특히, 기존의 폭발볼트 설계할 때 어려운 점으로 여겨졌던 폭발볼트의 최종 성능에 미치는 여러 가지 인자의 영향을 쉽게 평가할 수 있어, 이러한 설계능력향상, 시제품 제작 횟수의 감소, 개발기간의 단축 등은 최종적으로 시제개발 원가절감의 효과를 갖다 줄 것으로 판단된다.

• 한국추진공학회지
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• 제21권5호
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• pp.1-9
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• 2017

초임계 환경에서 와류형 분사기의 극저온 질소 분무 동적 특성 분석을 위하여 3차원 LES 난류 모델을 적용하였다. 초임계 상태에서 질소의 상태량들을 정확하게 예측하기 위해 SRK 실기체 상태방정식을 사용하였고, 점성계수와 열전도도는 Chung의 고압 상태 혼합물에 대한 방정식, 그리고 확산 계수는 Fuller의 이론에 Takahashi의 보정식을 적용하였다. 질소 분무 결과, 분사기 내, 외부에서 유동장과 음향장 사이의 상호작용으로 복잡한 유동구조가 형성된다. 복잡한 유동 현상을 분석하기 위해 FFT, POD 그리고 DMD 기법을 적용하여 해석을 수행하였다. FFT 해석을 수행하여 분사기 내, 외부에서 나타나는 특정 주파수를 파악하였으며, POD와 DMD를 통해 각 주파수가 어떠한 유동 구조를 갖는지에 대한 연구를 수행하였다. 또한, DMD를 통해 각 주파수의 감쇠 계수를 파악하여 이를 실험 결과와 비교하였다.

• Structural Engineering and Mechanics
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• 제13권4호
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• pp.369-385
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• 2002

Ductility capacity is comprehensively studied for steel moment-resisting frames. Local, story and global ductility are being considered. An appropriate measure of global ductility is suggested. A time domain nonlinear seismic response algorithm is used to evaluate several definitions of ductility. It is observed that for one-story structures, resembling a single degree of freedom (SDOF) system, all definitions of global ductility seem to give reasonable values. However, for complex structures it may give unreasonable values. It indicates that using SDOF systems to estimate the ductility capacity may be a very crude approximation. For multi degree of freedom (MDOF) systems some definitions may not be appropriate, even though they are used in the profession. Results also indicate that the structural global ductility of 4, commonly used for moment-resisting steel frames, cannot be justified based on this study. The ductility of MDOF structural systems and the corresponding equivalent SDOF systems is studied. The global ductility values are very different for the two representations. The ductility reduction factor $F_{\mu}$ is also estimated. For a given frame, the values of the $F_{\mu}$ parameter significantly vary from one earthquake to another, even though the maximum deformation in terms of the interstory displacement is roughly the same for all earthquakes. This is because the $F_{\mu}$ values depend on the amount of dissipated energy, which in turn depends on the plastic mechanism, formed in the frames as well as on the loading, unloading and reloading process at plastic hinges. Based on the results of this study, the Newmark and Hall procedure to relate the ductility reduction factor and the ductility parameter cannot be justified. The reason for this is that SDOF systems were used to model real frames in these studies. Higher mode effects were neglected and energy dissipation was not explicitly considered. In addition, it is not possible to observe the formation of a collapse mechanism in the equivalent SDOF systems. Therefore, the ductility parameter and the force reduction factor should be estimated by using the MDOF representation.

• 전기전자학회논문지
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• 제4권2호
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• pp.257-265
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• 2000

터보 부호의 복호기는 각 복호 단계마다 순방향과 역방향의 메트릭을 계산하여 복호할 비트의 잉여 정보를 추출하여 다음 복호 단계에서 이 정보를 이용하는 반복 복호 기술이다. 길쌈부호의 복호기인 Viterbi 복호기는 연속모드로 동작하는 반면에 터보부호의 복호기는 블록 단위로 동작한다. 터보부호의 복호기에서 사용되는 알고리즘은 매우 복잡한 계산이 필요한 MAP(maximum a posteriori) 알고리즘과 Hagenauer가 제안한 Viterbi 알고리즘을 이용한 SOVA(soft output Viterbi algorithm)가 있는데 복호 성능은 MAP 알고리즘이 우수하다고 알려져 있다. 복잡도가 MAP 알고리즘보다 절반인 SOVA를 채용하고 Robust 등화기법으로 복호 성능을 보완하여 모의 실험결과 기존의 MAP성능만큼 Robust 등화기법이 적용된 SOVA성능이 개선되었음을 보여준다.

• 대한치과보철학회지
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• 제43권4호
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• pp.415-425
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• 2005

Statement of problem : Fracture of composite resin core will be occulted by progress of crack. Bonding interface of different materials has large possibility of starting point of crack line. Therefore, the bond strength of glass fiber post to composite resin core is important for prevention of fracture. Purpose: This in vitro study tried to find out how to get the higher strength of glass fiber post to composite resin core through surveying the maximum load that fractures the post and cote complex. Materials and methods: 40 specimens made with glass fiber Posts(Style $post^{(R)}$, Metalor, Swiss) and composite resin core ($Z-100^{(R)}$, 3M, USA) were prepared and loaded to failure with push-out type shear-bond strength test in a universal test machine. The maximum fracture load and fracture mode were investigated in the specimens that were restored with four different surface treatments. With the data. ANOVA test was used to validate the significance between the test groups, and Bonferroni method was used to check if there is any significant statistical difference between each test group. Evely analysis was approved with 95% reliance. Results: On measuring the maximum fracture load of specimens, both the treatments of sandblasted and acid-etched one statistically showed the strength increase rather than the control group (p<0.005). The scanning electric microscope revealed that sand blasting made more micro-retention form not only on the resin matrix but on the glass fiber, and acid-etching contributed to increase in surface retention form, eliminated the inorganic particles in resin matrix. Specimen fracture modes investigation represented that sand blasted groups showed lower bonding failure than no-sand blasted groups. Conclusion: Referring to the values of maximum fracture load of specimens, the bonding strength was increased by sand blasting and acid-etching.

• 대한기계학회논문집A
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• 제39권8호
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• pp.823-830
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• 2015

구조최적설계는 구조물의 성능 개선을 추구하며, 최근에는 구조최적설계는 항공기와 같이 복잡하고 대형인 구조물의 설계에 적용되고 있다. 해석의 정확도를 높이기 위해 유한요소의 수가 증가하는 추세이나 이는 설계 비용의 증가로 이어진다. 이에 부분구조합성법으로써 구분모드합성법이 해석시간 단축을 위해 종종 사용되어 왔다. 본 연구에서는 구조물의 동적특성을 고려하고 해석의 정확도는 유지하면서, 설계에 소요되는 시간과 비용을 줄일 수 있는 설계방법을 제안한다. 제안한 방법은 등가정하중을 이용한 동적응답 최적설계에, 부분구조합성법을 적용하여 설계영역만을 고려한 구조최적설계를 수행하는 것이다. 제안한 방법의 유용성 검증을 위하여 선형 및 비선형 동적응답 최적설계의 예제를 풀이하고, 그 결과에 대해 토의한다.