• IMMUNE NETWORK
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• 제22권1호
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• pp.5.1-5.22
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• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• 한류연구
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• 제2권2호
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• pp.27-34
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• 2023

Purpose: The purpose of this study is to discuss on Daeryuk Baekje (the Continental Baekje), as new researches are beginning to emerge on the existing theory that Baekje exits only in the Korean Peninsula. Research design, data and methodology: We intend to systematically reveal this new theory by carefully examining the early founding process of Baekje, the process of determining its capital city and the ancient documents related to it. Objective analysis and research were conducted through literature research including not only domestic research data but, also research data from overseas. Results: Baekje existed on the Continent and on the Peninsula in the early days of Baekje establishment, before the Kingdom was established, so-called Hanseong Baekje. Conclusion: Biryu and Onjo settled down near Yoseo and Jinpyeong when they first moved to the south from Goguryeo. Biryu led hundred families to Michuhol and established Baekje. Onjo established Sipje at the Wirye Castle with ten of his servants. After Biryu's death the people of Baekje pledge allegiance to Onjo. The Sipje changed its country's name to Baekje. This illustrates that the country was operated with a capital in two regions, in the Continent and the Korean Peninsula. The country was ruled under two royal castles with 22 provincial governments (Dam-ro). Each area was ruled by the royal families and the competent prince among them succeeded to the next throne. It is a unique governing system and illustrates that Baekje existed in the Continent.

• 한국콘텐츠학회논문지
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• 제8권12호
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• pp.264-274
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• 2008

최근, 고령화사회로 진입하면서 인적자원의 효율적 관리가 무엇보다 중요해지고 있다. 이는 우리의 삶의 방식이 평균수명의 연장으로 '30+30+${\alopha}$'에서 '30+30+30'의 인생, 일명 트리플 30(triple 30s)으로 바뀌고 있기 때문이다. 따라서 공공부분의 경우에도 고령화의 급속한 진전에 적절하게 대응할 수 있는 퇴직관리시스템의 구축이 필요하다. 특히 21세기 지식기반사회에서 인적자원관리 측면에서의 고령화사회에 따른 유능한 퇴직공무원의 효율적 활용 문제는 국가경쟁력과도 직결된다. 이에 본 연구는 고령화사회에 따른 퇴직공무원의 퇴직관리시스템의 구축방안을 제시하고자 한다. 연구의 결과로 제시되는 퇴직관리의 방향으로는 첫째, 퇴직관리는 상시적으로 이루어져야 한다. 둘째, 맞춤형 퇴직관리가 이루어져야 한다. 셋째, 외부조직과 연계한 네트워크의 구축이 필요하다. 이를 위해서는 퇴직관리체계 모형의 설정과 퇴직관리 대상자 선정의 범위 문제, 퇴직관리 프로그램 등에 대한 심도 있는 연구와 사회적 합의가 요구된다.

• 한국경제지리학회지
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• 제10권3호
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• pp.263-280
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• 2007

최근 세계 여러 나라에서 문화 예술 활동의 진흥을 통해 지역경제를 활성화하고, 지역의 정체성을 강화하는 한편, 주민들의 삶의 질을 제고하고자 노력하고 있다. 특히 선진 공업국들은 제조업의 침체로 인해 도시경제가 쇠퇴하고, 도시기반시설이 노후화, 혹은 유휴화되는 상황에 직면하여 문화활동을 진흥하여 그러한 문제를 해결하고자 하고 있다. 본 연구에서 취급하고자 하는 캐나다 온타리오 주의 스트랫포드는 제조업의 침체에 대비하여 이미 1953년부터 셰익스피어 작품을 소재로 매년 연극축제를 개최하여 북미 최고 수준의 극단을 보유하고 연간 약 60만 명의 관객과 200만 명의 관광객을 유치할 수 있게 되었다. 스트랫포드 시는 또한 이 사업을 통해 북미 전체, 혹은 세계적으로 알려졌고, 문화산업 클러스터를 형성하여 지역경제도 활성화시켰다. 본 연구는 스트랫포드의 이러한 성공 사례를 분석하여 한국의 문화산업 정책에 시사하는 바를 도출하는 한편, 문화 예술 활동의 활성화 과정을 유도하는 혁신주체는 무엇인지, 그들간의 관계는 어떻게 설정되었는지를 규명하고자 한다.

• 한국중재학회지:중재연구
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• 제20권1호
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• pp.133-167
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• 2010

The enforcement of commercial arbitration awards in the People's Republic of China is one the controversial obstacles faced by foreign investors in China. The foreign investor will fail to enforce the arbitration award, if the Chinese court refuses the enforcement in China, even if the arbitration tribunal rules the award in favor of foreign investor who is in dispute with Chinese partners. In Korea, we have not many researches in the enforcement of foreign related awards and awards ruled by other jurisdiction. In recent times, Professor Kyung-Ja Cha(2005) and Professor Sun-Jeong Kim(2008) analyzed the enforcement of arbitration awards in China. Professor Kyung-Ja Cha(2005) reports the details of the enforcement statistics of CIETAC during 1990s. Professor Sun-Jeong Kim(2008) analyzed the obstacles of the enforcement of foreign related awards in China. This paper extends their researches in the field of the enforcement of arbitration awards in China. First, this paper extends Professor Kyung-Ja Cha(2005)'s study by introducing the Chinese enforcement situation during the period of 2000-2007. Second, this paper extends Professor Sunjung Kim(2008) emphasizes the local protectionism and the weakness of judiciary as key factors of obstacles to enforce the foreign related awards in People's Republic of China. This paper, additionally, highlights the role of the Guanxi and the antagonism of court toward arbitration institution to enforce the foreign related awards in People's Republic of China. Third, this study provides the recent developments of Supreme People's Court(SPC)'s rules to narrow down the gap between the practices of international arbitration and those of People's Republic of China. The Implications of this study are as follows. First, it is desirable for foreign investors to appoint the CIETAC or BAC as the arbitration commission in China. Second, the local competent attorney is the best choice to solve the respondent's insolvency in China. Third, foreign investors is required to monitor the provisions on the electronic instruments such as EDI and Email in Chinese law.

• Reproductive and Developmental Biology
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• 제36권4호
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• pp.237-241
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• 2012

Embryonic genome activation (EGA) is the first major transition that occurs after fertilization, and entails a dramatic reprogramming of gene expression that is essential for continued development. Although it has been suggested that EGA in porcine embryos starts at the four-cell stage, recent evidence indicates that EGA may commence even earlier; however, the molecular details of EGA remain incompletely understood. The RNA polymerase II of eukaryotes transcribes mRNAs and most small nuclear RNAs. The largest subunit of RNA polymerase II can become phosphorylated in the C-terminal domain. The unphosphorylated form of the RNA polymerase II largest subunit C-terminal domain (IIa) plays a role in initiation of transcription, and the phosphorylated form (IIo) is required for transcriptional elongation and mRNA splicing. In the present study, we explored the nuclear translocation, nuclear localization, and phosphorylation dynamics of the RNA polymerase II C-terminal domain in immature pig oocytes, mature oocytes, two-, four-, and eight-cell embryos, and the morula and blastocyst. To this end, we used antibodies specific for the IIa and IIo forms of RNA polymerase II to stain the proteins. Unphosphorylated RNA polymerase II stained strongly in the nuclei of germinal vesicle oocytes, whereas the phosphorylated form of the enzyme was confined to the chromatin of prophase I oocytes. After fertilization, both unphosphorylated and phosphorylated RNA polymerase II began to accumulate in the nuclei of early stage one-cell embryos, and this pattern was maintained through to the blastocyst stage. The results suggest that both porcine oocytes and early embryos are transcriptionally competent, and that transcription of embryonic genes during the first three cell cycles parallels expression of phosphorylated RNA polymerase II.

• 한국발생생물학회지:발생과생식
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• 제18권2호
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• pp.117-125
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• 2014

Vitrification method is widely used in oocyte cryopreservation for IVF but the birth rates are lower than that of the fresh oocyte. One of the known main reasons is structural instability of meiotic spindle and chromosome systems of mature oocyte. To get the best way for keeping competence of matured oocytes, we studied the best conditions for vitrification focused on equilibration times. The mature oocytes were underwent vitrification with current popular method and analyzed the survival rates, microtubule stability and DNA integrity. The survival rates of recovered oocyte are almost same between groups and are more than 93%. The structural configuration of meiotic spindle was well kept in 10 min equilibration group and the stability rate was almost same with that of control. The chromosomal breakdown was observed in all experimental groups, but the chromosomal stability was higher in 10 min equilibration group than the other groups. The 10 min equilibration group showed best condition compared with the other groups. Based on these results, the equilibration time is one of the key factors in successful keeping for competence of mature oocyte. Although, more fine analysis about the effects of physical stress on oocyte during vitrification is needed to define the optimal condition, it is suggested that the optimal equilibration time to get competent oocyte in mouse is 10 min. Information acquired this study may provide insight into intracellular structural events occurring in human oocytes after vitrification and application for cryopreservation of human oocyte.

• 한국경제지리학회지
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• 제14권4호
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• pp.486-505
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• 2011

한국의 경제발전은 세계적으로 잘 알려져 있고, 또한 많은 이론화의 대상이 되어 왔다. 이에 견주어 한국발전의 공간적 차원에 대해선 그렇지 못해 왔다. 사실, 한국의 지역(산업)정책은 한국의 발전레짐을 공간적으로 업그레이드시키는 데 주효한 역할을 했다. 이 논문은 한국의 지역산업정책을 산업경제를 바탕으로 했던 구지역정책과 신지식경제를 바탕으로 하는 신지역정책으로 구분하되, 특히 후자의 성공적 작동 요인을 분석하는 데 초점을 두고 있다. 한국경제의 선진화와 더불어 직면하게 되는 새로운 지역정책의 도전을 살펴보면서 지역정책의 향후 보완과제도 함께 검토한다.

• 수산해양교육연구
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• 제2권1호
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• pp.29-35
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• 1989

It is indispensable for the marine officers who are engaged in the international voyage to make command of maritime English fluently. The Marine Officers Act in Korea which is under ammending in 1989 prescribes the proportion of maritime Englishin English examination is made to be 60% for the 4th and 5th class marine officer-license examination. A concrete syllabus or content of maritime English is not established yet with the exception of a general prescription of minimun knowledge required for certification of marine officers in the IMO/STCW Convention. The authors, who rewrote the maritime English textbook for the course of the fisheries high, schools and the merchant marine high schools, settled the syllabi of nautical English and marine engineering English for the course as follows : 1. The syllabus of nautical English, includes maritime English readings, the IMO English dialogue on port entry, writing of logbooks, night order books, and docking and repair specifications. 2. The syllabus of marine engineering English includes maritime English readings, dialogue on oil supply, writing of engine logbooks and oil record books, standing orders, and docking and repair specifications. The authors propose that the realm of these class marine officer-license examination on maritime English should be limited within in the above mentioned textbook. As maritime English is made to be included in the 4th and 5th marine officer liscence examination since 1989, high schools concerned need to reform the curricula to complete at least 6 units for this subject. On the other hand, the competent authority of this examination must secure questions as much as possible to promote the reliability of them.

• 한국중재학회지:중재연구
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• 제20권3호
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• pp.3-24
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• 2010

In the approaching 21th century, the outstanding development in international trade and commerce has established arbitration as the preferred form of dispute resolution on international business transaction. Because the form of commercial dispute becomes more complicated and varied with the quantitative increase of them, the reasonable and rapid settlement of them must be the important problem simultaneously. In this article, the author discusses various issues on the recognition and enforcement of an foreign arbitral awards under Korean Arbitration Act, which is modeled after the Model Law on International Commercial Arbitration of the UNCITRAL of 1985. The Dec. 31, 1999 amendment to the Korean Arbitration Act admits the basis for enforcement of foreign arbitral awards rendered under United Nations Convention on the Recognition and Enforcement of Foreign Arbitral Awards of 1958(commonly known as the New York Convention). Korea has acceded to the New York Convention since 1973. When acceding to the convention, Korea declared that it will apply the Convention to the recognition and enforcement of awards made only in the territory of anther Contracting State on the basis of reciprocity. Also, Korea declared that it will apply the Convention only to differences arising out of legal relationships, whether contractual or not, which are considered as commercial under the national law of Korea. The provision relating to the enforcement of arbitral awards falling under the New York Convention consists of Article III, IV, V. In particular, Article V of the New York Convention enumerates the grounds for refusal of recognition foreign arbitral awards. The grounds are separated into two categories : One that abides by procedures and the others are based on national legal sovereignty. In Korea, a holder of a foreign arbitral award is obliged to request from the court a judgment ordering enforcement of awards. Because Korea requires enforcement to be based on a judgement, the result is that arbitral of award holders are forced to institute domestic litigation.