• Toxicological Research
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• 제35권3호
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• pp.249-255
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• 2019

Cadmium is a strong toxic heavy metal which presents in paints and liquid wastes and causes oxidative stress in fish. On the other hand, lead is widely used for different purposes, e.g. lead pipes, it targets vital organs such as liver and kidney causing biochemical alterations. The present study evaluates the effects of 60 days exposure to Cd and Pb either single or combined together in African catfish. Sixty-four fishes were divided into 3 groups and exposed to $CdCl_2$ (7.02 mg/L) or $PbCl_2$ (69.3 mg/L) or a combination of them along with control group. Activities of acid phosphatase (ACP), lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) were estimated. Moreover, gill, liver and kidney were assayed for activities of superoxide dismutase (SOD), catalase (CAT) and levels of glutathione (GSH) and malondialdehyde (MDA). Individual exposure showed that both Cd and Pb significantly decreased LDH activity and SOD activity in the kidney. Pb significantly increased G-6-PDH activity and decreased GSH level in the gill. CAT activity in liver and kidney elevated significantly on Cd exposure while lead caused a significant depletion in the liver and significant elevation in the kidney. Both Cd and Pb significantly increased MDA levels in liver and kidney while Pb increased its level in gills. The combined exposure resulted in normalization of LDH, G-6-PDH activity, and CAT activity in liver and kidney as well as GSH level in both tissues and MDA in gill and kidney. The combination increased SOD activity and MDA level in liver and decreased SOD activity in kidney and GSH level in gills. In conclusion, the antioxidant system of African catfish was adversely affected by prolonged exposure to Cd and Pb. The combined exposure caused less damage than individual exposure and returned most parameters to those of controls.

• 한국철도학회논문집
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• 제9권4호
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• pp.349-356
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• 2006

At present, the selecting system and analytic estimation criterion on repair materials and methods of the deteriorated RC structures have not yet been set up in domestic. Under these circumstances, deterioration such as shrinkage crack, corrosion of rebar has been often occurred after repair, and this finally results in too frequent repairs. In this study, three types of repair methods were experimentally investigated by the accelerating test in a combined deterioration chamber and long-term field exposure test. Three types of repair methods applied in this study belong to a group of polymer cement mortar, which is commonly used in repair works. According to the results of this study, durability of repair mortar layers and corrosion properties of recovered rebar could be investigated in short period by the accelerating test in a combined deterioration chamber, which can simulate the condition of repeated high-and-low temperature and repeated dry-and-wet environment, spraying chloride solution and emitting $CO_2$ gas. After 36 month long-term filed exposure test in the coastal area, harmful macro-cracks are observed in the polymer cement mortar layer of some repair methods. These crack are considered to result from drying shrinkage of polymer cement mortar. Also, after 36 month exposure, amount of corrosion area and weight loss of rebar are found to be different according to the types of repair methods.

• Journal of Preventive Medicine and Public Health
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• 제16권1호
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• pp.19-24
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• 1983

In order to study the effects of iron and zinc on the lead poisoning of rats, lead with iron and zinc, or lead alone were administered orally to a total of 98 adult rats of Sprague-Dawley Species. The concentrations of lead, zinc, and iron were measured by atomic absorption spectrophotometer at every 20 days intervals of 20th, 40th, 60th, 80th and 120th day as a final measurement. Those datas were analysed and compared with those of control groups. The results were summarized as follows; 1. The concentration of lead in blood, bone. and liver tissues kept increasing in case of lead exposure group whereas it started decreasing at 60-80th day when concentration of zinc started increasing in case of combined exposure group. However, in kidney tissue, the concentration of lead in combined exposure group kept increasing up to the end of observation showing special high concentration at the final measurement at 120th day. 2. Concentration of zinc in blood and liver tissues had increased from 60-80th day in case of combined exposure group. 3. Concentration of iron in blood showed decreasing from $44.15{\pm}9.67\;to\;32.44{\pm}2.69{\mu}g/ml$ in case of lead exposure group, whereas it showed constant level of $47.50{\sim}45.65{\mu}g/ml$. However, in liver tissue it kept constant as control did from 40th to 60th days, but from 100th day on it started increasing to show much higher concentration than control.

• Composites Research
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• 제22권5호
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• pp.37-42
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• 2009

온도, 수분 및 자외선과 같은 자연환경을 모사할 수 있는 가속노화시험장치를 적용하여 복합적인 환경인자에 노출된 탄소섬유/에폭시 복합재의 열분석 특성과 화학구조분석을 수행하였다. 복합적인 환경인자의 최대 노출시간은 3000시간으로 노출시간에 따른 복합재의 열분석 특성과 화학구조는 Modulated DSE와 FTIR을 통해 조사하였다. Modulated DSC 시험을 통한 연우-결과에 따르면 노출시간이 증가할수록 복합재 내에 치밀한 망사 구조가 형성되어 유리전이온도는 증가함을 알 수 있었다. 또한 노출시간이 증가할수록 복합재의 특성에 영향을 미치는 물리시효가 발생하여 엔탈피 완화현상을 나타내는 흡열 피크가 관찰되었다. 아울러 FTIR 시험을 통해 관찰된 피크의 위치는 노출시간에 큰 영향을 받지 않지만 피크의 세기는 노출시간이 증가할수록 에폭시기에 발생되는 경화 반응으로 인해 점차 감소함을 알 수 있었다.

• Composites Research
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• 제22권6호
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• pp.39-44
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• 2009

가속노화장치를 이용하여 노출시간에 따른 탄소섬유/에폭시 복합재 링 시편의 노화 특성을 평가하였다. 온도, 수분, 자외선 등의 복합적인 노출조건은 최대 3000시간까지 적용하였다. 노출시간에 따른 링 시편의 인장특성과 곡률의 영향이 고려된 굽힘특성은 하중시험장치를 이용하여 평가하였으며 노화표면은 전자현미경을 통해 관찰하였다. 연구결과에 따르면 인장강성은 환경인자의 노출시간에 큰 영향을 받지 않지만 인장강도는 노출 초기에 물리시효 현상과 경화 반응으로 다소 증가하지만 노출시간이 길어지면 열화 영향으로 감소하였다. 굽힘탄성계수와 굽힘강도는 노출초기에 다소 증가하지만 노출시간이 길어지면 감소하는 양상을 나타내었다. 또한 전자현미경을 통해 관찰된 노화표면은 환경인자의 노출시간에 따라 달라지기 때문에 환경인자의 노출시간에 따른 기계적 특성의 변화를 규명하기 위한 정보를 제공해 준다.

• 한국환경보건학회지
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• 제21권2호
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• pp.27-35
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• 1995

In order to investigate acute toxicity and bioconcentration of heavy metals for a freshwater fish, the fish used in this experiment was goldfish, Carassius auratus. Each ten goldfish was accommonidated in a water and was treated with different concentration of Pb and Cu compound. The 24 $hr-LC_{50}$ was obtained by plotting on the log-normal distribution graph. Furthermore, the combined effect of Pb and Cu was also investigated the fish was treated with Pb or Cu compound only, and Pb and Cu compound together, respectively. These results were summarized as follows: 1. The 24 $hr-LC_{50}'s$ of Pb and Cu were 7.48 mg/l and 0.666 mg/l, respectively. 2. When single or/and combined treatment with Pb(7.0 mg/l) or/and Cu(0.6 mg/l) to Carassius auratus for 24 hours were performed, there was significant difference between the single or/and the combined treatment in their bioaccumulated Cu concentrations. Cu concentrations in goldfish were higher in the combined treatment than in the single treatment. 3. When Carassius auratus was exposed to 0.748 mg/l (1/10 of 24 $hr-LC_{50}$) and 1.496 mg/l of Pb (1/5 of 24 $hr-LC_{50}$) for 7 days, the bioconcentration factors (BCF) were 79.14 and 100.11 for Pb, respectively. The BCF of Pb was obtained as a linearity according to the concentration and exposure time as follows log BCF=1.014 log $P\cdot T$+1.011 ($r^2$=0.9041) where, P: pollutant concentration(mg/l) T: exposure time(day) 4. When Carassius auratus was pxposed to 0.0666 mg/l (1/10 of 24 $hr-LC_{50}$) and 0.1332 mg/l of Cu (1/5 of 24 $hr-LC_{50}$) for 7 days, the bioconcentration factors (BCF) were 55.42 and 63.24 for Cu respectively. The BCF of Cu was obtained as a linearity according to the concentration and exposure time as follows log BCF=0.571 log $P\cdot T$+1.823 ($r^2$=0.8974) where, P: polutant concentration(mg/l) T: exposure time(day)

• 전자공학회논문지
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• 제52권1호
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• pp.111-120
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• 2015

HDR(high dynamic range) 영상 생성은 실세계의 고명암비 영상을 재현하는 방법이다. Exposure fusion은 여러 HDR 영상 생성방법 중 한 가지로 true-HDR 영상을 생성하지 않고, 바로 pseudo-HDR 영상을 생성하는 방법이다. 그러나 노출이 다른 여러 입력영상들 중에서 이동하는 물체가 존재하면 잔상 효과가 발생하여 pseudo-HDR 영상의 화질 열화를 가져온다. 이러한 단점을 해결하기 위해 본 논문에서는 시간 영역에서 일치성 평가를 통한 무 잔상 exposure fusion을 제안하였다. 먼저 다중 역치 및 밝기를 이용한 비트맵과 색도 일관성 맵을 이용하여 각 입력 영상들간의 일치성을 평가하였고, 이를 시간 영역 가중치 맵으로 나타내었다. 그리고 기존 exposure fusion에서의 공간 영역 가중치 맵과 결합하여 최종 가중치 맵을 생성하였다. 마지막으로 각각 입력 영상에 최종 가중치 맵을 적용한 후, 합성하여 잔상이 제거된 pseudo-HDR 영상을 생성하였다. 실험을 통해 제안된 방법의 pseudo-HDR이 기존의 방법보다 잔상이 더 많이 제거되어 화질이 개선됨을 확인하였고, 객관적인 평가 방법인 기준 영상 대비 오차도 더 적게 나타남을 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제33권1호
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• pp.125-133
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• 2000

Objectives : This study uses meta-analysis methodology to examine the statistical consistency and importance of random variation among results of epidemiologic studies of occupational electromagnetic field exposure and leukemia. Methods : Studies for this meta-analysis were identified from previous reviews and by asking researcher active in this field for recommendations. Overall, 27 studies of occupational electromagnetic field exposures and leukemia were reviewed. A variety of meta-analysis statistical methods have been used to assess combined effects, to identify heterogeneity, and to provide a single summary risk estimate based on a set of simiar epidemiologic studies. In this study, classification of exposure metircs on occupational epidemiologic studies are reported for (1) job classification (20 individual studies); (2) leukemia subtypes (13 individual studies); and (3) country (27 individual studies). Results : Results of this study, an inverse-variance weighted pooling of all the data leads to a small but significant elevation in risk of f 1% (OR=1.11, 95% CI : $1.06\sim1.16$) among 27 occupational epidemiologic studies. Publication bias was assessed by the 'fail-safe n' that may be not influence for all combined results exception a few categories, ie, 'power station operators' and 'electric utility workers' by job classification on occupational study. And ail combined odds ratio results were similar for fixed-effects models and random-effects models, with slightly higher risk estimates for the random-effects model in situations where there was significant heterogeneity, ie, Q-statistic significant (p<.05). Conclusions : We found a small elevation in risk of leukemia, but the ubiquitous nature of exposure to electromagnetic fields from workplace makes even a weak association a public health issue of substantial power to influence the present overall conclusion about relationship between electromagnetic fields exposure and leukemia.

• 환경생물
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• 제27권2호
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• pp.140-145
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• 2009

All organisms are being exposed to harmful factors present in the environmental. The combined action of various factors is a distinguishing feature of modern life. An interaction between two chemicals is considered as synergistic when the effect produced is greater than the sum of the two single responses. The biological effects due to the combined action of ionizing radiation with the other factor are hard to estimate and predict in advance. In the current study, we investigated the synergistic effects between ionizing and $HgCl_2$ using fish hepatoma cells (PLHC-1 cells). The results showed a dramatic decrease of cell viability after simultaneous treatment of PLHC-1 cells with ionizing radiation and $HgCl_2$. Neiither of the two had any cytotoxic effect when treated alone. The cytotoxicity of ionizing radiation was enhanced in the presence of $HgCl_2$. The synergistic effects were observed after exposure of the PLHC-1 cells to ionizing radiation combined with $HgCl_2$. The synergistic interaction was due to an increase of irreversibly damaged cells after the combined exposure. Analysis of the extent of synergistic interaction enables to make quantitative estimation of irreversibly damaged cells after the combined exposure. The present study suggests that PLHC-1 cells can serve as rapid screening tools for detecting the toxicity of harmful factors.

• Safety and Health at Work
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• 제14권3호
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• pp.279-286
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• 2023

Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors. Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios. Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio = 1.45: 95% confidence interval = 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects. Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.