• Clinical and Experimental Pediatrics
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• 제51권10호
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• pp.1042-1046
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• 2008

The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has been limited because of their potential to induce arthropathy in juvenile animals. Despite class label warnings against use in children, prescriptions for quinolone antibiotics to treat infections in children have become increasingly prevalent. The main use of fluoroquinolones in pediatrics should be, understandably, in serious life-threatening infections for which other antibiotics therapies are not effective or available. While most of the published studies failed to detect an increased rate of articular adverse effects in children treated with fluoroquinolones, an increase in the use of these compounds, particularly in community-acquired lower respiratory infections, could accelerate the emergence of multidrug-resistant (including fluoroquinolone) pneumococcal strains. This review will discus the main issues related to the use of fluoroquinolones in children, the major problems of resistance developing among these compounds, with special emphasis on the potential side effects and skilled use of these alternative potent drugs in pediatric infection.

• Journal of Preventive Medicine and Public Health
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• 제50권4호
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• pp.274-277
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• 2017

Objectives: Legionnaires' disease (LD) is a severe type of pneumonia caused by inhalation of aerosols contaminated with Legionella. On September 22, 2016, a single case of LD was reported from a newly built apartment building in Gyeonggi province. This article describes an epidemiologic investigation of LD and identification of the possible source of infection. Methods: To identify the source of LD, we interviewed the patient's husband using a questionnaire based on the Legionella management guidelines from the Korea Centers for Disease Control and Prevention. Water samples from the site were collected and analyzed. An epidemiological investigation of the residents and visitors in the apartment building was conducted for 14 days before the index patient's symptoms first appeared to 14 days after the implementation of environmental control measures. Results: Legionella pneumophila serogroup 1 was isolated from the heated-water samples from the patient's residence and the basement of the apartment complex. Thirty-two suspected cases were reported from the apartment building during the surveillance period, yet all were confirmed negative based on urinary antigen tests. Conclusions: The likely source of infection was the building's potable water, particularly heated water. Further study of effective monitoring systems in heated potable water should be considered.

• Journal of Microbiology and Biotechnology
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• 제24권8호
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• pp.1059-1064
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• 2014

Staphylococcus aureus is a major human pathogen, implicated in both community and hospital acquired infections. The therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult because of multidrug resistance and strong biofilm-forming properties. Schiff bases have attracted attention as promising antibacterial agents. In this study, we investigated the in vitro activity of taurine-5-bromosalicylaldehyde Schiff base (TBSSB) against MRSA. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) were determined using a microtiter broth dilution method. TBSSB effectively inhibited planktonic MRSA, with an MIC of $32{\mu}g/ml$. The time-kill curve confirmed that TBSSB exhibited bactericidal activity against MRSA. TBSSB was also found to significantly inhibit MRSA biofilm formation at 24 h, especially at $1{\times}MIC$ and sub-MIC levels. Furthermore, scanning electron microscopy and transmission electron microscopy showed remarkable morphological and ultrastructural changes on the MRSA cell surface, due to exposure to TBSSB. This study indicated that TBSSB may be an effective bactericidal agent against MRSA.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제18권3호
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• pp.209-215
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• 2015

Mycoplasma pneumoniae is responsible for approximately 20% to 30% of community-acquired pneumonia, and is well known for its diverse extrapulmonary manifestations. However, acute necrotizing pancreatits is an extremely rare extrapulmonary manifestation of M. pneumoniae infection. A 6-year-old girl was admitted due to abdominal pain, vomiting, fever, and confused mentality. Acute necrotizing pancreatitis was diagnosed according to symptoms, laboratory test results, and abdominal computed tomography scans. M. pneumoniae infection was diagnosed by a 4-fold increase in antibodies to M. pneumoniae between acute and convalescent sera by particle agglutination antibody assay. No other etiologic factors or pathogens were detected. Despite the occurrence of a large infected pseudocyst during the course, the patient was able to discharge without morbidity by early aggressive supportive care. This is the first case in Korea of a child with acute necrotizing pancreatitis associated with M. pneumoniae infection.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.81-83
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• 2005

The Plant Signaling Network Research Center (SigNet) is a government-funded (by Korea's Ministry of Science and Technology (MOST)/ Korea Science and Engineering Foundation (KOSEF)) research center established at the School of Life Sciences and Biotechnology of Korea University in 2003. The SigNet conducts plant biological studies, especially in the field of developmental and defense biology. The research purpose of SigNet is dissection and analysis of plant development and defense signaling network through multiscientific approaches. Knowledge acquired from SigNet research scientists will provide new integrated view of understanding and potential application of plant development and defense mechanism. The other important mission of the SigNet is nurturing Center of Excellence for future outstanding research scientists of Korea. The SigNet will continue to expend every effort to achieve the goals for the future. Through passionate research endeavor of each laboratory and partnerships within inside and outside laboratories, we will continue to develop world-leading plant research group and to educate new generations of innovative researchers. As the SigNet looks toward the future, the SigNet will try to achieve its mission of research, education and service to the community. And the defense response research of our lab will be presented at later part.

• 컴퓨터교육학회논문지
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• 제18권5호
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• pp.55-62
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• 2015

지금은 국내외적으로 소프트웨어 중심 사회로 컴퓨팅사고력기반의 문제해결능력을 갖춘 창의적 인재 양성을 하기 위해 많은 나라들이 힘을 쏟고 있다. 더욱이 직업생활과 밀접한 관련이 있는 대학에서는 소프트교육에 대한 중요성을 인식하며 IT계열이 아닌 전공자들을 대상으로 한 프로그래밍 교육을 진행하고 있으며 이는 더욱 확산되는 추세이다. 따라서 대학에서 프로그래밍을 처음 접하는 학습자들이 초보 학습단계에서 보이는 어려움의 정도를 사고단계별로 설문하여 이를 통해 얻어진 결과를 토대로 컴퓨팅 사고영역과의 관련성을 탐색하는 연구를 실시함으로써 모든 학생들이 배우는 프로그래밍 교육설계에 도움을 주고자 한다.

• 기본간호학회지
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• 제25권1호
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• pp.33-45
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• 2018

Purpose: Objectives of this study were to identify and describe cultural meaning for nursing students in the class in fundamental nursing practice. Methods: Data were collected from November 2016 to May 2017 included focus group interviews and participants observation. The key informants in this study included 23 nursing students divided into 3 focus groups who had taken the course in fundamental nursing practice in university U and university S in Kyungpook, and university D in Jeonnam. Interviews continued until no new information could be identified from transcripts. Data were analyzed using the taxonomic analysis method developed by Spradley. Results: Based on the data acquired from the interviews, cultural domains in the class "fundamental nursing practice" were classified as 'community oriented activities', 'learning and playing space', 'relationship of difference and discrimination', 'time for present and future'. Conclusion: The culture in the class "fundamental nursing practice" could be summarized as 'non-standardized learning with team dynamics'. Also nursing students learned about a small society whose members are becoming nurses. Results indicate that it is critical for professors to understand students' values, beliefs and their attitude in order to aid in adjustment to class.

• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.149-160
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• 2017

Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the leading causes of death worldwide. Many genetic factors of the host and various environmental factors surrounding it have been studied as important determinants of the pathophysiology and outcomes of pneumococcal infections. Various cytokines, including transforming growth factor $(TGF)-{\beta}1$, are involved in different stages of the progression of pneumococcal infection. $TGF-{\beta}1$ is a cytokine that regulates a wide range of cellular and physiological functions, including immune and inflammatory responses. This cytokine has long been known as an anti-inflammatory cytokine that is critical to preventing the progression of an acute infection to a chronic condition. On the other hand, recent studies have unveiled the diverse roles of $TGF-{\beta}1$ on different stages of pneumococcal infections other than mitigating inflammation. This review summarizes the recent findings of the role of $TGF-{\beta}1$ on the pathophysiology of pneumococcal infections, which is fundamental to developing novel therapeutic strategies for such infections in immune-compromised patients.

• 보건의료산업학회지
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• 제8권2호
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• pp.175-185
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• 2014

This study analyzed individual happiness exponent according to local residents' perception degree of Health-Cities. The data, which is accumulated by the survey on relationship between happiness and perception degree of Health-Cities targeting 662 of local residents living in Y-gu in Busan, were analyzed using PASW 18.0. The results are as follows. To begin with, the results of Correlation Analysis on the relation between happiness index and cognition degree of Health-Cites indicate that the higher perception of Health-Cities'facilities, administrations, services, education, health environment and transportation the local residents have, the lower individual happiness index they acquired. The cognition degree of transportation has effects on local society and daily life; the cognition degree of facilities and businesses has impact on financial stability. The cognition degree of administrations has influence on psychological relaxation, services have meaningful effects on psychological stability, work and residence, education have statistically meaningful effects on psychological stability, families and marriage, individual human relationships in respect.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 춘계 학술발표회
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• pp.123-131
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• 2009

본 연구에서는 2차원 및 3차원 유한요소 해석을 이용하여 심층혼합처리 공법에 의한 연약지반 개량시 개량 심도를 결정 하였고, 그 결과는 다음과 같았다. 1. 2차원 해석 결과는 3차원 해석 결과 보다 약 10% 정도 크게 해석되었다. 2. 연약지반의 치환율이 5%이하 일 때 침하량은 급격히 증가하였다. 3. 심층혼합공법으로 연약지반 개량시 횡방향 간격 3m, 종방향 간격 6m, 그리고 8m의 심도로 개량하는것이 가장 경제적인 것으로 나타났다. 4. 심층혼합공법으로 연약지반 개량시 2차원 유한요소 해석보다 3차원 유한요소 해석으로 결정되어야 한다.