• Journal of Pharmaceutical Investigation
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• 제39권5호
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• pp.339-343
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• 2009

Recently, co-delivery of drug and gene has been attempted for higher therapeutic effects of anticancer agents. In this study, cationic liposomes were prepared using 1,2-dioleoyl-3-trimethylammoniopropane (DOTAP) as a cationic lipid to investigate the effect of drug loading on the physicochemical characteristics of cationic liposomes/DNA complexes. The complex formation between cationic liposomes and negatively charged plasmid DNA was confirmed and the protection from DNase was observed. Particle size of complexes was reduced not by drug loading, but by the increased ratio of cationic lipid to plasmid DNA. Meanwhile, zeta potential of complex was increased by the addition of cationic liposomes to complexes and the effect of drug loading on the zeta potential was not much higher than on particle size. Gel retardation of complexes was indicated when the complexation weight ratios of cationic lipid to plasmid DNA were higher than 24:1 for drug free complexes and 20:1 for drug loaded ones, respectively. Agarose gel retardation showed the similar complexation between plasmid DNA and drug free liposomes or drug loaded liposomes. Both complexes protected plasmid DNA from DNase independent of complexation temperature. From the results, drug loading may affect not the complex formation of cationic liposomes and plasmid DNA, but the particle size of complex.

• Structural Engineering and Mechanics
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• 제32권2호
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• pp.337-350
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• 2009

Finite element simulations are increasingly used in structural analysis and design, especially in cases where complex structural and loading conditions are involved. Due to considerable progresses in computer technology as well as nonlinear finite-element analysis techniques in past years, it has become possible to pursue an accurate analysis of the complex blast-induced structural effects by means of numerical simulations. This paper aims to develop a better understanding of the behavior of steel-concrete composite beams (SCCB) under localized blast loading through a numerical parametric study. A finite element model is set up to simulate the blast-resistant features of SCCB using the transient dynamic analysis software LS-DYNA. It is demonstrated that there are three dominant failure modes for SCCB subjected to localized blast loading. The effect of loading position on the behavior of SCCB is also investigated. Finally, a simplified model is proposed for assessing the overall response of SCCB subjected to localized blast loading.

• Advances in materials Research
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• 제12권1호
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• pp.1-13
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• 2023

The combination of cobalt ferrite and natural rubber has a potential to enhance the functional properties of rubber ferrite composites available on the market. In this study, cobalt ferrite was synthesized by the sol-gel method with tapioca starch as a cheating agent and then incorporated into natural rubber using an internal mixer. The curing characteristics, magnetic hysteresis, complex permeability, and permittivity of the rubber ferrite composites were studied as a function of the loading from 0 to 25 phr. The cure time and scorch time tended to reduce with the addition of non-reinforced cobalt ferrite fillers. The remanent and saturation magnetizations were linearly proportional to the cobalt ferrite loading, consistent with the rule of mixture. On the other hand, the increase in cobalt ferrite loading from 5 to 25 phr slightly affected the coercive field and the complex permeability. Using the maximum loading of 25 phr, both real and imaginary parts of the permittivity were significantly raised and reduced with the frequency in the 10-300 MHz range.

• 한국환경농학회지
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• 제19권5호
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• pp.419-425
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• 2000

Rating curve method and SWMM (Storm Water Management Model) were applied to estimate pollutant loading from Hwa-Ong watershed in Kyunggi-Do. Rating curves were derived from sampling sites and applied to the whole watershed. SWMM version 4.4 was calibrated by field data of sampling sites and applied to the whole watershed. The pollutant loading estimated by rating curve was slightly higher than the one by SWMM, but the difference was not significant considering diffuse pollution characteristics of wide variation. Land use effect of the subcatchments could not be incorporated logically in rating curve method and difficulty in extrapolation was experienced, therefore, the estimate by rating curve method was thought to be less confident. SWMM was satisfactory in estimation of pollution loading, and its great flexibility worked well to describe complex nonurban land uses. Neither of them could exactly describe complex natural phenomena, but SWMM was preferred in this study due to its flexibility and logical hydrologic processes including land use effects. Use of reasonable watershed model rather than rating curve method for watershed pollutant loading estimate can be more practical and is recommended.

• Structural Engineering and Mechanics
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• 제8권4호
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• pp.421-438
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• 1999

In this paper a practical limit load estimating procedure is proposed for general pipe-elbow structures subjected to complex loading (in-plane and out-of-plane bending, internal pressure and axial force). The explicit calculating formulae are presented on the basis of theoretical analysis combined with numerical simulation. Von Mises' yield criterion is adopted in both analytical and numerical calculation. The finite element examination shows that the method provides a simple but satisfactory prediction of pipe structures in engineering plastic analysis.

• Structural Engineering and Mechanics
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• 제7권6호
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• pp.575-588
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• 1999

A boundary element method is applied to the analysis of crack trajectory in materials with complex microstructure, such as discontinuously reinforced composite materials, and systems subjected to complex loading, such as indentation. The path followed by the crack(s) has non-trivial geometry. A study of the stress intensity factors and fracture toughness of such systems must therefore be accompanied by an analysis of crack trajectory. The simulation is achieved using a dual boundary integral method in planar problems, and a single boundary integral method coupled with substructuring in axisymmetric problems. The direction of crack propagation is determined using the maximum mechanical energy release rate criterion. The method is demonstrated by application to (i) a composite material composed of components having the elastic properties of aluminium (matrix) and silicon carbide (reinforcement), and (ii) analysis of contact damage induced by the action of an indenter on brittle materials. The chief advantage of the method is the ease with which problems having complex geometry or loading (giving rise to complex crack trajectories) can be treated.

• Structural Engineering and Mechanics
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• 제87권1호
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• pp.57-68
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• 2023

Response spectrum method is still an effective approach for the design of buildings with supplemental dampers. In practice, complex complete quadratic combination (CCQC) rule is always used in the response spectrum method to consider the effect of non-classical damping. The conventional CCQC rule is based on exact complex mode vectors. Sometimes the calculated complex mode vectors may be not excited by the external loading and errors in the structural responses always arise due to the mode truncation. Load-dependent Ritz (LDR) vectors are associated with the external loading and LDR vectors not excited can be automatically excluded. Also, contributions of higher modes are implicitly contained in the LDR vectors in terms of static responses. To improve the calculation efficiency and accuracy, LDR vectors are introduced in the CCQC rule in the present study. Firstly, the generation procedure of LDR vectors suitable for non-classical damping system is presented. Compared to the conventional LDR vectors, the LDR vectors herein are complex-valued and named as complex LDR (CLDR) vectors. Based on the CLDR vectors, the CCQC rule is then rederived and an improved response spectrum method is developed. Finally, the effectiveness of the proposed method in this paper is verified through three typical non-classical damping buildings. Numerical results show that the CLDR vector is superior to the complex mode with the same number in the calculation. Since the generation of CLDR vectors requires less computational cost and storage space, the method proposed in this paper offers an attractive alternative, especially for structures with a large number of degrees of freedom.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.33-36
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• 2008

조개껍질과 같이 얇은 요소들이 생체적인 접착제에 의해서 겹겹이 쌓여 층 구조를 이루는 패각은 정적하중 및 충격하중에 대하여 뛰어난 저항 성능을 보이는 것으로 알려져 있다. 이러한 다양한 층 구조의 복합재료는 두 개의 서로 다른 매질이 적층되면서 단일 재질의 경우보다 충격, 완화 효율이 극대화될 것이라 판단된다. 본 연구에서는 충격을 견디고 최소화시키기 위한 분절 복합체(Segmented Composites)로써 층 구조의 형태를 가지는 복합 재료를 개발하기 위해 일반 모르타르와 일반 콘크리트 블록을 이용한 보 형태의 분절 복합체 부재를 제작하여 정적하중 및 충격하중 실험을 실시하였다. 그리고 분절 복합체의 성능 및 파괴형태를 콘크리트 블록과 같은 강도로 제작된 콘크리트 보 부재와 비교하였다.

• 한국항해항만학회지
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• 제29권4호
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• pp.305-312
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• 2005

Pick-up/delivery of consumer goods to offices, shops, and restaurants in order to support urban lives is one of the most vital activities in a city. With economic growth and technological innovation, a greater variety of goods have come to be supplied, and pick-up/delivery of consumer goods has become more complex. Efficient urban goods movement in Central Business District(CBD} starts with an efficient system for loading/unloading, and pick-up/delivery activities. Loading/unloading activity may be carried out on-street, or on especially designated space inside or outside buildings. Therefore, purpose of this study is to clarity the efficient urban goods movement in CBD(also called the pick-up/delivery activity) from the three different types of loading/unloading facilities. For this purpose, the differences in loading/unloading and truck-trip activity time of each loading/unloading facility was compared by performing the simulation analysis.

• Structural Engineering and Mechanics
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• 제5권6호
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• pp.679-689
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• 1997

The damage of concrete subjected to multiaxial complex loading involves strong anisotropy due to its highly heterogeneous nature and the geometrically anisotropic characteristic of the microcracks. A comprehensive description of concrete damage is proposed by introducing a fourth-order anisotropic damage tenser. The evolution of damage is assumed to be related to the principal components of the current states of stress and damage. The unilateral effect of damage due to the closure and opening of microcracks is taken into account by introducing projection tensors that are also determined by the current state of stress. The proposed damage model considers the different kinds of damage mechanisms that result in different failure modes and different patterns of microdefects that cause different unilateral effects. This damage model is embedded in a thermomechanically consistent constitutive equation in which hardening and the triaxial compression caused shear-enhanced compaction can also be taken into account. The validity of the proposed model is verified by comparing theoretical and experimental results of plain and steel fiber reinforced concrete subjected to complex triaxial stress histories.