• Journal of the Optical Society of Korea
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• v.8 no.4
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• pp.182-187
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• 2004

We synthesized and analyzed the optical transfer function(OTF) of the modified triangular interferometer (MTI) using two-pupil synthesis method. Also, we presented the optimal MTI, which can obtain any bipolar function by combining two wave plates and a linear polarizer. By using the proposed MTI, we can obtain the complex hologram without bias and conjugate image.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.4
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• pp.405-412
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• 2011

This paper introduces the generalized finite element method with global-local enrichment functions using the preconditioned conjugate gradient method. The proposed methodology is able to generate enrichment functions for problems where limited a-priori knowledge on the solution is available and to utilize a preconditioner and initial guess of good quality with only small addition of computational cost. Thus, it is very effective to analyze problems where a complex behavior is locally exhibited. Several numerical experiments are performed to confirm its effectiveness and show that it is computationally more efficient than the analysis utilizing direct solvers such as Gauss elimination method.

• The KSFM Journal of Fluid Machinery
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• v.18 no.2
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• pp.60-66
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• 2015

Conjugate heat transfer analysis was performed to investigate the flow and cooling performance of the high pressure turbine nozzle of gas turbine engine. The CHT code was verified by comparison between CFD results and experimental results of C3X vane. The combination of k-${\omega}$ based SST turbulence model and transition model was used to solve the flow and thermal field of the fluid zone and the material property of CMSX-4 was applied to the solid zone. The turbine nozzle has two internal cooling channels and each channel has a complex cooling configurations, such as the film cooling, jet impingement, pedestal and rib turbulator. The parabolic temperature profile was given to the inlet condition of the nozzle to simulate the combustor exit condition. The flow characteristics were analyzed by comparing with uncooled nozzle vane. The Mach number around the vane increased due to the increase of coolant mass flow flowed in the main flow passage. The maximum cooling effectiveness (91 %) at the vane surface is located in the middle of pressure side which is effected by the film cooling and the rib turbulrator. The region of the minimum cooling effectiveness (44.8 %) was positioned at the leading edge. And the results show that the TBC layer increases the average cooling effectiveness up to 18 %.

• Biomedical Science Letters
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• v.9 no.2
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• pp.67-74
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• 2003

Viral and non-viral vectors have been used in the delivery of genetic materials into animal cells and tissues, with each approach having pros and cons. Non-viral vectors have many useful merits such as easy preparation, low immunity and size tolerance of a transgene when compared to those of viral vectors. Delivery specificity may be achieved by complex formation between receptor ligands and a non-viral vector. In the present study, non-viral vector systems are investigated in an effort to find a practical delivery means for gene therapy, Receptor-ligand interaction between transferrin-receptor and transferrin was utilized for efficient gene transfer into cancer cells. A plasmid vector, pcDNA3 (LacZ) was ligated with a small duplexed oligo fragment in which a Biotin- VN$^{TM}$ phosphoramidite was placed in the middle of the oligo. The plasmid vector labeled by biotin was then conjugated with biotin-labeled transferrin via streptavidin. This trimeric conjugates were delivered to a hepatoma cell line, HepG2. The delivery efficiency of the trimeric conjugate was 2-fold higher than that of cationic liposomes used for transfection of a plasmid vector. These results demonstrate that a plasmid vector can be efficiently transferred into cells by forming a trimeric complex of plasmid vector-linker-ligand.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.8 s.99
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• pp.797-802
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• 2005

In this paper, we design a UHF band RFID tag antenna which is conjugate matched to an impedance of a chip and also mountable on conductive materials. The proposed tag antenna is very compact($50{\times}30{\times}4mm$) with a modified PIFA shape. The proposed tag antenna has an advantage of easy matching to various chip input impedances. The performance of the antenna is evaluated by monitoring RCS in the reader direction. The RCS of the designed tag is $-10.2\;dBm^2$ when the chip is shorted and is $-21\;dBm^2$ when the chip impedance is a complex conjugate of the antenna impedance.

• Clinical and Experimental Pediatrics
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• v.49 no.3
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• pp.235-241
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• 2006

Streptococus pneumoniae is an important cause of invasive infections as well as non-invasive infections such as acute otitis media and sinusitis both in children and adults. Resistance of S. pneumoniae to multiple antimicrobials is increasing and poses therapeutic challenges, and prevention became more important. 23-valent polysaccharide vaccine has been used for the last several decades, but is not effective in children <2 years of age, the highest risk group of invasive diseases. Recently, a 7-valent pneumococcal protein conjugate vaccine(PCV) which is effective in infants and young children has been developed. The efficacy of PCVs against invasive pneumococcal disease and pneumonia is well established and is documented in several well-conducted studies. However, the effect of PCVs on otitis media is less obvious and more complex. PCVs clearly reduce diseases caused by vaccine-type(VT) pneumococci, but replacement of VT serotypes by non-VT serotypes in nasopharyngeal carriage of S. pneumoniae is responsible for the increase in acute otitis media caused by non-VT serotypes. Three years after introduction of PCV in the US, some increase of invasive infections with serotype 19A possibly due to serotype switching within certain vaccine type strains has been noted. Since most antibiotic-resistance in S. pneumoniae is confined to VT serotypes, vaccine use also reduces antibiotic resistance. With development of PCV, there was a great advance in the prevention of pneumococcal diseases, but replacement with potential virulent organisms and development of antibiotic resistance in non-VT pneumococci is a possibility that needs careful monitoring.

• Journal of the military operations research society of Korea
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• v.34 no.1
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• pp.1-11
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• 2008

A methodology for the improvement of simulation based training system for the artillery is proposed in this paper. The complex nonlinear relationship inherent among parameters in artillery firing is difficult to model and analyze. By introducing neural network based simulation, accurate representation of artillery firing is made possible. The artillery training system can greatly benefit from the improved prediction. Neural networks learning is conducted using the conjugate gradient algorithm. The evaluation of the proposed methodology is performed through simulation. Prediction errors of both regression analysis model and neural networks model are analyzed. Implementation of neural networks to training system enables more realistic training, improved combat power and reduced budget.

• Polymer(Korea)
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• v.32 no.6
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• pp.544-548
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• 2008

The objective of this study is to obtain the anti-oxidant nanoparticles based on biocompatible polymers. It was chosen to conjugate with chitosan as the biodegradable polymer and lipoic acid as the hydrophobic anti-oxidant. Lipoic acid helps the regeneration of exogenous and endogenous anti-oxidants vitamin as well as glutathione and hence acts as antioxidant indirectly. Chitosan was prepared from chitin which was deacetylated under alkali solution for the various reaction time. Lipoic acid-chitosan complex was confirmed by $^1H$-NMR. The critical aggregation concentration was measured using pyrene and the values were about $5{\times}10^{-3}$ g/L. The particle shapes and sizes of the chitosan-lipoic acid nano-particles were about 135 nm that measured by DLS and TEM.

• Journal of Pharmaceutical Investigation
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• v.25 no.2
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• pp.145-152
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• 1995

The superoxide dismutase (SOD) mimetic activity of copper complex of 3,5-disopropylsalicylic acid (Cu(II)-DIPS) was tested and compared to those of human recombinant SOD (hrSOD) and its conjugate form with polyethyleneglycol (PEG) using fer- ricytochrome c reduction assay. Stability constant of Cu(II)-DIPS was measured po- tentiometrically using SCOGS2 program. In the presence of 10 g/L albumin, Cu(II)-DIPS lost most of its SOD mimetic activity. HrSOD was modified with polyethylene glycol (PEG) of M.W. 5000. These conjugates have markedly prolonged plasma half-lives of enzymatic activity (15.5 hr) compared to native hrSOD (5 min). In summary, efficient SOD mimetics should be stable enough not to dissociate in blood by serum protein. HrSOD could have longer half-life by conjugation with inert PEG for sustained SOD effect.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.8
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• pp.804-811
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• 2009

This paper deals with the relationship between zeros and step response of the second and third order LTI(Linear Time Invariant) SISO(Single-Input and Single-Output) systems. As well known, if a system has a single unstable zero, it shows the step response with undershoot and, on the other hand, a stable zero slower than the dominant pole causes the system to have the step response with overshoot. Generally, in the case of a system with two unstable real zeros, it is known to have B type undershoot[7]. But there are many complex cases of the step response extrema corresponding to zeros location in third order systems. This paper investigates the whole cases depending on DC gains of the additive equivalence systems and they are to be classified by the region of zeros which are related to the shape of the step response. Moreover, monotone nondecreasing conditions are proposed in the case of complex conjugate zeros as well as the case of two stable zeros.