• 대한한방소아과학회지
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• 제21권1호
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• pp.189-209
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• 2007

Objectives : In order to study the effect of Dangkwiyughwangtang and Okbyoungpoongsangamibang on the immune response induced by methotrexate in mice. Method : Delayed type of hypersensitivity, hemagglutinin titer, hemolysin titer, rosette forming cells, phagocytic activity for immune response, lymphocyte transformation, and productivity of Interleukin-2 were measured. Results : Body weight decreasing was significantly inhibited as compared with control group in both the Dangkwiyughwangtang and Okbyoungpoongsangamibang groups. Delayed type of hypersensitivity was significantly increased as compared with control group in both groups Hemagglutinin titer was significantly increased as compared with control group in both groups. Hemolysin titer was significantly increased as compared with control group in the Okbyoungpoongsangamibang group. Rosette forming cells were significantly increased as compared with control group in both groups. Phagocytic activity for immune response was slightly decreased in the Dangkwiyughwangtang group and slightly increased in the Okbyoungpoongsangamibang group insignificantly as compared with the control group. Lymphocyte transformation was significantly increased as compared with the control group in both the Dangkwiyughwangtang and Okbyoungpoongsangamibang groups. Productivity of Interleukin-2 was significantly increased as compared with the control group in both the Dangkwiyughwangtang and Okbyoungpoongsangamibang groups. Conclusion : Both the Dangkwiyughwangtang and Okbyoungpoongsangamibang groups enhance immunity in mice.

• 혜화의학회지
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• 제13권2호
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• pp.97-107
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• 2004

As a long-term goal for the development of new prescriptions for hyperlipidemia, SGHHT was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats began to show lower body weight beginning one week after SGHHT treatment compared to non-treated control group animals. 2. Cholesterol levels showed a significant decrease beginning three weeks after SGHHT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group.6. SGOT levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group whereas there was no significant change in SGPT levels. 7. HDL-cholesterol levels were significantly increased in SGHHT- treated animal group compared to the hyperlipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in SGHHT-treated animal group compared to the hyperlidemia-induced control group.

• The Journal of Korean Physical Therapy
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• 제15권2호
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• pp.19-51
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• 2003

To demonstrate the effect of massages on the skeletal muscles of immobilization ddY mice models induced by right side sciatic nerve neurectomy, the cross sectional histological profiles of the muscularis (M) gastrocnemius, M. tibialis cranialis and M. tibialis caudalis were observed after 28 days of treatment of massages with the changes of body weight, thickness of hind limb and individual muscle weights. In addition, changes of serum aspartate amino- transferase (AST) and creatine phosphokinase (CK) levels were also demonstrated with diameter of individual muscle fiber and muscle fasciculata, and number of muscle fiber in each of three types of muscles located in the calf. The experimental groups were divided into five groups, 1) Sham-operated group (Sham), 2) Neurectomized but not massage control group (Control), 3) Neurectomized and massage at knee joint regions (T1), 4) Neurectomized and massage at calf regions (T2), and 5) Neurectomized and massages at achilles tendon regions (T3). The experimental animals were used 5 per groups. The results are as follow: 1. No significant changes of body weight were demonstrated in this groups during whole experimental periods compared to that of Sham group. In addition, no significant changes of body weight gains during experimental periods (Day 0 - Day 27: 28 days of treatment) were also observed. 2. The thickness of intact left side hind limb was not changes in all tested groups compared to that of Sham group. However, the thickness of right side hind limb were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of thickness of hind limb between right and left sides were also significantly increased in Control and massage groups (T1, T2 and T3) compared to that of Sham group. However, the thickness of right side of hind limb were significantly increased and the differences of thickness between both sides of hind limb were dramatically decreased in massage groups compared to that of Control group in followed order: T1 > T3 > T2. 3. Absolute and relative weight of M. gastrocnemius in the intact left side of hind limb was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. gastrocnemius were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. gastrocnemius between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. gastrocnemius were significantly increased and the differences of weight between both sides of M. gastrocnemius were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 >. 4. Absolute and relative weight of M. tibialis cranialis in the intact left side was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. tibialis cranialis were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. tibialis cranialis between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. tibialis cranialis were significantly increased and . the differences of weight between both sides of M. tibialis cranialis were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 > T2. 5. Absolute and relative weight of M. tibialis caudalis in the intact left side was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. tibialis caudalis were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. tibialis caudalis between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. tibialis caudalis were significantly increased and the differences of weight between both sides of M. tibialis caudalis were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 > T2. 6. A significant increase of serum AST levels were demonstrated in Control group. However, serum AST levels of massage groups were significantly decreased compared to that of Control group in followed order: T3 > T1 > T2. In case of 73 group, the values decreased into similar levels compared to that of Sham group. 7. A significant increase of serum CK levels were demonstrated in Control group. However, serum CK levels of massage groups were significantly decreased compared to that of Control group in followed order: T3 > T1 > T2.

• 사상체질의학회지
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• 제19권2호
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• pp.40-52
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• 2007

1. Objectives and Methods The purpose of this study was to objectify the diagnosis of Sasang Constitution. 63 Male Juvenile's and 151 Female Juvenile's sentences were analyzed into 73 factors like Pitch, APQ, Shimmer, Octave and Energy, etc. Juvenile's sentences were classified into 6 categories: total Male Juvenile group, under 12 years old Male Juvenile grout, over 13 years old Male Juvenile group, total Female Juvenile group, under 12 years old Female Juvenile group and over 13 years old Female Juvenile group. 2. Results 1) In Total Male Juvenile group, there were no significant differences among constitutional groups in APQ and Octave segment. Taeumin's Center freq.(3) was significantly high compared with Soyangin group. Soeumin's Center freq.(5) was significantly high compared with Soyangin and Taeumin groups. Taeumin's Octave3 Shimmer was significantly high compared with Soeumin group. Soeumin's Octave6 Shimmer was significantly high compared with Taeumin group. Solyangin's D# Tot E was significantly high compared with Taeumin group. 2) In Under 12 years old Male Juvenile group, there were on significantly among constitutional groups in Pitch, APQ, Octave and Energy segment. Taeumin's Octave3 Shimmer and G Shimmer(1) were significantly high compared with Soeumin group. 3) In Over 13 years old Male Juvenile group, there were no signigicant differences among constitutional groups in Pitch, APQ and Shimmer segment. Soyangin's and Soeumin's Octave6 were significantly high compared with Taeumin group. Soyangin's $0k{\sim}2k$ Total Sum, $0k{\sim}2k$ Dev., $2k{\sim}4k$ Total Sum, $2k{\sim}4k$ Dev., A Dev.(1), D# Dev.(1) and G# Dev.(1) were significantly high compared with Taeumin group. Soyangin's and Soeumin's G# Tot E were significantly high compared with Taeumin group. 4) In Total Female Juvenile group, there were no significant differences among constitutional groups in Pitch and APQ segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's Octave6 was significantly high compared with Soeumin group. Solyangin's 2k-4k Total Sum and B Tot E were significantly high compared with Soeumin group. 5) In Under 12 years old Female Juvenile group, there were no significant differences among constitutional groups in APQ and Energy segment. Soeumin's and Taeumin's Center Pitch and Pitch were significantly high compared with Soyangin group. Soyangin's Center freq.(1) and Center freq.(7) were significantly high compared with Soeumin and Taeeunin groups. Soyangin's and Taeumin's B Shimmer(1) and F# Shimmer(1) were significantly high compared with Soeumin group. Soeumin's D Shimmer(1) was significantly high compared with Soyangin group. Taeumin's and Soeumin's G# Shimmer(1) were significantly high compared with Soyangin group. Soyangin's and Taeumin's Octave2 were significantly high compared with Soeumin group. 6) In Over 13 years old Female Juvenile group, there were no significant differences among constitutional groups in Pitch, APQ and Octave segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's B Dev.(1) and F Dev.(1) were significantly high compared with Soeumin group. 3. Conclusions In juvenile groups, some sound factors are regarded as useful. PSSC are thought to be the objertive way to diagnose the Consitution and more participants are needed to get more efficiencies using PSSC.

• 한국치위생학회지
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• 제17권2호
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• pp.181-191
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• 2017

Objectives: The objective of the study was to investigate the use of dental hygiene devices in Korean adolescents. Methods: The study subjects were 70,362 adolescents in 800 schools who completed the 2015 Korean Youth Risk Behavior Web-based survey. Dependent variables included usage of dental floss, interdental brushes and mouthwash solutions. Independent variables included demographic characteristics of the subjects, health state and behaviors, and oral health behaviors and experience of oral diseases. Results: The related factors of usage of dental hygiene devices included gender, where females showed higher usage (OR=1.10) compared to males, father and mother's level of education where usage was higher in above university graduates (OR=1.20, OR=1.14) compared to less than high school graduation, economic status where usage was higherin high and middle (OR=1.93, OR=1.26) compared to low, vigorous physical activity where usage was higher in those who responded yes (OR=1.35) compared to no, subjective weight recognition where usage was higher in normal (OR=1.07) compared to under weight, sleep time where usage was higher in enough (OR=1.12) compared to not enough, number of toothbrushing (day) where usage was higher in 2 times or over 3 times (OR=1.35, OR=1.75) compared to below 1, oral health education experience (OR=1.10), sealant experience (OR=1.17) and scaling experience (OR=1.45) where usage was higher in those who responded yes compared to no, school where usage was lower in high school (OR=0.64) compared to middle school, residential type where usage was lower in rural area (OR=0.74) compared to metropolitan area, living form where usage was lower in other (OR=0.77), compared to with family, smoking (OR=0.93), and alcohol drinking (OR=0.90) where usage was lower in those who engage in the activities compared to those who didn't, BMI where usage was lower in normal (OR=0.87) and over weight (OR=0.98) compared to under weight. Conclusions: To expand the use of dental hygiene devices in the adolescents, it is necessary to improve the continuing education program for need and motivation of dental hygiene device usage.

• 한방재활의학과학회지
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• 제15권2호
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• pp.55-65
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• 2005

Objectives : Mahwangkanghwal-tang(Mahuangqianghuo-tang;MKT) is a prescription that treat clinically arthritis. The purpose of this study is to investigate effects of MKT extract on the adjuvant arthritis in pathological rats induced by Freund's complete adjvant($0.2m{\ell}/kg$). Methods : Experimental groups were divided into 4 groups ; Normal group were administered DDW $1.0m{\ell}$ to normal rats for 14 days, Control group were administered DDW $1.0m{\ell}$ to arthritic rats for 14 days, Sample A group were administered MKT $300m{\ell}/kg$ $1.0m{\ell}$ to arthritic rats for 14 days, Sample B group were administered MKT $500m{\ell}/kg$ $1.0m{\ell}$ to arthritic rats for 14 days. The present author observed body weight, inhibitory effect of edema, analgesic effects by hot plate, WBC, RBC, hemoglobin, hematocrit, platelet, total serum protein level and total serum cholesterol level. Results : 1. All sample group were increased body weight compared with control group, sample B group were significantly increased body weighty compared with control group. 2. All sample group significantly inhibited the rated of paw edema compared with control group. 3. All sample group significantly prolongated the escaping time compared with control group, sample B group significantly prolongated the paw licking time compared with control group. 4. All sample group were significantly decreased WBC compared with control group, sample B group were significantly decreased RBC compared with control group. 5. All sample group ware decreased hemoglobin and hematocrit compared with control group. 6. All sample group ware increased total serum cholesterol compared with control group, sample B group were significantly decreased platelet compared with control group. 7. All sample group ware significantly decreased total serum protein level compared with control group. 8. All sample group ware increased total serum cholesterol compared with control group, sample B group were significantly increased total serum cholesterol level compared with control group. Conclusions : We thought that Mahwangkanghwal-tang(Mahuangqianghuo-tang) could be used for curing rheumatoid arthritis, anti-inflammatory effect was somewhat better in much than small dosage.

• 대한한방내과학회지
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• 제13권2호
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• pp.126-133
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• 1992

Comparative amino acid quantities on the blood analysis was carried out to investigate the amino acid specific characters on the blood in four type of physical constitution 1. In TAE-EUM-IN group, compared with control group, the proline and the serine were more observed. 2. In SO-EUM-IN group, compared with control group, the aspartic acid was more observed. 3. In SO-YANG-IN group, compared with control group, the proline was more observed. but the threonine and the aspartic acid were less observed. 4. In SO-EUM-IN group, compared with TAE-EUM-IN group, the aspartic acid and the serine were more observed. 5. In SO-YANG-IN group, compared with TAE-EUM-IN group, the serine and the proline were more observed, but the glutamic acid and the threonine were less observed. 6. In SO-YANG-IN group, compared with SO-EUM-IN group, the threonine and the aspartic acid were less observed.

• 대한한방종양학회지
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• 제2권1호
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• pp.1-23
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• 1996

In order to research the effects of Shipjundaebotang(SDT) and Orostachys Herba(OH) on anti-tumor and immune response, the author performed this experimental study. Experimental groups are divided into five groups, which are solid extract of Orostachys Herba by water(OHW), solid extract of Orostachys Herba by ethanol(OHE), solid extract of Shipjundaebotang (SDT), solid extract of Shipjundaebotang added by solid extract of Orostachys Herba by water(SDT+OHW) and solid extract of Shipjundaebotang added by solid extract of Orostachys Herba by ethanol (SDT+OHE). In these experimental studies, extension of survival days for anti-tumor effect was observed, and de layed type hypersensitivity and rosette forming cell for cell-mediated immune response, hemagglutinin titers and hemolysin titers for humeral immune response, spleenic natural killer cell activity and carbon clearance (K-index) in vitro were measured with mice. The result were summerized as follows: I. SDT, SDT+OHW and SDT+OHE treated groups were significantly recognized to extend the survival days of tumor bearing mice as compared with the control group. 2. Delayed type hypersensitivity was significantly increased in SDT, SDT+OHW and SDT+OHE treated groups as compared with control group. 3. Hemagglutinin titer was increasred in all sample groups as compared with control group, but not significantly. 4. Hemolysin titers was significantly increased in SDT, SDT+OHW and SDT+OHE treated groups as compared with control group, and SDT+OHE treated group showed the increasing effect with significance as compared with the other sample groups. 5. For the effect of roselle forming cell quantitation, SDT, SDT+OHW and SDT+OHE treated groups showed the increasing effect with significance as compared with control group. 6. Natural killer cell activity was significantly increased in SDT+OHW as compared with comrol group, but the other groups, except OHW and SDT+OHW treated groups, revealed the increasing effect as compared with control group, but the significance was not admitted. 7. For the effect of K-index(Carbon clearance), SDT, SDT+OHW and SDT+OHE treated groups showed the increas ing effect with significance as compared with control group. 8. The study didn't show that Orostachys herba had any significance with survival days, anti-tumor effect and immune re sponse.

• 동의신경정신과학회지
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• 제14권2호
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• pp.79-94
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• 2003

This study aimed to evaluate the anti-stress effects of Palmuljungjiwon and Gamipalmuljungjiwon on the contents of monoamines in the regional brain of mice immobilized stress. The experimental animals were immobilized in stress cylinder(height: 15cm, diameter: 3cm) for 15 minutes, and administered of Palmuljungjiwon(1.14mg/l0g) and Gamipalmuljungjiwon(1.17mg/10g) water extract for 7 days before stress. The monoamines contents were measured by HPLC method in various part(frontal cortex, hypothalamus, corpus striatum and hippocampus) of mice brain. The following results were obtained : 1. In frontal cortex, the contents of norepinephrine a little decreased in all of the administered group, but the statistical significance was not recognized. The contents of dopamine were decreased with statistical significantly in Gamipalmuljungjiwon administered group compared to control group. The contents of serotonin were decreased with statistical significance in PalmulJungjiwon administered group compared to control group. 2. In hypothalamus, the contents of norepinephrine were decreased with statistical significantly in all of the administered group compared to control group. The contents of dopamine were decreased in all of the administered group compared to control group, but the statistical significance was not recognized. The contents of serotonin were decreased with statistical significantly in Gamipalmuljungjiwon administered group compared to control group. 3. In corpus striatum, the contents of norepinephrine were decreased with statistical significantly in Gamipalmuljungjiwon administered group compared to control group. The contents of dopamine were decreased in all of the administered group compared to control group, but the statistical significance was not recognized. The contents of serotonin were decreased with statistical significance in all of the administered group compared to control group 4. In hippocampus, the content of norepinephrine and dopamine a little decreased in all of the administered group, but the statistical significance was not recognized. The contents of serotonin were decreased with statistical significance in all of the administered group compared to control group. In conclusion, this study shows that Palmuljungjiwon and Gamipalmuljungjiwon are significantly effective on reducing and preventing stress in mice.

• 대한한방내과학회지
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• 제15권2호
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• pp.174-196
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• 1994

In order to investigate the effect of Samulbyulgapchoengpitang(SB) and one herb added(SBA) on anti-tumor and immune response, the author performed this experimental study, Tumor weight(TW), mean survival days(MSD) and body weight(BW) in vivo, natural killer cell activity(NKCA). rosette forming cells(RFC), phagoctic activity in recticuloendomethrial system(PA), delayed type hypersensitivity(DTH), hemoagglutinin titer(HA) and hemolysine(HL) in vitro were measured in mice. 1. MSD was prolonged in both of treated groups(SB and SBA) as compared with control group. 2. TW was decreased in both of treated groups with statistical significance as compared with control group. 3. BW was increased in both of treated groups and just only in SB with statistical significance as compared with control group. 4. DTH was increased in both of treated groups with statistical significance as compared with control group. 5. HA was increased in both of treated groups with statistical significance as compared with control group. 6. HL was increased in both of treated groups with statistical significance as compared with control group. 7. RFC was increased in both of treated groups and just only in SB with statistical significance as compared with control group. 8. NKCA was increased in both of treated groups with statistical significance as compared with control group. 9. PA was increased in both of treated groups with statistical significance as compared with control group. According to the above experimental results, it is suggested that SB and SBA will have anti-tumor substance and enhance the effect of immune response. But we have to consider the longtime prescription of SBA because there have been no experiments in its side effect or accumulation in body.