• Journal of Acupuncture Research
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• v.25 no.3
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• pp.115-125
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• 2008

Diabetes mellitus is a worldwide epidemic. Global projections suggest that most nations will have a doubling of the incidence of Diabetes mellitus(DM) within 20years. The Herb-Combined Remedy(HCR) of DM was known as one of anti-hyperglycaemic agents. But it is unclear whether HCR can be used to treat patients with Diabetic nephropathy or not. The present study was designed to investigate the anti-hyperglycaemic and preventive effects from diabetic nephropathy of HCR in STZ-induced diabetic rats. Treatment with HCR regulated blood glucose levels, but did not affect body weights. In addition, HCR was able to decrease blood glucose levels after 120min. Serum BUN levels were not effective but, serum Creatinine levels were lowered by treatment with HCR or MF. In histopathological observation of renal tissue, both HCR and MF groups showed decreased tendency of inflammation and renal injury. In conclusion, these results demonstrate that HCR is effective to treat patients with DM and also has preventive activity on diabetic nephropathy.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.1166-1171
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• 2006

Drought is defined by differently for the several scientific and technical fields such as hydrological drought, agricultural drought, meteorological drought, climatological drought, atmospheric drought. A lot of drought indices have been developed to quantify drought severity levels. However these drought indices might be expressed differently as the drought conditions for specific period because the drought severity level is using different types of data on each condition. It is necessary for development of quantative drought representation methods by drought index application. In this research, the reaction to the historical droughts is analyzed after estimation of PDSI, SPI and MSWSI(Modified Surface Water Supply Index) in south korean territory. Lastly the drought representation methods were examiner combining the drought indices by drought indices. The arithmetic mean drought indices that include PDSI, SPI, in yearly basis from 1971 to 2001 and MSWSI in yearly basis from 1974 to 2001 were estimated through the whole nation. The applicability of drought indices are examined based on the observed drought data for national and regional droughts. The result shows that PDSI, SPI(3), SPI(6), and MSWSI have proven to be sensitive enough to the historical drought. The correlation analysis of each drought index was conducted whether they could show the long and short term drought equally. The analysis of how appropriately represent for the historical drought was used for determining for the combined drought index. Consequently, PDSI, SPI(3), SPI(6), and MSWSI have been appeared as suitable indices for the development of quantitative drought representation methods. For the decision of weight on combining PDSI, SPI(3), SPI(6), and MSWSI, drought map was made for eighteen alternative to decide weight. The results showed that PDSI(20%), SPI(3)(60%), SPI(6)(10%), and MSWSI(10%) have been the most well matched weights. Using selected weights of each drought indices and by reconstructing the national mean drought severity on yearly basis, the fact that the year of historical drought is in accordance with the verified one for drought representation. In short, the acquired technique using combined drought index can be used for useful and believable quantitative method of drought analysis.

• Proceedings of the Korean Society for Bio-Environment Control Conference
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• 2001.04b
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• pp.39-40
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• 2001

This experiment was conducted to investigate the effect of root zone heating on the growth of cut minirose Rosa hybrida L. ′Little Marble′ in winter season. Effects of four different root zone temperatures of 16, 20, 24$^{\circ}C$ and non-heating control on the growth and productivity were compared. Harvested cut-flowers were measured for stem length, stem diameter, fresh and dry weights, numbers of leaves, stems and flowers, days to flower, and chlorophyll concentration. The results showed that mean height was the greatest at 16$^{\circ}C$. Days to flower was the shortest at 24$^{\circ}C$. Fresh and dry weights of top (shoot＋leaf＋flower), shoot and leaf were the greatest at 2$0^{\circ}C$. Stem and flower numbers were the greatest at 16$^{\circ}C$, but leaf number was the greatest at 2$0^{\circ}C$. Mean cut flower yield was the greatest at 16$^{\circ}C$. Chlorophyll concentration was slightly higher at 16$^{\circ}C$, but was not significantly different among the treatments. Stem diameter was the greatest at 2$0^{\circ}C$. Dry matter was the greatest at 24$^{\circ}C$. Total yield of cut rose stems increased with increasing temperature. Combined heating could save 24% in fuel cost as compared to the air heating alone. The results obtained suggested that optimal root zone temperature for the growth of cut rose "Little Marble" was 2$0^{\circ}C$, and the greenhouse heating energy can be saved by minimal air heating combined with root zone heating to 2$0^{\circ}C$.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.05a
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• pp.210-212
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• 2021

In modern society, various digital equipment are being distributed due to the influence of the 4th industrial revolution, and they are used in a wide range of fields such as automated processes, intelligent CCTV, medical industry, robots, and drones. Accordingly, the importance of the preprocessing process in a system operating based on an image is increasing, and an algorithm for effectively reconstructing an image is drawing attention. In this paper, we propose a filter algorithm based on a combined weight value to reconstruct an image in a complex noise environment. The proposed algorithm calculates the weight according to the spatial distance and the weight according to the difference between the pixel values for the input image and the pixel values inside the filtering mask, respectively. The final output was filtered by applying the join weights calculated based on the two weights to the mask. In order to verify the performance of the proposed algorithm, we simulated it by comparing it with the existing filter algorithm.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1787-1790
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• 2013

This study evaluated the effects of ZD1839, an orally active, selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, on nasopharyngeal carcinoma (NPC) both in vitro and in vivo. Influence of ZD1839 alone or combined with cisplatin on the NPC cell line CNE2 was detected by MTT assay with flow cytometry assessment of cell cycle distribution and apoptosis rates. Nude mice NPC xenografts were also used to evaluate the effects of ZD1839 alone or combined with cisplatin. The Student's t test evaluated statistical significance. ZD1839 alone or combined with cisplatin inhibited CNE2 cell line proliferation. ZD1839 induced CNE2 cell cycle arrest in the G1 phase, and higher concentrations induced apoptosis. Xenograft tumors were significantly smaller when treated with 200 mg/kg ZD1839, cisplatin, or cisplatin combined with 100 mg/kg ZD1839 than untreated controls. ZD1839 (200 mg/kg) alone showed good tumor inhibition effects, reduction of tumor weights, and smaller tumor volume without loss of body weight. ZD1839 (200 mg/kg) might provide a good and effective therapeutic reagent for NPC.

• Journal of Environmental Health Sciences
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• v.18 no.2
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• pp.125-134
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• 1992

The purpose of this study is to investigate the effects of Ginseng saponin on the cadmium which is widely distributed in the environment, results in immune system alteration. For the experiments, 125 mice of ICR strain were used. The experimental groups were divided into 5 groups a control, a cadmium alone treatment group, three Cd and saponin (10, 50, 100 mg/kg) combined treatment groups. The mice were allocated 25 to each group and observed for 8 weeks. The results of experiment are as follows: 1. Body weight growth rates during 8 weeks were as this control group 36.47%, Cd alone group 32.48%, saponin combined treatment group (10, 50, 100 mg/kg) 32.49%, 39.17%, 24.27% respectively. 2. In all groups, the relative weights of liver and kidney were increased, compared with control group. In the case of spleen, saponin combined treatment group (50, 100 mg/kg) was high to the significant level compared with a control group (p<0.05). Thymus was not. 3. On blood lymphocyte count observation, Cd alone treament group has 25.6% less than control group, and saponin combined treatment group have increasing trends. but in thymus and spleen, there was no trends like blood. 4. On antibody titer, there was no difference among groups. 5. On total serum protein, saponin (100 mg/kg) combined treatment group was high to significant level compared with control group (p<0.05), and other treatment groups have increasing trends. 6. Cd accumulation in kidney was higher than in liver, and all treatment groups were high to the very significant level compared with the control group (p<0.05), but there was no difference among groups. From the results of this study, it can be concluded that the oral administration of Cd results in alteration of immune system and Ginseng saponin prevents this effect. But, Cd accumulation was not affected by saponin.

• Toxicological Research
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• v.21 no.3
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• pp.187-193
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• 2005

The rodent Hershberger assay is considered as a potential short term in vivo screening method for the detection of androgenic or anti-androgenic compounds. The objective of this study was to evaluate the anti-androgenic activities of di(2-ethylhexyl) phthalate (DEHP), di(n-butyl) phthalate (DBP), and butylbenzyl phthalate (BBP). A 10-day Hershberger assay was performed using immature Sprague-Dawley male rats castrated at 6 weeks of age. Tastosterone propionate (TP, 0.4 mg/kg/day) was administered s.c. to castrated male rats and followed by flutamide (1, 5, 10, or 20 mg/kg/day) treatment for 10 days by oral gavage. Similarly, DEHP, DBP, or BBP were also administered by oral gavage at 250, 500, or 1000 mg/kg/day after TP (0.4 mg/kg/day) administration. As expected, flutamide significantly inhibited the TP-induced re-growth of seminal vesicles, ventral prostate, and Levator ani plus bulbocavernosus muscles (LABC) at 1 mg/kg/day and above, and Cowper's glands and glans penis at 5 mg/kg/day and above. DEHP significantly (p<0.05) decreased the seminal vesicles, ventral prostate, LABC and Cowper's glands weights at 1000 mg/kg/day. BBP at 1000 mg/kg/day significantly inhibited TP-induced re-growth of the LABC in the immature castrated male rats, whereas ventral prostate, seminal vesicles, and Cowper's glands weights were unaffected. In contrast to DEHP, DBP did not affect accessory sex organ weights at any concentration. Body weights, combined adrenal glands, and kidney weights were not affected, but liver weights were significantly increased at high dosages in the DEHP, DBP, and BBP treatment groups. Our observations strongly suggest that DEHP acts as an androgen antagonist at the high dose (i.e., 1000 mg/kg/day).

• Journal of Korea Multimedia Society
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• v.20 no.8
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• pp.1175-1186
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• 2017

Human emotion recognition is one of the promising applications in the era of artificial super intelligence. Thus far, facial expression traits are considered to be the most widely used information cues for realizing automated emotion recognition. This paper proposes a novel facial expression recognition (FER) method that works well for recognizing emotion from image sequences. To this end, we develop the so-called weighted soft voting classification (WSVC) algorithm. In the proposed WSVC, a number of classifiers are first constructed using different and multiple feature representations. In next, multiple classifiers are used for generating the recognition result (namely, soft voting) of each face image within a face sequence, yielding multiple soft voting outputs. Finally, these soft voting outputs are combined through using a weighted combination to decide the emotion class (e.g., anger) of a given face sequence. The weights for combination are effectively determined by measuring the quality of each face image, namely "peak expression intensity" and "frontal-pose degree". To test the proposed WSVC, CK+ FER database was used to perform extensive and comparative experimentations. The feasibility of our WSVC algorithm has been successfully demonstrated by comparing recently developed FER algorithms.

• The KIPS Transactions:PartC
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• v.12C no.4 s.100
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• pp.519-524
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• 2005

Due to various types of errors added to dynamic weight measurement data, proper methods to reduce measurement errors are required to produce reliable weights. It is very difficult to reduce the measurement error due to excessive oscillation of the system. To cope with parasitic types of errors in real systems, information provided by the photo sensors are utilized and combined in such a way to reduce the measurement errors of load cells. In addition to four channels of load cells from a model trailer, photo sensors are used to obtain the information to compensate the error induced from vertical movement of the vehicle due to the variation of ground level. A model trailer system is run to verify the effectiveness of the proposed method to reduce noise of dynamic weight measurements.

• International Journal of Naval Architecture and Ocean Engineering
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• v.6 no.4
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• pp.947-964
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• 2014

Rubble mound breakwaters protect the coastal line against severe erosion caused by wave action. This study examined the performance of different sizes and properties (i.e. height of vertical wall and tetrapod size) of rubble mound breakwaters on reducing the overtopping discharge. The physical model used in this study was derived based on an actual rubble mound in Busan Yacht Harbor. This research attempts to fill the gap in practical knowledge on the combined effect of the armor roughness and vertical wall on wave overtopping in rubble mound breakwaters. The main governing parameters used in this study were the vertical wall height, variation of the tetrapod weights, initial water level elevation, and the volume of overtopping under constant wave properties. The experimental results showed that the roughness factor differed according to the tetrapod size. Furthermore, the overtopping discharge with no vertical wall was similar to that with relatively short vertical walls (${\gamma}_v=1$). Therefore, the experimental results highlight the importance of the height of the vertical wall in reducing overtopping discharge. Moreover, a large tetrapod size may allow coastal engineers to choose a shorter vertical wall to save cost, while obtaining better performance.