• Advances in environmental research
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• v.9 no.3
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• pp.151-160
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• 2020

Water quality demonstrates physical, chemical and biological characteristics of water. The quality of surface and groundwater is currently an important concern with population growth and industrialization. Over exploitation of water resources due to demand is causing the deterioration of surface water and ground water. Periodic water quality testing must be carried out to protect our water resources. The present research analyses the spatial variation of surface water and groundwater in and around the lakes of Hyderabad. Twenty-Seven lakes and their neighboring bore water samples are obtained for water quality monitoring. Samples are evaluated for specific physico-chemical parameters such as pH, Total Dissolved Solids (TDS), Cl, SO₄, Na, K, Ca, Mg, and Total Hardness (TH). The spatial variation of water quality parameters for the 27 lakes and groundwater were analysed. Correlation and multiple regression analysis were carried out to determine comparative study of lake and ground water. The study found that most of the lakes were polluted and this had an impact on surrounding ground water.

• Molecular & Cellular Toxicology
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• v.1 no.3
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• pp.157-163
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• 2005

Because of their widespread occurrence and substantial biological activity, halogenated aromatic hydrocarbons are one of the important classes of contaminants in the environment. We have performed comparative molecular field analysis (CoMFA) on structurally diverse ligands of Ah (dioxin) receptor to explore the physico-chemical requirements for binding. All CoMFA models have given $q^{2}$ value of more than 0.5 and $r^{2}$ value of more than 0.83. The predictive ability of the models was validated by an external test set, which gave satisfactory predictive $r^{2}$ values. Best predictions were obtained with CoMFA model of combined modified training set ($q^{2}=0.631,\;r^{2}=0.900$), giving predictive residual value = 0.002 log unit for the test compound. We have suggested a model comprises of four structurally different compounds, which offers a good predictability for various ligands. Our QSAR model is consistent with all previously established QSAR models with less structurally diverse ligands. The implications of the CoMFA/QSAR model presented herein are explored with respect to quantitative hazard identification of potential toxicants.

• International Journal of Oral Biology
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• v.39 no.3
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• pp.153-157
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• 2014

Natural biopolymers such as collagen and fibrin have been widely used in bone regenerative applications. Despite the frequent use, their comparative biological propertiesis are largely unknown. In a previous study, we found the superiority of fibrin to collagen in the adsorption of serum proteins and the proliferation and differentiation of cultured osteoblasts. In this study, we used an in vivo model to evaluate how effectively fibrin supports bone regeneration, as compared with collagen. Collagen and fibrin were placed in critical size defects made on rat calvarial bones. Compared with collagen, fibrin supported substantially more new bone tissue formation, which was confirmed by micro-CT measurement and histological analyses. The cells in the regenerative tissues of the fibrin-filled defects were immunostained strongly for Runx2, while collagen-placed defects were stained weakly. These in vivo results demonstrate that fibrin is superior to collagen in supporting bone regeneration.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.249-255
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• 2005

Angiotensin-converting enzyme (ACE) is primarily responsible for human hypertension. Current ACE drugs show serious cough and angiodema health problems due to the un-specific activity of the drug to ACE protein. The availability of ACE crystal structure (1UZF) provided the plausible biological orientation of inhibitors to ACE active site (C-domain). Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been constructed using the comparative molecula. field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a series of 28 ACE inhibitors. Alignment for CoMFA obtained by docking ligands to 1UZF protein using FlexX program showed better statistical model as compared to superposition of corresponding atoms. The statistical parameters indicate reasonable models for both CoMFA (q$^2$ = 0.530, r$^2$ = 0.998) and CoMSIA (q$^2$= 0.518, r$^2$ = 0.990). The 3D-QSAR analyses provide valuable information for the design of ACE inhibitors with potent activity towards C-domain of ACE. The group substitutions involving the phenyl ring and carbon chain at the propionyl and sulfonyl moieties of captopril are essential for specific activity to ACE.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.78-82
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• 2005

Three of the genus Pseudomonas (P. aeruginosa, P. putida, P. syringae) show highly different phenotypic characteristics among them. Two of the three members are pathogenic and the other is non-pathogenic. Comparative analyses of the complete genomes can elucidate the genomic similarities and differences among them. We analyzed the three genomes and the genes of them to reveal the degree of conservation of chromosomes and similarity of the genes. The 2-dimensional dot plot between the pathogenic P. aeruginosa and non-pathogenic P. putida shared higher portion of the nucleotide sequences than other two combinations. Comparison of the nucleotide compositions by calculating the genome-scale plot of G+C contents and GC skew showed the variation of location. Comparison of the metabolic capabilities using the functional classification of KEGG orthology revealed that the differences in the number of genes for the specific functional categories resulted in the phenotypic differences. Finally combination of the analyses using the protein homologs supported the evolutionary distance of the P. putida obtained from other genome-scale comparisons.

• Journal of Microbiology
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• v.44 no.1
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• pp.83-91
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• 2006

The sudden appearance and potential lethality of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) in humans has resulted in a focusing of new attention on the determination of both its origins and evolution. The relationship existing between SARS-CoV and other groups of coronaviruses was determined via analyses of phylogenetic trees and comparative genomic analyses of the coronavirus genes: polymerase (Orflab), spike (S), envelope (E), membrane (M) and nucleocapsid (N). Although the coronaviruses are traditionally classed into 3 groups, with SARS-CoV forming a $4^{th}$ group, the phylogenetic position and origins of SARS-CoV remain a matter of some controversy. Thus, we conducted extensive phylogeneitc analyses of the genes common to all coronavirus groups, using the Neighbor-joining, Maximum-likelihood, and Bayesian methods. Our data evidenced largely identical topology for all of the obtained phylogenetic trees, thus supporting the hypothesis that the relationship existing between SARS-CoV and group 2 coronavirus is a monophyletic one. Additional comparative genomic studies, including sequence similarity and protein secondary structure analyses, suggested that SARS-Co V may bear a closer relationship with group 2 than with the other coronavirus groups. Although our data strongly suggest that group 2 coronaviruses are most closely related with SARS-CoV, further and more detailed analyses may provide us with an increased amount of information regarding the origins and evolution of the coronaviruses, most notably SARS-CoV.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.6
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• pp.96-105
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• 2001

The purpose of this study is to establish landscape planning, and to find out to administrative system and improvement way on landscape plan in Korea. We have sought for research trend and the concept of landscape planning related to the landscape planning through the investigation of books and documents, and have analyzed the characteristics on the law for landscape plan in United State of America, United Kingdom,, France, Germany, Japan and Korea. As the results of this study are as follows; 1) A state developing local self-governing body as United State of America, United Kingdom and Germany carried out individually landscape plan. Especially, it raises clarity of administration to fix residents participation(Nonprofit Organization : NPO) and secures responsibility. 2) A state of centralized authoritarian rule as France and Japan applies common law to the nationwide but commission's concrete management or conference. 3) And so in Korea and applicable landscape plan was made on the basis of town-planning law and managed with ordinances for landscape. In here the important thing is division of role of central and local government and residents. This study proposes the system of planning and analyzed the related laws for the landscape formation and management. The future research on the character of the local areas, providing many chances with people in the community through publicity activities, and rearing the expert group on this matter should be made in the future.

• Journal of the Korean Institute of Rural Architecture
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• v.4 no.1
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• pp.71-86
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• 2002

This research aims to illustrate the structure of the ancient Korean wooden buildings by a comparative study of the historical resources such as stone remains, wall paintings historiographies and excavations. As stone pagodas are the most typical stone remains, I selected for analysis some stone pagodas which contain architectural elements and results of the study are as follows: 1) The number of stories and structural modes of the base stone part show the wooden architectural aspects: they have one or two stories and their base part is constructed in the mode of assembling rectangular stones. 2) The body of the pagoda contains such architectural elements as pillars, door and windows, crossbeams, balcony, bracket sets. 3) The roof of the stone pagoda contains such architectural elements as eaves, roofs and modes of stone assembling. The results inferred through this research could be of help for further comparative studies with the other secondary materials by providing basic knowledge for it.

• Journal of the Korean Institute of Rural Architecture
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• v.17 no.4
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• pp.41-48
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• 2015

The purpose of this study is to examine the Perception of local government officials, who are in charge of The Rural Village Development Project, and planners of local planning firms and Rural Research Institute participating the rural development planning and landscape planning, regarding the problems and improvements for rural landscape management. The results of this research can be summarized as follows. First, the majority of the subject were negative of creating rural landscape and its management. Both groups thought the living landscape was the most problematic. Second, the satisfaction about the rural landscape planning conducted through the Rural Village Development Project was very low. Nevertheless, it is considered that the rural landscape planning will be needed further. Third, the experience of conducting the rural landscape plans is not sufficient enough, which will cause tremendous confusion in the rural landscape administration in the future. Fourth, both groups believed that the rural landscape project will be most effective, while the landscape agreement is least effective. Finally, both groups agreed that strengthening the support for the landscape activities of residents is the most important way improving the further rural landscape management.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1047_1048
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• 2009

This paper describes comparative analysis results about the dynamic interaction of interconnected wind power system using the actual-size hardware simulator and the simulation model with PSCAD/EMTDC. The hardware simulator, which is composed of 2.0MVA induction motor with drive system and 1.5MW doubly-fed induction generator, was built and tested in Go-Chang Test Site of KEPCO for analyzing the dynamic interaction with the interconnected distribution system. The operation of hardware simulator was verified through comparative analysis between experimental results and simulation results obtained by simulation model with PSCAD/EMTDC. The developed hardware simulator and simulation model could be effectively used for analyzing the dynamic interaction, which has various phenomena depending on the wind variation and the network state of interconnected power system.