• 한국자동차공학회논문집
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• 제7권6호
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• pp.123-134
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• 1999

Nowadays since the automobile is regarded as the third living space, comfortable conditions are required in the passenger compartment. The customer's concern on air-conditioning/heating, ventilation and demisting/defrosting performances has been much increased. Both ventilation and demisting /defrosting performances are directly influenced by register location, shape of regist guide vane, ventilation flow rate, air distribution , and air circulation pattern. Diffuse plume of air from the register is desirable not only to maintain comfort when the comfort when the comfortable condition has been satisfied but to improve demisting /defrosting performance. In this study, experimental and numerical investigation about the flow field of six different register vane types were carried out , respectively. The numerical analysis, based upon the $textsc{k}$-$\varepsilon$ turbulence model , was applied to the air flow field. The results show that the shape of register guide vane should be considered as an important design paramter.

• 약학회지
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• 제46권1호
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• pp.63-68
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• 2002

The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors influencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, weight, sect creatinine (Scr) and dose and pharmacokinetic parameters were estimated with stepwise linear recession analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 h $r_{-1}$, CL/F was 37.71 L/hr, Vd/F was 200 L and t/ sub 1/2 / was 3.68 hrs for a male Korean with 170 m height and 1.0 mg/dL Scr.

• 한국ITS학회 논문지
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• 제11권1호
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• pp.53-65
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• 2012

최근 차량내 무선통신이 자동차 산업에서 큰 관심을 받고 있으며 UWB 기술이 차량내 통신 시스템에 유력한 기술로 고려되고 있다. 차량내 통신 채널의 측정과 모델링에 대한 많은 연구가 이루어져 왔으나, 차량내 통신환경에서 다양한 PHY Layer 기술에 대한 성능 분석은 여전히 많은 관심의 대상이 되고 있다. 본 논문의 목적은 차량내 채널환경에서 IEEE 802.15.4a PHY 시스템의 성능을 분석함에 있다. 새시와 엔진 부분의 채널 모델을 설정하고, 동기식 및 비동기식 수신기의 성능을 시뮬레이션을 통하여 분석하였다.

• 수산해양기술연구
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• 제52권2호
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• pp.88-95
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• 2016

Most grid sorting has been used to sort out flatfish in shrimp fisheries, while double grid systems have been tested to separate smaller shrimp. The escape of juvenile red seabream through separating panels made with steel grids or large mesh tested for masking effects in a two-species system. Fish behavior was observed in a circulating water tank. The escape rate was 20% greater with the separating codends than with the normal codend in the single-species experiments. The rates in the two-species experiments were 30% or 20% greater than the single-species rates for the normal or separating codends, respectively. The seabream retention rates in the grid separator codend decreased as rockfish retention increased, possibly due to a threat effect. Conversely, the retention rate of both species increased concurrently in the net separator, possibly due to a masking effect. The escape rates of juvenile red seabream varied by compartment in the mesh separating codend. These results suggest that grid separating codends can be used in the field as towed fishing gear to reduce juvenile catch.

• 한국화재소방학회논문지
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• 제12권2호
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• pp.17-28
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• 1998

건물 화재시 예상되는 내장재의 실째 화재성농올 기준으로 한 위험성 명가방법올 제시하였다. 이률 위해 ISO Room Corner Test. (9705)를 기준으로 Qui ntie re의 화재확산 모델을 이용하여 내장재의 열 적 특성과 플래쉬 오버 도달시간과의 상관성을 유도하고 스쩨덴의 실제 시험결과와 비교 분석하였다. 이 결과, 내장재의 상대척인 화재위험성은 화재확산 변수 b륨 기준으로 명가될 수 있었다.

• Nuclear Engineering and Technology
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• 제51권8호
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• pp.1939-1950
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• 2019

The MELCOR code useful for a plant-specific hydrogen risk analysis has inevitable limitations in prediction of a turbulent flow of a hydrogen mixture. To investigate the accuracy of the hydrogen risk analysis by the MELCOR code, results for the turbulent gas behavior at pipe rupture accident were compared with CFX results which were verified by the American National Standard Institute (ANSI) model. The postulated accident scenario was selected to be surge line failure induced by station blackout of an Optimized Power Reactor 1000 MWe (OPR1000). When the surge line failure occurred, the flow out of the surgeline was strongly turbulent, from which the MELCOR code predicted that a substantial amount of hydrogen could be released. Nevertheless, the results indicated nonflammable mixtures owing to the high steam concentration released before the failure. On the other hand, the CFX code solving the three-dimensional fluid dynamics by incorporating the turbulence closure model predicted that the flammable area continuously existed at the jet interface even in the rising hydrogen mixtures. In conclusion, this study confirmed that the MELCOR code, which has limitations in turbulence analysis, could underestimate the existence of local combustible gas at pipe rupture accident. This clear comparison between two codes can contribute to establishing a guideline for computational hydrogen risk analysis.

• 멤브레인
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• 제3권1호
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• pp.29-34
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• 1993

본 논문에서는 역삼투막 공정과 투과 증발막 공정이 Paul과 Ebra-Lima 모델을 사용하여 이론적으로 서로 비교되어졌다. 이 모델로부터 막내에 있는 액의 농도를 역삼투 공정의 경우 압력이 막의 윗쪽에 가하여졌을 때 (반면에 투과 증발 공정의 경우는 가하여진 압력이 무한대일 때) 막 -n-hexane 그리고 rubber 막-benzene 계들에 대하여 계산되어졌다. 또한 polyethylene-n-hexane 그리고 polyethlene-benzene 계들에 대하여 역삼투 및 투과 증발 공정의 투과도가 계산되어졌고 비교되어졌다. 이론적으로는, 투과 증발 공저으이 투과도가 역삼투 공저의 투과도 보다 더 컸음을 알 수 있었다.

• 국토계획
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• 제53권7호
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• pp.39-48
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• 2018

The purpose of this study is to verify the stable flight conditions of drones within a limited urban area by using the ICAO(International Civil Aviation Organization) reich model which is using to evaluate civil aircraft stability. The results of the study are summarized as follows. First, in order for the drones flying stably, the horizontal safety separation distance between a drone and another should be at least 1,852M. Second, assuming that no obstacles within 1,852M of horizontal space, two drones can be fly into upper and lower spaces. However there are obstacles such as buildings, it is impossible to secure a 1,852M distance between drones. Third, sensitivity analysis point out that the separation interval($s_x$) of drone aviation has the greatest influence on the TLS(Target Level of Safety). If future research is conducted to lower the numerical values, the safety distance between a drone and another drone will be drastically reduced, allowing more detailed urban space division, and will be presented as a scientific numerical value for establishing a dedicated path for the drones.

• 약학회지
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• 제59권3호
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• pp.92-97
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• 2015

KIOM-MA128 is a novel Korean herbal medicine with anti-atopic, anti-inflammatory and anti-asthmatic effects. This article presents the first pharmacokinetic study on KIOM-MA128. The purpose of this study was to characterize a pharmacokinetic characteristic of matrine, a potential marker of KIOM-MA128, in rats using population pharmacokinetic model. 1, 2 and 8 g/kg of KIOM-MA128 were administered to rats orally and plasma concentrations of matrine was determined by HPLC-MS/MS. Non-compartmental analysis (NCA) was performed using Phoenix$^{(R)}$ and pharmacokinetic model was built using NONMEM$^{(R)}$. This model was validated with internal validation which is visual predictive check (VPC) and bootstrap. The NCA result of matrine showed that $C_{max}$ was 294.24, 552.22 and 868.65 ng/ml, $AUC_{inf}$ was 1273.05, 2724.76 and $9743.25ng{\cdot}hr/ml$ and $T_{max}$ was 1, 1.3 and 2.3 hr for the doses of 1, 2, and 8 g/kg, respectively. The rat plasma concentrations were described very well with one-compartment model. Pharmacokinetic model for matrine was successfully developed and evaluated. Finally, our model is helpful to understand pharmacokinetic characteristic of KIOM-MA128.

• 한국임상약학회지
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• 제28권1호
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• pp.24-29
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• 2018

Background: Cyclosporine is an immunosuppressive agent used to treat and prevent graft versus host reaction (GVHR)-a complication associated with stem cell transplantation. This study aimed to develop a population pharmacokinetic model of cyclosporine and investigate factors affecting cyclosporine clearance in pediatric hematopoietic stem cell transplant patients. Methods: A total of 650 cyclosporine concentrations recorded in 65 patients who underwent hematopoietic stem cell transplantation were used. Data including age, sex, weight, height, body surface area (BSA), type of disease, chemotherapy before stem cell transplantation, type of donor, serum creatinine levels, total bilirubin concentration, hematocrit value, and type of concomitant anti-fungal agents and methylprednisolone used were retrospectively collected. Data related to cyclosporine dosage, administration time, and blood concentration were also collected. All data were analyzed using the non-linear mixed effect model; a two-compartment model with first-order elimination was used. Results: The population pharmacokinetic model of cyclosporine using the NONMEM program was as follows: $CL(L/h)=5.9{\times}(BSA/1.2)^{0.9}$, V2 (L) = 54.5, Q (L/h) = 3.5, V3 (L) = 1080.0, $k_a(h^{-1})=0.000377$. BSA was selected as a covariate of cyclosporine clearance, which increased with an increase in BSA. Conclusion: A population pharmacokinetic model for Korean pediatric hematopoietic stem cell transplant patients was developed, and the important factor affecting cyclosporine clearance was found to be BSA. The model might contribute to the development of the most appropriate dosing regimen for cyclosporine. Further studies on population pharmacokinetics should be carried out, prospectively targeting pediatric patients.