• 한국컴퓨터정보학회논문지
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• 제23권7호
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• pp.99-104
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• 2018

In this paper, we compare Fisher's continuous method with an exact discrete analog of Fisher's continuous method from permutation tests for combining p values. The discrete analog of Fisher's continuous method is known to be adequate for combining independent p values from discrete probability distributions. Also permutation tests are widely used as alternatives to conventional parametric tests since these tests are distribution-free, and yield discrete probability distributions and exact p values. In this paper, we obtain permutation p values from discrete probability distributions using Mann-Whitney test data sets (real data and hypothetical data) and combine p values by the exact discrete analog of Fisher's continuous method.

• 한국컴퓨터정보학회논문지
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• 제25권7호
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• pp.175-182
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• 2020

연속형 분포로부터 얻은 독립적인 p값들을 통합하는 Fisher의 고전적인 방법은 널리 사용되고 있지만 이산형 확률분포로부터 얻은 p값들을 통합하기에는 적절하지 않다. 대신에 유사 Fisher의 통합방법이 이산형 확률분포의 p값들을 통합하는 대안으로 사용된다. 본 논문에서는 첫째, 여러 표본들의 위치검정(Fisher-Pitman 검정과 Kruskal-Wallis 검정) 데이터와 관련된 이산형 확률분포로 부터 퍼뮤테이션 방법에 의해 p값들을 구하고, 둘째로 이 p값들을 유사 Fisher의 통합방법을 이용하여 통합한다. 그리고 Fisher의 고전적인 방법과 유사 Fisher의 통합방법의 결과를 비교한다.

• 응용통계연구
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• 제26권5호
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• pp.797-806
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• 2013

메타분석은 이전의 연구들의 결과를 결합하기 위해 많은 분야에서 널리 사용된다. 메타분석 방법들 중에 p-value의 통합은 가장 단순한 방법이며 Tippett (1931), Fisher (1932) Stouffer 등 (1949) 등이 p-value를 통합하는 다양한 방법들을 제안하였다. 이 논문에서 우리는 지수분포에 기초한 새로운 p-value의 통합 방법을 제안하였다. 또한, 몬테카를로 모의시험 연구를 통해 제안된 방법과 이전의 방법들의 검정력을 비교하였다.

• 응용통계연구
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• 제21권1호
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• pp.35-51
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• 2008

제 3상 임상시험에서 치료효과가 여러 반응변수(endpoints)로 측정될 때, 이들 반응 변수가 대둥하게 중요하여 주요 반응변수(primary endpoint)를 선택할 수 없는 상황이 발생할 수 있다. O'Brion (1984)은 이들 반응변수 모두를 종합하여 치료효과에 대한 단축검정(one-tailed testing) 통계량으로서 반응변수가 연속형(continuous) 자료로 측정되었을 때 Ordinary Least Square(OLS)와 Generalized Least Square(GLS) 검정 통계량을 제시하였다. Pocock 등 (1987)은 여러 형태, 즉 연속형, 이산형(binary), 생존(survival) 자료의 반응변수를 함께 분석할 수 있음을 언급하고 있으나 실제로 이와 같이 여러 형태의 반응변수 병합에 대한 문제점을 설명하거나 구체적으로 모의 실험으로서 이러한 경우의 OLS와 GLS통계량의 효율성을 알아보지는 않았다. 본 논문에서는 특히 여러 형태의 반응변수를 종합하여 치료효과에 대한 결론을 내리는데 P값의 병합 통계량을 제안하며, 이때 각 반응변수의 치료효과에 대한 검정 결과인 P값은 서로 상관성이 존재하는 P값이다. OLS 및 GLS 검정 통계량보다 장점을 지닌 P값의 병합방법 중, 방법 F와 G는 제 1종 오류가 유의수준보다 커서 검정의 결론이 잘못 내려질 수 있는 경우가 있고 방법 B는 제 1종의 오류가 잘 통계되고 또한 효율성이 높은 것으로 나타났다.

• Communications for Statistical Applications and Methods
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• 제22권6호
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• pp.639-646
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• 2015

We propose simultaneous tests for mean and variance under the normality assumption. After formulating the null hypothesis and its alternative, we construct test statistics based on the individual p-values for the partial tests with combining functions and derive the null distributions for the combining functions. We then illustrate our procedure with industrial data and compare the efficiency among the combining functions with individual partial ones by obtaining empirical powers through a simulation study. A discussion then follows on the intersection-union test with a combining function and simultaneous confidence region as a simultaneous inference; in addition, we discuss weighted functions and applications to the statistical quality control. Finally we comment on nonparametric simultaneous tests.

• 대한통합의학회지
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• 제11권2호
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• pp.69-76
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• 2023

Purpose : This study aimed to compare lung capacity measures (forced vital capacity; FVC, forced expiratory volume at 1 second; FEV1, and FEV1/FVC) and the activities of rectus femoris (RF) and gastrocnemius (GCM) muscles between young adults prescribed aerobic exercise combined with lower limb strength exercise (complex exercise) and those prescribed only aerobic exercise. Methods : We randomly divided 22 young adults into 2 groups: the complex exercise group that combined the leg strengthening and aerobic exercises (n = 11) and the aerobic-exercise-only group (n=11). Before the intervention, the FVC, FEV1, and FEV1/FVC values and the activities of RF and GCM muscles were measured. Measurements were in triplicates, and the average of the 3 measurements was used. The complex exercise group performed the treadmill exercise followed by squats and lunges, and the group performed only the treadmill exercise. Both groups were allocated the same time. Both groups performed the assigned exercise thrice a week for 3 weeks. After the intervention, the FVC, FEV1, and FEV1/FVC values and the activities of RF and GCM muscles were measured again. Results : The FVC and FEV1 values increased significantly in both groups after the intervention (p<.05). RF activity increased significantly after the intervention in the complex exercise group (p<.05), and the magnitude of change in RF activity after the intervention was significantly higher in the complex exercise group than in the aerobic-exercise-only group (p<.05). GCM activity also significantly increased after the intervention in both groups (p<.05). Conclusion : On the basis of our results, we recommend combining leg strengthening and aerobic exercise to improve leg muscle activity along with lung function.

• Imaging Science in Dentistry
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• 제50권2호
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• pp.153-159
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• 2020

Purpose: This study was conducted evaluate the influence of reconstruction parameters of micro-computed tomography (micro-CT) images on bone mineral density (BMD) analyses. Materials and Methods: The sample consisted of micro-CT images of the maxillae of 5 Wistar rats, acquired using a SkyScan 1174 unit (Bruker, Kontich, Belgium). Each acquisition was reconstructed following the manufacturer's recommendations(standard protocol; SP) for the application of artifact correction tools(beam hardening correction [BHC], 45%; smoothing filter, degree 2; and ring artifact correction [RAC], level 5). Additionally, images were reconstructed with 36 protocols combining different settings of artifact correction tools (P0 to P35). BMD analysis was performed for each reconstructed image. The BMD values obtained for each protocol were compared to those obtained using the SP through repeated-measures analysis of variance with the Dunnett post hoc test(α=0.05). Results: The BMD values obtained from all protocols that used a BHC of 45% did not significantly differ from those obtained using the SP (P>0.05). The other protocols all yielded significantly different BMD values from the SP(P<0.05). The smoothing and RAC tools did not affect BMD values. Conclusion: BMD values measured on micro-CT images were influenced by the BHC level. Higher levels of BHC induced higher values of BMD.

• 한국농공학회지
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• 제34권E호
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• pp.12-19
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• 1992

The effects of drainage system on evapotranspiration and drainage flows are studied. Data from drainage field experiment at Castalia in North Central Branch, Ohio Agricultural Research and Development Center were used in this study. A water table management model, ADATP (Agricultural Drainage and Pesticide Transport), which was developed by combining the GLEAMS and the subsurface drainage part of the DRAINMOD model with several modifications, was evaluated and used to predict hydrologic components. The ET is very much affected by the presence of tile drainage system but not significantly affected by the surface drainage system. The combined surface and subsurface drainage system gives the largest total outflow values while the surface drainage only system gives the smallest. Comparisons of model predicted and measured values of surface runoff only, subsurface drainage only, and combined surface runoff and subsurface drainage system are in satisfactory agreement. The model predicted values are within the range of the variations of the observed replications in general. Based on the results of the model evaluation study, it is concluded that ADAPT model can be used to design water table management systems.

• Current Research on Agriculture and Life Sciences
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• 제31권1호
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• pp.18-24
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• 2013

This work attempted to fabricate organic/inorganic nanocomposite by combining organic cellulose nanofibrils (CNFs), isolated by 2,2,6,6-tetramethylpiperidine-1-oxy radical (TEMPO)-mediated oxidation of native cellulose with inorganic nanoclay. The morphology and dimension of CNFs, and tensile properties and thermal stability of CNF/clay nanocomposites were characterized by transmission electron microscope (TEM), tensile test, and thermogravimetry (TG), respectively. TEM observation showed that CNFs were fibrillated structure with a diameter of about $4.86{\pm}1.341nm$. Tensile strength and modulus of the hybrid nanocomposite decreased as the clay content of the nanocomposite increased, indicating a poor dispersion of CNFs or inefficient stress transfer between the CNFs and clay. The elongation at break increased at 1% clay level and then continuously decreased as the clay content increased, suggesting increased brittleness. Analysis of TG and derivative thermogravimetry (DTG) curves of the nanocomposites identified two thermal degradation peak temperatures ($T_{p1}$ and $T_{p2}$), which suggested thermal decomposition of the nanocomposites to be a two steps-process. We think that $T_{p1}$ values from $219.6^{\circ}C$ to $235^{\circ}C$ resulted from the sodium carboxylate groups in the CNFs, and that $T_{p2}$ values from $267^{\circ}C$ to $273.5^{\circ}C$ were mainly responsible for the thermal decomposition of crystalline cellulose in the nanocomposite. An increase in the clay level of the CNF/clay nanocomposite predominately affected $T_{p2}$ values, which continuously increased as the clay content increased. These results indicate that the addition of clay improved thermal stability of the CNF/clay nanocomposite but at the expense of nanocomposite's tensile properties.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1045-1054
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• 2020

Objective: This study aimed to evaluate the diagnostic value of combining the quantitative parameters of shear wave elastography (SWE) and superb microvascular imaging (SMI) to breast ultrasound (US) to differentiate between benign and malignant breast masses. Materials and Methods: A total of 200 pathologically confirmed breast lesions in 192 patients were retrospectively reviewed using breast US with B-mode imaging, SWE, and SMI. Breast masses were assessed based on the breast imaging reporting and data system (BI-RADS) and quantitative parameters using the maximum elasticity (Emax) and ratio (Eratio) in SWE and the vascular index in SMI (SMI_VI). The area under the receiver operating characteristic curve (AUC) value, sensitivity, specificity, accuracy, negative predictive value, and positive predictive value of B-mode alone versus the combination of B-mode US with SWE or SMI of both parameters in differentiating between benign and malignant breast masses was compared, respectively. Hypothetical performances of selective downgrading of BI-RADS category 4a (set 1) and both upgrading of category 3 and downgrading of category 4a (set 2) were calculated. Results: Emax with a cutoff value of 86.45 kPa had the highest AUC value compared to Eratio of 3.57 or SMI_VI of 3.35%. In set 1, the combination of B-mode with Emax or SMI_VI had a significantly higher AUC value (0.829 and 0.778, respectively) than B-mode alone (0.719) (p < 0.001 and p = 0.047, respectively). B-mode US with the addition of Emax, Eratio, and SMI_VI had the best diagnostic performance of AUC value (0.849). The accuracy and specificity increased significantly from 68.0% to 84.0% (p < 0.001) and from 46.1% to 79.1% (p < 0.001), respectively, and the sensitivity decreased from 97.6% to 90.6% without statistical loss (p = 0.199). Conclusion: Combining all quantitative values of SWE and SMI with B-mode US improved the diagnostic performance in differentiating between benign and malignant breast lesions.