• Molecular & Cellular Toxicology
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• v.3 no.2
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• pp.90-97
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• 2007

8-Hydroxyquinoline is used as antibacterial agent and antioxidant based on its function inducing the chelation of ferrous ion present in host resulting in production of chelated complex. This complex being transported to cell membrane of bacteria and fungi exerts antibacterial and antifungal action. In this study, we have carried out in vitro genetic toxicity tests and microarray analysis to understand the underlying mechanisms and the mode of action of toxicity of 8-hydroxyquinoline. TA1535 and TA98 cells were treated with 8-hydroxyquinoline to test its toxicity by basic genetic toxicity test, Ames and two new in vitro micronucleus and COMET assays were applied using CHO cells and L5178Y cells, respectively. In addition, microarray analysis of differentially expressed genes in L5178Y cells in response to 8-hydroxyquinoline were analyzed using Affymatrix genechip. The result of Ames test was that 8-hydroxyquinoline treatment increased the mutations in base substitution strain TA1535 and likewise, 8-hydroxyquinoline also increased mutations in frame shift TA98. 8-Hydroxyquinoline increased micronuclei in CHO cells and DNA damage in L5178Y. 8-Hdroxyquinoline resulted in positive response in all three tests showing its ability to induce not only mutation but also DNA damage. 783 Genes were initially selected as differentially expressed genes in response to 8-hydroxyquinoline by microarray analysis and 34 genes among them were over 4 times of log fold changed. These 34 genes could be candidate biomarkers of genetic toxic action of 8-hydroxyquinoline related to induction of mutation and/or induction of micronuclei and DNA damage. Further confirmation of these candidate markers related to their biological function will be useful to understand the detailed mode of action of 8-hydroxyquinoline.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.11a
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• pp.604-605
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• 2008

Modal participation factor (MPF) is a widely used in a mode-coupling squeal noise problem for finding the most sensitive component over a complex brake system in a vehicle using eigenvectors of sub-components. This methodology requires the problematic total response of system by the unstable squeal noise at a specific frequency as well as eigenvectors of each component belonging to brake system. In this paper, a unit-force response analysis is performed for intact total system to obtain eigenvectors of each component and then such data is directly used for the contribution analysis of a squeal noise problem. Since the eigenvectors of each component induced from virtual unit-excitation is most reliable owing to the intact boundary condition, it can be expected that the corresponding contribution analysis with MPF also provides a trustworthy result.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.4
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• pp.301-307
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• 2013

MRU(motor reduction unit) for KTX is a assembled complex structure that is equipped with a lot of parts at the express train KTX and that is the core power source operating variable speeds. This study is recorded the dynamic characteristics analysis results tested by EMA which is done through the parts and assembly test, transient analysis and stoped train test in order to design the online monitoring system for KTX MRU. And the mode shapes result from critical vibration frequency explain the relation with variable speeds of express train over 250 km/hr. Also these variable speeds make variable operational frequencies at pinion, axle gear mesh frequency and normal bearing fault frequencies. As the specified speed can make resonance with natural frequencies of the MRU, for the train operating stability, this study also presents the MRU's critical speeds calculated by the each train speed.

• Wind and Structures
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• v.18 no.4
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• pp.347-373
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• 2014

Since its development in the early 1980's the force balance technique has become a standard method in the efficient determination of structural loads and responses. Its usefulness lies in the simplicity of the physical model, the relatively short records required from the wind tunnel testing and its versatility in the use of the data for different sets of dynamic properties. Its major advantage has been the ability to provide results in a timely manner, assisting the structural engineer to fine-tune their building at an early stage of the structural development. The analysis of the wind tunnel data has evolved from the simple un-coupled system to sophisticated methods that include the correction for non-linear mode shapes, the handling of complex geometry and the handling of simultaneous measurements on multiple force balances for a building group. This paper will review some of the components in the force balance data analysis both in historical perspective and in its current advancement. The basic formulation of the force balance methodology in both frequency and time domains will be presented. This includes all coupling effects and allows the determination of the resultant quantities such as resultant accelerations, as well as various load effects that generally were not considered in earlier force balance analyses. Using a building model test carried out in the wind tunnel as an example case study, the effects of various simplifications and omissions are discussed.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1791-1801
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• 2023

The multi-physics coupled methodologies that have been widely used to analyze the complex process occurring in nuclear reactors have also been used to the R&D of numerical reactors. The advancement in the field of computer technology has helped in the development of these methodologies. Herein, we report the integration of ADPRES code and RELAP5 code into the SALOME-ICoCo framework to form a multi-physics coupling platform. The platform exploits the supervisor architecture, serial mode, mesh one-to-one correspondence and explicit coupling methods during analysis, and the uncertainty analysis tool URANIE was used. The correctness of the platform was verified through the NEACRP-L-335 benchmark. The results obtained were in accordance with the reference values. The platform could be used to accurately determine the power peak. In addition, design margins could be gained post uncertainty analysis. The initial power, inlet coolant temperature and the mass flow of assembly property significantly influence reactor safety during the rod ejections accident (REA).

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.7
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• pp.688-694
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• 2008

A rotordynamic analysis is performed for a high thrust class liquid rocket engine turbopump considering the dynamic characteristics of ball bearings and pump noncontact seals. Complex eigenvalue problems are solved to predict the rotating natural frequencies and damping ratios as a function of rotating speeds. Synchronous rotor mass unbalance response and time transient response analyses are also performed to figure out the rotor critical speed and the onset speed of instability. From the numerical analysis, it is found that the rear bearing stiffness is most important parameter for the critical speed and instability because the 1st mode is turbine side shaft bending mode. The pump seal effect on the critical speed is enlarged as the rear bearing stiffness decreases and the front bearing stiffness increases.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.54 no.8
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• pp.365-370
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• 2005

Microwave diagnostics have been widely utilized to measure the important parameters of high temperature and high density plasmas. Reflectometry is known as a promising microwave diagnostic which has a number of merits to measure electron density profiles. In the KSTAR device, X-mode FM reflectometry is planned to measure the plasma density profiles. FM reflectometry is required to extract phase information on raw mixer IF signals, thereby obtaining time-of-flight of reflectometry signals. It is known that the data analysis method is crucial to determine the performance of FM reflectometry In fact, there are several analysis programs which have been utilized in various FM systems. Since each program was developed for a specific device, however, it is difficult to directly apply it to a different reactor like the KSTAR device. It is necessary, therefore, to develop a data analysis program for the KSTAR FM reflectometry. In this paper, complex digital demodulation (CDM) and wavelet transformation are examined in terms of the performance of density profile reconstruction. For the comparison of both methods, FM reflectometry signals are generated on the basis of assumed profiles and the interaction of the X-mode wave and the plasma. In order to see how well both methods work under various conditions, three types of profiles are assumed and noise effects are included. As a result, both methods work well under the condition of gentle density gradient and small noise level. As density gradient becomes steeper and noise level gets higher. the reconstruction performance of wavelet is better than that of CDM.

• Structural Engineering and Mechanics
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• v.33 no.5
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• pp.605-619
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• 2009

This paper presents the details of finite element (FE) modeling and analysis of an external prestressing technique to strengthen a prestressed concrete (PSC) end block. Various methods of external prestressing techniques have been discussed. In the proposed technique, transfer of external force is in shear mode on the end block creating a complex stress distribution. The proposed technique is useful when the ends of the PSC girders are not accessible. Finite element modeling issues have been outlined. Brief description about material nonlinearity including key aspects in modeling inelastic behaviour has been provided. Finite element (FE) modeling including material, loading has been explained in depth. FE analysis for linear and nonlinear static analysis has been conducted for varying external loadings. Various responses such as out-of-plane deformation and slip have been computed and compared with the corresponding experimental observations. From the study, it has been observed that the computed slope and slip of the steel bracket under external loading is in good agreement with the corresponding experimental observations.

• Journal of KSNVE
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• v.9 no.3
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• pp.593-599
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• 1999

A rotordynamic analysis is performed with a motor-bull gear rotor system supported on two partial bearings, which is intended to drive a high-speed turbo-chiller compressor impeller shaft through its built-in pinion gear. The motor-bull gear rotor system has a rated speed of 3,600 rpm, and is modeled utilizing the finite element method for analysis. As loadings on the bearings due to the gear action are significant in the system considered, each resultant bearing load is calculated statically by considering the generalized forces of the gear action as well as the rotor itself. The two support partial bearings are designed to take their varying loads along with their varying load angles, and they are also analyzed to give their rotordynamic coefficients. Then, a complex rotordynamic analysis of the motor-bull gear rotor-bearing system is carried out to evaluate its whirl natural frequencies and mode shapes and unbalance responses under various loading conditions. Results show that the bearings and entire rotor system are well designed regradless of operating conditions, i.e., loads and operating speeds.

• Advances in materials Research
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• v.11 no.1
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• pp.59-73
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• 2022

In the construction industry, thin-walled frame elements with very slender open cross-sections and low torsional stiffness are often subjected to a complex loading condition where axial, bending, shear and torsional stresses are present simultaneously. Hence, these often fail in instability even before the yield capacity is reached. One of the most common instability conditions associated with thin-walled structures is Lateral Torsional Buckling (LTB). In this study, a first order Generalized Beam Theory (GBT) formulation and numerical analysis of cold-formed steel lipped channel beams (C80×40×10×1, C90×40×10×1, C100×40×10×1, C80×40×10×1.6, C90×40×10×1.6 and C100×40×10×1.6) subjected to uniform moment is carried out to predict pure Lateral Torsional Buckling (LTB). These results are compared with the Finite Element Analysis of the beams modelled with shell elements using ABAQUS and analytical results based on Euler's buckling formula. The mode wise deformed shape and modal participation factors are obtained for comparison of the responses along with the effect of varying the length of the beam from 2.5 m to 10 m. The deformed shapes of the beam for different modes and GBTUL plots are analyzed for comparative conclusions.