• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.23 no.5
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• pp.505-511
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• 2014

The functional role of warehouses in modern industry is changing from an established concept of storage to a concept of circulation. The target of this study is to improve the stacker crane's efficiency for the internal operations of the Automated Storage and Retrieval System (AS/RS). Eight operating schemes are proposed under the combination of three conditions, namely, the storing method, the layout type, and the sequence of command execution. The moving distance of the stacker crane is calculated using the same gateway data through a simulation based on a C# program. The optimal operating scheme is proposed based on the analyzed simulation results. In conclusion, the combination of conditions of random storage, two-way type warehouse, and dual command execution elicits optimum results in travel efficiency for the stacker crane.

• Bulletin of the Korean Mathematical Society
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• v.59 no.6
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• pp.1495-1510
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• 2022

This paper aims to investigate the initial boundary value problem of the nonlinear viscoelastic Petrovsky type equation with nonlinear damping and logarithmic source term. We derive the blow-up results by the combination of the perturbation energy method, concavity method, and differential-integral inequality technique.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.1
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• pp.111-122
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• 2003

The purpose of this study is to investigate the effect of clothing coloring and type of pants/skirt as clothing cues on impression of college female students. The experimental materials developed for this study are a set of stimuli and response scales. Thirty two color pictures of various combinations of colors for shirt, and colors and type of pants/skirt were manipulated on computer drawing. For visual evaluation of women's casual wears about colors and type, 7-point scales were designed. The subjects consist of 192 female and male undergraduate students in Chinju city. The results of this study can be summaried as follow: As analyzing the impression of female figure by the color of shirt and the color and type of pants/skirt, five factors including appearance valuation, concentration of attention, clearness, stability, and activity were found to be important. Color of shirt have significant effects on appearance valuation, concentration of attention, clearness, stability, and activity. Color of pants and shirt also have significant effects on all five factors. Especially, they strongest predictors for stability and activity. Type of pants/skirt significantly effects on concentration of attention and activity. In the effects of interactions between each variable, the combination of pants colors and type of pants/skirt had significant effects on appearance valuation, stability factors. Also shirt and pants colors had an significant effects on appearance valuation, stability, and activity. But in the impression formation of concentration of attention and clearness, only the combination of shirt colors and pants forms was more significant.

• Archives of design research
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• v.14 no.3
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• pp.145-154
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• 2001

These days, the products like Walkman, mobile phone, notebook PC, PDA are moving together with our body, and in the imaginary world like internet, our other self, Avatar is moving in place of our body on the cyber world. These products are related with our human body, and when considering the ones, attached to the human body, and having the meaning of mental combination like these, as the combination of the human and the products, it is necessary to examine these products in approaching them with respect to the combination relation between the human and the products. As a result of examining we can understand that the products, said to combine with the human body, are coming oui steadily. and recently, the inclination on the combination and the movement appears strongly. As this background, there are a breakdown of dichotomy thought, mixed sexual imitation, cyber culture, techno culture. concept of informative nomands, phenomenon which the division of human and machine becomes vague. and the miniaturization of products. imitation of human, phenomenon that the Inclination on the combination with human is more accelerated by networking. These products combine with human body at each wearing type in the various forms. Its functions become multi-layered, and closer to the human body physically. or its communication becomes high·graded and, they have the recombined form through the existing products which the human has And, they communicate each other. have the strong fashionable property, and the characteristics like the imaginary product to imitate the human body and substitute for the human behave.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.993-1001
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• 2016

Type 2 diabetes mellitus patients are at increased risk of many forms of malignancies, especially of the pancreas, colon and hepatocellular cancer. Unfortunately, little is known of the possible interaction between antidiabetic drugs and anticancer agents. The present study investigates the influence of metformin (MET) and sitagliptin (SITA) on the in vitro anticancer activity of the microtubule depolymerization inhibitor agent epothilone A (EpoA). Hepatocellular liver carcinoma cell line (HepG2) viability and apoptosis were determined by the MTT test and by double staining with PO-PRO-1 and 7-aminoactinomycin D, respectively, after treatment with EpoA, metformin or sitagliptin. The levels of nuclear factor NF-${\kappa}B$ and p53 were evaluated in the presence and absence of inhibitors. While EpoA and MET inhibited HepG2 cell proliferation, SITA did not. EpoA and SITA induced higher p53 levels than MET. All tested drugs increased the level of NF-${\kappa}B$. Only MET enhanced the proapoptotic effect of EpoA. The EpoA+MET combination evoked the highest cytotoxic effect on HepG2 cells and led to apoptosis independent of p53, decreasing the level of NF-${\kappa}B$. These findings support the link between NF-${\kappa}B$ and p53 in the modulation of apoptotic effects in HepG2 cells treated by EpoA. Our studies indicate that the combination of EpoA and MET applied in subtoxic doses has a stronger cytotoxic effect on liver cancer cells than each of the compounds alone. The therapeutic advantages of the combination of EpoA with MET may be valuable in the treatment of patients with diabetes mellitus type 2 (T2DM) and liver cancer.

• Korean Journal of Pharmacognosy
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• v.30 no.1
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• pp.40-47
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• 1999

To search for less toxic antiherpetic agents, the inhibitory effects of natural hesperetin on the plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Vero cells were examined by the plaque reduction assay in vitro. Hesperetin inhibited plaque formations of HSV-1 and HSV-2 in a dose dependent manner. It also exhibited more potent antiherpetic activity on HSV-2 with selectivity index (SI) of 9.8 than on HSV-1 with SI of 8.4. The combined antiherpetic effects of hesperetin with nucleoside antiherpetic agents, acyclovir and vidarabine, were examined on the multiplication of these two strains of herpesviruses in Vero cells by the combination assay. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combinations of hesperetin with acyclovir on HSV-1 and HSV-2 showed synergistic effects with CI values of $0.29{\sim}0.73$ for 50%, 70%, 90% effective levels and those with vidarabine showed partially synergistic or additive effects with CI values of $0.83{\sim}1.33$.

• The Korean Journal of Food And Nutrition
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• v.23 no.2
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• pp.141-146
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• 2010

Cisplatin(cis-diamminedichloroplatium) is one of the most effective anti-cancer drugs being clinically used in the treatment of solid tumors. Despite its therapeutic benefits, its use in clinical practice is often limited because of dose related toxicity. It is known that yeast cell wall beta-glucans possess immuno-modulating properties, which allows for their application in antitumor therapy. IS2 is a kind of beta-glucan derived from the cell wall of mutated Saccharomyces cerevisiae, which exhibits anti-cancer activity in vitro and in vivo. The present study explored the possibility of combination therapy of IS2 with cisplatin. In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of IS-2 in combination with cisplatin effectively inhibited tumor metastasis compared with cisplatin alone or IS-2 treatment in vivo. IS-2 effectively enhanced Th1 type cytokines including IFN-$\gamma$, IL-2, IL-12 and GM-CSF. Simultaneously, this combined treatment inhibited production of Th2 type cytokines compared with control. These results suggested that IS-2 can be applied in combination therapy with anti-cancer drugs to minimize their side effects.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.6
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• pp.490-494
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• 2004

An efficacy test of PRP (polyribosylribitol phosphate)-TT (Tetanus toxoid) conjugate vaccines was carried out using BALB/c mice as an animal model by inoculating Haemophilus in­fluenzae type b (Hib) with a virulence enhancement factor (VEF). Three administrations of the conjugate vaccines at 2-week intervals elicited a significantly high level of PRP antibodies (P>0.0001). The protective activity of the PRP immunization was challenged with either Hib with iron dextran (Hib/) or with a combination of mucin and hemoglobin (Hibmh) as a VEF. The me­dium lethal dose $(LD_{50})$ for Hibmh and Hibiwas measured as 10 CFU (Colony Forming Unit) and $2.5{\times}10^{8}$ CFU respectively. Each immunized animal was challenged with five or ten times the $LD_{50}$ level of bacteria with a VEF. A significant difference in mortality between the immunized and control mice (P> 0.01) was observed with the Hibmh challenge inoculation but not with the Hibi challenge inoculation. These results show that a combination of mucin and hemoglobin was able to enhance the virulence of Hib in BALB/c mice to cause a lethal infection, thus suggesting that BALB/c mice introduced to this method can be an effective model animal for testing the protective efficacy of H. influenzae conjugate vaccines.

• Journal of the Ergonomics Society of Korea
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• v.33 no.3
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• pp.241-253
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• 2014

Objective: The objective of this study was to examine multi-modal interaction effects of input-mode switching on the use of smart phones. Background: Multi-modal is considered as an efficient alternative for input and output of information in mobile environments. However, there are various limitations in current mobile UI (User Interface) system that overlooks the transition between different modes or the usability of a combination of multi modal uses. Method: A pre-survey determined five representative tasks from smart phone tasks by their functions. The first experiment involved the use of a uni-mode for five single tasks; the second experiment involved the use of a multi-mode for three dual tasks. The dependent variables were user preference and task completion time. The independent variable in the first experiment was the type of modes (i.e., Touch, Pen, or Voice) while the variable in the second experiment was the type of tasks (i.e., internet searching, subway map, memo, gallery, and application store). Results: In the first experiment, there was no difference between the uses of pen and touch devices. However, a specific mode type was preferred depending on the functional characteristics of the tasks. In the second experiment, analysis of results showed that user preference depended on the order and combination of modes. Even with the transition of modes, users preferred the use of multi-modes including voice. Conclusion: The order of combination of modes may affect the usability of multi-modes. Therefore, when designing a multi-modal system, the fact that there are frequent transitions between various mobile contents in different modes should be properly considered. Application: It may be utilized as a user-centered design guideline for mobile multi modal UI system.

• The Research Journal of the Costume Culture
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• v.12 no.3
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• pp.354-368
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• 2004

The purpose of this study is to investigate the effect of Shirts-color(Different-color, Same-color) and Hat color(Red, Blue, Beige, Grey), Hat design (Beret, Cloche, Bowler, and Capeline) on impression formation. The experimental materials developed for this study were a set of stimulus and response scales. The 7-point semantic thirty stimuli color pictures of various combination of hair length, hair style, and type of hat design were manipulated by computer drawing. The subjects were 360 undergraduates living in Seoul, Kyunggi and Kyungnam. The experimental design was composed of 3 factorial designs. The result of the study can be summarized as follows; Impression factor of the stimulus consisted of the 5 different dimensions. (concentration of attention, attractiveness, gracefulness, activity, tenderness). Concentration of attention, elegance, and tenderness in case of a hat as a clue, elegance and tenderness in case of the color of upper clothes as a clue, and all the factors except attractiveness and elegance in case of the type of hat as a clue were significant factors to differences of appearance. In regarding the effect of interaction between each variable, the combination of Hat color and Shirts-color had significant effects on tenderness, Hat color and type of hat design on concentration of attention, elegance and activity.