• 대한한방내과학회지
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• 제42권2호
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• pp.207-214
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• 2021

Objectives: This study aimed to identify whether herbal medicine improves the clinical symptoms and abnormal blood tests of a patient with fatty liver accompanied by hypertriglyceridemia. Methods: A 44-year-old man with fatty liver and hypertriglyceridemia was prescribed Saenggangunbi-tang from July 20, 2020, to November 11, 2020, to reduce fatigue and to improve laboratory findings, such as liver enzymes and the lipid profile. We observed changes in symptoms, serum levels of liver enzymes, and the lipid profile during about 4-month treatment. We also recorded changes in the bioelectrical impedance analyzer findings during that time. Results: In this case study, an approximately 4-month treatment with Saenggangunbi-tang led to considerable improvement in laboratory findings and visceral fat area. In particular, the patient experienced a noticeable decrease in triglyceride levels compared with the baseline parameters of the first visit. In addition, no side effects-including weight gain and liver enzyme increases-were observed during treatment. Conclusion: This study suggests that appropriately prescribed herbal medicine is a therapeutic option to manage fatty liver combined with hypertriglyceridemia.

• International Journal of Computer Science & Network Security
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• 제23권3호
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• pp.193-202
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• 2023

Numerous articles under the study and the examination of heavy metals in human teeth have been published in recent years. The heavy metal poisoning is a widespread issue emerged in toxicology area these days. It has been discovered that long-term exposure to heavy metals typically present in traces, in our everyday meals, drinking water, and in the environment as pollution causes heavy metal poisoning in human beings. Industrial effluents, Coal and Oil, as well as a variety of consumer items, such as cosmetics, can all cause this type of exposure. Teeth, which are often thought of as exoskeleton parts, store heavy metals with a high affinity and represent long-term exposure information. In this study, we have chosen and examined the sections of dentine instead, then examined the entire tooth. We have combined the work done on the examination of heavy metals in human teeth using several instrumental approaches e.g. "Optical Spectroscopic Techniques" to detect elemental profile of human teeth in the current study.

• Wind and Structures
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• 제38권2호
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• pp.129-146
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• 2024

Aiming at the problem of non-stationary wind field simulation of downbursts, a non-stationary down-burst generation system was designed by adding a nozzle and program control valve to the inlet of the original wall jet model. The computational fluid dynamics (CFD) method was used to simulate the downburst. Firstly, the two-dimensional (2D) model was used to study the outflow situation, and the database of working conditions was formed. Then the combined superposition of working conditions was carried out to simulate the full-scale measured downburst. The three-dimensional (3D) large eddy simulation (LES) was used for further verification based on this superposition condition. Finally, the wind tunnel test is used to further verify. The results show that after the valve is opened, the wind ve-locity at low altitude increases rapidly, then stays stable, and the wind velocity at each point fluctuates. The velocity of the 2D model matches the wind velocity trend of the measured downburst well. The 3D model matches the measured downburst flow in terms of wind velocity and pulsation characteris-tics. The time-varying mean wind velocity of the wind tunnel test is in better agreement with the meas-ured time-varying mean wind velocity of the downburst. The power spectrum of fluctuating wind ve-locity at different vertical heights for the test condition also agrees well with the von Karman spectrum, and conforms to the "-5/3" law. The vertical profile of the maximum time-varying average wind veloci-ty obtained from the test shows the basic characteristics of the typical wind profile of the downburst. The effectiveness of the downburst generation system is verified.

• 콘크리트학회논문집
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• 제15권6호
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• pp.829-839
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• 2003

최근 원전 구조물을 비롯한 해양에 인접한 콘크리트 구조물의 경우 외부의 염소이온 확산에 의한 철근 부식과 관련한 문제가 콘크리트의 내구성과 관련된 중요한 요인으로 인식되고 있으며, 이와 관련된 다양한 연구들이 국 내외 적으로 수행되고 있다. 그러나, 탄산화를 비롯한 복합열화 환경에서의 염소이온 확산에 대한 연구결과는 아직까지 미흡한 실정으로 본 연구에서는 이와 관련하여 탄산화 작용이 콘크리트 중의 염소이온 확산에 미치는 영향에 대한 실험적인 연구를 수행하였다. 본 연구에서 수행한 5% 염화나트륨 용액 침지 및 10% $CO_2$ 촉진탄산화 반복실험 결과 콘크리트의 탄산화는 콘크리트 내부로의 염소이온 확산 정도를 증가시키는 것으로 나타났으며, 이것은 탄산화 영역에서 고정된 염소이온의 유리에 따른 염소이온 농도 구배의 증가 때문인 것으로 판단된다. 한편, 플라이애쉬를 혼입한 콘크리트의 경우 표면부에서 일정한 깊이까지는 촉진탄산화의 영향에 의한 높은 염소이온 침투량을 나타내지만 경계를 넘어선 영역에서는 플라이애쉬를 혼입하지 않은 경우와 거의 유사한 정도의 염소이온 침투량을 보였다. 본 연구를 통해 탄산화 작용이 콘크리트 내부로의 염소이온 침투에 미치는 영향과 관련한 기초적인 실험자료를 축적하였으며 향후 추가적인 연구를 통해 콘크리트 구조물의 내구수명을 산출하는데 기여를 할 수 있을 것으로 기대된다.

• 대한감각통합치료학회지
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• 제21권3호
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• pp.39-53
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• 2023

목적 : 본 연구는 발달장애아동에게 아이트래커를 병행한 감각통합치료가 감각처리 및 시지각에 미치는 효과를 알아보고자 하였다. 연구방법 : 본 연구의 설계는 단일대상연구의 대상자간 중다기초선 설계이며, 중재는 아이트래커를 병행한 감각통합치료를 적용하였다. 기초선 기간과 중재 기간의 매 회기 평가로 시각-운동 속도와 단속적 눈의 움직임을 평가하였으며, 사전·사후 평가로 감각프로파일, 한국판시지각발달검사, 선잇기검사를 실시하였다. 매 회기 평가와 사전·사후 평가는 시각적 분석 및 경향선 분석을 통해 중재의 효과를 연구하였다. 결과 : 회기별 평가 결과, 시각-운동속도와 단속적 눈의 움직임에서 모든 아동의 경향선 기울기가 기초선기간보다 중재기간에 급격하게 증가하였다. 사전·사후 평가결과, 감각처리에서는 움직임, 몸위치, 시각의 감각처리가 또래보다 많음에서 또래와 유사 수준으로 변화하였으며, 시지각에서는 모든 아동의 시각통합능력이 증가하였다. 또한, 아동의 시각추적 및 시각-운동 능력의 향상을 확인하기 위해 실시한 선잇기검사 결과, 모든 아동이 사전보다 사후에 수행시간이 감소하였다. 결론 : 발달장애아동의 아이트래커를 병행한 감각통합치료는 감각처리 및 시지각에 긍정적인 영향을 미쳤으며, 최근 기술의 향상과 스마트기기의 보급과 맞추어 아동의 흥미와 동기를 부여할 수 있어 임상적으로 중요한 역할을 할 것으로 사료된다.

• 대기
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• 제20권4호
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• pp.483-494
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• 2010

The vertical profiles of the extinction coefficient, the backscatter coefficient, and the lidar ratio (i.e., extinction-to-backscattering ratio) for Asian dust and pollution aerosols are determined from Raman (inelastic) and elastic backscatter signals. The values of lidar ratios during two polluted days is found between 52 and 82 sr (July 22, 2009) and 40~60 sr (July 31, 2009) at 52 nm, with relatively low value of particle depolarization ratio (<5%) and high value of sun photometer-derived Angstrom exponent (> 1.2). However, lidar ratios between 25 and 40 sr are found during two Asian dust periods (October 20, 2009 and March 15, 2010), with 10~20% of particle depolarization ratio and the relatively low value of sun photometer-derived Angstrom exponent (< 0.39). The lidar ratio, particle depolarization ratio and color ratio are useful optical parameter to distinguish non-spherical coarse dust and spherical fine pollution aerosols. The comparison of aerosol extinction profiles determined from inelastic-backscatter signals by the Raman method and from elastic-backscatter signals by using the Fernald method with constant value of lidar ratio (50 sr) have shown that reliable aerosol extinction coefficients cannot be determined from elastic-backscatter signals alone, because the lidar ratio varies with aerosol types. A combined Raman and elastic backscatter lidar system can provide reliable information about the aerosol extinction profile and the aerosol lidar ratio.

• 대한약침학회지
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• 제19권2호
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• pp.114-121
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• 2016

Objectives: Lung cancer remains a deadly disease with unsatisfactory overall survival. Cisplatin, a standard platinum (Pt)-based chemotherapeutic agent, has the potential to inhibit the growth of lung cancer. Its use, however, is occasionally limited by severe organ toxicity. However, until now, no systematic study has been conducted to verify its efficacy with proper experimental support in vivo. Therefore, we examined whether biosynthesized Pt nanoparticles (NPs) inhibited human lung cancer in vitro and in vivo to validate their use in alternative and complementary medicine. Methods: We evaluated the in vitro and the in vivo anticancer efficiencies of biosynthesized Pt NPs in a subcutaneous xenograft model with A549 cells. Severe combined immune deficient mice (SCID) were divided into four groups: group 1 being the vehicle control group and groups 2, 3 and 4 being the experimental groups. Once the tumor volume had reached $70-75mm^3$, the progression profile of the tumor growth kinetics and the body weights of the mice were measured every week for 6 weeks after oral administration of Pt NPs. Doses of Pt NPs of 500, 1,000 and 2,000 mg/kg of body weight were administered to the experimental groups and a dose of honey was administered to the vehicle control group. The efficacy was quantified by using the delay in tumor growth following the administration of Pt NPs of A549 human-lung-cancer xenografts growing in SCID mice. Results: The in vitro cytotoxicity evaluation indicated that Pt NPs, in a dose-dependent manner, inhibited the growth of A549 cells, and the in vivo evaluation showed that Pt NPs at the mid and high doses effectively inhibited and delayed the growth of lung cancer in SCID mice. Conclusion: These findings confirm the antitumor properties of biosynthesized Pt NPs and suggest that they may be a cost-effective alternative for the treatment of patients with lung cancer.

• Geomechanics and Engineering
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• 제12권4호
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• pp.723-738
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• 2017

Rock is a heterogeneous material, which introduces complexity in the analysis of rock slopes, since both the existing discontinuities within the rock mass and the intact rock contribute to the degradation of strength. Rock failure is often catastrophic due to the brittle nature of the material, involving the sliding along structural planes and the fracturing of rock bridge. This paper proposes an advanced discretization method of rock mass based on block theory. An in-house software, GeoSMA-3D, has been developed to generate the discrete fracture network (DFN) model, considering both measured and artificial joints. Measured joints are obtained from the photogrammetry analysis on the excavation face. Statistical tools then facilitate to derive artificial joints within the rock mass. Key blocks are searched to provide guidance on potential reinforcement measures. The discretized blocky system is subsequently implemented into a discontinuous deformation analysis (DDA) code. Strength reduction technique is employed to analyze the stability of the slope, where the factor of safety can be obtained once excessive deformation of slope profile is observed. The combined analysis approach also provides the failure mode, which can be used to guide the choice of strengthening strategy if needed. Finally, an illustrated example is presented for the analysis of a rock slope of 20 m height inclined at $60^{\circ}$ using combined GeoSMA-3D and DDA calculation.

• Food Science and Biotechnology
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• 제16권6호
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• pp.910-917
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• 2007

The aim of this study is to determine the anti-obesity effects of genistein and exercise, separately and in combination, in mice. Fifty male C57BL/6J mice were divided into 5 treatment groups: normal diet (ND), high fat diet (HD), high fat diet with exercise (HD+Ex), high fat diet with 0.2% genistein (HD+G), high fat diet with 0.2% genistein, and exercise (HD+G+Ex). They were allowed free access to feed and water, and exercised mice engaged in swimming on a regular basis for 12 weeks. Genistein supplemented mice gained less weight, had lower energy intake, better lipid profiles, and lower leptin than the HD mice. Furthermore, when genistein was combined with exercise (HD+G+Ex) the effects were even greater. HD, HD+Ex, and HD+G mice exhibited increased hepatic CPT-1 mRNA expression. Therefore, genistein and exercise has anti-obesity effects, as shown by changes in body weight, fat accumulation, energy intake, and leptin levels.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권3호
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• pp.217-225
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• 2015

Objectives : The objective of this study was to compare the Korean Personality Rating Scale for Children (K-PRC) profile between children with attention-deficit hyperactivity disorder (ADHD) and typically developing children. We also aimed to investigate the association of K-PRC and ADHD symptoms. Methods : Ninety-nine youth (age $8.3{\pm}2.4$ years, 72 boys) with ADHD and 84 controls (age $9.2{\pm}2.5$ years, 43 boys) were recruited from the Department of Pediatric Psychiatry of the Asan Medical Center Children's Hospital. Diagnoses of ADHD and comorbid psychiatric disorders were confirmed with the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). The parents of the subjects completed the ADHD rating scale, and K-PRC. Independent t-tests, analysis of covariance, partial correlation analyses, and Mc Nemar test were used for analysis. Results : Children and adolescents with ADHD showed higher K-PRC scores in verbal development, physical development, depression, delinquency, hyperactivity, family dysfunction and psychoticism. Delinquency and hyperactivity were significantly correlated with parent-rated ADHD rating scales and ADHD scores on K-SADS-PL. The hyperactive/impulsive and combined subtypes showed higher scores on hyperactivity and delinquency than the inattentive subtype, and the inattentive subtype showed higher scores on depression and social dysfunction of the K-PRC. Conclusion : Our results suggest that K-PRC could be used to comprehensively evaluate symptoms, combined psychopathologies, developmental delay and family dysfunction of children with ADHD.