• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.130-138
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• 2018

Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed. Therefore, the present study was designed to investigate the combined antidiabetic action of quercetin (QE) and resveratrol (RS) in streptozotocin (STZ)-induced diabetic rats. To test the effects of co-treated with these compounds on diabetes, serum glucose, insulin, lipid profiles, oxidative stress biomarkers, and ions were determined. Additionally, the activities of hepatic glucose metabolic enzymes and histological analyses of pancreatic tissues were evaluated. 50 male Sprague-Dawley rats were divided into five groups; normal control, 50 mg/kg STZ-induced diabetic, and three (30 mg/kg QE, 10 mg/kg RS, and combined) compound-treated diabetic groups. The elevated serum blood glucose levels, insulin levels, and dyslipidemia in diabetic rats were significantly improved by QE, RS, and combined treatments. Oxidative stress and tissue injury biomarkers were dramatically inhibited by these compounds. They also shown to improve the hematological parameters which were shown to the hyperlactatemia and ketoacidosis as main causes of diabetic complications. The compounds treatment maintained the activities of hepatic glucose metabolic enzymes and structure of pancreatic ${\beta}-cells$ from the diabetes, and it is noteworthy that cotreatment with QE and RS showed the most preventive effect on the diabetic rats. Therefore, our study suggests that cotreatment with QE and RS has beneficial effects against diabetes. We further suggest that cotreatment with QE and RS has the potential for use as an alternative therapeutic strategy for diabetes.

• Journal of the Korean Society of Safety
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• v.16 no.4
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• pp.123-127
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• 2001

Numerous PSC bridges are stregthened by the combined use of continuity of simple spans and addition of external prestressing. In this case prestressing sequences should be carefully checked due to the effect on the stress and camber of girders and slab. Various prestressing sequences were applied in this field test and measured values were analysed. This results show that preatressing sequences affact the stress and deflection of bridge members, so the prestressing sequence should be considered at the desist and construction stages of deteriorated bridges.

• Structural Engineering and Mechanics
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• v.6 no.4
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• pp.467-471
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• 1998

A mathematical model is developed to predict the fatigue notch factor of butt welds subject to number of parameters such as weld geometry, residual stresses under dynamic combined loading conditions (tensile and bending). Linear elastic fracture mechanics, finite element analysis, dimensional analysis and superposition approaches are used for the modelling. The predicted results are in good agreement with the available experimental data. As a result, scatters of the fatigue data can be significantly reduced by plotting S-N curve as ($S{\cdot}K_f$) vs. N.

• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2004.05a
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• pp.263-267
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• 2004

This study presents the combined effect of electric field application and mechanical compressive stress loading on deformation in a multilayer ceramic actuator, designed with stacking 0.2($PbMn_{1/3}Nb_{2/3}O_{3}$)-0.8($PbZr_{0.475}Ti_{0.525}O_{3}$) ceramics and Ag-Pd electrode, alternately. The deformation behaviors were attributed to relative $180^{\circ}$domain, determined by pre-loaded compressive stress and electric field. The non-linearity of piezoelectricity and strain are dependent upon the young's modulus resulting from the domain reorientation.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.3 s.192
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• pp.84-90
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• 2007

As a result of vehicle maintenance of rocker arm shaft for 4-cylinder SOHC engine, failure stress analysis of rocker arm shaft is needed. Because more than 30% of vehicles investigated have been fractured. Failure stress analysis is classified into an naked eyes, microscope, striation and X-ray fractography etc. Failure stress analysis by using striation is already established technology as means for seeking cause of fracture. But, although it is well known that striation spacing corresponds to the crack growth rate da/dN, it is not possible to determine ${\sigma}_{max}\;and\;{\sigma}_{min}$ under service loading only from striation spacing. This is because the value of striation spacing is influenced not only by ${\Delta}K$ but also by the stress ratio R. In the present paper, we determine the stress ratio using orthogonal array and ANOVA, and propose a prediction method of failure stress which is combined with FEM and striation.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.142-147
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• 2004

In this paper, a new procedure is proposed to accomplish the primary plus secondary stress(P+Q) at the 'structural element' instead of 'transition element'. For the P+Q evaluation, the calculated stresses by FEA are linearized along a stress classification line to extract the stress category, then the stress intensity is calculated to compare with the $3S_{m}$ limit. Also, in this paper, the 'design by analysis' criteria, adopted fundamental concepts and a new approach to calculate $K_{e}$ factors are explained. The new procedure combined with 3-D FEA has been applied to motor operated valve in order to the over conservatism and the rack of margin. The evaluation results show a good applicability and can be utilized for fatigue life evaluation by using P+Q.

• Journal of the Korean Society for Precision Engineering
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• v.3 no.4
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• pp.53-63
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• 1986

In this study, the stress distribution of rectangular bar under torsion, when warping of both ends is free or constrained, is investigated. Method of separation of variable and Fourier Series are used for the theoretical analysis, and 3dimensional photoelastic stress-freezing method for experimental analysis. The main results are as follows; 1) In the case of warping-constrained rectangular bar, the normal stresses are negligible because they are less then 0.5% of the shear stresses. The maximum normal stress is placed on the point of y=0.61 b when b/a=1 and it gradually moves to the corner y=b when the value of b/a is increased. 2) According to increase of the value of b/a, on the crossection, the maximum shear stress is placed on the middle point of the long side (x=${\pm}a$, y=0) when warping of both ends is free but the middle of the short side (x=0, y=${\pm} b$) when warping is constrained. The stress distribution is straight line when warping is constrained, namely, the stress distribution is proportional to the distance from the axis of centroid, but parabolic when warping is free. 3) The values of the combined stress of warping-constrained bar, if the influence of the loaded point is neglected, are generally smaller than those of warping-free.

• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.346-351
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• 2012

Cells show various stress signs when they are challenged with severe physiological problems. Majority of such cellular stresses are conveyed to endoplasmic reticulum (ER) and unfolded protein response (UPR) serves as typical defense mechanism against ER stress. This study investigated an interaction between ER stress agents using macropage cell line Raw 264.7. When activated by lipopolysaccharide (LPS), the cell lines showed typical indicators of ER stress. Along with molecular chaperones, the activation process leads to the production of additional inflammatory mediators. Following activation, the macrophage cell line was further treated with TUN and characterized in terms of chaperone expression and cytokine secretion. When treated with TUN, the activated macrophage cell leads to increased secretion of IL-6 although expression of ER stress markers, GRP94 and GRP78 increased. The secretion of cytokines continued until the addition of BFA which inhibits protein targeting from ER to Golgi. However, secretion of cytokines was ceased upon dual treatments with BFA and TG. This result strongly implies that cells may differently deal with various polypeptides depending on the urgency in cellular function under ER stress. Considering IL-6 is one of the most important signal molecules in macrophage, the molecule might be able to circumvent ER stress and UPR to reach its targeting site.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.2
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• pp.436-444
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• 1991

A computational method has been developed to analyze the bone-remodeling induced by external fixator. The method was based on the Finite Element Method (FEM) in combination with numerical formulation of adaptive bone-remodeling theories. As a feed-back control variable, compressive strain and effective stress were used to determine the surface remodeling and internal (density) remodeling respectively. Surface remodeling and internal remodeling were combined at each time step to predict the rel situation. A noticeable shape and density change were detected at the region between two pins and density change was decreased with time increment. At final time step, the shape and density distribution were converged closely to its original intact bone model. Similar change was detected in stress distribution. The altered stress distribution due to the pin and external fixator converged to the intact stress distribution with time.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.05a
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• pp.106-109
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• 2001

The use of ceramic inserts in hot extrusion dies offers significant technical and economic advantages over other forms of manufacture. These potential benefits can however only be realized by optimal design of the tools so that the ceramic inserts are not subjected to stresses that lead to their premature failure. In this paper, process simulation and stress analysis are thus combined during the design, and a data exchange program has been developed that enables optimal design of the dies taking into account the elastic deflections generated in shrink fitting the die inserts and that caused by the stresses generated in the process. The stress analysis of the dies is used to determine the stress conditions on the ceramic insert by considering contact and interference effects under both mechanical and thermal loads. The results are compared with the experimental ones for verification.