• Title/Summary/Keyword: Complex Linkage

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Current Understanding in Neurobiology of Depressive Disorders : Imaging Genetic Studies on Serotonin Transporter (우울장애의 신경생물학적 최신 지견 : 세로토닌 전달체에 대한 영상 유전학적 연구를 중심으로)

  • Ham, Byung-Joo
    • Korean Journal of Biological Psychiatry
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    • v.18 no.4
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    • pp.176-180
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    • 2011
  • Depressive disorders have strong genetic components. However, conventional linkage and association studies have not yielded definitive results. These might be due to the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. Imaging genetics explores the influences of genetic variation on the brain function or structure. This technique could provide a more sensitive assessment than traditional behavioral measures in psychiatric studies. Imaging genetics is a relatively new field of psychiatric researches, and may improve our understanding on neurobiology of psychiatric disorders. In this review, current understanding in neurobiology of depressive disorders, especially imaging genetic studies on serotonin transporter will be discussed.

A Study on VV&A Application Method for Credibility Improvement of The DM&S for C4I Test and Evaluation (C4I체계 시험평가 국방M&S 신뢰도 향상을 위한 VV&A 적용방안 연구)

  • Kim, Kyung-Hee;Kang, Seok-Joong
    • Journal of the Korea Institute of Military Science and Technology
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    • v.13 no.6
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    • pp.1080-1090
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    • 2010
  • A study for improvement of credibility on test & evaluation result of interoperability in battle management information system which focused in C4I systems is very essential in rapid change of battle field environment. Realization of effective operation process with integration of developed IT also core factor for reducing of operational response time such as information gathering from sensor to shooter, time for commander's decision making. Therefore, by required to meet of high technical T&E, meet of complex software's user requirement, long-term system development period, system integration ability's request by various linkage of systems, it is high a M&S dependency to optimal performance, interpoerability's guarantee. Especially credibility on test & evaluation using M&S is very important. This paper will propse a VV&A applied methods using other VV&A case to improve credibility of M&S on test & evaluation.

1H NMR Study of Aziridine Derivatives Coordinated to the Paramagnetic Undecatungstocobalto(II)silicate and -nickelo(II)silicate Anions

  • 박석민;서현수
    • Bulletin of the Korean Chemical Society
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    • v.18 no.9
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    • pp.1002-1006
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    • 1997
  • 1H NMR spectra of D2O solutions containing 2,2-dimethylaziridine (1) or 2-methylaziridine (2) and [SiW11COⅡO39]6- (SiW11Co) or [SiW11NiⅡO39]6- (SiW11Ni) exhibit separate signals for the free ligand and the complex, indicating that the ligand exchange is slow on the NMR time scale. Identified are two linkage isomers with the methyl group of 2 at trans or cis position with respect to the metal. The isotropic shifts of 1 and 2 coordinated to SiW11Ni originate mainly from the contact shifts, and they agree reasonably with the relative values reported for similar ligands coordinated to bis(2,4-pentanedionato)nickel(Ⅱ). The isotropic shifts for the SiW11Co complexes were separated into contact and pseudocontact contributions. The pseudocontact shifts show that (χ∥-χ⊥) is positive, while that for the SiW11Co complexes of pyridine derivatives is negative. This result indicates that the ordering of dxy and dxz, dyz orbitals in SiW11Co complexes can be reversed by ligands.

$^1H$ NMR Study of 4-Aminopyrimidine Coordinated to the Paramagnetic Undecatung-stocobalto(Ⅱ)silicate Anion: Rates of Internal Rotation of the Amine Group

  • 김병안;소현수
    • Bulletin of the Korean Chemical Society
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    • v.20 no.10
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    • pp.1149-1152
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    • 1999
  • 1H NMR spectrum of a DMF-d7 solution containing 4-aminopyrimidine and [SiW11CoIIO39]6- (SiW11Co) shows separate peaks from two linkage isomers, a and b, in which N(1) and N(3) of the pyrimidine ring are coordinated to SiW11Co, respectively. The signal from the amine group in the isomer a exhibits temperature dependence that is characteristic of a two-site exchange problem. Rates of internal rotation of the amine group were determined by simulating the NMR spectra at 5-35℃. The amine group of free 4-aminopyrimidine also shows temperature-dependent spectra at lower temperatures; rates of internal rotation at (-25)-25℃ were determined. The internal rotation of the amine group in the complex is much slower than that for free 4-aminopyrimidine, indicating that π-character of the C-N bond increases on coordination to SiW11Co. The amine group in the isomer b does not show such behavior. It is probable that hydrogen bonding between N-H and a bridging oxygen atom of SiW11Co prevents it from rotating at low temperatures.

A Study on the Planning Direction of Local Connected School Facilities for the Neighborhood Regeneration (근린재생을 위한 지역연계형 학교시설 계획방향 연구)

  • Kim, Ji-Su;Yoo, Hae-Yeon
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.36 no.5
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    • pp.71-82
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    • 2020
  • As the number of students continues to decline, alternatives to regional linkage and utilization of school facilities in the region are being sought. Therefore, the purpose of this study is to propose programs and remodeling directions for school facilities for neighborhood regeneration in urban regeneration revitalization areas. To this end, first, this study analyzed changes in educational courses and policies in Korea. Second, domestic and foreign cases of combined operation of school facilities were analyzed. Third, implications for the improvement of local-linked school facilities were derived through policies and case analysis. Finally, the direction of the plan considering this was proposed.

Federation Trader Model Supporting Interface Between Object Groups (객체그룹간의 상호접속을 지원하는 연합 트레이더 모델)

  • Jeong, Chang-Won;Ju, Su-Jong
    • Journal of KIISE:Computer Systems and Theory
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    • v.26 no.9
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    • pp.1126-1134
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    • 1999
  • 최근 다양한 멀티미디어 서비스를 지원하기 위한 통신망 관리와 서비스 관리가 통합된 개방형 정보 통신망의 구조가 요구되고 있다. 이러한 구조를 기반으로, TINA-C(Tele-communications Information Networking Architecture-Consortium)에서는 분산 환경에서 분산 어플리케이션 객체들에 대한 복잡한 서비스 및 관리 인터페이스들을 간결하도록 객체그룹의 개념을 정의하고 있다. 이러한 환경 속에서 트레이딩 서비스는 통신 서비스를 제공하는 객체그룹간의 상호작용을 지원하는데 매우 중요하다.따라서, 본 논문에서는 객체그룹간의 상호접속을 지원할 수 있는 트레이딩 기능과 이들 트레이더들간의 연동을 위한 트레이더 연합 모델을 제시하고자 한다. 이를 위해 우리는 트레이더의 중개자로서 Cooperator를 설계하여 기존의 트레이더와 연동시켰다. 이러한 결과로서 우리의 새로운 트레이더 연합 모델에서 Cooperator는 객체그룹간의 상호접속에서 객체들의 접속 권한의 체크 기능과 기존의 트레이더 연합모델의 문제점인 트레이더들간의 단 방향 연결문제를 보완하여 양방향 연결 기능을 갖도록 하였다. 끝으로, 이러한 해결 과정을 보이기 위해 트레이더와 Cooperator들로 이루어진 본 연합모델에서 분산 객체그룹간의 상호접속 절차과정과 사건 추적 다이어그램을 보였다.Abstract Recently, the open networking architecture is required to support various multimedia services as integrated functions of network management and service management. Based on this architecture, TINA-C defines an object group concept for simplifying complex management and service interfaces, when distributed application is executed in distributed environments. Within the support environment the trading service is an important of the interacting object groups which provide a telecommunication service.Hence, we suggest the trader federation model for supporting interconnections between object groups and among existing traders by using the cooperator we designed, as an intermediator among traders. Our cooperator has functions for checking access rights of objects in object groups, and for providing bidirectional linkage among traders. Up to now, the existing trader federation models have a single directional linkage for interactions among traders. Finally, we showed the interface procedure and the event trace diagram of distributed object groups using our model consisted of traders and the cooperators.

A Kinematic Approach to Answering Similarity Queries on Complex Human Motion Data (운동학적 접근 방법을 사용한 복잡한 인간 동작 질의 시스템)

  • Han, Hyuck;Kim, Shin-Gyu;Jung, Hyung-Soo;Yeom, Heon-Y.
    • Journal of Internet Computing and Services
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    • v.10 no.4
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    • pp.1-11
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    • 2009
  • Recently there has arisen concern in both the database community and the graphics society about data retrieval from large motion databases because the high dimensionality of motion data implies high costs. In this circumstance, finding an effective distance measure and an efficient query processing method for such data is a challenging problem. This paper presents an elaborate motion query processing system, SMoFinder (Similar Motion Finder), which incorporates a novel kinematic distance measure and an efficient indexing strategy via adaptive frame segmentation. To this end, we regard human motions as multi-linkage kinematics and propose the weighted Minkowski distance metric. For efficient indexing, we devise a new adaptive segmentation method that chooses representative frames among similar frames and stores chosen frames instead of all frames. For efficient search, we propose a new search method that processes k-nearest neighbors queries over only representative frames. Our experimental results show that the size of motion databases is reduced greatly (${\times}1/25$) but the search capability of SMoFinder is equal to or superior to that of other systems.

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A development of system dynamics model for water, energy, and food nexus (W-E-F nexus)

  • Wicaksono, Albert;Jeong, Gimoon;Kang, Doosun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2015.05a
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    • pp.220-220
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    • 2015
  • Water, energy, and food security already became a risk that threatens people around the world. Increasing of resources demand, rapid urbanization, decreasing of natural resources and climate change are four major problems inducing resources' scarcity. Indeed, water, energy, and food are interconnected each other thus cannot be analyzed separately. That is, for simple example, energy needs water as source for hydropower plant, water needs energy for distribution, and food needs water and energy for production, which is defined as W-E-F nexus. Due to their complicated linkage, it needs a computer model to simulate and analyze the nexus. Development of a computer simulation model using system dynamics approach makes this linkage possible to be visualized and quantified. System dynamics can be defined as an approach to learn the feedback connections of all elements in a complex system, which mean, every element's interaction is simulated simultaneously. Present W-E-F nexus models do not calculate and simulate the element's interaction simultaneously. Existing models only calculate the amount of water and energy resources that needed to provide food, water, or energy without any interaction from the product to resources. The new proposed model tries to cope these lacks by adding the interactions, climate change effect, and government policy to optimize the best options to maintain the resources sustainability. On this first phase of development, the model is developed only to learn and analyze the interaction between elements based on scenario of fulfilling the increasing of resources demand, due to population growth. The model is developed using the Vensim, well-known system dynamics model software. The results are amount of total water, energy, and food demand and production for a certain time period and it is evaluated to determine the sustainability of resources.

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Advances of Self-incompatibility Genetics in Genus Fagopyrum

  • Woo Sun-Hee;Soo-Jeong Kwon;Sung-Hyun Yun;Min-Young Park;Probir Kumar Mittra;Swapan Kumar Roy;Seong-Woo Cho
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.191-191
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    • 2022
  • Heterostyly continues to fascinate evolutionary biologists interested in heredity, evolution, breeding, and adaptive function. Polymorphism demonstrates how simply inherited developmental changes in the location of plant sexual associations can have important consequences for population pollination and mating biology. In contrast to homozygous self incompatibility, only a small number of mating phenotypes can be maintained in the population because insect pollinators have limitations in achieving multiple segregation sites for pollen deposition. Field studies of pollen tube growth have shown that reciprocal style-stamen polymorphisms function to increase the capacity of insect-mediated cross-pollination. The genetic pattern of style morphs is well established in various taxa, but despite recent advances, the identity, number, and structure of the genes controlling the heteromorphic syndrome have been poorly elucidated. The phenomenon of heterostyly in buckwheat has been controlled by gene complex concentrate to S-locus. Homomorphic autogamous buckwheat strains were established by the interspecific hybridization. Backcrossing of this line to the common buckwheat (pin) and selecting homostylar progenies made it possible to introduce the self-compatible gene into common buckwheat. In the result, we obtained the BC9F2 generation, and defined the strong linkage between flower type and self-incompatibility by microscopic observation of pollen tube growth. This finding suggests that self-incompatibility character is not controlled by one gene. Moreover, we defined the strong linkage between flower type and self-incompatibility. It strongly supports the S supergene theory. Therefore, we have plan to elucidate the heterostyly self-incompatibility by using molecular genetics, proteome analysis and apply to exploitation of buckwheat improvement. In near future, the expression of heterozygous syndromes in genus Fagopyrum with single isolated heterozygous species may provide clues to early stages of polymorphic assembly and shed light on evolutionary models of heterozygous strains.

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Analysis of Taxi Combined Surcharge System Using DTG Data (DTG 데이터를 활용한 택시 복합할증제 분석)

  • Kim, Seoung bum;Kim, Ho seon;Jung, Jong heon
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.19 no.6
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    • pp.152-162
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    • 2020
  • In the urban and rural complex, taxis move from downtown to rural areas for business purposes, and operate a combined surcharge system that preserves losses when they back to downtown. However, complaints related to the abolition of the compound surcharge system are increasing due to deformed operation that does not fit the purpose of the system. When the combinedsurcharge system is abolished, the taxi industry can be hit hard by the decrease in profits, and local governments are inevitable to support it. However, it is difficult to set the size of the subsidy considering the decrease of actual income. This study is to estimate the income reduction in the abolition of the combined surcharge system by scientific and objective method by analyzing the DTG data and the sales data collected from the digital driving recorder installed in the corporate taxi of the urban and rural complex area (e.g., Tongyeong city). This study is meaningful in that it used DTG data to solve the current issues in the real region and suggested the use of new DTG data.