• Structural Engineering and Mechanics
• /
• 제55권5호
• /
• pp.953-964
• /
• 2015

A model has been proposed that can predict the ultimate torsional strength of single-box multi-cell reinforced concrete box girder under combined loading of bending, shear and torsion. Compared with the single-cell box girder, this model takes the influence of inner webs on the distribution of shear flow into account. According to the softening truss theory and thin walled tube theory, a failure criterion is presented and a ultimate torsional strength calculating procedure is established for single-box multi-cell reinforced concrete box girder under combined actions, which considers the effect of tensile stress among the concrete cracks, Mohr stress compatibility and the softened constitutive law of concrete. In this paper the computer program is also compiled to speed up the calculation. The model has been validated by comparing the predicted and experimental members loaded under torsion combined with different ratios of bending and shear. The theoretical torsional strength was in good agreement with the experimental results.

• 한국지반신소재학회논문집
• /
• 제19권3호
• /
• pp.9-21
• /
• 2020

본 연구에서는 사질토와 점성토가 혼재하는 해안 매립지반에서 조합형 Sheet Pile 공법의 설계법을 고찰하였고 지반 굴착시의 거동을 해석하였다. 조합형 Sheet Pile 공법의 형태(Built up, Interlocking, Welding) 및 해석방법(엄지말뚝법, 연속벽법)에 따라 흙막이 가시설의 예측 거동이 상이함을 탄소성 해석으로부터 확인하였다. Sheet Pile(측면말뚝) 부재력의 경우 연속벽체 해석법의 결과가 가장 보수적인 결과를 예측하였다. 조합형 Sheet Pile 공법의 최대 부재력을 토대로 각 부재별 응력비(발생/허용)를 분석하면 측면말뚝의 경우 휨, 버팀보의 경우 조합응력에서 최대값을 나타내었다. 유한요소해석결과 측면말뚝의 부재력은 단기 유효응력 해석 조건에서 가장 크게 나타난 반면, 버팀보의 압축력은 압밀 해석에서 크게 나타났다. 탄소성 해석과 유한요소해석 결과를 비교하면, 측면말뚝의 전단력과 버팀보의 축력은 탄소성 해석에서 크게 평가되었고, 측면말뚝의 휨은 유한요소해석의 단기 유효응력 조건에서 가장 큰 것으로 나타났다. 또한, 측면말뚝의 변위는 탄소성 해석보다는 유한요소해석에서 더 크게 예측되었다.

• 산업융합연구
• /
• 제19권1호
• /
• pp.87-97
• /
• 2021

본 연구는 우리나라에서 연구된 의미요법의 스트레스 감소 효과에 관한 문헌을 체계적으로 살펴보고 의미요법의 특성과 스트레스 감소 효과를 분석하기 위하여 실시되었다. 2020년 4월까지 국내에서 출판된 연구논문과 미출판 학위논문 중 스트레스 감소를 목적으로 한 의미요법 연구를 검색하였다. 두 명의 연구자가 Scottish Intercollegiate Guidelines Network criteria를 사용하여 비뚤림 위험과 연구의 질평가를 수행하였다. 국내 학술 데이터베이스 7개를 사용하여 검색한 결과, 최종 선정된 논문은 7편이었다. 7편의 의미요법은 전 연령층을 대상으로 시행한 것이었고 5편의 연구에서 의미요법이 스트레스 감소에 효과적이라는 결과를 보고하였다. 단일중재와 병합중재 모두 스트레스 감소에 효과적이나 단일중재보다 의미요법에 기반한 병합중재가 더 많이 실시되고 있었다. 효과가 유의하지 않았던 연구는 시험과 진학 스트레스 특성을 반영하지 못한 것이었다. 향후 수험생의 스트레스 관리에 적합한 의미요법을 개발할 필요가 있다.

• 대한기계학회논문집A
• /
• 제38권11호
• /
• pp.1207-1214
• /
• 2014

균열이 존재하는 구조물의 균열 선단에서 과도한 소성 상태에 도달하게 되면 파괴역학 매개변수에 의하여 예측되는 균열 선단의 응력장이 실제와는 매우 다르게 나타난다. 구조물의 크기와 형상 그리고 하중의 형태에 따라 균열 선단의 응력장이 유일하지 않다. 이는 균열 선단의 구속 효과가 단일 매개변수 파괴역학으로 표현 될 수 없기 때문이다. 따라서 전통적으로 사용되었던 K, J를 이용한 단일 매개변수 파괴역학을 보완하기 위하여 다양한 시도가 있었고, 대표적으로 Q-응력이 있다. 본 논문에서는 Q-응력을 이용하여 원주방향으로 완전히 발달한 표면 균열이 있을 경우의 균열 선단의 구속 효과를 확인하였다. 고려된 하중은 일차하중으로 축 방향 인장하중과 반경방향 열구배에 의한 이차하중의 복합하중이다. 이차하중이 일차하중보다 구속효과가 더 심하며 기계하중보다 열하중이 뒤에 가해지는 열충격조건에서 구속효과가 더 심하게 나타남을 확인하였다.

• 대한조선학회논문집
• /
• 제56권1호
• /
• pp.82-93
• /
• 2019

In this paper, the ductile fracture criteria for a marine structural steel (EH36) are presented and validated. The theoretical background of the recently developed Hosford-Coulomb (HC) fracture strain model and the DSSE fracture strain model which was developed to apply to the shell elements is described. In order to accurately estimate the flow stress in the large strain range up to the fracture, the material constants for the combined Swift-Voce constitutive equation were derived by the numerical analyses of the smooth and notched specimens made from the EH36 steel. As a result of applying the Swift-Voce flow stress to the other notched specimen model, a very accurate load - displacement curve could be derived. The material constants of the HC fracture strain and DSSE fracture strain models were independently calibrated based on the numerical analyses for the smooth and notch specimen tests. The user subroutine (VUMAT of Abaqus) was developed to verify the accuracy of the combined HC-DSSE fracture strain model. An asymmetric notch specimen was used as verification model. It was confirmed that the fracture of the asymmetric specimen can be accurately predicted when a very small solid elements are used together with the HC fracture strain model. On the other hand, the combined HC-DSSE fracture strain model can predict accurately the fracture of shell element model while the shell element size effect becomes less sensitive.

• Journal of Microbiology and Biotechnology
• /
• 제31권3호
• /
• pp.398-407
• /
• 2021

Using salt-tolerant bacteria to protect plants from salt stress is a promising microbiological treatment strategy for saline-alkali soil improvement. Here, we conducted research on the growth-promoting effect of Brevibacterium frigoritolerans on wheat under salt stress, which has rarely been addressed before. The synergistic effect of B. frigoritolerans combined with representative salt-tolerant bacteria Bacillus velezensis and Bacillus thuringiensis to promote the development of wheat under salt stress was also further studied. Our approach involved two steps: investigation of the plant growth-promoting traits of each strain at six salt stress levels (0, 2, 4, 6, 8, and 10%); examination of the effects of the strains (single or in combination) inoculated on wheat in different salt stress conditions (0, 50, 100, 200, 300, and 400 mM). The experiment of plant growth-promoting traits indicated that among three strains, B. frigoritolerans had the most potential for promoting wheat parameters. In single-strain inoculation, B. frigoritolerans showed the best performance of plant growth promotion. Moreover, a pot experiment proved that the plant growth-promoting potential of co-inoculation with three strains on wheat is better than single-strain inoculation under salt stress condition. Up to now, this is the first report suggesting that B. frigoritolerans has the potential to promote wheat growth under salt stress, especially combined with B. velezensis and B. thuringiensis.

• 대한기계학회논문집A
• /
• 제26권6호
• /
• pp.1099-1106
• /
• 2002

This paper provides engineering J-integral and crack opening displacement (COD) estimation equations for circumferential through-wall cracked pipes under internal pressure and under combined internal pressure and bending. Based on selected 3-D finite element calculations for the circumferential through-wall cracked pipes under internal pressure using the idealized power law materials, the elastic and plastic influence functions for fully plastic J-integral and COD solutions are found as a function of the normalized crack length and the mean radius-to-thickness ratio. These developed GE/EPRI-type solutions are then re-formulated based on the enhanced reference stress method. Such re-formulation not only provides simpler equations for J-integral and COD estimations, but also can be easily extended to combined internal pressure and bending. The proposed equations are compared with elastic-plastic finite element results using actual stress-strain data, which shows overall excellent agreement.

• 대한조선학회논문집
• /
• 제44권6호
• /
• pp.598-604
• /
• 2007

The purpose of this study is to establish the predictive method of welding distortion and residual stress for the channel I butt SA (submerged arc) weldment using FEA. In order to do it, the heat input model for the weldment was defined as the combined heat source with the surface heat flux of gaussian distribution and volumetric heat source uniformly distributed within weld groove by comparing the shapes of molten pool and temperature distribution obtained by FEA with those of experiments. The arc efficiency of SA welding for two-dimensional FE analysis was evaluated as 0.85. The welding distortion and residual stress of the weldment obtained by FEA and heat input model proposed have a good agreement with those obtained by experiment. Based on the results, it was suggested that the proper heat input model should be required to evaluate the welding distortion for weldment.

• Biomolecules & Therapeutics
• /
• 제29권4호
• /
• pp.434-444
• /
• 2021

BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic BRAF inhibitor, PLX4720, increased basal autophagic flux in BRAF-mutated cells compared to wild-type (WT) BRAF cells. Interestingly, early autophagy inhibition improved the effectiveness of PLX4720 regardless of BRAF mutation, whereas late autophagy inhibition did not. Although ATG5 knockout led to PLX4720 resistance in both WT and BRAF-mutated cells, the MEK inhibitor trametinib exhibited a synergistic effect on PLX4720 sensitivity in WT BRAF cells but not in BRAF-mutated cells. Conversely, the prolonged inhibition of endoplasmic reticulum (ER) stress reduced basal autophagy in BRAF-mutated cells, thereby increasing PLX4720 sensitivity. Taken together, our results suggest that the combined inhibition of ER stress and BRAF may simultaneously suppress both pro-survival ER stress and autophagy, and may therefore be suitable for treatment of BRAF-mutated tumors whose autophagy is increased by chronic ER stress. Similarly, for WT BRAF tumors, therapies targeting MEK signaling may be a more effective treatment strategy. Together, this study presents a rational combination treatment strategy to improve the efficacy of BRAF inhibitors depending on BRAF mutation status.

• 한국생산제조학회지
• /
• 제8권2호
• /
• pp.73-79
• /
• 1999

Most of mechanical structures are combined of substructures such as beams and/or plates. There are few systems with unibody structures but are many systems with united body structures. Generally the dynamic a nalysis of whole structures is performed under alternation load. In the structure design, the analysis of each bolted joint is more important than others for zero severity. This paper presents the analysis method of contact stress distribution factor in the bolted joint with variable fastening torque on joints in the structure. At first, a static vibration test was performed to find out a nominal stress of bolt jointed plates from the relationship between natural frequency and nominal stress. Then a contact stress was computed at contact point between bolt and plate in the structure. It is believed that the proposed method has promisiong implications for safer design with index of contact stress distribution factor and has merits for cost-down and saving time at the beginning of vehicle development.