• 생약학회지
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• 제20권3호
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• pp.188-195
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• 1989

Hyangsayangwee-Tang, a combined preparation of crude drugs, which has been used for stomach and intestinal disorder, was examined for anti-spasmodic, anti-ulcerative and anti-emetive effects. Spontaneous motility of isolated ileum was strongly suppressed and inhibitory effects against contraction of isolated ileum induced by acetylcholine and barium chloride were shown in mice. And, contraction of isolated guinea-pig ileum by histamine was inhibited. In rats fundus preparations, Hyangsayangwee-Tang elicited strong relaxation and had antagonist effects against the spasm induced by acetylcholine and barium chloride. A significant inhibitory effect on the intestinal propulsion of barium sulfate in mice was shown. In pylorus-ligated rats, Hyangsangwee-Tang inhibited gastric secretion and showed a strong anti-peptic activity. Protective effects against gastric ulceration induced by pyloric ligation, water-immersion stress, histamine and aspirin were significantly recognized in mice and rats. Hyangsayangwee-Tang decreased cupric sulfate-induced vomitting in frogs.

• 대한암한의학회지
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• 제28권1호
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• pp.45-53
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• 2023

Objectives: To report the reduction of adverse effects of chemotherapy and improvement in the quality of life in recurrent liver metastasis by Korean medicine treatments. Methods: In 2018, a 75-year-old male patient underwent surgery for primary cancer in the ampulla of Vater. In 2021, he was diagnosed with recurrent liver metastasis. Following the failure of tumor treatment with gemcitabine/cisplatin and the development of severe side effects, he decided to discontinue chemotherapy. Subsequently, with a significantly enlarged liver tumor, he resumed capecitabine/oxaliplatin treatment, alongside moxibustion, acupuncture, and herbal prescriptions from August 2021 to August 2023. The changes of chief complaints, abdominal CT, and laboratory findings were investigated. Results: After combined treatment of Korean traditional medicine and chemotherapy, the mass was decreased. Laboratory findings, and chief complaints of hand-foot syndrome, fatigue, abdominal distension, nausea and anorexia were improved. Conclustions: This case study suggests that Korean traditional medicine is effective in enhancing anticancer effects, suppressing the side effects of chemotherapy, and improving general conditions.

• 대한한방종양학회지
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• 제6권1호
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• pp.165-180
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• 2000

Clinical studies were carried out 83 cases of patients with colorectal cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by colorectal cancer, by sex, showed that Male is more then Female, by age, showed that the number of fifties is majority. 2. Distribution of diagnostic stage, in descending order; stage III(53%, top), stage IV(45.8%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(83.3%) and combined treatment of western and oriental therapy(92.1%) were observed. The effects of the symptoms were as follows: diarrhea(37.3%), abdominal pain (25.3%), general body weakness(22.9%), nausea(20.5%) and etc. in orders. 4. Analysis of hematology attached by colorectal cancer, maintenance and increasing of WBC(89.9%), RBC(74.7%), Hgb(81.1%), Platelet(92.4%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.9%), ALT(94.8%), GTP(87.5%), Creatinine(90.9%) were observed. 5. of IL-12 and $IFN-\gammer$ attached by colorectal cancer, increasing of IL-12(53.3%), IFN-{\gammer}(80%)$) were observed. 6. Analysis of QOL attached by colorectal cancer, maintenance and improvement of combined treatment of western and oriental therapy(89.6%), traditional oriental therapy(83.3%) were observed. 7. Analysis of survival in patients with IV stage of colorectal cancer, above 7 months(18.4%), 12 months(65.8%). 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(83.3%) and maintenance and improvement of combined treatment of western and oriental therapy(80.5%) were observed. Analysis of tumor marker attached by colorectal cancer, maintenance and decreasing of CEA(78.8%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(83.3%), combined treatment of western and oriental therapy(72.7%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for colorectal cancer patients by combination with western therapy or alone.

• 혜화의학회지
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• 제10권1호
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• pp.121-131
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• 2001

Clinical studies were carried out 62 cases of patients with lung cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by lung cancer, by sex, showed that Male is more then Female, by age, showed that the number of sixties is majority. 2. Distribution of diagnostic stage, in descending order; stage IV(43.6%,top), stage III(35.5%), stage II(17.7%), stage I(3.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(83.3%) and combined treatment of western and oriental therapy(84.0%) were observed. The effects of the symptoms were as follows; cough(50.0%), anorexia(48.4%), chest discomfort(31.0%), sputum(24.2%), general body weakness(11.3%), hemoptysis(9.7%) and etc. in orders. 4. Analysis of hematology attached by lung cancer, maintenance and increasing of WBC(98.4%), RBC(74.2%), Hgb(71.0%), Platelet(96.7%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(91.5%), ALT(93.2%), ${\gamma}-GTP$(95.0%), BUN(82.7%), Creatinine(93.3%) were observed. 5. Analysis of IL-12 and $IFN-{\gamma}$ attached by lung cancer, increasing of IL-12(31.3%), $IFN-{\gamma}$(72.7%) were observed. 6. Analysis of QOL attached by lung cancer, maintenance and improvement of combined treatment of western and oriental therapy(94.0%), traditional oriental therapy(91.7%) were observed. 7. Analysis of survival in patients with IV stage of lung cancer, above 7 months(22.2%), 12 months(70.4%). 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(50.0%) and maintenance and improvement of combined treatment of western and oriental therapy(80.0%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(50.0%), combined treatment of western and oriental therapy(60.0%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for lung cancer patients by combination with western therapy or alone.

• 한국노년학
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• 제32권3호
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• pp.703-714
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• 2012

고령기의 생활을 위협하는 비만 여성고령자를 대상으로 sarcopenia 동반에 따른 16주간의 운동중재가 신체조성 및 심폐체력에 미치는 변화를 알아보기 위한 실험이다. 비만 여성고령자를 sarcopenia 동반유무에 따라 sarcopenic obestiy group(SOG)과 non-sarcopenic obesity group(NOG)으로 나누어 16주간, 주 3회, 50-60분간 복합운동 실시 후 신체조성 및 심폐체력에 미치는 영향을 분석하여 다음과 같은 결론을 얻었다. 신체조성의 경우 시기와 그룹간 상호작용효과는 fat free mass(FFM)에서만 나타났으며, 운동 전 후의 변화에서는 SOG의 경우 % body fat은 감소하였고, FFM과 ASM에서는 차이가 없었다. NOG의 경우 %body fat은 감소하였으며, FFM과 ASM에서는 증가하였다. 심폐체력에서는 두 그룹 모두 $\dot{V}O2peak$가 증가하였다. 따라서, sarcopenic obesity 여성고령자가 non-sarcopenic obesity 여성고령자에 비해 근육량(FFM, ASM)에서 운동효과가 지연되는 것을 발견할 수 있었다.

• Computers and Concrete
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• 제25권6호
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• pp.537-549
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• 2020

Geometrically nonlinear axisymmetric bending analysis of shear deformable circular plates on a nonlinear three-parameter elastic foundation was made. Plates ranging from "thin" to "moderately thick" were investigated for three types of material: isotropic, transversely isotropic, and orthotropic. The differential equations were discretized by means of the finite difference method (FDM) and the differential quadrature method (DQM). The Newton-Raphson method was applied to find the solution. A parametric investigation using seven unknowns per node was presented. The novelty of the paper is that detailed numerical simulations were made to highlight the combined effects of the material properties and the boundary conditions on (i) the deflection, (ii) the stress resultants, and (iii) the external load. The formulation was verified through comparison studies. It was observed that the results are highly influenced from the boundary conditions, and from the material properties.

• 생약학회지
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• 제13권2호
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• pp.79-86
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• 1982

In order to investigate pharmacological actions of combined preparations of crude drugs, 'Jakyakgamcho-Tang' were studied. The 'Jakyakgamcho-Tang' using abdominal pain and convulsion of pediatric diseases are composed of Glycyrrhizae Radix and Paeoniae Radix alba. This study was undertaken to investigate the effect of 'Jakyakgamcho-Tang'(S-I) and parched 'Jakyakgamcho-Tang'(S-II) on anticonvulsive, analgesic, antipyretic and sedative actions. The results of this study were summarized as follows; Both 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' showed anticonvulsive effects against convulsions induced by strychnine, picrotoxine and caffeine. 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' also showed analgesic and antipyretic effects. Parched 'Jakyakgamcho-Tang' only prolonged the duration of hypnosis induced by sodium pentobarbital.

• 한국해양공학회지
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• 제5권2호
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• pp.16-30
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• 1991

A numerical procedure is described for predicting the dynamic responses of combined systems of floating breakwaters and huge offshore structures supported by a large numer of the floating bodies in waves. The hydrodynamic interactins among tatal floating bodies are taken into account in their exact form within the context of linear potential theory. Wave control effects are discussed with both hydrodynamic interactions and hydrodynamic-structure interaction effects. The method presented is applicalbe to combined systems of floating breakwaters and huge structures for ocean space utilization for which a number of practical uses are seen in the future.

• 한국해양공학회지
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• 제5권2호
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• pp.156-156
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• 1991

A numerical procedure is described for predicting the dynamic responses of combined systems of floating breakwaters and huge offshore structures supported by a large numer of the floating bodies in waves. The hydrodynamic interactins among tatal floating bodies are taken into account in their exact form within the context of linear potential theory. Wave control effects are discussed with both hydrodynamic interactions and hydrodynamic-structure interaction effects. The method presented is applicalbe to combined systems of floating breakwaters and huge structures for ocean space utilization for which a number of practical uses are seen in the future.

• Journal of Advanced Marine Engineering and Technology
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• 제31권7호
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• pp.823-832
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• 2007

This paper presents the static characteristics of EGR-WI combined system. The water injection system was statically characterized by recording the engine exhaust outlet $NO_x$ emissions for comparison with baseline $NO_x$ emissions. Effects of the water injection system on CO and HC emissions and fuel consumption were examined. The research engine used for these experiments was a 103 kW turbocharged, intercooled, 2.5 L VM Motori CIDI engine equipped with a cooled EGR system. Water injection in the intake system demonstrated the potential for significant reductions in engine outlet $NO_x$ emissions. The system has reduced engine outlet $NO_x$ emissions by 40-50%, but caused significant increases in CO and HC emissions, particularly at low loads. Fuel consumption effects were minimal.